Jane Oliaro

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  The EMBO Journal

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Madison J Kelly, Jessica Michie, Lizzy Pijpers, Ricky W Johnstone, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cell Reports

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery

A Wilson, HD Law, CB Knobbe-Thomsen, CJ Kearney, J Oliaro, C Binsfeld, G Burgio, L Starrs, D Brenner, KL Randall, A Brustlel

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery

Alicia S Wilson, Hsei Di Law, Christiane B Knobbe-Thomsen, Conor J Kearney, Jane Oliaro, Carole Binsfeld, Gaetan Burgio, Lora Starrs, Dirk Brenner, Katrina L Randall, Anne Brustle

Journal article  |  2019  |  European Journal of Immunology

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy

Emily J Lelliott, Carleen Cullinane, Claire A Martin, Rachael Walker, Kelly M Ramsbottom, Fernando Souza-Fonseca-Guimaraes, Shatha Abuhammad, Jessica Michie, Laura Kirby, Richard J Young, Alison Slater, Peter Lau, Katrina Meeth, Jane Oliaro, Nicole Haynes, Grant A McArthur, Karen E Sheppard

Journal article  |  2019  |  Scientific Reports

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke, Jane Oliaro

Journal article  |  2017  |  Cell Death & Differentiation

DOCK8 Drives Src-Dependent NK Cell Effector Function

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Andrew J Freeman, Jessica Michie, Jane Peake, Jean-Laurent Casanova, Capucine Picard, Stuart G Tangye, Cindy S Ma, Ricky W Johnstone, Katrina L Randall, Jane Oliaro

Journal article  |  2017  |  The Journal of Immunology

DOCK8 regulates signal transduction events to control immunity

Conor J Kearney, Katrina L Randall, Jane Oliaro

Journal article  |  2017  |  Cellular & Molecular Immunology

Scribble acts as an oncogene in E mu-myc-driven lymphoma

ED Hawkins, J Oliaro, KM Ramsbottom, A Newbold, PO Humbert, RW Johnstone, SM Russell

Journal article  |  2016  |  Oncogene

Lethal giant larvae-1 deficiency enhances the CD8( ) effector T-cell response to antigen challenge in vivo

Kelly M Ramsbottom, Faruk Sacirbegovic, Edwin D Hawkins, Axel Kallies, Gabrielle T Belz, Vanessa Van Ham, Nicole M Haynes, Michael J Durrant, Patrick O Humbert, Sarah M Russell, Jane Oliaro

Journal article  |  2016  |  Immunology and Cell Biology

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

Conor J Kearney, Kelly M Ramsbottom, Ilia Voskoboinik, Phillip K Darcy, Jane Oliaro

Journal article  |  2016  |  OncoImmunology

Asymmetric cell division during T cell development controls downstream fate

Pham Kim, Raz Shimoni, Mirren Charnley, Mandy J Ludford-Menting, Edwin D Hawkins, Kelly Ramsbottom, Jane Oliaro, David Izon, Stephen B Ting, Joseph Reynolds, Grant Lythe, Carmen Molina-Paris, Heather Melichar, Ellen Robey, Patrick O Humbert, Min Gu, Sarah M Russell

Journal article  |  2015  |  The Journal of Cell Biology

The Role of the Immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor Immunity

Conor J Kearney, Amelia J Brennan, Phillip K Darcy, Jane Oliaro

Journal article  |  2015  |  Critical Reviews in Immunology

A Method for Detecting Intracellular Perforin in Mouse Lymphocytes

Amelia J Brennan, Imran G House, Jane Oliaro, Kelly M Ramsbottom, Magdalena Hagn, Hideo Yagita, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2014  |  The Journal of Immunology

Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia

Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell

Journal article  |  2014  |  PLoS ONE

Cutting Edge: DNAX Accessory Molecule 1-Deficient CD8 T Cells Display Immunological Synapse Defects That Impair Antitumor Immunity

Kelly M Ramsbottom, Edwin D Hawkins, Raz Shimoni, Mairi McGrath, Christopher J Chan, Sarah M Russell, Mark J Smyth, Jane Oliaro

Journal article  |  2014  |  The Journal of Immunology

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity

Edwin D Hawkins, Jane Oliaro, Axel Kallies, Gabrielle T Belz, Andrew Filby, Thea Hogan, Nicole Haynes, Kelly M Ramsbottom, Vanessa Van Ham, Tanja Kinwell, Benedict Seddon, Derek Davies, David Tarlinton, Andrew M Lew, Patrick O Humbert, Sarah M Russell

Journal article  |  2013  |  Nature Communications

Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function

Ivan Fung, Sarah M Russell, Jane Oliaro

Journal article  |  2012  |  Clinical & Developmental Immunology

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

Katrina L Randall, Stephanie S-Y Chan, Cindy S Ma, Ivan Fung, Yan Mei, Mehmet Yabas, Andy Tan, Peter D Arkwright, Wafaa Al Suwairi, Saul Oswaldo Lugo Reyes, Marco A Yamazaki-Nakashimada, Maria de la Luz Garcia-Cruz, Joanne M Smart, Capucine Picard, Satoshi Okada, Emmanuelle Jouanguy, Jean-Laurent Casanova, Teresa Lambe, Richard J Cornall, Sarah Russell, et al.

Journal article  |  2011  |  Journal of Experimental Medicine

Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues

Heather J Melichar, Ou Li, Paul Herzmark, Raghav K Padmanabhan, Jane Oliaro, Mandy J Ludford-Menting, Philippe Bousso, Sarah M Russell, Badrinath Roysam, Ellen A Robey

Journal article  |  2011  |  Immunology and Cell Biology

Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

John T Chang, Maria L Ciocca, Ichiko Kinjyo, Vikram R Palanivel, Courtney E McClurkin, Caitlin S De Jong, Erin C Mooney, Jiyeon S Kim, Natalie C Steinel, Jane Oliaro, Catherine C Yin, Bogdan I Florea, Herman S Overkleeft, Leslie J Berg, Sarah M Russell, Gary A Koretzky, Martha S Jordan, Steven L Reiner

Journal article  |  2011  |  Immunity

The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts.

Mandy J Ludford-Menting, Blessing Crimeen-Irwin, Jane Oliaro, Anupama Pasam, David Williamson, Natalie Pedersen, Patricia Guillaumot, Dale Christansen, Serge Manie, Katharina Gaus, Sarah M Russell

Journal article  |  2011  |  Journal of Lipids

Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now bei..

CD46 signaling in T cells: Linking pathogens with polarity

Edwin D Hawkins, Jane Oliaro

Journal article  |  2010  |  FEBS Letters

Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms

Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Kim Pham, Mandy J Ludford-Menting, Nigel J Waterhouse, Michael Bots, Edwin D Hawkins, Sally V Watt, Leonie A Cluse, Chris JP Clarke, David J Izon, John T Chang, Natalie Thompson, Min Gu, Ricky W Johnstone, Mark J Smyth, Patrick O Humbert, et al.

Journal article  |  2010  |  Journal of Immunology

A method for prolonged imaging of motile lymphocytes

Daniel Day, Kim Pham, Mandy J Ludford-Menting, Jane Oliaro, David Izon, Sarah M Russell, Min Gu

Journal article  |  2009  |  Immunology and Cell Biology

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

KA Sedelies, A Ciccone, CJP Clarke, J Oliaro, VR Sutton, FL Scott, J Silke, O Susanto, DR Green, RW Johnstone, PI Bird, JA Trapani, NJ Waterhouse

Journal article  |  2008  |  Cell Death & Differentiation

Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation

Jane Oliaro, Anupama Pasam, Nigel J Waterhouse, Kylie A Browne, Mandy J Ludford-Menting, Joseph A Trapani, Sarah M Russell

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

A 'polarized' look at alpha-tubulin cleavage by granzyme B

NJ Waterhouse, J Oliaro, MJ Pinkoski

Journal article  |  2006  |  Cell Death & Differentiation

Compartmentalization in T-cell signalling: Membrane microdomains and polarity orchestrate signalling and morphology

S Russell, J Oliaro

Journal article  |  2006  |  Immunology and Cell Biology

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation

MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, SJ Thomas, A Pasam, R Iazzolino, LE Dow, NJ Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert, SM Russell

Journal article  |  2005  |  Immunity