Jane Oliaro

NKG7 Enhances CD8 T Cell Synapse Efficiency to Limit Inflammation

Emily J Lelliott, Kelly M Ramsbottom, Mark R Dowling, Carolyn Shembrey, Tahereh Noori, Conor J Kearney, Jessica Michie, Ian A Parish, Margaret A Jordan, Alan G Baxter, Neil D Young, Amelia J Brennan, Jane Oliaro

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer c..

BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Lisa C Wellinger, Simon J Hogg, Dane M Newman, Thomas Friess, Daniela Geiss, Jessica Michie, Kelly M Ramsbottom, Marina Bacac, Tanja Fauti, Daniel Marbach, Laura Jarassier, Phillip Thienger, Axel Paehler, Leonie A Cluse, Conor J Kearney, Stephin J Vervoort, Joseph A Trapani, Jane Oliaro, Jake Shortt, Astrid Ruefli-Brasse, et al.

Journal article  |  2022  |  CANCER IMMUNOLOGY RESEARCH

Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well..

Unleashing TNF cytotoxicity to enhance cancer immunotherapy

Andrew J Freeman, Conor J Kearney, John Silke, Jane Oliaro

Journal article  |  2021  |  TRENDS IN IMMUNOLOGY

Tumor necrosis factor (TNF) is a proinflammatory cytokine that is produced and secreted by cytotoxic lymphocytes upon tumor target..

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W Johnstone, et al.

Journal article  |  2021  |  CANCER DISCOVERY

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive brea..

HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis

Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro

Journal article  |  2021  |  EMBO REPORTS

The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which t..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance

Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..

Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma

Emily J Lelliott, Grant A McArthur, Jane Oliaro, Karen E Sheppard

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

The recent advent of targeted and immune-based therapies has revolutionized the treatment of melanoma and transformed outcomes for..

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Izabela Todorovski, Emily J Lelliott, Magnus Zethoven, Lizzy Pijpers, Ben P Martin, Timothy Semple, Luciano Martelotto, Joseph A Trapani, Ian A Parish, Nichollas E Scott, Jane Oliaro, Ricky W Johnstone

Journal article  |  2021  |  SCIENCE ADVANCES

Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular different..

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Emily J Lelliott, Stefano Mangiola, Kelly M Ramsbottom, Magnus Zethoven, Lydia Lim, Peter KH Lau, Amanda J Oliver, Luciano G Martelotto, Laura Kirby, Claire Martin, Riyaben P Patel, Alison Slater, Carleen Cullinane, Anthony T Papenfuss, Nicole M Haynes, Grant A McArthur, Jane Oliaro, Karen E Sheppard

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

Combined inhibition of BRAF, MEK, and CDK4/6 is currently under evaluation in clinical trials for patients with melanoma harboring..