Michael Berk

Translational evidence for the Inflammatory Response System (IRS)/Compensatory Immune Response System (CIRS) and neuroprogression theory of major depression.

Monojit Debnath, Michael Berk, Michael Maes

Journal article  |  2021  |  Prog Neuropsychopharmacol Biol Psychiatry

Major depressive disorder (MDD) is a common, severe and disabling neuropsychiatric disorder with a heterogenous etiology. Among th..

Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial.

Chiara C Bortolasci, Alyna Turner, Mohammadreza Mohebbi, Zoe Sj Liu, Melanie Ashton, Laura Gray, Wolfgang Marx, Adam J Walker, Greg M Kowalski, Felice Jacka, Michael Berk, Olivia M Dean, Ken Walder

Journal article  |  2021  |  J Psychiatr Res

N-acetylcysteine (NAC) acts on glutamatergic and redox systems, two systems implicated in the pathophysiology of bipolar disorder ..

Statins: Neurobiological underpinnings and mechanisms in mood disorders

Adam J Walker, Yesul Kim, Igor Borissiouk, Rodolfo Rehder, Seetal Dodd, Gerwyn Morris, Andrew A Nierenberg, Michael Maes, Brisa S Fernandes, Olivia M Dean, Lana J Williams, Harris A Eyre, Sung-Wan Kim, Sophia Zoungas, Andre F Carvalho, Michael Berk

Journal article  |  2021  |  NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) treat dyslipidaemia and cardiovascular disease by inhibiting ..

The lipid paradox in neuroprogressive disorders: Causes and consequences.

Gerwyn Morris, Michael Berk, Ken Walder, Adrienne O'Neil, Michael Maes, Basant K Puri

Journal article  |  2021  |  Neurosci Biobehav Rev

Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density ..

Anticonvulsant use and fracture: a case-control study

Vinoomika Chandrasekaran, Amanda L Stuart, Julie A Pasco, Sharon L Brennan-Olsen, Michael Berk, Jason M Hodge, Rasika M Samarasinghe, Lana J Williams

Journal article  |  2021  |  JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS

OBJECTIVES: We aimed to investigate fracture risk associated with anticonvulsant use in a population-based sample of men and women..

Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Michael Bauer, Tasha Glenn, Eric D Achtyes, Martin Alda, Esen Agaoglu, Kursat Altinbas, Ole A Andreassen, Elias Angelopoulos, Raffaella Ardau, Edgar Arrua Vares, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P Behere, Prakash B Behere, Habte Belete, et al.

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS

BACKGROUND: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous explorato..

Biological mechanism(S) underpinning the association between antipsychotic drugs and weight gain

B Panizzutti, CC Bortolasci, B Spolding, S Kidnapillai, T Connor, MF Richardson, TTT Truong, ZSJ Liu, L Gray, JH Kim, OM Dean, M Berk, K Walder

Journal article  |  2021  |  Journal of Clinical Medicine

Weight gain and consequent metabolic alterations are common side-effects of many antipsychotic drugs. Interestingly, several studi..

A protocol for the first episode psychosis outcome study (FEPOS): >= 15 year follow-up after treatment at the Early Psychosis Prevention and Intervention Centre, Melbourne, Australia

Sue Cotton, Kate Filia, Amity Watson, Andrew J Mackinnon, Leanne Hides, John FM Gleeson, Michael Berk, Philippe Conus, Martin Lambert, Benno Schimmelmann, Helen Herrman, Victoria Rayner, Aswin Ratheesh, Patrick D McGorry

Journal article  |  2021  |  EARLY INTERVENTION IN PSYCHIATRY

BACKGROUND: Specialist early intervention (SEI) service models are designed to treat symptoms, promote social and vocational recov..

Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response

Gerwyn Morris, Elizabeth Gamage, Nikolaj Travica, Michael Berk, Felice N Jacka, Adrienne O'Neil, Basant K Puri, Andre F Carvalho, Chiara C Bortolasci, Ken Walder, Wolfgang Marx

Journal article  |  2021  |  FREE RADICAL BIOLOGY AND MEDICINE

The pathophysiology of psychiatric and neurodegenerative disorders is complex and multifactorial. Polyphenols possess a range of p..

Gender, age at onset and duration of being ill as predictors for the long-term course and outcome of Schizophrenia: An international multi-center study.

Konstantinos N Fountoulakis, Elena Dragioti, Antonis T Theofilidis, Tobias Wiklund, Xenofon Atmatzidis, Ioannis Nimatoudis, Erik Thys, Martien Wampers, Luchezar Hranov, Trayana Hristova, Daniil Aptalidis, Roumen Milev, Felicia Iftene, Filip Spaniel, Pavel Knytl, Petra Furstova, Tiina From, Henry Karlsson, Maija Walta, Raimo KR Salokangas, et al.

Journal article  |  2021  |  CNS Spectr

Introduction: The aim of the current study was to explore the effect of gender, age at onset and duration on the long term course ..