Prof Michael Berk

Professor Michael Berk is currently a NHMRC Senior Principal research Fellow, and is Alfred Deakin Chair of Psychiatry at Deakin University and Barwon Health, where he heads the IMPACT Strategic Research Centre. He also is an Honorary Professorial Research fellow in the Department of Psychiatry, the Florey Institute for Neuroscience and Mental Health and Orygen Youth Health at Melbourne University, as well as in the School of Public Health and Preventive Medicine at Monash University.

He is past president of the International Society for Bipolar disorders and the Australasian Society or Bipolar and Depressive Disorders. He is an ISI highly cited researcher who has published over 800 papers predominantly in mood disorders. His major interests are in the discovery and implementation of novel therapies, and risk factors and prevention of psychiatric disorders. He is the recipient of a number of national and international awards including the Brain and behaviour Foundation Colvin prize, and holds grants from the National Institutes of Health (US), Simon Autism Foundation, NHMRC CRE and project grants, Beyondblue and Stanley Medical Research Institute and is a lead investigator in a Collaborative Research Centre.

Find out more about Michael Berk's experience

Michael Berk's highlights

FEATURED Journal article

A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder

Michael Berk's selected work

[[A.I Role Only]] - N-Acetylcysteine In Bipolar Depression

Research Grant

Supplements supercharge antidepressants

NEWS ARTICLE

Induced ketosis as a treatment for neuroprogressive disorders: Food for thought?

Journal article

Termination - Depression And Physical Illness: The Link With Pain, Cardiovascular Risk Fac..

Research Contracts

Neurodevelopmental pathways in bipolar disorder.

Journal article

1/2 A Randomized Trial Of Internet Based Interventions For Bipolar Disorder

Research Grant

Projects

Displaying the 16 most recent projects by Michael Berk.

[[A.I Role Only]] - N-Acetylcysteine In Bipolar Depression

The brain's antioxidant defences, particularly glutathione, are reduced in bipolar disorder. Treatment with N-acetylcysteine (NAC), a natura..

2012 - 2015

Completed

Termination - Depression And Physical Illness: The Link With Pain, Cardiovascular Risk Factors And Osteoporosis

2012

Active

1/2 A Randomized Trial Of Internet Based Interventions For Bipolar Disorder

2011 - 2017

Completed

Project 4.7 - Biomarkers For Other Psychiatric Disorders

2011 - 2018

Completed

Project 4.8 - Biomarkers And Intervention Of Oxidative Stress In Clinical Trials

2011 - 2015

Completed

Neuroprotective Properties Of Quetiapine Vs. Lithium In A First-Episode Mania Cohort: 12 Month Neurocognitive Effects And Preliminary Data Of Prophylactic Properties

2008 - 2011

Completed

The Vital D Study - Mental Health Substudy

Vitamin D is commonly deficient in Western populations, more so in the winter months and in the elderly. A link between depression and vitam..

2008 - 2008

Completed

The Link Between Depression And Osteoporosis.

Both depression and osteoporosis are common, debilitating and expensive diseases and there is research to suggest that these conditions are ..

2008 - 2010

Completed

Letter Of Agreement B/W UOM And Southern Health - Neuroprotective Properties Of Quetiapine Vs. Lithium In A First-Episode Mania Cohort: 12 Month Neuroanatomical, Neurochemical, And Neurocognitive Effects And Preliminary Data Of Prophylactic Properties

Efficacy Of Agomelatine (25 To 50 Mg/Day) Given Orally On Quality Of Remission In Elderly Depressed Patients, After A 12-Week Treatment Period

Depression And Physical Illness: The Link With Pain, Cardiovascular Risk Factors And Osteoporosis

Bipolar Depression Rating Scale

Neuroprotective Properties Of Quetiapine Vs. Lithium In A First-Episode Mania Cohort: 12 Month Neuroanatomical, Neurochemical, And Neurocognitive Effects And Preliminary Data Of Prophylactic Properties

Olanzapine Versus Mood Stabilizers In The Treatment & Outcome Of Outpatients With Bipolar 1 Disorder

Neuroprotective Properties Of Quetiapine Vs. Lithium In A First-Episode Mania Cohort: 12 Month Neurocognitive Effects And Preliminary Data Of Prophylactic Properties

Completed

A Randomised Trial Of Internet Based Interventions For Bipolar Disorder

Completed

16

Projects

Project Types

Research Contracts

Research Grant

Scholarly Works

Displaying the 1400 most recent scholarly works by Michael Berk.

A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder

TW Guu, D Mischoulon, J Sarris, J Hibbeln, RK McNamara, K Hamazaki, MP Freeman, M Maes, YJ Matsuoka, RH Belmaker, W Marx, C Pariante, M Berk, F Jacka, KP Su

Journal article | 2020 | Journal of Affective Disorders

Induced ketosis as a treatment for neuroprogressive disorders: Food for thought?

Gerwyn Morris, Basant K Puri, Andre Carvalho, Michael Maes, Michael Berk, Anu Ruusunen, Lisa Olive

Journal article | 2020 | International Journal of Neuropsychopharmacology

Induced ketosis (or ketone body ingestion) can ameliorate several changes associated with neuroprogressive disorders including sch..

Neurodevelopmental pathways in bipolar disorder.

Stefan Kloiber, Joshua D Rosenblat, Muhammad I Husain, Abigail Ortiz, Michael Berk, Joao Quevedo, Eduard Vieta, Michael Maes, Boris Birmaher, Jair C Soares, Andre F Carvalho

Journal article | 2020 | Neuroscience & Biobehavioral Reviews

Aberrations in neurodevelopmental trajectories have been implicated in the neurobiology of several mental disorders and evidence i..

Differences in the immune-inflammatory profiles of unipolar and bipolar depression

Andre R Brunoni, Thitiporn Supasitthumrong, Antonio Lucio Teixeira, Erica LM Vieira, Wagner F Gattaz, Isabela M Bensenor, Paulo A Lotufo, Beny Lafer, Michael Berk, Andre F Carvalho, Michael Maes

Journal article | 2020 | Journal of Affective Disorders

BACKGROUND: Major depressive disorder (MDD) and bipolar depression (BD) both share increased immune-inflammatory activation. Howev..

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study

Bruno Agustini, Mohammadreza Mohebbi, Robyn L Woods, John J McNeil, Mark R Nelson, Raj C Shah, Anne M Murray, Michael E Ernst, Christopher M Reid, Andrew Tonkin, Jessica E Lockery, Michael Berk

Journal article | 2020 | Journal of Human Hypertension

Cardiovascular drugs impact many pathways involved in depression pathophysiology and treatment. However, their distinct impact on ..

The effect of combined treatment with SSRIs and renin-angiotensin system (RAS) drugs: A propensity score matched cohort study.

Ole Köhler-Forsberg, Liselotte Petersen, Michael Berk, Christiane Gasse, Søren Dinesen Østergaard

Journal article | 2020 | European Neuropsychopharmacology

Drugs acting on the renin-angiotensin system (RAS) may have beneficial effects on mental health. We investigated whether use of dr..

Mental, behavioral and neurodevelopmental disorders in the ICD-11: an international perspective on key changes and controversies.

Dan J Stein, Peter Szatmari, Wolfgang Gaebel, Michael Berk, Eduard Vieta, Mario Maj, Ymkje Anna de Vries, Annelieke M Roest, Peter de Jonge, Andreas Maercker, Chris R Brewin, Kathleen M Pike, Carlos M Grilo, Naomi A Fineberg, Peer Briken, Peggy T Cohen-Kettenis, Geoffrey M Reed

Journal article | 2020 | BMC Medicine

An update of the chapter on Mental, Behavioral and Neurodevelopmental Disorders in the International Classification of Diseases an..

Clozapine and the Course of Bipolar Disorder in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Marta H Costa, Mauricio Kunz, Andrew A Nierenberg, Thilo Deckersbach, Michael Berk, Pedro VS Magalhaes

Journal article | 2020 | The Canadian Journal of Psychiatry

Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses.

J Velosa, A Delgado, E Finger, M Berk, F Kapczinski, T de Azevedo Cardoso

Journal article | 2020 | Acta Psychiatrica Scandinavica

OBJECTIVES: To assess whether bipolar disorder (BD) increases the rate of dementia and whether lithium is related to a lower risk ..

Youth Depression Alleviation with Anti-inflammatory Agents (YoDA-A): a randomised clinical trial of rosuvastatin and aspirin.

Michael Berk, Mohammadreza Mohebbi, Olivia M Dean, Sue M Cotton, Andrew M Chanen, Seetal Dodd, Aswin Ratheesh, G Paul Amminger, Mark Phelan, Amber Weller, Andrew Mackinnon, Francesco Giorlando, Shelley Baird, Lisa Incerti, Rachel E Brodie, Natalie O Ferguson, Simon Rice, Miriam R Schäfer, Edward Mullen, Sarah Hetrick, et al.

Journal article | 2020 | BMC Medicine

BACKGROUND: Inflammation contributes to the pathophysiology of major depressive disorder (MDD), and anti-inflammatory strategies m..

Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurite outgrowth

Srisaiyini Kidnapillai, Ben Wade, Chiara C Bortolasci, Bruna Panizzutti, Briana Spolding, Timothy Connor, Tamsyn Crowley, Stephane Jamain, Laura Gray, Marion Leboyer, Michael Berk, Ken Walder

Journal article | 2020 | Journal of Psychopharmacology

BACKGROUND: The drugs commonly used to treat bipolar disorder have limited efficacy and drug discovery is hampered by the paucity ..

Vitamin D supplementation compared to placebo in people with First Episode psychosis - Neuroprotection Design (DFEND): a protocol for a randomised, double-blind, placebo-controlled, parallel-group trial.

Fiona Gaughran, Dominic Stringer, Michael Berk, Shubulade Smith, David Taylor, Eromona Whiskey, Sabine Landau, Robin Murray, Philip McGuire, Poonam Gardner-Sood, Gabriella Wojewodka, Simone Ciufolini, Harriet Jordan, Jessie Clarke, Lauren Allen, Amir Krivoy, Brendon Stubbs, Philippa Lowe, Maurice Arbuthnott, Shanaya Rathod, et al.

Journal article | 2020 | Trials

BACKGROUND: People experiencing their first episode of psychosis are often deficient in vitamin D. Observational studies have repo..

TinyFSCV: FSCV for the Masses

Scott D Adams, Egan H Doeven, Susannah J Tye, Kevin E Bennet, Michael Berk, Abbas Z Kouzani

Journal article | 2020 | IEEE Transactions on Neural Systems and Rehabilitation Engineering

Opportunities in the Australian national education initiative for promoting mental health in schools

Erin Hoare, Andrew Thorp, Nadine Bartholomeusz-Raymond, Alicia McCoy, Michael Berk

Journal article | 2020 | The Lancet Child & Adolescent Health

Depression, stress and vascular function from childhood to adolescence: A longitudinal investigation

Lisa S Olive, Walter P Abhayaratna, Don Byrne, Rohan M Telford, Michael Berk, Richard D Telford

Journal article | 2020 | General Hospital Psychiatry

BACKGROUND: Psychological distress is associated with risk markers for cardiovascular disease, including increased arterial stiffn..

Impact of antipsychotic medication on IL-6/STAT3 signaling axis in peripheral blood mononuclear cells of drug-naive schizophrenia patients

Manjula Subbanna, Venkataram Shivakumar, Deepthi Venugopal, Janardhanan C Narayanaswamy, Michael Berk, Shivarama Varambally, Ganesan Venkatasubramanian, Monojit Debnath

Journal article | 2020 | Psychiatry and Clinical Neurosciences

AIM: Immunopathogenesis remains a widely appreciated etiopathological model of schizophrenia. Persistent efforts have aimed to ide..

The compensatory antioxidant response system with a focus on neuroprogressive disorders

Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Berk, Ken Walder, Chiara C Bortolasci, Wolfgang Marx, Andre F Carvalho, Michael Maes

Journal article | 2019 | Progress in Neuro-Psychopharmacology and Biological Psychiatry

Major antioxidant responses to increased levels of inflammatory, oxidative and nitrosative stress (ONS) are detailed. In response ..

Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia

Caitlin OB Yolland, Donal Hanratty, Erica Neill, Susan L Rossell, Michael Berk, Olivia M Dean, David J Castle, Eric J Tan, Andrea Phillipou, Anthony WF Harris, Ana Rita Barreiros, Abigail Hansen, Dan Siskind

Journal article | 2019 | Australian & New Zealand Journal of Psychiatry

Association between childhood trauma exposure and pro-inflammatory cytokines in schizophrenia and bipolar-I disorder.

Yann Quidé, Chiara C Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Oliver J Watkeys, Sarah Cohen-Woods, Michael Berk, Vaughan J Carr, Ken Walder, Melissa J Green

Journal article | 2019 | Psychological Medicine

BACKGROUND: Elevated levels of pro-inflammatory cytokines are consistently reported in schizophrenia (SZ) and bipolar-I disorder (..

Improving functional outcomes in early-stage bipolar disorder: The protocol for the REsearch into COgnitive and behavioural VERsatility trial

Sue M Cotton, Michael Berk, Henry Jackson, Greg Murray, Kate Filia, Melissa Hasty, Andrew Chanen, Christopher Davey, Barnaby Nelson, Aswin Ratheesh, Craig MacNeil

Journal article | 2019 | Early Intervention in Psychiatry

AIM: Young people with bipolar disorder (BD) commonly experience reduced quality of life, persistent symptoms and impaired functio..

An immune gate of depression - Early neuroimmune development in the formation of the underlying depressive disorder

Malgorzata Kowalczyk, Janusz Szemraj, Katarzyna Blizniewska, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki

Journal article | 2019 | Pharmacological Reports

The prevalence of depression worldwide is increasing from year to year and constitutes a serious medical, economic and social prob..

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Chiara C Bortolasci, Ken Walder, Michael Berk

Journal article | 2019 | Neuroscience & Biobehavioral Reviews

Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and consequent mitochondrial aberrations are invo..

Physical Activity as a Predictor of Clinical Trial Outcomes in Bipolar Depression: A Subanalysis of a Mitochondrial-Enhancing Nutraceutical Randomized Controlled Trial

Melanie M Ashton, Mohammadreza Mohebbi, Alyna Turner, Wolfgang Marx, Michael Berk, Gin S Malhi, Chee H Ng, Sue M Cotton, Seetal Dodd, Jerome Sarris, Malcolm Hopwood, Brendon Stubbs, Olivia M Dean

Journal article | 2019 | The Canadian Journal of Psychiatry

OBJECTIVES: Individuals with bipolar disorder (BD) generally engage in low levels of physical activity (PA), and yet few studies h..

ENACT: a protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis

SM Cotton, M Berk, A Watson, S Wood, K Allott, CF Bartholomeusz, CC Bortolasci, K Walder, B O'Donoghue, OM Dean, A Chanen, GP Amminger, PD McGorry, A Burnside, J Uren, A Ratheesh, S Dodd

Journal article | 2019 | Trials

BACKGROUND: First-episode psychosis (FEP) may lead to a progressive, potentially disabling and lifelong chronic illness; however, ..

Depression in the medically ill

Joshua D Rosenblat, Paul Kurdyak, Fiammetta Cosci, Michael Berk, Michael Maes, Andre R Brunoni, Madeline Liz, Gary Rodinz, Roger S McIntyre, Andre F Carvalho

Journal article | 2019 | Australian & New Zealand Journal of Psychiatry

BACKGROUND: Depressive disorders are significantly more common in the medically ill compared to the general population. Depression..

S-Adenosylmethionine (SAMe) monotherapy for depression: an 8-week double-blind, randomised, controlled trial

Jerome Sarris, Jenifer Murphy, Con Stough, David Mischoulon, Chad Bousman, Patricia MacDonald, Laura Adams, Sonia Nazareth, Georgina Oliver, Lachlan Cribb, Karen Savage, Ranjit Menon, Suneel Chamoli, Michael Berk, Chee H Ng, Gerard J Byrne

Journal article | 2019 | Psychopharmacology

RATIONALE: Dysregulation of the one carbon cycle is documented in depression. Thereby, S-adenosylmethionine (SAMe), a one-carbon c..

The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review.

Wolfgang Marx, Meghan Hockey, Amelia J McGuinness, Melissa Lane, John Christodoulou, Ingrid van der Mei, Michael Berk, Olivia M Dean, Bruce Taylor, Simon Broadley, Jeannette Lechner-Scott, Felice N Jacka, Robyn M Lucas, Anne-Louise Ponsonby, undefined RELIEF Trial team

Journal article | 2019 | Multiple Sclerosis and Related Disorders

BACKGROUND: Due to the considerable burden of multiple sclerosis (MS)-related symptoms and the need to identify effective interven..

The open access mandate: Be careful what you wish for

Bruno Agustini, Michael Berk

Journal article | 2019 | Australian & New Zealand Journal of Psychiatry

A STUDY PROTOCOL FOR THE N-ICE TRIAL: A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY OF THE SAFETY AND EFFICACY OF N-ACETYL-CYSTEINE AS A PHARMACOTHERAPY FOR METHAMPHETAMINE DEPENDENCE

Rebecca McKetin, Olivia M Dean, Alyna Turner, Peter J Kelly, Brendan Quinn, Dan I Lubman, Paul M Dietze, Gregory Carter, Peter Higgs, Amanda L Baker, Barbara Sinclair, David Reid, Victoria Manning, Nina Te Pas, Wenbin Liang, Tamsin Thomas, Ramez Bathish, Margaret Kent, Dayle K Raftery, Shalini Arunogiri, et al.

Conference Proceedings | 2019 | DRUG AND ALCOHOL REVIEW

Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study

Konstantinos N Fountoulakis, Elena Dragioti, Antonis T Theofilidis, Tobias Wikilund, Xenofon Atmatzidis, Ioannis Nimatoudis, Erik Thys, Martien Wampers, Luchezar Hranov, Trayana Hristova, Daniil Aptalidis, Roumen Milev, Felicia Iftene, Filip Spaniel, Pavel Knytl, Petra Furstova, Tiina From, Henry Karlsson, Maija Walta, Raimo KR Salokangas, et al.

Journal article | 2019 | International Journal of Neuropsychopharmacology

INTRODUCTION: A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current st..

Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive N-acetylcysteine and mitochondrial agents in adults with bipolar disorder: A sub-study of a randomised placebo-controlled trial

Melanie M Ashton, Olivia M Dean, Wolfgang Marx, Mohammadreza Mohebbi, Michael Berk, Gin S Malhi, Chee H Ng, Sue M Cotton, Seetal Dodd, Jerome Sarris, Malcolm Hopwood, Keshav Faye-Chauhan, Yesul Kim, Sarah R Dash, Felice N Jacka, Nitin Shivappa, James R Hebert, Alyna Turner

Journal article | 2019 | Australian & New Zealand Journal of Psychiatry

AIMS: We aimed to explore the relationships between diet quality, dietary inflammatory potential or body mass index and outcomes o..

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis ? A possible therapeutic mechanism

Srisaiyini Kidnapillai, Chiara C Bortolasci, Bruna Panizzutti, Briana Spolding, Timothy Connor, Kamila Bonifacio, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stephane Jamain, Laura Gray, Marion Leboyer, Michael Berk, Ken Walder

Journal article | 2019 | The World Journal of Biological Psychiatry

Objectives: To understand the therapeutic mechanisms of bipolar disorder (BD) drugs at molecular and cellular levels. Methods: Nex..

Does N-acetylcysteine improve behaviour in children with autism?: A mixed-methods analysis of the effects of N-acetylcysteine

Olivia M Dean, Kylie Gray, Seetal Dodd, Kristi-Ann Villagonzalo, Ellie Brown, Bruce Tonge, Michael Berk, Linda K Byrne

Journal article | 2019 | Journal of Intellectual & Developmental Disability

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials

Joseph Firth, Scott B Teasdale, Kelly Allott, Dan Siskind, Wolfgang Marx, Jack Cotter, Nicola Veronese, Felipe Schuch, Lee Smith, Marco Solmi, Andre F Carvalho, Davy Vancampfort, Michael Berk, Brendon Stubbs, Jerome Sarris

Journal article | 2019 | World Psychiatry

Early intervention for bipolar disorder - Do current treatment guidelines provide recommendations for the early stages of the disorder?

Chia Ming Fang, Sue Cotton, Kate Filia, Mark Phelan, Philippe Conus, Sameer Jauhar, Steven Marwaha, Patrick D McGorry, Christopher Davey, Michael Berk, Aswin Ratheesh

Journal article | 2019 | Journal of Affective Disorders

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

Oliver D Robertson, Nieves G Coronado, Rickinder Sethi, Michael Berk, Seetal Dodd

Journal article | 2019 | Early Intervention in Psychiatry

AIM: Neuropsychiatric disorders including depression, bipolar and schizophrenia frequently exhibit a neuroprogressive course from ..

Emerging role of innate B1 cells in the pathophysiology of autoimmune and neuroimmune diseases: Association with inflammation, oxidative and nitrosative stress and autoimmune responses

Gerwyn Morris, Basant K Puri, Lisa Olive, Andre F Carvalho, Michael Berk, Michael Maes

Journal article | 2019 | Pharmacological Research

B1 lymphocytes may be subdivided by CD5 and CD11b/Mac1 expression into B1a, with the CD5 and CD11b/Mac1 phenotype, and B1b, which ..

The case for improved care and provision of treatment for people with first-episode mania

Sameer Jauhar, Aswin Ratheesh, Christopher Davey, Lakshmi N Yatham, Patrick D McGorry, Phillip McGuire, Michael Berk, Allan H Young

Journal article | 2019 | The Lancet Psychiatry

The care of people with first-episode mania has been overlooked in comparison with the care of patients with other non-affective p..

First episode mania: we should have intervened earlier.

Sameer Jauhar, Aswin Ratheesh, Christopher Davey, Lakshmi N Yatham, Patrick D McGorry, Phillip McGuire, Michael Berk, Allan H Young

Journal article | 2019 | The Lancet Psychiatry

Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities

Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Ken Walder, Catherine Mazza, Michael Berk

Journal article | 2019 | Pharmacological Research

Myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a common and disabling condition with a paucity of effective a..

EPA and DHA as markers of nutraceutical treatment response in major depressive disorder.

Kiki P van der Burg, Lachlan Cribb, Joseph Firth, Diana Karmacoska, David Mischoulon, Gerard J Byrne, Chad Bousman, Con Stough, Jenifer Murphy, Georgina Oliver, Michael Berk, Chee H Ng, Jerome Sarris

Journal article | 2019 | European Journal of Nutrition

PURPOSE: Depression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment ..

An International Society of Bipolar Disorders task force report: Precursors and prodromes of bipolar disorder

Gianni L Faedda, Ross J Baldessarini, Ciro Marangoni, Andreas Bechdolf, Michael Berk, Boris Birmaher, Philippe Conus, Melissa P DelBello, Anne C Duffy, Manon HJ Hillegers, Andrea Pfennig, Robert M Post, Martin Preisig, Aswin Ratheesh, Paola Salvatore, Mauricio Tohen, Gustavo H Vazquez, Eduard Vieta, Lakshmi N Yatham, Eric A Youngstrom, et al.

Journal article | 2019 | Bipolar Disorders

N-acetylcysteine for cessation of tobacco smoking: rationale and study protocol for a randomised controlled trial

Lauren Arancini, Chiara C Bortolasci, Seetal Dodd, Olivia M Dean, Michael Berk

Journal article | 2019 | Trials

A case of antibiotic-associated mania in a 67-year-old woman

Pablo Navalon, Yolanda Canada, Milton Merizalde, Pilar Sierra, Ana Garcia-Blanco, Alberto Dominguez-Carabantes, Michael Berk

Journal article | 2019 | Bipolar Disorders

Mapping Cancer incidence across Western Victoria: the association with age, accessibility, and socioeconomic status among men and women

Stephanie P Cowdery, Muhammad A Sajjad, Kara L Holloway-Kew, Mohammadreza Mohebbi, Lana J Williams, Mark A Kotowicz, Patricia M Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L Dunning, Susan Brumby, Richard S Page, Alasdair G Sutherland, Sharon L Brennan-Olsen, Michael Berk, David Campbell, Julie A Pasco

Journal article | 2019 | BMC Cancer

Promotion of Wellbeing for Children of Parents With Mental Illness: A Model Protocol for Research and Intervention

Charlotte Reedtz, Karin van Doesum, Giulia Signorini, Camilla Lauritzen, Therese van Amelsvoort, Floor van Santvoort, Allan H Young, Philippe Conus, Richard Musil, Thomas Schulze, Michael Berk, Argyris Stringaris, Genevieve Piche, Giovanni de Girolamo

Journal article | 2019 | Frontiers in Psychiatry

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Rickinder Sethi, Nieves Gomez-Coronado, Adam J Walker, Oliver D'Arcy Robertson, Bruno Agustini, Michael Berk, Seetal Dodd

Journal article | 2019 | Frontiers in Psychiatry

Are remitted affective disorders and familial risk of affective disorders associated with metabolic syndrome, inflammation and oxidative stress? - a monozygotic twin study.

Ninja Meinhard Ottesen, Iselin Meluken, Ruth Frikke-Schmidt, Peter Plomgaard, Thomas Scheike, Brisa S Fernandes, Michael Berk, Henrik Enghusen Poulsen, Lars Vedel Kessing, Kamilla Miskowiak, Maj Vinberg

Journal article | 2019 | Psychological Medicine

BACKGROUND: Metabolic syndrome (MetS) is associated with reduced life expectancy in patients with affective disorders, however, wh..

Lessons from Iceland: Developing scalable and sustainable community approaches for the prevention of mental disorders in young Australians

E Hoare, IE Thorisdóttir, AL Kristjansson, ID Sigfusdóttir, J Hayward, S Allender, C Strugnell, N Reavley, G Patton, M Berk, F Jacka

Journal article | 2019 | Mental Health & Prevention

International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder

Ta-Wei Guu, David Mischoulon, Jerome Sarris, Joseph Hibbeln, Robert K McNamara, Kei Hamazaki, Marlene P Freeman, Michael Maes, Yutaka J Matsuoka, RH Belmaker, Felice Jacka, Carmine Pariante, Michael Berk, Wolfgang Marx, Kuan-Pin Su

Journal article | 2019 | Psychotherapy and Psychosomatics

Has the sun set for seasonal affective disorder and HPA axis studies? A systematic review and future prospects

Bruno Agustini, Mariia Bocharova, Adam J Walker, Michael Berk, Allan H Young, Mario F Juruena

Journal article | 2019 | Journal of Affective Disorders

OBJECTIVE: Seasonal Affective Disorder (SAD) is a form of cyclic mood disorder that tends to manifest as winter depression. SAD ha..

ANZJP this month September 2019: Acculturating the brain?

Michael Berk

Journal article | 2019 | Australian & New Zealand Journal of Psychiatry

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial

Christopher G Davey, Andrew M Chanen, Sarah E Hetrick, Sue M Cotton, Aswin Ratheesh, Guenter P Amminger, John Koutsogiannis, Mark Phelan, Edward Mullen, Ben J Harrison, Simon Rice, Alexendra G Parker, Olivia M Dean, Amber Weller, Melissa Kerr, Amelia L Quinn, Lisa Catania, Nikolaos Kazantzis, Patrick D McGarry, Michael Berk

Journal article | 2019 | The Lancet Psychiatry

Childbirth and prevention of bipolar disorder: an opportunity for change

Verinder Sharma, Veerle Bergink, Michael Berk, Prabha S Chandra, Trine Munk-Olsen, Adele C Viguera, Lakshmi N Yatham

Journal article | 2019 | The Lancet Psychiatry

The recent conceptualisation of bipolar disorder as a neuroprogressive illness has highlighted the potential importance of prevent..

Beyond evidence-based treatment of bipolar disorder: Rational pragmatic approaches to management

Robert M Post, Lakshmi N Yatham, Eduard Vieta, Michael Berk, Andrew A Nierenberg

Journal article | 2019 | Bipolar Disorders

The evidence for efficacy of many currently available treatments for bipolar disorder is based on studies of non-refractory patien..

Staged treatment and acceptability guidelines in early psychosis study (STAGES): A randomized placebo controlled trial of intensive psychosocial treatment plus or minus antipsychotic medication for first-episode psychosis with low-risk of self-harm or aggression. Study protocol and baseline characteristics of participants

Brian O'Donoghue, Shona M Francey, Barnaby Nelson, Aswin Ratheesh, Kelly Allott, Jessica Grahann, Lara Baldwin, Mario Alvarez-Jinnenez, Andrew Thonnpson, Alex Fornito, Andrea Polari, Michael Berk, Craig Macneil, Kingsley Crisp, Christos Pantelis, Hok P Yuen, Susy Harrigan, Patrick McGorry

Journal article | 2019 | Early Intervention in Psychiatry

Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States

Mohammadreza Mohebbi, Bruno Agustini, Robyn L Woods, John J McNeil, Mark R Nelson, Raj C Shah, Nguyen Van, Elsdon Storey, Anne M Murray, Christopher M Reid, Brenda Kirpach, Rory Wolfe, Jessica E Lockery, Michael Berk

Journal article | 2019 | International Journal of Geriatric Psychiatry

Faecal microbiota transplants for depression - Who gives a crapsule?

Jessica Green, David Castle, Michael Berk, Christopher Hair, Amy Loughman, John Cryan, Andrew Nierenberg, Eugene Athan, Felice Jacka

Journal article | 2019 | Australian & New Zealand Journal of Psychiatry

Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations

Gerwyn Morris, Michael Berk, Michael Maes, Andre F Carvalho, Basant K Puri

Journal article | 2019 | Molecular Neurobiology

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

Wolfgang Marx, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka, Olivia M Dean

Journal article | 2019 | Nutrition Reviews

CONTEXT: Saffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry. OBJECTIVE: This systematic review..

Biomarker-Guided Anti-inflammatory Therapies: From Promise to Reality Check

Michael Berk, Adam J Walker, Andrew A Nierenberg

Journal article | 2019 | JAMA Psychiatry

New drug candidates for bipolar disorder-A nation-wide population-based study

Lars V Kessing, Helene C Rytgaard, Thomas A Gerds, Michael Berk, Claus T Ekstrom, Per K Andersen

Journal article | 2019 | Bipolar Disorders

OBJECTIVE: Drug repurposing is an increasingly promising idea in many fields of medicine. We systematically used Danish nation-wid..

Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study

Bruno Agustini, Mohammadreza Mohebbi, Robyn L Woods, John J McNeil, Mark R Nelson, Raj C Shah, Anne M Murray, Michael E Ernst, Christopher M Reid, Andrew Tonkin, Jessica E Lockery, Michael Berk

Journal article | 2019 | CNS Drugs

A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine ("ice") dependence

Rebecca McKetin, Olivia M Dean, Alyna Turner, Peter J Kelly, Brendan Quinn, Dan I Lubman, Paul Dietze, Gregory Carter, Peter Higgs, Amanda L Baker, Barbara Sinclair, David Reid, Victoria Manning, Nina te Pas, Wenbin Liang, Tamsin Thomas, Ramez Bathish, Margaret Kent, Dayle Raftery, Shalini Arunogiri, et al.

Journal article | 2019 | Trials

Childhood Trauma Exposure and Inflammation in Psychotic Disorders

Yann Quide, Chiara Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Oliver Watkeys, Sarah Cohen-Woods, Michael Berk, Vaughan Carr, Ken Walder, Melissa Green

Conference Proceedings | 2019 | EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY

The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence

Martin Schon, Aya Mousa, Michael Berk, Wern L Chia, Jozef Ukropec, Arshad Majid, Barbara Ukropcova, Barbora de Courten

Journal article | 2019 | Nutrients

Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review

Melanie M Ashton, Michael Berk, Chee H Ng, Malcolm Hopwood, Bianca Kavanagh, Lana J Williams, Jerome Sarris, Olivia M Dean

Journal article | 2019 | BMJ Open

Supporting Engagement, Adherence, and Behavior Change in Online Dietary Interventions

Claire Young, Sara Campolonghi, Stephanie Ponsonby, Samantha L Dawson, Adrienne O'Neil, Frances Kay-Lambkin, Sarah A McNaughton, Michael Berk, Felice N Jacka

Journal article | 2019 | Journal of Nutrition Education and Behavior

Role of personality disorder in randomised controlled trials of pharmacological interventions for adults with mood disorders: a protocol for a systematic review and meta-analysis

Bianca E Kavanagh, Sharon Lee Brennan-Olsen, Alyna Turner, Olivia M Dean, Michael Berk, Melanie M Ashton, Heli Koivumaa-Honkanen, Lana J Williams

Journal article | 2019 | BMJ Open

Association between solar insolation and a history of suicide attempts in bipolar I disorder

Michael Bauer, Tasha Glenn, Martin Alda, Ole A Andreassen, Elias Angelopoulos, Raffaella Ardau, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T Baune, Claudia Becerra-Palars, Frank Bellivier, Robert H Belmaker, Michael Berk, Yuly Bersudsky, Sule Bicakci, Harriet Birabwa-Oketcho, Thomas D Bjella, Jorge Cabrera, Eric Y Wo Cheung, et al.

Journal article | 2019 | Journal of Psychiatric Research

Unravelled facets of milk derived opioid peptides: a focus on gut physiology, fractures and obesity

Hajara Aslam, Anu Ruusunen, Michael Berk, Amy Loughman, Leni Rivera, Julie A Pasco, Felice N Jacka

Journal article | 2019 | International Journal of Food Sciences and Nutrition

Does stage of illness influence recovery-focused outcomes after psychological treatment in bipolar disorder? A systematic review protocol

Halley Tremain, Kathryn Fletcher, Jan Scott, Carla McEnery, Michael Berk, Greg Murray

Journal article | 2019 | Systematic Reviews

Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial.

Bianca E Kavanagh, Lana J Williams, Michael Berk, Alyna Turner, Henry J Jackson, Mohammadreza Mohebbi, Buranee Kanchanatawan, Melanie M Ashton, Chee H Ng, Michael Maes, Lesley Berk, Gin S Malhi, Nathan Dowling, Ajeet B Singh, Olivia M Dean

Journal article | 2019 | Brazilian Journal of Psychiatry

OBJECTIVE: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depress..

Variation in the prevalence of depression and patterns of association, sociodemographic and lifestyle factors in community-dwelling older adults in six low- and middle-income countries

Mojtaba Lotfaliany, Erin Hoare, Felice N Jack, Paul Kowal, Michael Berk, Mohammadreza Mohebbi

Journal article | 2019 | Journal of Affective Disorders

Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial

Melanie M Ashton, Michael Berk, Chee H Ng, Malcolm Hopwood, Seetal Dodd, Alyna Turner, Ellie Brown, Felice N Jacka, Susan M Cotton, Jon-Paul Khoo, Mary Lou Chatterton, Bianca E Kavanagh, Sarah E Nadjidai, Samantha L Lo Monaco, Brian H Harvey, Jerome Sarris, Gin S Malhi, Nathan L Dowling, Olivia M Dean

Journal article | 2019 | Brazilian Journal of Psychiatry

QUANTITATIVE HEEL ULTRASOUND (QUS) AND ANTICONVULSANT USE IN A POPULATION-BASED STUDY

V Chandrasekaran, A Stuart, J Pasco, J Hodge, S Brennan-Olsen, M Berk, L Williams

Conference Proceedings | 2019 | OSTEOPOROSIS INTERNATIONAL

Co-occurrence of depression with chronic diseases among the older population living in low- and middle-income countries: A compound health challenge

Mojtaba Lotfaliany, Bruno Agustini, Paul Kowal, Michael Berk, Mohammadreza Mohebbi

Journal article | 2019 | Annals of Clinical Psychiatry

Buffering against maladaptive perfectionism in bipolar disorder: The role of self-compassion

Kathryn Fletcher, Yan Yang, Sheri L Johnson, Michael Berk, Tania Perich, Sue Cotton, Steven Jones, Sara Lapsley, Erin Michalak, Greg Murray

Journal article | 2019 | Journal of Affective Disorders

Protocol and Rationale: A 24-week Double-blind, Randomized, Placebo Controlled Trial of the Efficacy of Adjunctive Garcinia mangostana Linn. (Mangosteen) Pericarp for Schizophrenia

Alyna Turner, John J McGrath, Olivia M Dean, Seetal Dodd, Andrea Baker, Susan M Cotton, James G Scott, Bianca E Kavanagh, Melanie M Ashton, Adam J Walker, Ellie Brown, Michael Berk

Journal article | 2019 | Clinical Psychopharmacology and Neuroscience

The impact of urbanization on mood disorders: an update of recent evidence

Erin Hoare, Felice Jacka, Michael Berk

Journal article | 2019 | Current Opinion in Psychiatry

Bipolar disorder and bone health: A systematic review

Vinoomika Chandrasekaran, Sharon L Brennan-Olsen, Amanda L Stuart, Julie A Pasco, Michael Berk, Jason M Hodge, Lana J Williams

Journal article | 2019 | Journal of Affective Disorders

Protocol update and statistical analysis plan for CADENCE-BZ: a randomized clinical trial to assess the efficacy of sodium benzoate as an adjunctive treatment in early psychosis

Carmen Lim, Andrea Baker, Sukanta Saha, Sharon Foley, Anne Gordon, David Ward, Bjorn Burgher, Frances Dark, Martin Beckmann, Stephen Stathis, George Bruxner, Alex Ryan, Drew Richardson, Sean Hatherill, Michael Berk, Olivia Dean, John McGrath, James Scott

Journal article | 2019 | Trials

From conventional to novel immune markers guiding novel therapy development in psychiatry?

M Berk

Conference Proceedings | 2019 | EUROPEAN PSYCHIATRY

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Gerwyn Morris, Michael Maes, Michael Berk, Basant K Puri

Journal article | 2019 | Metabolic Brain Disease

The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

Melanie M Ashton, Olivia M Dean, Adam J Walker, Chiara C Bortolasci, Chee H Ng, Malcolm Hopwood, Brian H Harvey, Marisa Moller, John J McGrath, Wolfgang Marx, Alyna Turner, Seetal Dodd, James G Scott, Jon-Paul Khoo, Ken Walder, Jerome Sarris, Michael Berk

Journal article | 2019 | Frontiers in Psychiatry

Diet and Depression-From Confirmation to Implementation

Michael Berk, Felice N Jacka

Journal article | 2019 | JAMA

Statins and Inflammation: New Therapeutic Opportunities in Psychiatry

Sung-Wan Kim, Hee-Ju Kang, Min Jhon, Ju-Wan Kim, Ju-Yeon Lee, Adam J Walker, Bruno Agustini, Jae-Min Kim, Michael Berk

Journal article | 2019 | Frontiers in Psychiatry

Association of depression with mortality in an elderly treated hypertensive population

Enayet K Chowdhury, Michael Berk, Mark R Nelson, Lindon MH Wing, Christopher M Reid

Journal article | 2019 | International Psychogeriatrics