Dr Jess Fletcher completed her PhD at the University of Sydney in 2013 investigating the molecular basis of inherited diseases (lysosomal storage disease) affecting the brain. In 2015 she joined the University of Melbourne, as a Multiple Sclerosis Research Australia Postdoctoral Fellow, and was awarded the Melbourne Neuroscience Institute (MNI) Fellowship in 2018.
Her research focus is determining the molecular events required for myelin plasticity and regeneration in the brain and understanding how oligodendroglia (the myelin producing cells) influence healthy brain function. Her goal is to use this knowledge to design therapies for conditions where myelin perturbations and oligodendrocyte dysfunction contribute to disability, such as Multiple Sclerosis, traumatic injury and anxiety.
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Jessica Fletcher's selected work
Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflect..
Characterisation Of A Novel Therapeutic Target In Progressive Multiple Sclerosis
Internal Research Grant
TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Co..
Displaying the 3 most recent projects by Jessica Fletcher.
Displaying the 23 most recent scholarly works by Jessica Fletcher.
Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain
Jessica L Fletcher, Rhiannon J Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa R Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan E Northfield, Richard A Hughes, David G Gonsalvez, Junhua Xiao, Simon S Murray
Journal article | 2018 | The Journal of Neuroscience
BDNF haploinsufficiency exerts a transient and regionally different influence upon oligodendroglial lineage cells during postnatal development
Madeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, Maarten van den Buuse, Simon S Murray, Junhua Xiao
Journal article | 2018 | Molecular and Cellular Neuroscience
A Brain-Derived Neurotrophic Factor-Based p75(NTR) Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination
David G Gonsalvez, Giang Tran, Jessica L Fletcher, Richard A Hughes, Suzanne Hodgkinson, Rhiannon J Wood, Sang Won Yoo, Mithraka De Silva, Wong W Agnes, Catriona McLean, Paul Kennedy, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Journal article | 2017 | ENEURO
The effects of intracisternal enzyme replacement versus sham treatment on central neuropathology in preclinical canine fucosidosis
Gauthami Sudhamayee Kondagari, Jessica Louise Fletcher, Rachel Cruz, Peter Williamson, John J Hopwood, Rosanne Maree Taylor
Journal article | 2015 | Orphanet Journal of Rare Diseases
Mitochondrial DNA analyses of the saltwater crocodile (Crocodylus porosus) from the Northern Territory of Australia
Naomi L Luck, Kristen C Thomas, Victoria E Morin-Adeline, Sophie Barwick, Amanda Y Chong, Eliza L Carpenter, LinXiao Wan, Cali E Willet, Shannan M Langford-Salisbury, Mary Abdelsayd, Rachel A Ang, Sarah J Atkinson, Fabian G Barcelo, Melanie E Booth, Emma J Bradbury, Thomas L Branighan, Jennifer Brown, Lesley E Castillo, Nichola D Chandler, Josephine Y Chong, et al.
Journal article | 2012 | Australian Journal of Zoology
Inhibiting Bone Morphogenetic Protein 4 Type I Receptor Signaling Promotes Remyelination by Potentiating Oligodendrocyte Differentiation.
Alistair E Govier-Cole, Rhiannon J Wood, Jessica L Fletcher, David G Gonsalvez, Daniel Merlo, Holly S Cate, Simon S Murray, Junhua Xiao
Journal article | eneuro
Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone mo..
Displaying the most recent news article by Jessica Fletcher.
Honours, Awards and Fellowships
Melbourne Neuroscience Institute Research Fellowship
Multiple Sclerosis Research Australia Postdoctoral Fellowship
Research Fellow - Neuroscience
Anatomy And Neuroscience
Doctor of Philosophy
University of Sydney
Bachelor of Animal and Veterinary Bioscience (Hons I)
University of Sydney