Kerstin Brinkmann

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.

Mila Daoud, Pia Nora Broxtermann, Fabian Schorn, J Paul Werthenbach, Jens Michael Seeger, Lars M Schiffmann, Kerstin Brinkmann, Domagoj Vucic, Thomas Tüting, Cornelia Mauch, Dagmar Kulms, Paola Zigrino, Hamid Kashkar

Journal article  |  2022  |  EMBO Rep

Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma sugge..

Some mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood.

Francine FS Ke, Kerstin Brinkmann, Anne K Voss, Andreas Strasser

Journal article  |  2022  |  Cell Death Dis

Programmed cell death, in particular the intrinsic apoptotic pathway, has been shown to play a critical role in the shaping of tis..

What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Andreas Strasser

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL..

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells

Diane Moujalled, Adam G Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S Cross, Misty R Jenkins, Duong Nhu, Zilu Wang, Melissa X Shi, Ruth M Kluck, Guillaume Lessene, Stephanie Grabow, Ashley Bush, Andreas Strasser

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer, with treatment options often constrained due..

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser

Journal article  |  2020  |  The EMBO Journal

Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, lit..

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa, Saskia Diana Guenther, Martin Kroenke, Thorsten Hoppe, Hamid Kashkar

Journal article  |  2020  |  CELL DEATH & DISEASE

The BH3-only protein NOXA is a regulator of mitochondrial apoptosis by specifically antagonizing the anti-apoptotic protein MCL-1...

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Ladina Di Rago, Craig D Hyland, Eugenio Morelli, Jai Rautela, Nicholas D Huntington, Andreas Strasser, Warren S Alexander, Marco J Herold

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and throug..

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Ranja Salvamoser, Kerstin Brinkmann, Lorraine A O'Reilly, Lachlan Whitehead, Andreas Strasser, Marco J Herold

Journal article  |  2019  |  CELL DEATH AND DIFFERENTIATION

Caspases exert critical functions in diverse cell death pathways, including apoptosis and pyroptosis, but some caspases also have ..

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX..

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold, Andreas Strasser

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

A common therapeutic strategy to combat human cancer is the use of combinations of drugs, each targeting different cellular proces..