Alexander Dobrovic

Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients following liver transplantation

Osamu Yoshino, Boris Ka Leong Wong, Daniel RA Cox, Eunice Lee, Graham Hepworth, Christopher Christophi, Robert Jones, Alexander Dobrovic, Vijayaragavan Muralidharan, Marcos Perini

Journal article  |  2021  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND AND AIM: The role of circulating mitochondrial DNA (cmtDNA) in transplantation remains to be elucidated. cmtDNA may be ..

A Synthetic DNA Construct to Evaluate the Recovery Efficiency of Cell-Free DNA Extraction and Bisulfite Modification.

Su Kah Goh, Daniel RA Cox, Boris Ka Leong Wong, Ashan Musafer, Tom Witkowski, Hongdo Do, Vijayaragavan Muralidharan, Alexander Dobrovic

Journal article  |  2021  |  Clin Chem

BACKGROUND: Despite improvements in the genetic and epigenetic analysis of cell-free DNA (cfDNA), there has been limited focus on ..

Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance.

Rachel M Hurley, Cordelia D McGehee, Ksenija Nesic, Cristina Correia, Taylor M Weiskittel, Rebecca L Kelly, Annapoorna Venkatachalam, Xiaonan Hou, Nicholas M Pathoulas, X Wei Meng, Olga Kondrashova, Marc R Radke, Paula A Schneider, Karen S Flatten, Kevin L Peterson, Marc A Becker, Ee Ming Wong, Melissa S Southey, Alexander Dobrovic, Kevin K Lin, et al.

Journal article  |  2021  |  NAR Cancer

Acquired PARP inhibitor (PARPi) resistance in BRCA1- or BRCA2-mutant ovarian cancer often results from secondary mutations that re..

PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma

Sagun Parakh, Ashan Musafer, Sabrina Paessler, Tom Witkowski, Connie SN Li Wai Suen, Candani SA Tutuka, Matteo S Carlino, Alexander M Menzies, Richard A Scolyer, Jonathan Cebon, Alexander Dobrovic, Georgina V Long, Oliver Klein, Andreas Behren

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

A significant number of patients (pts) with metastatic melanoma do not respond to anti-programmed cell death 1 (PD1) therapies. Id..

Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

Elizabeth M Swisher, Tanya T Kwan, Amit M Oza, Anna Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L Coleman, Carol Aghajanian, Gottfried E Konecny, David M O'Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S Kristeleit, Oliver Dorigo, Ashan Musafer, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

ARIEL2 (NCT01891344) is a single-arm, open-label phase 2 study of the PARP inhibitor (PARPi) rucaparib in relapsed high-grade ovar..

Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses

Jessica Da Gama Duarte, Katherine Woods, Luke T Quigley, Cyril Deceneux, Candani Tutuka, Tom Witkowski, Simone Ostrouska, Chris Hudson, Simon Chang-Hao Tsao, Anupama Pasam, Alexander Dobrovic, Jonathan M Blackburn, Jonathan Cebon, Andreas Behren

Journal article  |  2021  |  CANCERS

Antibodies that block immune regulatory checkpoints (programmed cell death 1, PD-1 and cytotoxic T-lymphocyte-associated antigen 4..

Hypoxia differently modulates the release of mitochondrial and nuclear DNA

Boris KL Wong, Fan Zhang, Hongdo Do, Adam Testro, Vijayaragavan Muralidharan, Alexander Dobrovic, Daniel RA Cox

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain

Zimeng Ye, Zac Chatterton, Jahnvi Pflueger, John A Damiano, Lara McQuillan, Anthony Simon Harvey, Stephen Malone, Hongdo Do, Wirginia Maixner, Amy Schneider, Bernadette Nolan, Martin Wood, Wei Shern Lee, Greta Gillies, Kate Pope, Michael Wilson, Paul J Lockhart, Alexander Dobrovic, Ingrid E Scheffer, Melanie Bahlo, et al.

Journal article  |  2021  |  BRAIN COMMUNICATIONS

Brain somatic mutations are an increasingly recognized cause of epilepsy, brain malformations and autism spectrum disorders and ma..

The Development of a Tissue Methylation-Specific Cell Free DNA Biomarker for Organ Rejection Following Liver Transplantation

DRA Cox, N Low, SK Goh, C Christophi, A Testro, A Dobrovic, V Muralidharan

Journal article  |  2021  |  HPB

Donor-specific cell-free DNA as a biomarker in liver transplantation: A review.

Tess McClure, Su Kah Goh, Daniel Cox, Vijayaragavan Muralidharan, Alexander Dobrovic, Adam G Testro

Journal article  |  2020  |  World J Transplant

Due to advances in modern medicine, liver transplantation has revolutionised the prognosis of many previously incurable liver dise..