Alexander Dobrovic

Elevated Plasma Levels of Cell-Free DNA During Liver Transplantation Are Associated With Activation of Coagulation

Osamu Yoshino, Vijayaragavan Muralidharan, Alexander Dobrovic, Su Kah Goh

Journal article  |  2020  |  Liver Transplantation

Cell-free DNA (cfDNA) is emerging as an immuno-modulator in numerous medical conditions including in malignancy, chronic inflammat..

Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.

Brett W Stringer, Bryan W Day, Rochelle CJ D'Souza, Paul R Jamieson, Kathleen S Ensbey, Zara C Bruce, Yi Chieh Lim, Kate Goasdoué, Carolin Offenhäuser, Seçkin Akgül, Suzanne Allan, Thomas Robertson, Peter Lucas, Gert Tollesson, Scott Campbell, Craig Winter, Hongdo Do, Alexander Dobrovic, Po-Ling Inglis, Rosalind L Jeffree, et al.

Journal article  |  2020  |  Scientific Reports

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

Molecular Genomic Profiling of Melanocytic Nevi

Andrew J Colebatch, Peter Ferguson, Felicity Newell, Stephen H Kazakoff, Tom Witkowski, Alexander Dobrovic, Peter A Johansson, Robyn PM Saw, Jonathan R Stretch, Grant A McArthur, Georgina Long, John F Thompson, John Pearson, Graham J Mann, Nicholas K Hayward, Nicola Waddell, Richard A Scolyer, James S Wilmott

Journal article  |  2019  |  Journal of Investigative Dermatology

Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts

Anthony Tachtsidis, Anh Viet-Phuong Le, Tony Blick, Devika Gunasinghe, Emma De Sousa, Mark Waltham, Alex Dobrovic, Erik W Thompson

Journal article  |  2019  |  Clinical & Experimental Metastasis

A new normalization for Nanostring nCounter gene expression data

Ramyar Molania, Johann A Gagnon-Bartsch, Alexander Dobrovic, Terence P Speed

Journal article  |  2019  |  Nucleic Acids Research

The Nanostring nCounter gene expression assay uses molecular barcodes and single molecule imaging to detect and count hundreds of ..

A case-control study of constitutional BRCA1 methylation in a mammographically screened cohort

Basant Ebaid, Hongdo Do, Jia Min Pang, Lisa Devereux, Alexander Dobrovic

Conference Proceedings  |  2019  |  Molecular and Cellular Biology / Genetics

The Measurement of Donor-Specific Cell-Free DNA Identifies Recipients With Biopsy-Proven Acute Rejection Requiring Treatment After Liver Transplantation

Su Kah Goh, Hongdo Do, Adam Testro, Julie Pavlovic, Angela Vago, Julie Lokan, Robert M Jones, Christopher Christophi, Alexander Dobrovi, Vijayaragavan Muralidhara

Journal article  |  2019  |  Transplantation Direct

Background: Assessment of donor-specific cell-free DNA (dscfDNA) in the recipient is emerging as a noninvasive biomarker of organ ..

Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study

Olga Kondrashova, Gwo-Yaw Ho, George Au-Yeung, Leakhena Leas, Tiffany Boughtwood, Kathryn Alsop, Giada Zapparoli, Alexander Dobrovic, Yi-An Ko, Arthur L Hsu, Clare J Love, Sebastian Lunke, Matthew J Wakefield, Orla McNally, Michael Quinn, Sumitra Ananda, Deborah Neesham, Anne Hamilton, Marisa Grossi, Alison Freimund, et al.

Journal article  |  2019  |  JCO Precision Oncology

Gene expression profiling of T-cell inflammation in small cell lung cancer.

Gareth Rivalland, Ulf Schmitz, Ramyar Molania, Chuck Bailey, Gavin Michael Wright, Alexander Dobrovic, John Rasko, Thomas John

Conference Proceedings  |  2019  |  JOURNAL OF CLINICAL ONCOLOGY

Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel

Elin S Gray, Tom Witkowski, Michelle Pereira, Leslie Calapre, Karl Herron, Darryl Irwin, Brett Chapman, Muhammad A Khattak, Jeanette Raleigh, Athena Hatzimihalis, Jonathan Cebon, Shahneen Sandhu, Grant A McArthur, Michael Millward, Melanie Ziman, Alexander Dobrovic, Stephen Q Wong

Journal article  |  2019  |  The Journal of Molecular Diagnostics

Standard dose osimertinib for erlotinib refractory T790M-negative EGFR-mutant non-small cell lung cancer with leptomeningeal disease

Surein Arulananda, Hongdo Do, Gareth Rivalland, Zoe Loh, Ashan Musafer, Eddie Lau, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2019  |  Journal of Thoracic Disease

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Erinna F Lee, Tiffany J Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K Haass, Marco J Herold, W Douglas Fairlie

Journal article  |  2019  |  Cell Death & Disease

TERT gene: its function and dysregulation in cancer

Andrew J Colebatch, Alexander Dobrovic, Wendy A Cooper

Journal article  |  2019  |  Journal of Clinical Pathology

In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regula..

A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma

Brett W Stringer, Bryan W Day, Rochelle CJ D'Souza, Paul R Jamieson, Kathleen S Ensbey, Zara C Bruce, Yi Chieh Lim, Kate Goasdoue, Carolin Offenhauser, Seckin Akgul, Suzanne Allan, Thomas Robertson, Peter Lucas, Gert Tollesson, Scott Campbell, Craig Winter, Hongdo Do, Alexander Dobrovic, Po-Ling Inglis, Rosalind L Jeffree, et al.

Journal article  |  2019  |  Scientific Reports

The interplay between stromal density, epithelial mesenchymal transition and chemoresistance in breast cancer

V Agarwal, LJ Spalding, T Blick, A Dobrovic, EW Thompson, A Redfern

Conference Proceedings  |  2019  |  Poster Session Abstracts

Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer

Daniel Shepshelovich, Amanda R Townsend, Osvaldo Espin-Garcia, Lidija Latifovic, Chris J O'Callaghan, Derek J Jonker, Dongsheng Tu, Eric Chen, Eric Morgen, Timothy J Price, Jeremy Shapiro, Lillian L Siu, Michiaki Kubo, Alexander Dobrovic, Mark J Ratain, Wei Xu, Taisei Mushiroda, Geoffrey Liu

Journal article  |  2018  |  Cancer Medicine

Can mammographic breast density predict complete pathological response in patients with locally advanced breast cancer following neoadjuvant chemotherapy?

Veenoo Agarwal, Lisa Spalding, Tony Blick, Erik Rik W Thompson, Alexander Dobrovic, Andrew Redfern

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Monitoring of Early Stage Lung Cancer Using Liquid Biopsies

A Dobrovic

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma

Surein Arulananda, Bibhusal Thapa, Marzena Walkiewicz, Giada V Zapparoli, David S Williams, Alexander Dobrovic, Thomas John

Journal article  |  2018  |  Journal of Thoracic Oncology

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria Harrell, Giada Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H Kaufmann, et al.

Journal article  |  2018  |  Nature Communications

DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum-Implications for the Choice of Circulating Tumour DNA Methylation Markers

Viet-Phuong Le Anh, Marcin Szaumkessel, Tuan Zea Tan, Jean-Paul Thiery, Erik W Thompson, Alexander Dobrovic

Journal article  |  2018  |  International Journal of Molecular Sciences

Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR

Su Kah Goh, Boris Ka Leong Wong, Vijayaragavan Muralidharan, Christopher Christophi, Hongdo Do, Alexander Dobrovic

Journal article  |  2018  |  Clinical Chemistry

Australian Ovarian Cancer Assortment Trial-Allocating ovarian cancer patients into clinical trials based on molecular profiling.

Olga Kondrashova, George Au-Yeung, Leakhena Leas, Gwo-Yaw Ho, Sebastian Lunke, Kathryn Alsop, Clare Scott, Anne Hamilton, Sumitra Ananda, Alison Freimund, Michael Quinn, Orla McNally, Nadia Traficante, Tiffany Cowie, Matthew Wakefield, Arthur Hsu, Alex Dobrovic, Michael Christie, Graham Taylor, David Bowtell, et al.

Conference Proceedings  |  2018  |  CLINICAL CANCER RESEARCH

Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance

Rachel M Hurley, Ksenija Nesic, Cordelia McGehee, Olga Kondrashova, Maria I Harrell, Paula A Schneider, Xiaonan Hou, Cristina Correia, Karen S Flatten, Giada V Zapparoli, Alexander Dobrovic, Kevin K Lin, Thomas C Harding, Andrea E Wahner Hendrickson, Elizabeth M Swisher, Matthew Wakefield, S John Weroha, Clare L Scott, Scott H Kaufmann

Conference Proceedings  |  2018  |  Experimental and Molecular Therapeutics

Donor-Specific Cell-Free DNA as an Emerging Biomarker of Organ Rejection after Liver Transplantation

Su Kah Goh, Hongdo Do, Vijayaragavan Muralidharan, Robert Jones, Alexander Dobrovic, Christopher Christophi

Conference Proceedings  |  2018  |  Transplantation

Somatic GNAQ mutation in the forme fruste of Sturge-Weber syndrome

Michael S Hildebrand, A Simon Harvey, Stephen Malone, John A Damiano, Hongdo Do, Zimeng Ye, Lara McQuillan, Wirginia Maixner, Renate Kalnins, Bernadette Nolan, Martin Wood, Ezgi Ozturk, Nigel C Jones, Greta Gillies, Kate Pope, Paul J Lockhart, Alexander Dobrovic, Richard J Leventer, Ingrid E Scheffer, Samuel F Berkovic

Journal article  |  2018  |  Neurology Genetics

BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition

Tania Moujaber, Dariush Etemadmoghadam, Catherine J Kennedy, Yoke-Eng Chiew, Rosemary L Balleine, Catherine Saunders, Gerard Wain, Bo Gao, Russell Hogg, Sivatharsny Srirangan, Casina Kan, Sian Fereday, Nadia Traficante, Ann-Marie Patch, John Pearson, Nicola Waddell, Sean M Grimmond, Alexander Dobrovic, David DL Bowtell, Paul R Harnett, et al.

Journal article  |  2018  |  JCO Precision Oncology

Optimizing Amplification of the GC-Rich TERT Promoter Region Using 7-Deaza-dGTP for Droplet Digital PCR Quantification of TERT Promoter Mutations

Andrew J Colebatch, Tom Witkowski, Paul M Waring, Grant A McArthur, Stephen Q Wong, Alexander Dobrovic

Journal article  |  2018  |  Clinical Chemistry

Fresh Frozen Plasma Transfusion Can Confound the Analysis of Circulating Cell-Free DNA

Su Kah Goh, Vijayaragavan Muralidharan, Christopher Christophi, Alexander Dobrovic

Journal article  |  2018  |  Clinical Chemistry

White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk: A Perspective

Alexander Dobrovic

Journal article  |  2018  |  Annals of Internal Medicine

In Reply to Leone.

Hongdo Do, Surein Arulananda, Thomas John, Alexander Dobrovic

Journal article  |  2018  |  Journal of Thoracic Oncology

The Association of FCGR2A and FCGR3A polymorphisms with outcomes in cetuximab treated metastatic colorectal cancer patients: CCTG and AGITG CO.20 trial analysis.

Daniel Shepshelovich, Amanda Rose Townsend, Osvaldo Espin-Garcia, Lidija Latifovic, Christopher J O'Callaghan, Derek J Jonker, Dongsheng Tu, Eric Chen, Eric Morgen, Timothy Jay Price, Jeremy David Shapiro, Lillian L Siu, Kouros Owzar, Mark J Ratain, Michiaki Kubo, Alexander Dobrovic, Wei Xu, Taisei Mushiroda, Geoffrey Liu

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  Clinical Cancer Research

TERT structural rearrangements in metastatic pheochromocytomas

Trisha Dwight, Aidan Flynn, Kaushalya Amarasinghe, Diana E Benn, Richard Lupat, Jason Li, Daniel L Cameron, Annette Hogg, Shiva Balachander, Ida LM Candiloro, Stephen Q Wong, Bruce G Robinson, Anthony T Papenfuss, Anthony J Gill, Alexander Dobrovic, Rodney J Hicks, Roderick J Clifton-Bligh, Richard W Tothill

Journal article  |  2018  |  Endocrine-Related Cancer

GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly

Daniel L Cameron, Jan Schroder, Jocelyn Sietsma Penington, Hongdo Do, Ramyar Molania, Alexander Dobrovic, Terence P Speed, Anthony T Papenfuss

Journal article  |  2017  |  Genome Research

Sensitive quantitative detection of somatic mosaic mutation in "double cortex" syndrome

John A Damiano, Hongdo Do, Ezgi Ozturk, Rosemary Burgess, Renate Kalnins, Nigel C Jones, Alexander Dobrovic, Samuel F Berkovic, Michael S Hildebrand

Journal article  |  2017  |  Epileptic Disorders

Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis

EK Morgen, H-J Lenz, DJ Jonker, D Tu, G Milano, F Graziano, J Zalcberg, CS Karapetis, A Dobrovic, CJ O'Callaghan, G Liu

Journal article  |  2017  |  The Pharmacogenomics Journal

Diagnosis of Leptomeningeal Disease and Clonal Heterogeneity with Digital Droplet PCR (ddPCR) in EGFR Mutated NSCLC

G Rivalland, H Do, S Arulananda, P Mitchell, A Dobrovic, T John

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

Profiling DNA Repair in Lung Cancer

A Dobrovic, H Do, G Wright

Conference Proceedings  |  2017  |  JOURNAL OF THORACIC ONCOLOGY

Combination Osimertinib and Gefitinib in C797S and T790M EGFR-Mutated Non-Small Cell Lung Cancer

Surein Arulananda, Hongdo Do, Ashan Musafer, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2017  |  Journal of Thoracic Oncology

LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness

Jia-Min B Pang, Ramyar Molania, Ashwini Chand, Kevin Knower, Elena A Takano, David J Byrne, Thomas Mikeska, Ewan KA Millar, Cheok Soon Lee, Sandra A O'Toole, Colin Clyne, Kylie L Gorringe, Alexander Dobrovic, Stephen B Fox

Journal article  |  2017  |  Oncotarget

DNA Breathing Enables Closed-Tube Mutant Allele Enrichment for Circulating Tumor DNA Analysis

Alexander Dobrovic

Journal article  |  2017  |  Clinical Chemistry

EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma

Timothy D Clay, Prudence A Russell, Hongdo Do, Vijaya Sundararajan, Matthew Conron, Gavin M Wright, Benjamin Solomon, Alexander Dobrovic, Sue-Anne McLachlan, Melissa M Moore

Journal article  |  2017  |  Medical Oncology

BRCA2 carriers with male breast cancer show elevated tumour methylation

Siddhartha Deb, Kylie L Gorringe, Jia-Min B Pang, David J Byrne, Elena A Takano, Alexander Dobrovic, Stephen B Fox

Journal article  |  2017  |  BMC Cancer

Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase

Hongdo Do, Ramyar Molania, Paul L Mitchell, Rita Vaiskunaite, John D Murdoch, Alexander Dobrovic

Journal article  |  2017  |  Clinical Chemistry

De novo activating epidermal growth factor mutations (EGFR) in small-cell lung cancer

Alesha Thai, Puey L Chia, Prudence A Russell, Hongdo Do, Alex Dobrovic, Paul Mitchell, Thomas John

Journal article  |  2017  |  Internal Medicine Journal

DNA methylation profiling of breast cancer cell lines along the epithelial mesenchymal spectrum - implications for the choice of circulating tumour DNA methylation markers

Anh Viet-Phuong Le, Marcin Szaumkessel, Tuan Zea Tan, Jean-Paul Thiery, Erik Thompson, Alexander Dobrovic

Journal article  |  2017

Abstract Epithelial-mesenchymal plasticity (EMP) is a dynamic process whereby epithelial carcinoma cells reversibly acquire morpho..

Liquid Biopsies in BRAF Mutant Melanoma: A New Frontier in Monitoring Response to Therapy

G Peters, T Witkowski, J Cebon, D Kee, A Dobrovic

Conference Proceedings  |  2017  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

Jia-Min B Pang, Peter Savas, Andrew P Fellowes, Gisela Mir Arnau, Tanjina Kader, Ravikiran Vedururu, Chelsee Hewitt, Elena A Takano, David J Byrne, David YH hoong, Ewan KA Millar, C Soon Lee, Sandra A O'Toole, Sunil R Lakhani, Margaret C Cummings, G Bruce Mann, Ian G Campbell, Alexander Dobrovic, Sherene Loi, Kylie L Gorringe, et al.

Journal article  |  2017  |  Modern Pathology

Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences

Ida LM Candiloro, Thomas Mikeska, Alexander Dobrovic

Journal article  |  2017  |  Clinical Epigenetics

Evaluation of Different Oligonucleotide Base Substitutions at CpG Binding sites in Multiplex Bisulfite-PCR sequencing

Jennifer Lu, Kelin Ru, Ida Candiloro, Alexander Dobrovic, Darren Korbie, Matt Trau

Journal article  |  2017  |  Scientific Reports

Multiplex bisulfite-PCR sequencing is a convenient and scalable method for the quantitative determination of the methylation state..

Erratum: An optimised direct lysis method for gene expression studies on low cell numbers.

Anh Viet-Phuong Le, Dexing Huang, Tony Blick, Erik W Thompson, Alexander Dobrovic

Journal article  |  2017  |  Scientific Reports

Probe-Free Digital PCR Quantitative Methodology to Measure Donor-Specific Cell-Free DNA after Solid-Organ Transplantation

Su Kah Goh, Vijayaragavan Muralidharan, Christopher Christophi, Hongdo Do, Alexander Dobrovic

Journal article  |  2017  |  Clinical Chemistry

GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly

Daniel Cameron, Jan Schroeder, Jocelyn Sietsma Penington, Hongdo Do, Ramyar Molania, Alexander Dobrovic, Terence Speed, Anthony Papenfuss

Journal article  |  2017

ABSTRACT The identification of genomic rearrangements, particularly in cancers, with high sensitivity and specificity using massiv..

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

Cristina Gamell, Twishi Gulati, Yaara Levav-Cohen, Richard J Young, Hongdo Do, Pat Pilling, Elena Takano, Neil Watkins, Stephen B Fox, Prudence Russell, Doron Ginsberg, Brendon J Monahan, Gavin Wright, Alex Dobrovic, Sue Haupt, Ben Solomon, Ygal Haupt

Journal article  |  2017  |  Science Signaling

Analysis of DNA methylation in clinical samples: Methods and applications

A Dobrovic

Book Chapter  |  2017

LIQUID BIOPSIES FROM SOLID TUMORS

Alexander Dobrovic

Conference Proceedings  |  2016  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

Andrew J Colebatch, Leon Di Stefano, Stephen Q Wong, Ross D Hannan, Paul M Waring, Alexander Dobrovic, Grant A McArthur, Anthony T Papenfuss

Journal article  |  2016  |  ONCOTARGET

TCR beta sequencing to determine clonal T-cell populations in melanoma patients undergoing immunotherapy

T Witkowski, A Behren, K Woods, B Fritz, SQ Wong, A Colebatch, G McArthur, J Cebon, A Dobrovic

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Temporal changes of EGFR mutations and T790M levels in tumour and plasma DNA following AZD9291 treatment

Puey Ling Chia, Hongdo Do, Adrienne Morey, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2016  |  Lung Cancer

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas

Annette M Lim, Nicholas C Wong, Ruth Pidsley, Elena Zotenko, June Corry, Alexander Dobrovic, Susan J Clark, Danny Rischin, Benjamin Solomon

Journal article  |  2016  |  Clinical Epigenetics

Comparison of 3 Methodologies for Genotyping of Small Deletion and Insertion Polymorphisms

Su Kah Goh, Ashan Musafer, Tom Witkowski, Vijayaragavan Muralidharan, Christopher Christophi, Hongdo Do, Alexander Dobrovic

Journal article  |  2016  |  Clinical Chemistry

Investigating epithelial-mesenchymal plasticity in circulating tumour cells from breast cancer xenograft models

AVP Le, A Tachtsidis, T Blick, D Gunasinghe, M Waltham, A Dobrovic, E Thompson

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF CANCER

Donor-specific cell-free DNA as a non-invasive marker of organ rejection after liver transplantation: A pilot study

Su Kah Goh, Hongdo Do, Vijayaragan Muralidharan, Alexander Dobrovic, Christopher Christophi

Conference Proceedings  |  2016  |  TRANSPLANTATION

Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer

Geoffrey Liu, Dongsheng Tu, Marcia Lewis, Dangxiao Cheng, Leslie A Sullivan, Zhuo Chen, Eric Morgen, John Simes, Timothy J Price, Niall C Tebbutt, Jeremy D Shapiro, G Mark Jeffery, J Daniel Mellor, Thomas Mikeska, Shakeel Virk, Lois E Shepherd, Derek J Jonker, Christopher J O'Callaghan, John R Zalcberg, Christos S Karapetis, et al.

Journal article  |  2016  |  Clinical Cancer Research

Clustered somatic mutations are frequent in transcription factor binding sites in melanoma and other cutaneous malignancies.

AJ Colebatch, L di Stefano, SQ Wong, PJ Waring, A Dobrovic, GA McArthur, AT Papenfuss

Conference Proceedings  |  2016  |  Pathology

MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing

Nicholas C Wong, Bernard J Pope, Ida L Candiloro, Darren Korbie, Matt Trau, Stephen Q Wong, Thomas Mikeska, Xinmin Zhang, Mark Pitman, Stefanie Eggers, Stephen R Doyle, Alexander Dobrovic

Journal article  |  2016  |  BMC Bioinformatics

Predictive value of de novo and induced epithelial-mesenchymal transition in locally advanced breast cancer treated with neoadjuvant chemotherapy

AD Redfern, SA McLaren, V Dissanayake, A Chan, N Zeps, A Dobrovic, L Soon, EW Thompson, SM Christobel

Conference Proceedings  |  2016  |  Poster Session Abstracts

Realising the Value of Linked Data to Health Economic Analyses of Cancer Care: A Case Study of Cancer 2015

Paula K Lorgelly, Brett Doble, Rachel J Knott

Journal article  |  2016  |  PharmacoEconomics

Digital PCR of Genomic Rearrangements for Monitoring Circulating Tumour DNA

Hongdo Do, Daniel Cameron, Ramyar Molania, Bibhusal Thapa, Gareth Rivalland, Paul L Mitchell, Carmel Murone, Thomas John, Anthony Papenfuss, Alexander Dobrovic

Journal article  |  2016  |  Advances in Experimental Medicine and Biology

Epigenetic basis of human cancer

T Mikeska, A Dobrovic

Book Chapter  |  2016

Associations between the IASLC/ATS/ERS lung adenocarcinoma classification and EGFR and KRAS mutations

TD Clay, PA Russell, H Do, V Sundararajan, M Conron, GM Wright, A Dobrovic, MM Moore, SA McLachlan

Journal article  |  2016  |  Pathology

"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic

John P Parisot, Heather Thorne, Andrew Fellowes, Ken Doig, Mark Lucas, John J McNeil, Brett Doble, Alexander Dobrovic, Thomas John, Paul A James, Lara Lipton, David Ashley, Theresa Hayes, Paul McMurrick, Gary Richardson, Paula Lorgelly, Stephen B Fox, David M Thomas

Journal article  |  2015  |  Journal of Personalized Medicine

Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

Nicholas C Wong, Bernard J Pope, Ida Candiloro, Darren Korbie, Matt Trau, Stephen Q Wong, Thomas Mikeska, Bryce JW van Denderen, Erik W Thompson, Stefanie Eggers, Stephen R Doyle, Alexander Dobrovic

Journal article  |  2015  |  GigaScience

EPITHELIAL-MESENCHYMAL PLASTICITY STATUS IN CIRCULATING TUMOUR CELLS OF BREAST CANCER XENOGRAFT MODELS

Erik W Thompson, Viet-Phuong Le Anh, Anthony Tachtsidis, Tony Blick, Devika Gunasinghe, Mark Waltham, Alexander Dobrovic

Conference Proceedings  |  2015  |  Asia-Pacific Journal of Clinical Oncology

PREDICTIVE VALUE OF DE NOVO AND INDUCED EPITHELIAL-MESENCHYMAL TRANSITION IN LOCALLY ADVANCED BREAST CANCER TREATED WITH NEOADJUVANT CHEMOTHERAPY

Erik W Thompson, Sally A McLaren, Vijani Dissanayake, Andrew Redfern, Arlene Chan, Alexander Dobrovic, Lilian Soon, Christobel M Saunders

Conference Proceedings  |  2015  |  Asia-Pacific Journal of Clinical Oncology

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

Katie T Huang, Thomas Mikeska, Jason Li, Elena A Takano, Ewan KA Millar, Peter H Graham, Samantha E Boyle, Ian G Campbell, Terence P Speed, Alexander Dobrovic, Stephen B Fox

Journal article  |  2015  |  BMC Cancer

Copy number analysis of ductal carcinoma in situ with and without recurrence

Kylie L Gorringe, Sally M Hunter, Jia-Min Pang, Ken Opeskin, Prue Hill, Simone M Rowley, David YH Choong, Ella R Thompson, Alexander Dobrovic, Stephen B Fox, G Bruce Mann, Ian G Campbell

Journal article  |  2015  |  Modern Pathology

An optimised direct lysis method for gene expression studies on low cell numbers

Viet-Phuong Le Anh, Dexing Huang, Tony Blick, Erik W Thompson, Alexander Dobrovic

Journal article  |  2015  |  Scientific Reports

The role of BRAF mutations in primary melanoma growth rate and survival

VJ Mar, W Liu, B Devitt, SQ Wong, A Dobrovic, GA McArthur, R Wolfe, JW Kelly

Journal article  |  2015  |  British Journal of Dermatology

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

Imran G House, Kevin Thia, Amelia J Brennan, Richard Tothill, Alexander Dobrovic, Wei Z Yeh, Richard Saffery, Zac Chatterton, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2015  |  Immunology & Cell Biology

Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

Simon Chang-Hao Tsao, Jonathan Weiss, Christopher Hudson, Christopher Christophi, Jonathan Cebon, Andreas Behren, Alexander Dobrovic

Journal article  |  2015  |  Scientific Reports

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Jia-Min B Pang, Kylie L Gorringe, Stephen Q Wong, Alexander Dobrovic, Ian G Campbell, Stephen B Fox

Journal article  |  2015  |  Breast Cancer Research

High-Resolution Assessment of Copy Number Variation

Alexander Dobrovic

Journal article  |  2015  |  Clinical Chemistry

Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients

SQ Wong, A Fellowes, K Doig, J Ellul, TJ Bosma, D Irwin, R Vedururu, AY-C Tan, J Weiss, KS Chan, M Lucas, DM Thomas, A Dobrovic, JP Parisot, SB Fox

Journal article  |  2015  |  British Journal of Cancer

Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC

Michael Michael, Shane C White, Ehtesham Abdi, Louise Nott, Phillip Clingan, Allan Zimet, Peter Button, Daniel Gregory, Benjamin Solomon, Alexander Dobrovic, Hongdo Do, Stephen Clarke

Journal article  |  2015  |  Asia-Pacific Journal of Clinical Oncology

Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value

Clare Stirzaker, Elena Zotenko, Jenny Z Song, Wenjia Qu, Shalima S Nair, Warwick J Locke, Andrew Stone, Nicola J Armstong, Mark D Robinson, Alexander Dobrovic, Kelly A Avery-Kiejda, Kate M Peters, Juliet D French, Sandra Stein, Darren J Korbie, Matt Trau, John F Forbes, Rodney J Scott, Melissa A Brown, Glenn D Francis, et al.

Journal article  |  2015  |  Nature Communications

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Karoline B Kuchenbaecker, Susan J Ramus, Jonathan Tyrer, Andrew Lee, Howard C Shen, Jonathan Beesley, Kate Lawrenson, Lesley McGuffog, Sue Healey, Janet M Lee, Tassja J Spindler, Yvonne G Lin, Tanja Pejovic, Yukie Bean, Qiyuan Li, Simon Coetzee, Dennis Hazelett, Alexander Miron, Melissa Southey, Mary Beth Terry, et al.

Journal article  |  2015  |  Nature Genetics

DNA Ligase-Based Strategy for Quantifying Heterogeneous DNA Methylation without Sequencing

Eugene JH Wee, Sakandar Rauf, Muhammad JA Shiddiky, Alexander Dobrovic, Matt Trau

Journal article  |  2015  |  Clinical Chemistry

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

SQ Wong, A Behren, VJ Mar, K Woods, J Li, C Martin, KE Sheppard, R Wolfe, J Kelly, J Cebon, A Dobrovic, GA McArthur

Journal article  |  2015  |  Oncotarget

Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T chang..

Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

Hongdo Do, Alexander Dobrovic

Journal article  |  2015  |  Clinical Chemistry

Role of p53 in the progression of gastric cancer

Rita A Busuttil, Giada V Zapparoli, Sue Haupt, Christina Fennell, Stephen Q Wong, Jia-Min B Pang, Elena A Takeno, Catherine Mitchell, Natasha Di Costanzo, Stephen Fox, Ygal Haupt, Alexander Dobrovic, Alex Boussioutas

Journal article  |  2014  |  ONCOTARGET

Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M Hunter, Ian Campbell, Alexander Dobrovic, et al.

Journal article  |  2014  |  Clinical Cancer Research

Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome

Annette M Lim, Ida LM Candiloro, Nicholas Wong, Marnie Collins, Hongdo Do, Elena A Takano, Christopher Angel, Richard J Young, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Danny Rischin, Benjamin Solomon, Alexander Dobrovic

Journal article  |  2014  |  Clinical Epigenetics

Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations

S Deb, SQ Wong, J Li, H Do, J Weiss, D Byrne, A Chakrabarti, T Bosma, A Fellowes, A Dobrovic, SB Fox

Journal article  |  2014  |  Br J Cancer

Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma

Victoria J Mar, Stephen Q Wong, Aleksandra Logan, Nguyen Trung, Jonathan Cebon, John W Kelly, Rory Wolfe, Alexander Dobrovic, Catriona McLean, Grant A McArthur

Journal article  |  2014  |  PIGMENT CELL & MELANOMA RESEARCH

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151

Stuart J Gallagher, Branka Mijatov, Dilini Gunatilake, Kavitha Gowrishankar, Jessamy Tiffen, Wilmott James, Lei Jin, Gulietta Pupo, Carleen Cullinane, Grant A McArthur, Peter J Tummino, Helen Rizos, Peter Hersey

Journal article  |  2014  |  Pigment Cell & Melanoma Research

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

John RB Perry, Felix Day, Cathy E Elks, Patrick Sulem, Deborah J Thompson, Teresa Ferreira, Chunyan He, Daniel I Chasman, Toenu Esko, Gudmar Thorleifsson, Eva Albrecht, Wei Q Ang, Tanguy Corre, Diana L Cousminer, Bjarke Feenstra, Nora Franceschini, Andrea Ganna, Andrew D Johnson, Sanela Kjellqvist, Kathryn L Lunetta, et al.

Journal article  |  2014  |  Nature

Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer

Siddhartha Deb, Ida Johansson, David Byrne, Cecilia Nilsson, Leonie Constable, Marie-Louise Fjallskog, Alexander Dobrovic, Ingrid Hedenfalk, Stephen B Fox

Journal article  |  2014  |  Modern Pathology

Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

Annette M Lim, Hongdo Do, Richard J Young, Stephen Q Wong, Christopher Angel, Marnie Collins, Elena A Takano, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Stephen B Fox, Danny Rischin, Alexander Dobrovic, Benjamin Solomon

Journal article  |  2014  |  International Journal of Cancer

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

Richard J Young, Kelly Waldeck, Claire Martin, Jung H Foo, Donald P Cameron, Laura Kirby, Hongdo Do, Catherine Mitchell, Carleen Cullinane, Wendy Liu, Stephen B Fox, Ken Dutton-Regester, Nicholas K Hayward, Nicholas Jene, Alexander Dobrovic, Richard B Pearson, James G Christensen, Sophia Randolph, Grant A McArthur, Karen E Sheppard

Journal article  |  2014  |  PIGMENT CELL & MELANOMA RESEARCH

Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

Stephen Q Wong, Jason Li, Angela Y-C Tan, Ravikiran Vedururu, Jia-Min B Pang, Hongdo Do, Jason Ellul, Ken Doig, Anthony Bell, Grant A McArthur, Stephen B Fox, David M Thomas, Andrew Fellowes, John P Parisot, Alexander Dobrovic

Journal article  |  2014  |  BMC Medical Genomics

The Clinical Relevance of Pathologic Subtypes in Metastatic Lung Adenocarcinoma

Timothy D Clay, Hongdo Do, Vijaya Sundararajan, Melissa M Moore, Matthew Conron, Gavin M Wright, Sue-Anne McLachlan, Alexander Dobrovic, Prudence A Russell

Journal article  |  2014  |  JOURNAL OF THORACIC ONCOLOGY

Bioinformatics Pipelines for Targeted Resequencing and Whole-Exome Sequencing of Human and Mouse Genomes: A Virtual Appliance Approach for Instant Deployment

Jason Li, Maria A Doyle, Isaam Saeed, Stephen Q Wong, Victoria Mar, David L Goode, Franco Caramia, Ken Doig, Georgina L Ryland, Ella R Thompson, Sally M Hunter, Saman K Halgamuge, Jason Ellul, Alexander Dobrovic, Ian G Campbell, Anthony T Papenfuss, Grant A McArthur, Richard W Tothill

Journal article  |  2014  |  PLOS ONE

Mapping of actionable mutations to histologic subtype domains in lung adenocarcinoma: implications for precision medicine

GM Wright, Hongdo Do, Jonathan Weiss, NZ Alam, Vivek Rathi, Marzena Walkiewicz, PA Russell, A Dobrovic

Journal article  |  2014  |  Oncotarget

Precision medicine depends on the accurate identification of actionable mutations in a tumor sample. It is unknown how heterogeneo..

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

Hongdo Do, Nicholas C Wong, Carmel Murone, Thomas John, Benjamin Solomon, Paul L Mitchell, Alexander Dobrovic

Journal article  |  2014  |  Scientific Reports

Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features

Jia-Min B Pang, Siddhartha Deb, Elena A Takano, David J Byrne, Nicholas Jene, Alice Boulghourjian, Anne Holliday, Ewan Millar, C Soon Lee, Sandra A O'Toole, Alexander Dobrovic, Stephen B Fox

Journal article  |  2014  |  Breast Cancer Research

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Nichola Johnson, Frank Dudbridge, Nick Orr, Lorna Gibson, Michael E Jones, Minouk J Schoemaker, Elizabeth J Folkerd, Ben P Haynes, John L Hopper, Melissa C Southey, Gillian S Dite, Carmel Apicella, Marjanka K Schmidt, Annegien Broeks, Laura J Van't Veer, Femke Atsma, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, et al.

Journal article  |  2014  |  Breast Cancer Research

Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors

Puey Ling Chia, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2014  |  Clinical Epidemiology

Characterization of a Novel Tumorigenic Esophageal Adenocarcinoma Cell Line: OANC1

Nicholas J Clemons, Hongdo Do, Christina Fennell, Siddhartha Deb, Andrew Fellowes, Alexander Dobrovic, Wayne A Phillips

Journal article  |  2014  |  Digestive Diseases and Sciences

EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma

Prudence A Russell, Yong Yu, Hongdo Do, Timothy D Clay, Melissa M Moore, Gavin M Wright, Matthew Conron, Zoe Wainer, Alexander Dobrovic, Sue-Anne McLachlan

Journal article  |  2014  |  PATHOLOGY

Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours

Stephen Q Wong, Jason Li, Renato Salemi, Karen E Sheppard, Hongdo Do, Richard W Tothill, Grant A McArthur, Alexander Dobrovic

Journal article  |  2013  |  Scientific Reports

BRAF Inhibitor-Driven Tumor Proliferation in a KRAS-Mutated Colon Carcinoma Is Not Overcome by MEK1/2 Inhibition

Miles C Andrews, Andreas Behren, Fiona Chionh, John Mariadason, Laura J Vella, Hongdo Do, Alexander Dobrovic, Niall Tebbutt, Jonathan Cebon

Journal article  |  2013  |  Journal of Clinical Oncology

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

Jesslyn Saw, David J Curtis, Damian J Hussey, Alexander Dobrovic, Peter D Aplan, Christopher I Slape

Journal article  |  2013  |  LEUKEMIA RESEARCH

EXTRACTING HIGH QUALITY RNA FROM FFPE SAMPLES FOR GENE EXPRESSION STUDIES

Jonathan Weiss, Hongdo Do, Prudence A Russell, Gavin Wright, Alexander Dobrovic

Conference Proceedings  |  2013  |  JOURNAL OF THORACIC ONCOLOGY

Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors

Matthew Anaka, Christopher Hudson, Pu-Han Lo, Hongdo Do, Otavia L Caballero, Ian D Davis, Alexander Dobrovic, Jonathan Cebon, Andreas Behren

Journal article  |  2013  |  BMC Medical Genomics

Reducing Sequence Artifacts in Amplicon-Based Massively Parallel Sequencing of Formalin-Fixed Paraffin-Embedded DNA by Enzymatic Depletion of Uracil-Containing Templates

Hongdo Do, Stephen Q Wong, Jason Li, Alexander Dobrovic

Journal article  |  2013  |  Clinical Chemistry: international journal of molecular diagnostics and laboratory medicine

BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage

Victoria J Mar, Stephen Q Wong, Jason Li, Richard A Scolyer, Catriona McLean, Anthony T Papenfuss, Richard W Tothill, Hojabr Kakavand, Graham J Mann, John F Thompson, Andreas Behren, Jonathan S Cebon, Rory Wolfe, John W Kelly, Alexander Dobrovic, Grant A McArthur

Journal article  |  2013  |  Clinical Cancer Research

High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort

Gillian Mitchell, Mandy L Ballinger, Stephen Wong, Chelsee Hewitt, Paul James, Mary-Anne Young, Arcadi Cipponi, Tiffany Pang, David L Goode, Alex Dobrovic, David M Thomas

Journal article  |  2013  |  PLOS ONE

Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George, Kathryn Alsop, Dariush Etemadmoghadam, Heather Hondow, Thomas Mikeska, Alexander Dobrovic, Anna DeFazio, Gordon K Smyth, Douglas A Levine, Gillian Mitchell, David D Bowtell

Journal article  |  2013  |  CLINICAL CANCER RESEARCH

Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection

Giada V Zapparoli, Robert N Jorissen, Chelsee A Hewitt, Michelle McBean, David A Westerman, Alexander Dobrovic

Journal article  |  2013  |  BMC Cancer

A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma

Anna Richter, Fabienne Grieu, Amerigo Carrello, Benhur Amanuel, Kateh Namdarian, Aleksandra Rynska, Amanda Lucas, Victoria Michael, Anthony Bell, Stephen B Fox, Chelsee A Hewitt, Hongdo Do, Grant A McArthur, Stephen Q Wong, Alexander Dobrovic, Barry Iacopetta

Journal article  |  2013  |  Scientific Reports

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic

Journal article  |  2013  |  JOURNAL OF OVARIAN RESEARCH

Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophagogastric cancer: the AGITG ATTAX2 trial

NC Tebbutt, MM Parry, D Zannino, AH Strickland, GA Van Hazel, N Pavlakis, V Ganju, D Mellor, A Dobrovic, VJ Gebski

Journal article  |  2013  |  British Journal of Cancer

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

James D Mellor, Michael P Brown, Helen R Irving, John R Zalcberg, Alexander Dobrovic

Journal article  |  2013  |  Journal of Hematology & Oncology

PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

Siddhartha Deb, Hongdo Do, David Byrne, Nicholas Jene, Alexander Dobrovic, Stephen B Fox

Journal article  |  2013  |  Breast Cancer Research

DNA methylation in ductal carcinoma in situ of the breast

Jia-Min B Pang, Alexander Dobrovic, Stephen B Fox

Journal article  |  2013  |  Breast Cancer Research

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer

EJH Wee, K Peters, SS Nair, T Hulf, S Stein, S Wagner, P Bailey, SY Lee, WJ Qu, B Brewster, JD French, A Dobrovic, GD Francis, SJ Clark, MA Brown

Journal article  |  2012  |  Oncogene

DRAMATIC REDUCTION OF SEQUENCE ARTEFACTS FROM DNA EXTRACTED FROM FORMALIN-FIXED CANCER BIOPSIES BY TREATMENT WITH URACIL-DNA GLYCOSYLASE

H Do, A Dobrovic

Conference Proceedings  |  2012  |  JOURNAL OF THORACIC ONCOLOGY

THE RISE AND FALL OF COMPANION DIAGNOSTICS.

A Dobrovic

Conference Proceedings  |  2012  |  JOURNAL OF THORACIC ONCOLOGY

EXTRACTING HIGH QUALITY RNA FROM FFPE SAMPLES FOR GENE EXPRESSION STUDIES

J Weiss, H Do, G Wright, P Russell, A Dobrovic

Conference Proceedings  |  2012  |  JOURNAL OF THORACIC ONCOLOGY

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

Kathryn Alsop, Sian Fereday, Cliff Meldrum, Anna deFazio, Catherine Emmanuel, Joshy George, Alexander Dobrovic, Michael J Birrer, Penelope M Webb, Colin Stewart, Michael Friedlander, Stephen Fox, David Bowtell, Gillian Mitchell

Journal article  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia

Thomas Mikeska, Dennis A Carney, John F Seymour, Alexander Dobrovic

Journal article  |  2012  |  Leukemia and Lymphoma

Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis

Angela Y-C Tan, Stephen Q Wong, Charlotte Guldborg Nyvold, Dennis A Carney, Andrew Wei, John F Seymour, Peter Hokland, undefined Westerman, Alexander Dobrovic

Journal article  |  2012  |  Leukemia and Lymphoma

DNA methylation biomarkers in cancer: progress towards clinical implementation

Thomas Mikeska, Christoph Bock, Hongdo Do, Alexander Dobrovic

Journal article  |  2012  |  Expert Reviews in Molecular Medicine

Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders

Piers A Blombery, Stephen Q Wong, Chelsee A Hewitt, Alexander Dobrovic, Ellen L Maxwell, Surender Juneja, George Grigoriadis, David A Westerman

Journal article  |  2012  |  Haematologica

Dual Targeting of the Epidermal Growth Factor Receptor Using the Combination of Cetuximab and Erlotinib: Preclinical Evaluation and Results of the Phase II DUX Study in Chemotherapy-Refractory, Advanced Colorectal Cancer

Andrew J Weickhardt, Tim J Price, Geoff Chong, Val Gebski, Nick Pavlakis, Terrance G Johns, Arun Azad, Effie Skrinos, Kate Fluck, Alexander Dobrovic, Renato Salemi, Andrew M Scott, John M Mariadason, Niall C Tebbutt

Journal article  |  2012  |  Journal of Clinical Oncology

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase.

Hongdo Do, Alexander Dobrovic

Journal article  |  2012  |  Oncotarget

Epithelial mesenchymal plasticity in xenograft models of circulating and disseminated tumour cells from human breast cancer

Anthony Tachtsidis, Devika Gunasinghe, Tony Blick, Dexing Huang, Emma L de Sousa, Alexander Dobrovic, Mark Waltham, Erik W Thompson

Conference Proceedings  |  2012  |  Tumor Biology

Reducing sequence artefacts from FFPE DNA for cancer diagnostics

Hongdo Do, Alexander Dobrovic

Conference Proceedings  |  2012  |  Molecular and Cellular Biology

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes.

Lasse Sommer Kristensen, Michael Raynor, Ida Candiloro, Alexander Dobrovic

Journal article  |  2012  |  Oncotarget

Incorporating Epithelial Mesenchymal Plasticity (EMP) in the Detection and Isolation of Circulating and Disseminated Tumour Cells

N Jacobsen, A Dobrovic, A Tachtsidis, T Blick, E Thomas, A Dowling, D Huang, N Zeps, C Saunders, E Thompson

Conference Proceedings  |  2012  |  EUROPEAN JOURNAL OF CANCER

Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers

JL Hopper, MA Jenkins, JG Dowty, GS Dite, C Apicella, L Keogh, AK Win, JP Young, D Buchanan, MD Walsh, C Rosty, L Baglietto, G Severi, KA Phillips, EM Wong, A Dobrovic, P Waring, I Winship, SJ Ramus, GG Giles, et al.

Journal article  |  2012  |  Pathology

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase.

H Do, A Dobrovic

Journal article  |  2012  |  Oncotarget

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes

LS Kristensen, M Raynor, I CANDILORO, A Dobrovic

Journal article  |  2012  |  Oncotarget

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer

EJW Wee, K Peters, SS Nair, T Hulf, S Stein, S Wagner, P Bailey, SY Lee, WJ Qu, B Brewster, JD French, A Dobrovic, GD Francis, SJ Clark, MA Brown

Journal article  |  2012  |  Oncogene

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer

Katie T Huang, Elena A Takano, Thomas Mikeska, David J Byrne, Alexander Dobrovic, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research and Treatment

Sensitive Quantification of Somatic Mutations Using Molecular Inversion Probes

Rena Hirani, Ashley R Connolly, Lisa Putral, Alexander Dobrovic, Matt Trau

Journal article  |  2011  |  Analytical Chemistry

Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma

Bianca Devitt, Wendy Liu, Renato Salemi, Rory Wolfe, John Kelly, Chin-Yuan Tzen, Alexander Dobrovic, Grant McArthur

Journal article  |  2011  |  Pigment Cell & Melanoma Research

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes

Heather L Hondow, Stephen B Fox, Gillian Mitchell, Rodney J Scott, Victoria Beshay, Stephen Q Wong, Alexander Dobrovic

Journal article  |  2011  |  BMC Cancer

ACCURATE ESTIMATION OF DNA METHYLATION FREQUENCY IN NON-SMALL CELL LUNG CANCER

Hongdo Do, Paul Mitchell, Thomas John, Alexander Dobrovic

Conference Proceedings  |  2011  |  JOURNAL OF THORACIC ONCOLOGY

DETECTION OF LKB1/STK11 MUTATIONS IN NSCLC PATIENTS USING HIGH RESOLUTION MELTING ANALYSIS.

Hongdo Do, Guenaelle Levallet, Emmanuel Bergot, Martine Antoine, Franck Morin, Bernard Milleron, Gerard Zalcman, Alexander Dobrovic

Conference Proceedings  |  2011  |  JOURNAL OF THORACIC ONCOLOGY

Assessing combined methylation-sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation

Ida LM Candiloro, Thomas Mikeska, Alexander Dobrovic

Journal article  |  2011  |  Epigenetics

METHYLATION PORTRAITS OF DNA REPAIR GENES IN NON-SMALL CELL LUNG CARCINOMA REVEALS BOUTIQUE TARGETS FOR THERAPY

H Do, T John, PL Mitchell, A Dobrovic

Conference Proceedings  |  2011  |  JOURNAL OF THORACIC ONCOLOGY

TECHNIQUES - HOW TO MEASURE BIOMARKERS

A Dobrovic

Conference Proceedings  |  2011  |  JOURNAL OF THORACIC ONCOLOGY

Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome

Musa Drini, Nicholas C Wong, Hamish S Scott, Jeffrey M Craig, Alexander Dobrovic, Chelsee A Hewitt, Christofer Dow, Joanne P Young, Mark A Jenkins, Richard Saffery, Finlay A Macrae

Journal article  |  2011  |  PLoS One

Analysing DNA Methylation Using Bisulphite Pyrosequencing

Thomas Mikeska, Joerg Felsberg, Chelsee A Hewitt, Alexander Dobrovic

Journal article  |  2011  |  Methods in Molecular Biology

Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer

Ee Ming Wong, Melissa C Southey, Stephen B Fox, Melissa A Brown, James G Dowty, Mark A Jenkins, Graham G Giles, John L Hopper, Alexander Dobrovic

Journal article  |  2011  |  Cancer prevention research

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

GM Newnham, M Conron, S McLachlan, A Dobrovic, H Do, J Li, K Opeskin, N Thompson, GM Wright, DM Thomas

Journal article  |  2011  |  BMC Cancer

BACKGROUND: The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that ..

The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

Peter Chan, Andreas Moeller, Mira CP Liu, Jaclyn E Sceneay, Christina SF Wong, Nic Waddell, Katie T Huang, Alexander Dobrovic, Ewan KA Millar, Sandra A O'Toole, Catriona M McNeil, Robert L Sutherland, David D Bowtell, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research

Assessing Gene-Specific Methylation Using HRM-Based Analysis

Ee Ming Wong, Alexander Dobrovic

Journal article  |  2011  |  Methods in molecular biology (Clifton, N.J.)

Methylation-sensitive High Resolution Melting for the Rapid Analysis of DNA Methylation

Thomas Mikeska, Alexander Dobrovic

Book Chapter  |  2011

Closed-Tube PCR Methods for Locus-Specific DNA Methylation Analysis

Ida LM Candiloro, Thomas Mikeska, Alexander Dobrovic

Book Chapter  |  2011  |  Methods in Molecular Biology

A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues

Elena A Takano, Thomas Mikeska, Alexander Dobrovic, David J Byrne, Stephen B Fox

Journal article  |  2010  |  BMC Biotechnology

No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer

Katie T Huang, Alexander Dobrovic, Stephen B Fox

Journal article  |  2010  |  Breast Cancer Research and Treatment

Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung

Hongdo Do, Renato Salemi, Carmel Murone, Paul L Mitchell, Alexander Dobrovic

Journal article  |  2010  |  Cell Cycle

DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast

Katie T Huang, Alexander Dobrovic, Max Yan, Rooshdiya Z Karim, C Soon Lee, Sunil R Lakhani, Stephen B Fox

Journal article  |  2010  |  Breast Cancer Research and Treatment

DNA methylation analysis of the HIF-1 alpha prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas

Katie T Huang, Thomas Mikeska, Alexander Dobrovic, Stephen B Fox

Journal article  |  2010  |  Histopathology

The implications of heterogeneous DNA methylation for the accurate quantification of methylation

Thomas Mikeska, Ida LM Candiloro, Alexander Dobrovic

Journal article  |  2010  |  Epigenomics

DUX study A phase 11 study of evaluating dual targeting of the EGFR using the combination of cetuximab and erlotinib in patients with chemotherapy refractory metastatic colorectal cancer.

AJ Weickhardt, TJ Price, N Pavlakis, E Skrinos, A Dobrovic, R Salemi, AM Scott, J Mariadason, G Chong, NC Tebbutt

Conference Proceedings  |  2010  |  Journal of Clinical Oncology

Clinical outcome and pathologic features associated with NRAS mutation in cutaneous melanoma

BA Devitt, W Liu, R Salemi, R Wolfe, J Kelly, A Dobrovic, GA McArthur

Conference Proceedings  |  2010  |  Journal of Clinical Oncology

Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT

D Handolias, AL Hamilton, R Salemi, A Tan, K Moodie, L Kerr, A Dobrovic, GA McArthur

Journal article  |  2010  |  British Journal of Cancer

Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure

Despina Handolias, Renato Salemi, William Murray, Angela Tan, Wendy Liu, Amaya Viros, Alexander Dobrovic, John Kelly, Grant A McArthur

Journal article  |  2010  |  Pigment Cell & Melanoma Research

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

Leonard Da Silva, Peter T Simpson, Chanel E Smart, Sibylle Cocciardi, Nic Waddell, Annette Lane, Brian J Morrison, Ana Cristina Vargas, Sue Healey, Jonathan Beesley, Pria Pakkiri, Suzanne Parry, Nyoman Kurniawan, Lynne Reid, Patricia Keith, Paulo Faria, Emilio Pereira, Alena Skalova, Michael Bilous, Rosemary L Balleine, et al.

Journal article  |  2010  |  Breast Cancer Research

A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting

Vicki Whitehall, Kayla Tran, Aarti Umapathy, Fabienne Grieu, Chelsee Hewitt, Tiffany-Jane Evans, Tuty Ismail, Wei Qi Li, Peter Collins, Paul Ravetto, Barbara Leggett, Manuel Salto-Tellez, Richie Soong, Stephen Fox, Rodney J Scott, Alexander Dobrovic, Barry Iacopetta

Journal article  |  2009  |  Journal of Molecular Diagnostics

Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies

Hongdo Do, Alexander Dobrovic

Journal article  |  2009  |  Molecular Cancer

Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism

Ida LM Candiloro, Alexander Dobrovic

Journal article  |  2009  |  Cancer prevention research

No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.

Katie T Huang, Alexander Dobrovic, Stephen B Fox

Journal article  |  2009  |  BMC Research Notes

BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also kno..

Limited copy number - high resolution melting for the detection of low frequency mutations

Hongdo Do, Alexander Dobrovic

Conference Proceedings  |  2009  |  JOURNAL OF THORACIC ONCOLOGY

RASSF1/hippo pathway molecular dissection in patients with resectable non-small cell lung cancer (NSCLC) treated by perioperative chemotherapy (CT) in the phase III trial IFCT-0002

Gerard Zalcman, Guenaelle Levallet, Hongdo Do, Florence De Fraipont, Mounia Mounawar, Michele Beau-Faller, Emmanuel Bergot, Franck Morin, Christian Creveuil, Alexander Dobrovic, Pierre Hainaut, Bernard Milleron

Conference Proceedings  |  2009  |  JOURNAL OF THORACIC ONCOLOGY

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf

Hui-Hua Zhang, Francesca Walker, Sara Kiflemariam, Robert H Whitehead, David Williams, Wayne A Phillips, Thomas Mikeska, Alexander Dobrovic, Antony W Burgess

Journal article  |  2009  |  International Journal of Cancer

Validation of a primer optimisation matrix to improve the performance of reverse transcription - quantitative real-time PCR assays.

Thomas Mikeska, Alexander Dobrovic

Journal article  |  2009  |  BMC Research Notes

BACKGROUND: The development of reverse transcription - quantitative real-time PCR (RT-qPCR) platforms that can simultaneously meas..

Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR

Michael P Raynor, Sally-Anne Stephenson, Kenneth B Pittman, David CA Walsh, Michael A Henderson, Alexander Dobrovic

Journal article  |  2009  |  Journal of Hematology & Oncology

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

Maya Kansara, Michael Tsang, Laurent Kodjabachian, Natalie A Sims, Melanie K Trivett, Mathias Ehrich, Alexander Dobrovic, John Slavin, Peter FM Choong, Paul J Simmons, Igor B Dawid, David M Thomas

Journal article  |  2009  |  Journal of Clinical Investigation

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs (vol 99, pg 294, 2008)

DM Ashley, CD Riffkin, MM Lovric, T Mikeska, A Dobrovic, JA Maxwell, HS Friedman, KJ Drummond, AH Kaye, HK Gan, TG Johns, CJ Hawkins

Journal article  |  2009  |  British Journal of Cancer

DNA Methylation of the ABO Promoter Underlies Loss of ABO Allelic Expression in a Significant Proportion of Leukemic Patients

Tina Bianco-Miotto, Damian J Hussey, Tanya K Day, Denise S O'Keefe, Alexander Dobrovic

Journal article  |  2009  |  PLoS ONE

DNA methylation, epimutations and cancer predisposition

Alexander Dobrovic, Lasse S Kristensen

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

Melting curve assays for DNA methylation analysis.

Tomasz K Wojdacz, Alexander Dobrovic

Journal article  |  2009  |  Methods in molecular biology (Clifton, N.J.)

The ability of sodium bisulfite to modify cytosines in a methylation-dependent manner allows the conservation of DNA methylation i..

Rapid Detection of Methylation Change at H19 in Human Imprinting Disorders Using Methylation-Sensitive High-Resolution Melting

Tomasz K Wojdacz, Alexander Dobrovic, Elizabeth M Algar

Journal article  |  2008  |  Human Mutation

Detection of NPM1 exon 12 mutations and FLT3-internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

Angela YC Tan, David A Westerman, Dennis A Carney, John F Seymour, Surender Juneja, Alexander Dobrovic

Journal article  |  2008  |  Journal of Hematology & Oncology

A new approach to primer design for the control of PCR bias in methylation studies.

Tomasz K Wojdacz, Lise Lotte Hansen, Alexander Dobrovic

Journal article  |  2008  |  BMC Research Notes

Primer design for PCR-based methylation analysis following bisulfite conversion of DNA is considerably more complex than primer de..

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs

DM Ashley, CD Riffkin, MM Lovric, T Mikeska, A Dobrovic, JA Maxwell, HS Friedman, KJ Drummond, AH Kaye, HK Gan, TG Johns, CJ Hawkins

Journal article  |  2008  |  British Journal of Cancer

High resolution melting allows sensitive high-throughput assessment of methylation in tumour samples

TK Wojdacz, E Algar, A Dobrovic, LL Hansen

Conference Proceedings  |  2008  |  EJC Supplements

G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history

Theodore Anagnostopoulos, Maroulio Pertesi, Irene Konstantopoulou, Sofia Armaou, Smaragda Kamakari, George Nasioulas, Athanassios Athanasiou, Alex Dobrovic, Mary-Anne Young, David Goldgar, George Fountzilas, Drakoulis Yannoukakos

Journal article  |  2008  |  Breast Cancer Research and Treatment

High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

Hongdo Do, Michael Krypuy, Paul L Mitchell, Stephen B Fox, Alexander Dobrovic

Journal article  |  2008  |  BMC Cancer

Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.

Hongdo Do, Benjamin Solomon, Paul L Mitchell, Stephen B Fox, Alexander Dobrovic

Journal article  |  2008  |  BMC Research Notes

BACKGROUND: A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in..

Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis

Lasse S Kristensen, Alexander Dobrovic

Journal article  |  2008  |  Cancer Epidemiology, Biomarkers & Prevention

Sensitive Melting Analysis after Real Time-Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection

Lasse S Kristensen, Thomas Mikeska, Michael Krypuy, Alexander Dobrovic

Journal article  |  2008  |  Nucleic Acids Research

Complete molecular response of e6a2 BCR-ABL-positive acute myeloid leukemia to imatinib then dasatinib

David S Ritchie, Michelle McBean, David A Westerman, Sergey Kovalenko, John F Seymour, Alexander Dobrovic

Journal article  |  2008  |  Blood

Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis

Elena A Takano, Gillian Mitchell, Stephen B Fox, Alexander Dobrovic

Journal article  |  2008  |  BMC Cancer

Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail

Salim Essakali, Dennis Carney, David Westerman, Peter Gambell, John F Seymour, Alexander Dobrovic

Journal article  |  2008  |  BMC Biotechnology

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype

Cameron Snell, Michael Krypuy, Ee Ming Wong, Maurice B Loughrey, Alexander Dobrovic

Journal article  |  2008  |  Breast Cancer Research

Methylation-sensitive high-resolution melting

Tomasz K Wojdacz, Alexander Dobrovic, Lise Lotte Hansen

Journal article  |  2008  |  Nature Protocols

Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene

Ida LM Candiloro, Thomas Mikeska, Peter Hokland, Alexander Dobrovic

Journal article  |  2008  |  Epigenetics and Chromatin

High resolution melting for mutation scanning of TP53 exons 5-8

Michael Krypuy, Ahmed Ashour Ahmed, Dariush Etemadmoghadam, Sarah J Hyland, Anna deFazio, Stephen B Fox, James D Brenton, David D Bowtell, Alexander Dobrovic

Journal article  |  2007  |  BMC CANCER

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

A simple, rapid, and sensitive method for the detection of the JAK2 V617F mutation

Angela YC Tan, David A Westerman, Alexander Dobrovic

Journal article  |  2007  |  American Journal of Clinical Pathology

Distinct clinical and pathological features are associated with the BRAF (T1799A(V600E)) mutation in primary melanoma

Wendy Liu, John W Kelly, Melanie Trivett, William K Murray, John P Dowling, Rory Wolfe, Graham Mason, Jill Magee, Christopher Angel, Alexander Dobrovic, Grant A McArthur

Journal article  |  2007  |  Journal of Investigative Dermatology

Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation

Tomasz K Wojdacz, Alexander Dobrovic

Journal article  |  2007  |  Nucleic Acids Research

Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer

MB Loughrey, PM Waring, A Tan, M Trivett, S Kovalenko, V Beshay, M-A Young, G McArthur, A Boussioutas, A Dobrovic

Journal article  |  2007  |  Familial Cancer

High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer

Michael Krypuy, Genni M Newnham, David M Thomas, Matthew Conron, Alexander Dobrovic

Journal article  |  2006  |  BMC Cancer

Sensitive detection of KIT D816V in patients with mastocytosis

Angela Tan, David Westerman, Grant A McArthur, Kevin Lynch, Paul Waring, Alexander Dobrovic

Journal article  |  2006  |  Clinical Chemistry

Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

Honor Hugo, Alina Cures, Nirosha Suraweera, Yvette Drabsch, Damian Purcell, Theo Mantamadiotis, Wayne Phillips, Alex Dobrovic, Gabriella Zupi, Thomas J Gonda, Barry Iacopetta, Robert G Ramsay

Journal article  |  2006  |  Genes, Chromosomes & Cancer

Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors

Maurice B Loughrey, Paul M Waring, Alex Dobrovic, George Demetri, Serge Kovalenko, Grant McArthur

Journal article  |  2006  |  Clinical Cancer Research

DNA repair gene inactivation in non-Hodgkin's lymphoma

Alexander Dobrovic

Journal article  |  2006  |  Leukemia & Lymphoma

Platelet-derived growth factor receptor a mutation in gastrointestinal stromal tumors: A report of two cases and review of the literature

Maurice Loughrey, Serge Kovalenko, Melanie Trivett, Alex Dobrovic, Paul Waring

Conference Proceedings  |  2006  |  MODERN PATHOLOGY

Pathological response of gastrointestinal stromal tumour to imatinib treatment correlates with tumour KIT mutational status in individual tumour clones

MB Loughrey, V Beshay, A Dobrovic, J Zalcberg, PM Waring

Journal article  |  2006  |  Histopathology

KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib

MB Loughrey, M Trivett, V Beshay, A Dobrovic, S Kovalenko, W Murray, S Lade, H Turner, GA McArthur, J Zalcberg, PM Waring

Journal article  |  2006  |  Histopathology

Empirical array quality weights in the analysis of microarray data

Matthew E Ritchie, Dileepa Diyagama, Jody Neilson, Ryan van Laar, Alexander Dobrovic, Andrew Holloway, Gordon K Smyth

Journal article  |  2006  |  BMC BIOINFORMATICS

Methods for analysis of DNA methylation

A Dobrovic

Book Chapter  |  2005

The BRAF (T1799A) mutation is associated with distinct clinical characteristics in invasive primary melanoma

W Liu, W Murray, J Dowling, J Kelly, R Wolfe, G Mason, J Magee, C Angel, A Dobrovic, G McArthur

Conference Proceedings  |  2005  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Novel methods for the sensitive detection of c-KIT D816V and other Exon 17 mutations in patients with mastocytosis

AY Tan, DA Westerman, KP Lynch, GA McArthur, A Dobrovic

Conference Proceedings  |  2005  |  BLOOD

Gastrointestinal stromal tumour with acquired resistance to kinase inhibitor therapy associated with multiple secondary KIT mutations: radiological, autopsy and molecular correlation

MB Loughrey, V Beshay, S Kovalenko, R Cameron, A Dobrovic, PM Waring, G McArthur

Conference Proceedings  |  2005  |  JOURNAL OF PATHOLOGY

A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer

E Thompson, RL Dragovic, SA Stephenson, DM Eccles, IG Campbell, A Dobrovic

Journal article  |  2005  |  BMC Cancer

The BRAF (T1799A) mutation in melanoma is associated with tumour pigmentation but not rate of proliferation

W Liu, WK Murray, JP Dowling, JW Kelly, R Wolfe, G Mason, J Magee, C Angel, A Dobrovic, GA McArthur

Conference Proceedings  |  2005  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Screening for and analysis of methylation differences using methylation-sensitive single-strand conformation analysis

A Dobrovic, T Bianco, LW Tan, T Sanders, D Hussey

Journal article  |  2002  |  Methods

Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells

M Raynor, SA Stephenson, DCA Walsh, KB Pittman, A Dobrovic

Journal article  |  2002  |  BMC Cancer

To the editor: Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis

DJ Hussey, A Dobrovic

Journal article  |  2002  |  Blood

Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer

LW Tan, T Bianco, A Dobrovic

Journal article  |  2002  |  Carcinogenesis

Methylation analysis of formalin-fixed, paraffin-embedded sections using a nontoxic DNA extraction protocol

LW Tan, A Dobrovic

Journal article  |  2001  |  BioTechniques

Loss of red cell A, B, and H antigens is frequent in myeloid malignancies

T Bianco, BJ Farmer, RE Sage, A Dobrovic

Journal article  |  2001  |  Blood

Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies

AE Varga, A Dobrovic, GC Webb, R Hutchinson

Journal article  |  2001  |  Cancer Genetics and Cytogenetics

Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation

Damian J Hussey, Sarah Moore, Mario Nicola, Alexander Dobrovic

Journal article  |  2001  |  BMC Genetics

Nuclear and cytoplasmic localisation of the leukemia associated nup98-rap1gds1 fusion protein

DJ Hussey, NO Albanese, A Dobrovic

Journal article  |  2000  |  Blood

Nuclear and cytoplasmic localisation of the leukemia associated NUP98-RAP1GDS1 fusion protein.

DJ Hussey, NO Albanese, A Dobrovic

Conference Proceedings  |  2000  |  BLOOD

Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer

T Bianco, G Chenevix-Trench, DCA Walsh, JE Cooper, A Dobrovic

Journal article  |  2000  |  Carcinogenesis

Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

JE Hardingham, PJ Hewett, RE Sage, JL Finch, JD Nuttall, D Kotasek, A Dobrovic

Journal article  |  2000  |  International Journal of Cancer

Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma

LM Butler, A Dobrovic, T Bianco, PA Cowled

Journal article  |  2000  |  British Journal of Cancer

The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia

DJ Hussey, M Nicola, S Moore, GB Peters, A Dobrovic

Journal article  |  1999  |  Blood

Methylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylation

T Bianco, D Hussey, A Dobrovic

Journal article  |  1999  |  Human Mutation

Somatic mutations, acetylator status, and prognosis in colorectal cancer

JE Hardingham, WJ Butler, D Roder, A Dobrovic, RB Dymock, RE Sage, IC Roberts-Thomson

Journal article  |  1998  |  Gut

NUP98 is the gene at the chromosome 11 breakpoint of the translocation, t(4;11)(q21;p15.5) in a patient with acute lymphocytic leukemia.

A Dobrovic, D Hussey, RE Sage

Conference Proceedings  |  1997  |  BLOOD

Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5

DJ Hussey, NJ Parker, ND Hussey, PFR Little, A Dobrovic

Journal article  |  1997  |  Genomics

Methylation of the BRCA1 gene in sporadic breast cancer

A Dobrovic, D Simpfendorfer

Journal article  |  1997  |  Cancer Research

Immunobead RT-PCR: A sensitive method for detection of circulating tumor cells

MC Eaton, JE Hardingham, D Kotasek, A Dobrovic

Journal article  |  1997  |  BioTechniques

Decreased stability of the O allele mRNA transcript of the ABO gene

DS OKeefe, A Dobrovic

Journal article  |  1996  |  Blood

A rapid and reliable PCR method for genotyping the ABO blood group .2. A(2) and O-2 alleles

DS OKeefe, A Dobrovic

Journal article  |  1996  |  Human Mutation

DETECTION OF CIRCULATING TUMOR-CELLS IN COLORECTAL-CANCER BY IMMUNOBEAD-PCR IS A SENSITIVE PROGNOSTIC MARKER FOR RELAPSE OF DISEASE

JE HARDINGHAM, D KOTASEK, RE SAGE, MC EATON, VH PASCOE, A DOBROVIC

Journal article  |  1995  |  Molecular Medicine

SIGNIFICANCE OF MOLECULAR MARKER-POSITIVE CELLS AFTER AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION FOR NON-HODGKINS-LYMPHOMA

JE HARDINGHAM, D KOTASEK, RE SAGE, LT GOOLEY, JX MI, A DOBROVIC, JE NORMAN, AE BOLTON, BM DALE

Journal article  |  1995  |  Journal of Clinical Oncology

A RAPID AND RELIABLE PCR METHOD FOR GENOTYPING THE ABO BLOOD-GROUP (VOL 2, PG 67, 1993)

DS OKEEFE, A DOBROVIC

Journal article  |  1994  |  Human Mutation

LOCALIZATION OF THE HUMAN GROWTH ARREST-SPECIFIC GENE (GAS1) TO CHROMOSOME BANDS 9Q21.3-Q22, A REGION FREQUENTLY DELETED IN MYELOID MALIGNANCIES

A EVDOKIOU, GC WEBB, GB PETERS, A DOBROVIC, DS OKEEFE, IJ FORBES, PA COWLED

Journal article  |  1993  |  Genomics

MAPPING OF THE CHROMOSOME-11 BREAKPOINT OF THE T(4, 11)(Q21, P14-15) TRANSLOCATION

V KALATZIS, GB PETERS, A DOBROVIC

Journal article  |  1993  |  Cancer Genetics and Cytogenetics

IMPRINTING AND LOSS OF ABO ANTIGENS IN LEUKEMIA

A DOBROVIC, D OKEEFE, RE SAGE, E BATCHELDER

Journal article  |  1993  |  Blood

IMMUNOBEAD-PCR - A TECHNIQUE FOR THE DETECTION OF CIRCULATING TUMOR-CELLS USING IMMUNOMAGNETIC BEADS AND THE POLYMERASE CHAIN-REACTION

JE HARDINGHAM, D KOTASEK, B FARMER, RN BUTLER, JX MI, RE SAGE, A DOBROVIC

Journal article  |  1993  |  Cancer Research

A RAPID AND RELIABLE PCR METHOD FOR GENOTYPING THE ABO BLOOD-GROUP

DS OKEEFE, A DOBROVIC

Journal article  |  1993  |  Human Mutation

MOLECULAR-DETECTION OF RESIDUAL LYMPHOMA-CELLS IN PERIPHERAL-BLOOD STEM-CELL HARVESTS AND FOLLOWING AUTOLOGOUS TRANSPLANTATION

JE HARDINGHAM, D KOTASEK, RE SAGE, A DOBROVIC, T GOOLEY, BM DALE

Journal article  |  1993  |  Bone Marrow Transplantation

SCL GENE IN HUMAN TUMORS

S ROCKMAN, CG BEGLEY, G KANNOURAKIS, GJ MANN, AN DOBROVIC, RF KEFFORD, K MCGRATH

Journal article  |  1992  |  Leukemia

RELATIONSHIP BETWEEN M-BCR BREAKPOINT POSITION IN BLAST CRISIS AND LENGTH OF CHRONIC PHASE IN CHRONIC MYELOID-LEUKEMIA

B STEIN, A DOBROVIC

Journal article  |  1992  |  Blood

A RARE TRANSLOCATION (4-11)(Q21-P14-15) IN AN ACUTE LYMPHOBLASTIC-LEUKEMIA EXPRESSING T-CELL AND MYELOID MARKERS

JE HARDINGHAM, GB PETERS, A DOBROVIC, BM DALE, D KOTASEK, HE FORD, CJ STORY, RE SAGE

Journal article  |  1991  |  Cancer Genetics and Cytogenetics