Alexander Dobrovic

A Synthetic DNA Construct to Evaluate the Recovery Efficiency of Cell-Free DNA Extraction and Bisulfite Modification.

Su Kah Goh, Daniel RA Cox, Boris Ka Leong Wong, Ashan Musafer, Tom Witkowski, Hongdo Do, Vijayaragavan Muralidharan, Alexander Dobrovic

Journal article  |  2021  |  Clin Chem

BACKGROUND: Despite improvements in the genetic and epigenetic analysis of cell-free DNA (cfDNA), there has been limited focus on ..

PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma

Sagun Parakh, Ashan Musafer, Sabrina Paessler, Tom Witkowski, Connie SN Li Wai Suen, Candani SA Tutuka, Matteo S Carlino, Alexander M Menzies, Richard A Scolyer, Jonathan Cebon, Alexander Dobrovic, Georgina V Long, Oliver Klein, Andreas Behren

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

A significant number of patients (pts) with metastatic melanoma do not respond to anti-programmed cell death 1 (PD1) therapies. Id..

Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

Elizabeth M Swisher, Tanya T Kwan, Amit M Oza, Anna Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L Coleman, Carol Aghajanian, Gottfried E Konecny, David M O'Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S Kristeleit, Oliver Dorigo, Ashan Musafer, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

ARIEL2 (NCT01891344) is a single-arm, open-label phase 2 study of the PARP inhibitor (PARPi) rucaparib in relapsed high-grade ovar..

Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses

Jessica Da Gama Duarte, Katherine Woods, Luke T Quigley, Cyril Deceneux, Candani Tutuka, Tom Witkowski, Simone Ostrouska, Chris Hudson, Simon Chang-Hao Tsao, Anupama Pasam, Alexander Dobrovic, Jonathan M Blackburn, Jonathan Cebon, Andreas Behren

Journal article  |  2021  |  CANCERS

Antibodies that block immune regulatory checkpoints (programmed cell death 1, PD-1 and cytotoxic T-lymphocyte-associated antigen 4..

Hypoxia differently modulates the release of mitochondrial and nuclear DNA

Boris KL Wong, Fan Zhang, Hongdo Do, Adam Testro, Vijayaragavan Muralidharan, Alexander Dobrovic, Daniel RA Cox

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain

Zimeng Ye, Zac Chatterton, Jahnvi Pflueger, John A Damiano, Lara McQuillan, Anthony Simon Harvey, Stephen Malone, Hongdo Do, Wirginia Maixner, Amy Schneider, Bernadette Nolan, Martin Wood, Wei Shern Lee, Greta Gillies, Kate Pope, Michael Wilson, Paul J Lockhart, Alexander Dobrovic, Ingrid E Scheffer, Melanie Bahlo, et al.

Journal article  |  2021  |  BRAIN COMMUNICATIONS

Brain somatic mutations are an increasingly recognized cause of epilepsy, brain malformations and autism spectrum disorders and ma..

The Development of a Tissue Methylation-Specific Cell Free DNA Biomarker for Organ Rejection Following Liver Transplantation

DRA Cox, N Low, SK Goh, C Christophi, A Testro, A Dobrovic, V Muralidharan

Journal article  |  2021  |  HPB

Donor-specific cell-free DNA as a biomarker in liver transplantation: A review.

Tess McClure, Su Kah Goh, Daniel Cox, Vijayaragavan Muralidharan, Alexander Dobrovic, Adam G Testro

Journal article  |  2020  |  World J Transplant

Due to advances in modern medicine, liver transplantation has revolutionised the prognosis of many previously incurable liver dise..

High Speed Centrifugation Before Frozen Storage of Plasma Is Critical for Quantitative Analysis of Mitochondrial-Derived Cell-Free DNA

Daniel RA Cox, Boris KL Wong, Luija Yang, Osamu Yoshino, Badam Testro, Vijayaragavan Muralidharan, Alexander Dobrovic

Journal article  |  2020  |  CLINICAL CHEMISTRY

NTRK and ALK rearrangements in malignant pleural mesothelioma, pulmonary neuroendocrine tumours and non-small cell lung cancer

Jose Luis Leal, Geoffrey Peters, Marcin Szaumkessel, Trishe Leong, Khashayar Asadi, Gareth Rivalland, Hongdo Do, Clare Senko, Paul L Mitchell, Chai Zi Quing, Alexander Dobrovic, Bibhusal Thapa, Thomas John

Journal article  |  2020  |  LUNG CANCER

OBJECTIVES: Gene rearrangements involving NTRK1, NTRK2, NTRK3, ROS1 and ALK have been identified in many types of cancer, includin..