Ying Zhang

From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James M Murphy, Guillaume Lessene

Journal article  |  2023  |  JOURNAL OF MEDICINAL CHEMISTRY

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an inflammatory phenotype. This process..

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Annette Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus JA Kersten, Andre L Samson, Mark F van Delft, David CS Huang, Helene Jousset Sabroux, Guillaume Lessene, John Silke, James M Murphy

Journal article  |  2022  |  CELL DEATH & DISEASE

Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed line..

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-medi..

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Jaclyn S Pearson, Cristina Giogha, Sabrina Muhlen, Ueli Nachbur, Chi LL Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, et al.

Journal article  |  2017  |  NATURE MICROBIOLOGY

Cell death signalling pathways contribute to tissue homeostasis and provide innate protection from infection. Adaptor proteins suc..

Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ

Ying Zhang, Sabrina Muehlen, Clare V Oates, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The type III secretion system effector protein NleE from enteropathogenic Escherichia coli plays a key role in the inhibition of N..

Mutagenesis and Functional Analysis of the Bacterial Arginine Glycosyltransferase Effector NleB1 from Enteropathogenic Escherichia coli

Tania Wong Fok Lung, Cristina Giogha, Kristina Creuzburg, Sze Ying Ong, Georgina L Pollock, Ying Zhang, Ka Yee Fung, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2016  |  INFECTION AND IMMUNITY

Enteropathogenic Escherichia coli (EPEC) interferes with host cell signaling by injecting virulence effector proteins into enteroc..

Post-modern pathogens: surprising activities of translocated effectors from E-coil and Legionella

Jaclyn S Pearson, Ying Zhang, Hayley J Newton, Elizabeth L Hartland

Journal article  |  2015  |  CURRENT OPINION IN MICROBIOLOGY

Many bacterial pathogens have the ability to manipulate cellular processes and interfere with host cell function through the trans..