Benjamin Solomon

Patient-reported quality of life and toxicity in unilateral and bilateral radiotherapy for early-stage human papillomavirus associated tonsillar carcinoma

L McDowell, G Casswell, M Bressel, K Gough, A Drosdowsky, A Coleman, S Shrestha, I D'Costa, T Fua, A Tiong, C Liu, SP Ng, B Solomon, D Rischin

Journal article  |  2020  |  Clinical and Translational Radiation Oncology

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-driven malignancies.

Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Kevin Ebata, Brian B Tuch, Satoshi Yoda, Justin F Gainor, Lecia V Sequist, Geoffrey R Oxnard, Oliver Gautschi, Alexander Drilon, Vivek Subbiah, Christine Khoo, Edward Y Zhu, Michele Nguyen, Dahlia Henry, Kevin R Condroski, Gabrielle R Kolakowski, et al.

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: Novel RET-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unprecedented effic..

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427).

Toan Pham, Lloyd Pereira, Sara Roth, Laura Galletta, Emma Link, Tim Akhurst, Ben Solomon, Michael Michael, Phillip Darcy, Shienny Sampurno, Alexander Heriot, Robert Ramsay, Jayesh Desai

Journal article  |  2019  |  Contemporary Clinical Trials Communications

Background: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid c..

Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1-2 trial

Alice T Shaw, Benjamin J Solomon, Rita Chiari, Gregory J Riely, Benjamin Besse, Ross A Soo, Steven Kao, Chia-Chi Lin, Todd M Bauer, Jill S Clancy, Holger Thurm, Jean-Francois Martini, Gerson Peltz, Antonello Abbattista, Sherry Li, Sai-Hong Ignatius Ou

Journal article  |  2019  |  The Lancet Oncology

BACKGROUND: Lorlatinib is a potent, brain-penetrant, third-generation tyrosine kinase inhibitor (TKI) that targets ALK and ROS1 wi..

Australian consensus statement for best practice ROS1 testing in advanced non-small cell lung cancer

Nick Pavlakis, Caroline Cooper, Thomas John, Steven Kao, Sonja Klebe, Chee Khoon Lee, Trishe Leong, Michael Millward, Ken O'Byrne, Prudence A Russell, Benjamin Solomon, Wendy A Cooper, Stephen Fox

Journal article  |  2019  |  Pathology

Lung cancer is the most commonly diagnosed malignancy and the leading cause of death from cancer globally. Diagnosis of advanced n..

Sex and gender in health research: updating policy to reflect evidence

Zoe Wainer, Cheryl Carcel, Martha Hickey, Londa Schiebinger, Annette Schmiede, Briar McKenzie, Christine Jenkins, Jacqui Webster, Mark Woodward, Angela Hehir, Benjamin Solomon, Caroline de Costa, Caroline Lukaszyk, Deborah J Colville, Erika Dempsey, Gavin M Wright, Gita D Mishra, Jane RW Fisher, Jayashri Kulkarni, Julie Anne Mitchell, et al.

Journal article  |  2019  |  Medical Journal of Australia

iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric

Kortnye Smith, Sophie O'Haire, Khuong-Quang Dong-Anh, Ben Markman, Hui Gan, Paul G Ekert, Ken O'Byrne, Michael Milward, Ben Solomon, Ben Tran, Clare Scott, Grant McArthur, Damien Kee, Andrew Fellowes, Huiling Xu, Melissa Martyn, Elly Lynch, Paula Lorgelly, Clara Gaff, Stephen Fox, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

CANOPY-1: Phase 3 Study of Canakinumab/Placebo plus Pembrolizumab plus PlatinumChemotherapy in Untreated Stage IIIB-IV NSCLC Patients

BE Johnson, GD Castro, A Greystoke, B Solomon, DSW Tan, V Passos, S Deudon, AL Louveau, E Felip

Conference Proceedings  |  2019  |  JOURNAL OF THORACIC ONCOLOGY

CANOPY-1: A phase III, placebo-controlled study of pembrolizumab (PEM) plus platinum-based doublet chemotherapy (Ctx) with/without canakinumab in untreated patients (pts) with stage IIIB/IIIC-IV NSCLC

DSW Tan, TM Kim, BJ Solomon, WL Tan, C-J Yu, S Geater, G De Castro, A Greystoke, E Felip, BE Johnson, S Deudon, A-L Louveau, VQ Passos, BC Cho

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Drug-induced physiologic changes and response to cancer therapies: Focus on immune checkpoint inhibitors and antibiotics in advanced melanoma

Mitchell Dyer, Karen Sheppard, Sonia Mailer, Alesha Thai, Ben Solomon, Marliese Alexander

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Mitogen-Activated Protein Kinase Pathway Inhibition for Redifferentiation of Radioiodine Refractory Differentiated Thyroid Cancer: An Evolving Protocol

Amir Iravani, Benjamin Solomon, David A Pattison, Price Jackson, Aravind Ravi Kumar, Grace Kong, Michael S Hofman, Tim Akhurst, Rodney J Hicks

Journal article  |  2019  |  Thyroid

Background: Some patients with metastatic differentiated thyroid cancer (DTC) lack iodine avidity and are the..

Targeted therapy for advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer

LB Cameron, N Hitchen, V Jordan, R Manser, BJ Solomon

Journal article  |  2019  |  Cochrane Database of Systematic Reviews

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

Intracranial and extracranial efficacy of lorlatinib in the post second-generation ALK tyrosine kinase inhibitor (TKI) setting

DR Camidge, BJ Solomon, E Felip, B Besse, A Bearz, S Peters, F Toffalorio, A Abbattista, H Thurm, G Peltz, R Wiltshire, AT Shaw

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Interaction of Lorlatinib with CYP2B6, CYP2C9, UGT, and P-gp Probe Drugs in Patients with Advanced Non-Small Cell Lung Cancer

J Chen, A Bearz, D Kim, H Mamdani, J Bauman, R Chiari, S Ou, B Solomon, R Soo, E Felip, A Shaw, J Clancy, K Lee, M O'Gorman, C Tanski, Y Pithavala

Conference Proceedings  |  2019  |  Journal of Thoracic Oncology

Safety of lorlatinib in subgroups of patients from a phase I/II trial

E Felip, BJ Solomon, B Besse, TM Bauer, RA Soo, DR Camidge, R Chiari, A Bearz, C-C Lin, SM Gadgeel, E-H Tan, T Seto, GR Oxnard, G Peltz, A Abbattista, H Thurm, F Toffalorio, S-HI Ou, AT Shaw

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Systemic or Local Treatment: What to Do First?

B Solomon

Conference Proceedings  |  2019  |  Journal of Thoracic Oncology

Registrational results of LOXO-292 in patients with RET-altered thyroid cancers

L Wirth, A Drilon, B Solomon, B Robinson, J Lorch, C McCoach, J Patel, S Leboulleux, F Worden, T Owonikoko, M Brose, M Taylor, A Italiano, O Gautschi, M-E Garcia, SM Rothenberg, V Subbiah, M Shah, M Cabanillas

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

A Prospective Study of Swallowing and Voice Outcomes After Treatment for Small-Cell Lung Cancer

J Frowen, K Gough, J Phipps-Nelson, R Hughes, S Siva, A Drosdowsky, B Solomon, N Kiss, M Duffy, D Ball

Conference Proceedings  |  2019  |  Journal of Thoracic Oncology

CANOPY phase III program: Three studies evaluating canakinumab in patients with non-small cell lung cancer (NSCLC)

L Paz-Ares, EB Garon, A Ardizzoni, F Barlesi, BC Cho, G de Castro Junior, P De Marchi, E Felip, Y Goto, A Greystoke, S Lu, DW-T Lim, VA Papadimitrakopoulou, M Reck, BJ Solomon, D Spigel, DSW Tan, M Thomas, JC-H Yang, B Johnson

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

ALKternate: A Proof of Concept Study in ALK-Rearranged NSCLC Alternating Lorlatinib with Crizotinib After Disease Progression

M Itchins, S Hayes, A Hudson, V Howell, SWD Tan, S Clarke, B Solomon, N Pavlakis

Conference Proceedings  |  2019  |  Journal of Thoracic Oncology

Registrational Results of LIBRETTO-001: A Phase 1/2 Trial of LOXO-292 in Patients with RET Fusion-Positive Lung Cancers

A Drilon, G Oxnard, L Wirth, B Besse, O Gautschi, SWD Tan, H Loong, T Bauer, YJ Kim, A Horiike, K Park, M Shah, C McCoach, L Bazhenova, T Seto, M Brose, N Pennell, J Weiss, I Matos, N Peled, et al.

Conference Proceedings  |  2019  |  Journal of Thoracic Oncology

CANOPY-1: Phase 3 Study of Canakinumab/Placebo plus Pembrolizumab plus Platinum-Chemotherapy in Untreated Stage IIIB-IV NSCLC Pts

E Felip, G Castro, A Greystoke, B Solomon, D Tan, V Passos, S Deudon, A Louveau, B Johnson

Conference Proceedings  |  2019  |  Journal of Thoracic Oncology

Identification of an excellent prognosis subset of human papillomavirus-associated oropharyngeal cancer patients by quantification of intratumoral CD103( ) immune cell abundance

B Solomon, RJ Young, M Bressel, J Cernelc, P Savas, H Liu, D Urban, A Thai, C Cooper, T Fua, P Neeson, S Loi, SV Porceddu, D Rischin

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: Accurate prognostic stratification of human papillomavirus-associated oropharyngeal cancers (HPV+OPSCC) is required to..

Sexual Satisfaction and Relationship Status in Long-term Survivors of Human Papillomavirus-Associated Oropharyngeal Carcinoma

G Casswell, K Gough, A Drosdowsky, M Bressel, S Shrestha, A Coleman, D Rischin, I D'Costa, T Fua, AC Tiong, C Liu, B Solomon, LJ McDowell

Conference Proceedings  |  2019  |  International Journal of Radiation Oncology*Biology*Physics

Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry

J Mazieres, A Drilon, A Lusque, L Mhanna, AB Cortto, L Mezquita, AA Thai, C Mascaux, S Couraud, R Veillon, M Van Den Heuvel, J Neal, N Peled, M Fruh, TL Ng, V Gounant, S Popat, J Diebold, J Sabari, VW Zhu, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: Anti-PD1/PD-L1 directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small c..

Clinical Management of Adverse Events Associated with Lorlatinib

Todd M Bauer, Enriqueta Felip, Benjamin J Solomon, Holger Thurm, Gerson Peltz, Marc D Chioda, Alice T Shaw

Journal article  |  2019  |  The Oncologist

Lorlatinib is a novel, highly potent, brain-penetrant, third-generation ALK/ROS1 tyrosine kinase inhibitor (TKI), which has broad-..

Targeting ROS1 Rearrangements in Non-small Cell Lung Cancer: Crizotinib and Newer Generation Tyrosine Kinase Inhibitors.

Tessa A Morris, Christine Khoo, Benjamin J Solomon

Journal article  |  2019  |  Drugs

ROS1 gene rearrangements exist in 1-2% of non-small cell lung cancers, typically occurring in younger, never or light smokers with..

Advanced-Stage Non-Small Cell Lung Cancer: Advances in Thoracic Oncology 2018

Jordi Remon, Myung-Ju Ahn, Nicolas Girard, Melissa Johnson, Dong-Wan Kim, Gilberto Lopes, Rathi N Pillai, Benjamin Solomon, Guillermo Villacampa, Qing Zhou

Journal article  |  2019  |  Journal of Thoracic Oncology

Crizotinib in ROS1-rearranged advanced non-small-cell lung cancer (NSCLC): updated results, including overall survival, from PROFILE 1001

AT Shaw, GJ Riely, Y-J Bang, D-W Kim, DR Camidge, BJ Solomon, M Varella-Garcia, AJ Iafrate, G Shapiro, T Usari, SC Wang, KD Wilner, JW Clark, S-H Ou

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: In the ongoing phase 1 PROFILE 1001 study, crizotinib showed antitumor activity in patients with ROS1-rearranged advan..

Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells

Kimberley M Hanssen, Christine C Gana, Madeleine S Wheatley, Denise M Yu, Claudia L Flemming, Richard Young, Gavin M Wright, Gwenaelle Conseil, Catherine J Kennedy, Anna deFazio, Ben Solomon, Susan P Cole, Murray D Norris, Michelle Haber, Jamie I Fletcher

Conference Proceedings  |  2019  |  Experimental and Molecular Therapeutics

Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors

MD Hellmann, T-W Kim, CB Lee, B-C Goh, WH Miller, D-Y Oh, R Jamal, C-E Chee, LQM Chow, JF Gainor, J Desai, BJ Solomon, M Das Thakur, B Pitcher, P Foster, G Hernandez, MJ Wongchenko, E Cha, Y-J Bang, LL Siu, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: Preclinical evidence suggests that MEK inhibition promotes accumulation and survival of intratumoral tumor-specific T ..

Supercharging adoptive T cell therapy to overcome solid tumor-induced immunosuppression

Sherly Mardiana, Benjamin J Solomon, Phillip K Darcy, Paul A Beavis

Journal article  |  2019  |  Science Translational Medicine

ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer

Alice T Shaw, Benjamin J Solomon, Benjamin Besse, Todd M Bauer, Chia-Chi Lin, Ross A Soo, Gregory J Riely, Sai-Hong Ignatius Ou, Jill S Clancy, Sherry Li, Antonello Abbattista, Holger Thurm, Miyako Satouchi, D Ross Camidge, Steven Kao, Rita Chiari, Shirish M Gadgeel, Enriqueta Felip, Jean-Francois Martini

Journal article  |  2019  |  Journal of Clinical Oncology

The CANOPY program: Canakinumab in patients (pts) with non-small cell lung cancer (NSCLC).

Luis G Paz-Ares, Edward B Garon, Andrea Ardizzoni, Fabrice Barlesi, Byoung Chul Cho, Gilberto Castro, Pedro De Marchi, Enriqueta Felip, Yasushi Goto, Alastair Greystoke, Shun Lu, Darren Wan Teck Lim, Vassiliki Papadimitrakopoulou, Martin Reck, Benjamin J Solomon, David R Spigel, Daniel Shao-Weng Tan, Michael Thomas, James Chih-Hsin Yang, Bruce E Johnson

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Early circulating tumor (ct)DNA dynamics and efficacy of lorlatinib in patients (pts) with advanced ALK-positive non-small cell lung cancer (NSCLC).

Alice Tsang Shaw, Jean-Francois Martini, Benjamin Besse, Todd Michael Bauer, Chia-Chi Lin, Ross A Soo, Gregory J Riely, Sai-Hong Ignatius Ou, Antonello Abbattista, Francesca Toffalorio, Holger C Thurm, Miyako Satouchi, D Ross Camidge, Steven Chuan-Hao Kao, Rita Chiari, Shirish M Gadgeel, Enriqueta Felip, Benjamin J Solomon

Conference Proceedings  |  2019  |  JOURNAL OF CLINICAL ONCOLOGY

ALINA: A phase III study of alectinib versus chemotherapy as adjuvant therapy in patients with stage IB IIIA anaplastic lymphoma kinase-positive (ALK plus ) non-small cell lung cancer (NSCLC).

Benjamin J Solomon, Jin Seok Ahn, Fabrice Barlesi, Rafal Dziadziuszko, Makoto Nishio, Alice Tsang Shaw, Walter Bordogna, Christoph Meyenberg, Yi-Long Wu

Conference Proceedings  |  2019  |  JOURNAL OF CLINICAL ONCOLOGY

Mesenchyme to epithelial transition protein expression, gene copy number and clinical outcome in a large non-small cell lung cancer surgical cohort

Gareth Rivalland, Paul Mitchell, Carmel Murone, Khashayer Asadi, Adrienne L Morey, Maud Starmans, Paul C Boutros, Marzena Walkiewicz, Benjamin Solomon, Gavin Wright, Simon Knight, Thomas John

Journal article  |  2019  |  Translational Lung Cancer Research

Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial

David Ball, G Tao Mai, Shalini Vinod, Scott Babington, Jeremy Ruben, Tomas Kron, Brent Chesson, Alan Herschtal, Marijana Vanevski, Angela Rezo, Christine Elder, Marketa Skala, Andrew Wirth, Greg Wheeler, Adeline Lim, Mark Shaw, Penelope Schofield, Louis Irving, Benjamin Solomon

Journal article  |  2019  |  The Lancet Oncology

Radiotherapy and immunotherapy: a synergistic effect in cancer care

Guy-Anne Turgeon, Andrew Weickhardt, Arun A Azad, Benjamin Solomon, Shankar Siva

Journal article  |  2019  |  Medical Journal of Australia

Dynamic Thromboembolic Risk Modelling to Target Appropriate Preventative Strategies for Patients with Non-Small Cell Lung Cancer

Marliese Alexander, David Ball, Benjamin Solomon, Michael MacManus, Renee Manser, Bernhard Riedel, David Westerman, Sue M Evans, Rory Wolfe, Kate Burbury

Journal article  |  2019  |  Cancers

Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study

Benjamin J Solomon, Benjamin Besse, Todd M Bauer, Enriqueta Felip, Ross A Soo, D Ross Camidge, Rita Chiari, Alessandra Bearz, Chia-Chi Lin, Shirish M Gadgeel, Gregory J Riely, Eng Huat Tan, Takashi Seto, Leonard P James, Jill S Clancy, Antonello Abbattista, Jean-Francois Martini, Joseph Chen, Gerson Peltz, Holger Thurm, et al.

Journal article  |  2018  |  The Lancet Oncology

Rheumatic immune-related adverse events secondary to anti-programmed death-1 antibodies and preliminary analysis on the impact of corticosteroids on anti-tumour response: A case series

Emma L Mitchell, Peter Kar Han Lau, Chloe Khoo, David Liew, Jessica Leung, Bonnia Liu, Adam Rischin, Albert G Frauman, Damien Kee, Kortnye Smith, Benjamin Brady, Danny Rischin, Andrew Gibson, Linda Mileshkin, Oliver Klein, Andrew Weickhardt, Surein Arulananda, Mark Shackleton, Grant McArthur, Andrew Ostor, et al.

Journal article  |  2018  |  European Journal of Cancer

Alectinib as first-line therapy for ALK-rearranged NSCLC: a no-brainer?

AA Thai, BJ Solomon

Journal article  |  2018  |  Annals of Oncology

Sex-Dependent Staging in Non-Small-Cell Lung Cancer; Analysis of the Effect of Sex Differences in the Eighth Edition of the Tumor, Node, Metastases Staging System

Zoe Wainer, Gavin M Wright, Karla Gough, Marissa G Daniels, Prudence A Russell, Peter Choong, Matthew Conron, David Ball, Benjamin Solomon

Journal article  |  2018  |  Clinical Lung Cancer

A phase 2 trial of durvalumab and tremelimumab with chemotherapy in metastatic EGFR mutant non-small cell lung cancer following progression on EGFR tyrosine kinase inhibitors (ILLUMINATE)

Chee Khoon Lee, Antony Mersiades, Jenna Mitchell, Chris Brown, Hannora Jurkovic, Ben Solomon, Thomas John, Martin Stockler, James Chi-Hsin Yang

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Quality of life in the CHISEL randomized trial of stereotactic ablative radiotherapy (SABR) versus standard radiotherapy for stage I non-small cell lung cancer (Trans-Tasman Radiation Oncology Group 09.02)

D Ball, GT Mai, S Vinod, S Babington, J Ruben, T Kron, B Chesson, A Herschtal, M Vanevski, A Rezo, C Elder, M Skala, A Wirth, G Wheeler, A Lim, M Shaw, P Schofield, L Irving, B Solomon

Conference Proceedings  |  2018  |  ANNALS OF ONCOLOGY

Feasibility of 5-fluorouracil pharmacokinetic monitoring using the My-5FU PCM (TM) system in a quaternary oncology centre

Michael Moloney, David Faulkner, Emma Link, Danny Rischin, Ben Solomon, Annette M Lim, John R Zalcberg, Michael Jefford, Michael Michael

Journal article  |  2018  |  Cancer Chemotherapy and Pharmacology

ASTRIS real world study of osimertinib in patients (pts) with EGFR T790M NSCLC: Efficacy analysis by tissue or plasma T790M test

HC Freitas, K Park, D-W Kim, M Tiseo, MJ Hochmair, G-C Chang, Y-K Shi, T Moran, Y Chen, J Laskin, B Solomon, M Miranda, J Rigas, PK Cheema, S-W Kim

Conference Proceedings  |  2018  |  ANNALS OF ONCOLOGY

Clinical Activity of LOXO-292, a Highly Selective RET Inhibitor, in Patients with RET Fusion plus Non-Small Cell Lung Cancer

G Oxnard, V Subbiah, K Park, T Bauer, L Wirth, V Velcheti, M Shah, B Besse, V Boni, K Reckamp, H Loong, L Bazhenova, B Solomon, D Tan, J Patel, M Johnson, A Gazzah, T Mok, S Smith, B Tuch, et al.

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

Clinical Activity of Lorlatinib in Patients with ROS1 Advanced Non-Small Cell Lung Cancer: Phase 2 Study Cohort EXP-6

S Ou, A Shaw, G Riely, R Chiari, J Bauman, J Clancy, H Thurm, G Peltz, A Abbattista, B Solomon

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

MORPHEUS: A phase Ib/II umbrella study platform evaluating the safety and efficacy of multiple cancer immunotherapy (CIT)-based combinations in different tumour types

I Chau, GM Haag, OE Rahma, TM Macarulla, SL McCune, DA Yardley, BJ Solomon, M Johnson, GA Vidal, P Schmid, G Argiles, K Dimick, S Mahrus, H Abdullah, X He, P Sayyed, H Barak, C Bleul, E Cha, A Drakaki

Conference Proceedings  |  2018  |  ANNALS OF ONCOLOGY

Efficacy of lorlatinib in patients (pts) with ROS1-positive advanced non-small cell lung cancer (NSCLC) and ROS1 kinase domain mutations

BJ Solomon, J-F Martini, S-HI Ou, R Chiari, RA Soo, A Bearz, S Li, H Thurm, C-C Lin, GJ Riely, TM Bauer, AT Shaw

Conference Proceedings  |  2018  |  ANNALS OF ONCOLOGY

Impact of lorlatinib on patient-reported outcomes (PROs) in patients (Pts) with advanced ALK or ROS1 non-small cell lung cancer (NSCLC)

S Peters, AT Shaw, B Besse, E Felip, BJ Solomon, RA Soo, A Bearz, SM Gadgee, C-C Lin, S Kao, T Seto, ET Masters, A Abbattista, JS Clancy, H Thurm, A Reisman, DR Camidge

Conference Proceedings  |  2018  |  ANNALS OF ONCOLOGY

Detection and clearance of RET variants in plasma cell free DNA (cfDNA) from patients (pts) treated with LOXO-292

B Besse, V Subbiah, A Drilon, M Shah, LJ Wirth, TM Bauer, V Velcheti, N Lakhani, V Boni, BJ Solomon, M Johnson, K Park, J Patel, ME Cabanillas, E Sherman, E Zhu, K Gordon, K Ebata, B Tuch, G Oxnard

Conference Proceedings  |  2018  |  ANNALS OF ONCOLOGY

Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments

Benjamin Solomon, Richard J Young, Danny Rischin

Journal article  |  2018  |  Seminars in Cancer Biology

Immunotherapy for Non-Small Cell Lung Cancers (NSCLC) with Oncogenic Driver Mutations: New Results from the Global IMMUNOTARGET Registry

O Gautschi, A Drilon, J Milia, A Lusque, L Mhanna, B Li, J Sabari, A Cortot, B Besse, L Mezquita, B Solomon, A Thai, S Couraud, R Veilion, C Mascaux, F Barlesi, M Van den Heuvel, R Schouten, H Wakelee, A Mah, et al.

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

First-Line Lorlatinib Versus Crizotinib for Advanced Anaplastic Lymphoma Kinase-Positive (ALK plus ) NonSmall Cell Lung Cancer

A Shaw, T Bauer, T Takahashi, C Balk, Y Goto, A Polli, M Carpentieri, J Martini, B Solomon

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

Updated Antitumor Activity of Crizotinib in Patients with MET Exon 14-Altered Advanced Non-Small Cell Lung Cancer

A Drilon, J Clark, J Weiss, S Ou, DR Camidge, B Solomon, G Otterson, L Villaruz, G Riely, R Heist, G Shapiro, D Murphy, S Wang, T Usari, S Li, K Wilner, P Paik

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

IMpower030: Phase III Study Evaluating Neoadjuvant Treatment of Resectable Stage II-IIIB NSCLC with Atezolizumab plus Chemotherapy

N Rizvi, D Gandara, B Solomon, A Kim, A Brunelli, S Sun, B Gitlitz, K Tajima, W Lin, A Sandler, S Peters

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

Mind the Graph: Foregone Health Gains in Lung Cancer

Laird Cameron, Richard Sullivan, Brendan Luey, Ben Solomon

Journal article  |  2018  |  Seminars in Oncology

Navigating Through New, First-Line Treatment Options for Lung Cancer

Benjamin Solomon

Journal article  |  2018  |  Journal of Oncology Practice

Correlation of extent of ALK FISH positivity and crizotinib efficacy in three prospective studies of ALK-positive patients with non-small-cell lung cancer

J-C Soria, SN Ho, M Varella-Garcia, AJ Iafrate, BJ Solomon, AT Shaw, F Blackhall, TS Mok, Y-L Wu, K Pestova, KD Wilner, A Polli, J Paolini, S Lanzalone, S Green, DR Camidge

Journal article  |  2018  |  Annals of Oncology

Unilateral Radiotherapy Treatment for p16/Human Papillomavirus-Positive Squamous Cell Carcinoma of Unknown Primary in the Head and Neck

Albert Tiong, Danny Rischin, Richard J Young, Alan Herschtal, Ben Solomon, Ieta D'Costa, Tsien Fua, Chen Liu, Andrew Coleman, Stephen Kleid, Benjamin J Dixon, June Corry

Journal article  |  2018  |  The Laryngoscope

Final Overall Survival Analysis From a Study Comparing First-Line Crizotinib Versus Chemotherapy in ALK-Mutation-Positive Non-Small-Cell Lung Cancer

Benjamin J Solomon, Dong-Wan Kim, Yi-Long Wu, Kazuhiko Nakagawa, Tarek Mekhail, Enriqueta Felip, Federico Cappuzzo, Jolanda Paolini, Tiziana Usari, Yiyun Tang, Keith D Wilner, Fiona Blackhall, Tony S Mok

Journal article  |  2018  |  Journal of Clinical Oncology

Good clinical response to alectinib, a second generation ALK inhibitor, in refractory neuroblastoma

John A Heath, Marty A Campbell, Alison Thomas, Ben Solomon

Journal article  |  2018  |  Pediatric Blood & Cancer

Crizotinib versus Chemotherapy in Asian Patients with ALK-Positive Advanced Non-small Cell Lung Cancer

Makoto Nishio, Dong-Wan Kim, Yi-Long Wu, Kazuhiko Nakagawa, Benjamin J Solomon, Alice T Shaw, Satoshi Hashigaki, Emiko Ohki, Tiziana Usari, Jolanda Paolini, Anna Polli, Keith D Wilner, Tony Mok

Journal article  |  2018  |  Cancer Research and Treatment

Efficacy of lorlatinib in patients (pts) with advanced ALK-positive non-small cell lung cancer (NSCLC) and ALK kinase domain mutations

Alice T Shaw, Jean-Francois Martini, Benjamin Besse, Todd M Bauer, Chia-Chi Lin, Ross A Soo, Gregory J Riely, Sai-Hong Ignatius Ou, Jill S Clancy, Sherry Li, Holger Thurm, Miyako Satouchi, D Ross Camidge, Steven Kao, Rita Chiari, Shirish Gadgeel, Enriqueta Felip, Benjamin J Solomon

Conference Proceedings  |  2018  |  Clinical Trials

A phase 1 study of LOXO-292, a potent and highly selective RET inhibitor, in patients with RET-altered cancers.

Alexander E Drilon, Vivek Subbiah, Geoffrey R Oxnard, Todd Michael Bauer, Vamsidhar Velcheti, Nehal J Lakhani, Benjamin Besse, Keunchil Park, Jyoti D Patel, Maria E Cabanillas, Melissa Lynne Johnson, Karen L Reckamp, Valentina Boni, Herbert HF Loong, Martin Schlumberger, Ben Solomon, Scott Cruickshank, Stephen M Rothenberg, Manisha H Shah, Lori J Wirth

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Dynamic thromboembolism risk modelling in patients with non-small cell lung cancer: a prospective cohort study

M Alexander, D Ball, B Solomon, M MacManusb, R Manser, B Riedel, D Westerman, SM Evans, R Wolfe, K Burbury

Conference Proceedings  |  2018  |  Thrombosis Research

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

Julie George, Vonn Walter, Martin Peifer, Ludmil B Alexandrov, Danila Seidel, Frauke Leenders, Lukas Maas, Christian Mueller, Ilona Dahmen, Tiffany M Delhomme, Maude Ardin, Noemie Leblay, Graham Byrnes, Ruping Sun, Aurelien De Reynies, Anne McLeer-Florin, Graziella Bosco, Florian Malchers, Roopika Menon, Janine Altmuller, et al.

Journal article  |  2018  |  Nature Communications

EGFR Genotyping of Matched Urine, Plasma , and Tumor Tissue in Patients With Non-Small-Cell Lung Cancer Treated With Rociletinib, an EGFR Tyrosine Kinase Inhibitor

Jonathan W Goldman, Chris Karlovich, Lecia Sequist, Vlada Melnikova, Aleksandra Franovic, Shirish M Gadgeel, Karen L Reckamp, D Ross Camidge, Maurice Perol, Sai-Hong Ignatius Ou, Stephen Liu, Helena A Yu, Jean-Charles Soria, Mark A Socinski, Tarek M Mekhail, Benjamin J Solomon, Ronald B Natale, Gregory A Otterson, Vassiliki Papadimitrakopoulou, Corey J Langer, et al.

Journal article  |  2018  |  JCO Precision Oncology

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology

Neat I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric H Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, et al.

Journal article  |  2018  |  The Journal of Molecular Diagnostics

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology

Neal I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric H Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, et al.

Journal article  |  2018  |  Journal of Thoracic Oncology

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology

Neal I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric H Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, et al.

Journal article  |  2018  |  Archives of Pathology & Laboratory Medicine

Treatment of ALK-positive nonsmall cell lung cancer: recent advances

Alesha A Thai, Benjamin J Solomon

Journal article  |  2018  |  Current Opinion in Oncology

Prognostic Significance of PD-L1( ) and CD8( ) Immune Cells in HPV Oropharyngeal Squamous Cell Carcinoma

Benjamin Solomon, Richard J Young, Mathias Bressel, Damien Urban, Shona Hendry, Alesha Thai, Christopher Angel, Afaf Haddad, Marcin Kowanetz, Tsien Fua, June Corry, Stephen Fox, Danny Rischin

Journal article  |  2018  |  Cancer Immunology Research

Development of a hospital-based patient-reported outcome framework for lung cancer patients: a study protocol

Natasha Moloczij, Karla Gough, Benjamin Solomon, David Ball, Linda Mileshkin, Mary Duffy, Mei Krishnasamy

Journal article  |  2018  |  Health and Quality of Life Outcomes

Thromboembolism in Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer

Marliese Alexander, Benjamin Solomon, Kate Burbury

Journal article  |  2018  |  Clinical Lung Cancer

Genomic Characterization of Lung Cancer and Its Impact on the Use and Timing of PET in Therapeutic Response Assessment

Lavinia Tan, Benjamin Solomon

Journal article  |  2018  |  PET Clinics

Survival difference according to mutation status in a prospective cohort study of Australian patients with metastatic non-small-cell lung carcinoma

Lavinia Tan, Marliese Alexander, Ann Officer, Michael MacManus, Linda Mileshkin, Ross Jennens, Dishan Herath, Richard de Boer, Stephen B Fox, David Ball, Benjamin Solomon

Journal article  |  2018  |  Internal Medicine Journal

Impact of sex on prognostic host factors in surgical patients with lung cancer

Zoe Wainer, Gavin M Wright, Karla Gough, Marissa G Daniels, Peter Choong, Matthew Conron, Prudence A Russell, Naveed Z Alam, David Ball, Benjamin Solomon

Journal article  |  2017  |  ANZ Journal of Surgery

Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial

Alice T Shaw, Enriqueta Felip, Todd M Bauer, Benjamin Besse, Alejandro Navarro, Sophie Postel-Vinay, Justin F Gainor, Melissa Johnson, Jorg Dietrich, Leonard P James, Jill S Clancy, Joseph Chen, Jean-Francois Martini, Antonello Abbattista, Benjamin J Solomon

Journal article  |  2017  |  The Lancet Oncology

Phase 2 Study of Lorlatinib in Patients with Advanced ALK( )/ROS1( ) Non-Small-Cell Lung Cancer

B Solomon, A Shaw, S Ou, B Besse, E Felip, T Bauer, R Soo, A Bearz, C Lin, J Clancy, A Abbattista, H Thurm, G Peltz, E Masters, J Martini, L James, T Seto

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

Thrombogenic Biomarkers in Patients with NSCLC - Associations with Thrombosis, Progression, and Survival

M Alexander, D Ball, B Solomon, M Macmanus, R Manser, B Riedel, D Westerman, S Evans, R Wolfe, K Burbury

Conference Proceedings  |  2017  |  JOURNAL OF THORACIC ONCOLOGY

Quality of Data Informing Epidemiological Studies in Patients with Lung Cancer

M Alexander, S Evans, R Wolfe, A Officer, R Stirling, M Macmanus, B Solomon, D Ball, K Burbury

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

The Lung Cancer Prognostic Index - a Risk Score to Predict Overall Survival after the Diagnosis of Non-Small Cell Lung Cancer

M Alexander, R Wolfe, D Ball, M Conron, R Stirling, B Solomon, M Macmanus, A Officer, S Karnam, K Burbury, S Evans

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

Ceritinib in Anaplastic Lymphoma Kinase (ALK) plus NSCLC Patients Pretreated With Only Crizotinib: ASCEND-1 Subgroup Analysis

A Shaw, D Kim, B Solomon, E Felip, G Riely, M Schuler, D Tan, L Chow, DR Camidge, P Urban, C Ortmann, I Malet, R Mehra

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

Plasma Genomic Profiling and Outcomes of Patients with MET Exon 14-Altered NSCLCs Treated with Crizotinib on PROFILE 1001

A Drilon, J Clark, J Weiss, S Ou, DR Camidge, B Solomon, G Otterson, L Villaruz, G Riely, R Heist, G Shapiro, D Murphy, Y Liu, S Wang, T Usari, K Wilner, P Paik

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

Developing a Lung Cancer Clinical Quality Registry Framework to Collect Longitudinal Patient-Reported Outcomes

N Moloczij, M Duffy, K Gough, D Ball, B Solomon, L Mileshkin, M Krishnasamy

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

Next-Generation Sequencing Shows Mechanisms of Intrinsic Resistance in ALK-Positive NSCLC Patients Treated with Crizotinib

B Solomon, J Soria, F Blackhall, A Shaw, DR Camidge, D Kim, T Mok, J Fernandez-Banet, Z Kan, S Li, Y Liu, S Ho

Conference Proceedings  |  2017  |  Journal of Thoracic Oncology

OSCILLATE - Phase 2 Trial of Alternating Osimertinib with Gefitinib in Patients with EGFR-T790M Mutation Positive Advanced NSCLC

B Solomon, P Kok, A Livingstone, S Yip, C Brown, S Dawson, S Wong, N Pavlakis, M Stockler

Conference Proceedings  |  2017  |  JOURNAL OF THORACIC ONCOLOGY

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen van de Vijver, MV Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin Solomon, Cinzia Solinas, Gert GGM Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, et al.

Journal article  |  2017  |  Advances In Anatomic Pathology

EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma

Timothy D Clay, Prudence A Russell, Hongdo Do, Vijaya Sundararajan, Matthew Conron, Gavin M Wright, Benjamin Solomon, Alexander Dobrovic, Sue-Anne McLachlan, Melissa M Moore

Journal article  |  2017  |  Medical Oncology

Correlation between molecular analysis, diagnosis according to the 2015 WHO classification of unresected lung tumours and TTF1 expression in small biopsies and cytology specimens from 344 non-small cell lung carcinoma patients

Prudence A Russell, Toni-Maree Rogers, Benjamin Solomon, Naveed Alam, Stephen A Barnett, Vivek Rathi, Richard A Williams, Gavin M Wright, Matthew Conron

Journal article  |  2017  |  Pathology

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen van de Vijver, MV Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin sss Solomon, Cinzia Solinas, Gert GGM Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, et al.

Journal article  |  2017  |  Advances In Anatomic Pathology

Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer

Marliese Alexander, Rory Wolfe, David Ball, Matthew Conron, Robert G Stirling, Benjamin Solomon, Michael MacManus, Ann Officer, Sameer Karnam, Kate Burbury, Sue M Evans

Journal article  |  2017  |  British Journal of Cancer

Scientific Advances in Thoracic Oncology 2016

Ross A Soo, Emily CA Stone, K Michael Cummings, James R Jett, John K Field, Harry JM Groen, James L Mulshine, Yasushi Yatabe, Lukas Bubendorf, Sanja Dacic, Ramon Rami-Porta, Frank C Detterbeck, Eric Lim, Hisao Asamura, Jessica Donington, Heather A Wakelee, Yi-Long Wu, Kristin Higgins, Suresh Senan, Benjamin Solomon, et al.

Journal article  |  2017  |  Journal of Thoracic Oncology

Treatment of ALK-rearranged non- small cell lung cancer: A review of the landscape and approach to emerging patterns of treatment resistance in the Australian context

M Itchins, PL Chia, SA Hayes, VM Howell, AJ Gill, WA Cooper, T John, P Mitchell, M Millward, SJ Clarke, B Solomon, N Pavlakis

Journal article  |  2017  |  Asia-Pacific Journal of Clinical Oncology

Final results of the large-scale multinational trial PROFILE 1005: efficacy and safety of crizotinib in previously treated patients with advanced/metastatic ALK-positive non-small-cell lung cancer

Fiona Blackhall, D Ross Camidge, Alice T Shaw, Jean-Charles Soria, Benjamin J Solomon, Tony Mok, Vera Hirsh, Pasi A Jaenne, Yuankai Shi, Pan-Chyr Yang, Tommaso De Pas, Toyoaki Hida, Javier De Castro Carpeno, Silvana Lanzalone, Anna Polli, Shrividya Iyer, Arlene Reisman, Keith D Wilner, Dong-Wan Kim

Journal article  |  2017  |  ESMO Open

Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma

Clare E Weeden, Aliaksei Z Holik, Richard J Young, Stephen B Ma, Jean-Marc Garnier, Stephen B Fox, Phillip Antippa, Louis B Irving, Daniel P Steinfort, Gavin M Wright, Prudence A Russell, Matthew E Ritchie, Christopher J Burns, Benjamin Solomon, Marie-Liesse Asselin-Labat

Journal article  |  2017  |  Molecular Cancer Therapeutics

Prospective Study of Cetuximab, Carboplatin, and Radiation Therapy for Patients With Locally Advanced Head and Neck Squamous Cell Cancer Unfit for Cisplatin

June Corry, Mathias Bressel, Tsien Fua, Alan Herschtal, Benjamin Solomon, Sandro V Porceddu, Chris Wratten, Danny Rischin

Journal article  |  2017  |  International Journal of Radiation Oncology*Biology*Physics

First-line treatment options for ALK-rearranged lung cancer

Benjamin Solomon

Journal article  |  2017  |  The Lancet

Crizotinib Associated Renal Cysts [CARCs]: incidence and patterns of evolution

Laird B Cameron, Damian HS Jiang, Kate Moodie, Catherine Mitchell, Benjamin Solomon, Bimal Kumar Parameswaran

Journal article  |  2017  |  Cancer Imaging

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

Cristina Gamell, Twishi Gulati, Yaara Levav-Cohen, Richard J Young, Hongdo Do, Pat Pilling, Elena Takano, Neil Watkins, Stephen B Fox, Prudence Russell, Doron Ginsberg, Brendon J Monahan, Gavin Wright, Alex Dobrovic, Sue Haupt, Ben Solomon, Ygal Haupt

Journal article  |  2017  |  Science Signaling

Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer

C Gamell, T Gulati, B Solomon, S Haupt, Y Haupt

Journal article  |  2017  |  Molecular & Cellular Oncology

Trials and Tribulations of EGFR and MET Inhibitor Combination Therapy in NSCLC

Benjamin Solomon

Journal article  |  2017  |  Journal of Thoracic Oncology

The Role of the Tumor vasculature in the Host immune Response: implications for Therapeutic Strategies Targeting the Tumor Microenvironment

Shona A Hendry, Rae H Farnsworth, Benjamin Solomon, Marc G Achen, Steven A Stacker, Stephen B Fox

Journal article  |  2016  |  Frontiers in Immunology

A New Theranostic Paradigm for Advanced Thyroid Cancer

David A Pattison, Benjamin Solomon, Rodney J Hicks

Journal article  |  2016  |  Journal of Nuclear Medicine

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Clinicopathologic Features of NSCLC Diagnosed During Pregnancy or the Peripartum Period in the Era of Molecular Genotyping

Ibiayi Dagogo-Jack, Justin F Gainor, Rebecca L Porter, Katherine R Schultz, Benjamin J Solomon, Sara Stevens, Christopher G Azzoli, Lecia V Sequist, Inga T Lennes, Alice T Shaw

Journal article  |  2016  |  Journal of Thoracic Oncology

The continuum of care for ALK-positive NSCLC: from diagnosis to new treatment options - an overview

B Solomon, J-C Soria

Journal article  |  2016  |  Annals of Oncology

Intracranial Efficacy of Crizotinib Versus Chemotherapy in Patients With Advanced ALK-Positive Non-Small-Cell Lung Cancer: Results From PROFILE 1014

Benjamin J Solomon, Federico Cappuzzo, Enriqueta Felip, Fiona H Blackhall, Daniel B Costa, Dong-Wan Kim, Kazuhiko Nakagawa, Yi-Long Wu, Tarek Mekhail, Jolanda Paolini, Jennifer Tursi, Tiziana Usari, Keith D Wilner, Paulina Selaru, Tony SK Mok

Journal article  |  2016  |  Journal of Clinical Oncology

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas

Annette M Lim, Nicholas C Wong, Ruth Pidsley, Elena Zotenko, June Corry, Alexander Dobrovic, Susan J Clark, Danny Rischin, Benjamin Solomon

Journal article  |  2016  |  Clinical Epigenetics

Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686)

Chris Karlovich, Jonathan W Goldman, Jong-Mu Sun, Elaina Mann, Lecia V Sequist, Krzysztof Konopa, Wei Wen, Philipp Angenendt, Leora Horn, David Spigel, Jean-Charles Soria, Benjamin Solomon, D Ross Camidge, Shirish Gadgeel, Cloud Paweletz, Lin Wu, Sean Chien, Patrick O'Donnell, Shannon Matheny, Darrin Despain, et al.

Journal article  |  2016  |  Clinical Cancer Research

The Influence of Comorbidity and the Simplified Comorbidity Score on Overall Survival in Non-Small Cell Lung Cancer-A Prospective Cohort Study

Marliese Alexander, Sue M Evans, Robert G Stirling, Rory Wolfe, Ann Officer, Michael MacManus, Benjamin Solomon, Kate Burbury, David Ball

Journal article  |  2016  |  Journal of Thoracic Oncology

Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non-Small Cell Lung Cancer: Results of a Phase I Study

Pasi A Janne, Alice T Shaw, D Ross Camidge, Giuseppe Giaccone, S Martin Shreeve, Yiyun Tang, Zelanna Goldberg, Jean-Francois Martini, Huiping Xu, Leonard R James, Benjamin J Solomon

Journal article  |  2016  |  Journal of Thoracic Oncology

p16-positive lymph node metastases from cutaneous head and neck squamous cell carcinoma: No association with high-risk human papillomavirus or prognosis and implications for the workup of the unknown primary

Lachlan J McDowell, Richard J Young, Meredith L Johnston, Tze-Jian Tan, Stephen Kleid, Chen S Liu, Mathias Bressel, Vanessa Estall, Danny Rischin, Benjamin Solomon, June Corry

Journal article  |  2016  |  Cancer

Weekly cisplatin and radiotherapy for low risk, locoregionally advanced human papillomavirus-positive oropharyngeal squamous cell carcinoma

Damien Urban, June Corry, Ben Solomon, Annette M Lim, Tsien Fua, Andrew Coleman, Ieta D'Costa, Albert Tiong, Chen Liu, Lester J Peters, Danny Rischin

Journal article  |  2016  |  Head & Neck

Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial

Dong-Wan Kim, Ranee Mehra, Daniel SW Tan, Enriqueta Felip, Laura QM Chow, D Ross Camidge, Johan Vansteenkiste, Sunil Sharma, Tommaso De Pas, Gregory J Riely, Benjamin J Solomon, Juergen Wolf, Michael Thomas, Martin Schuler, Geoffrey Liu, Armando Santoro, Santosh Sutradhar, Siyu Li, Tomasz Szczudlo, Alejandro Yovine, et al.

Journal article  |  2016  |  The Lancet Oncology

BRAF Inhibition in BRAF(V600E)-Positive Anaplastic Thyroid Carcinoma

Annette M Lim, Graham R Taylor, Andrew Fellowes, Laird Cameron, Belinda Lee, Rodney J Hicks, Grant A McArthur, Christopher Angel, Benjamin Solomon, Danny Rischin

Journal article  |  2016  |  Journal of the National Comprehensive Cancer Network

A First-Time-In-Human Phase I Clinical Trial of Bispecific Antibody-Targeted, Paclitaxel-Packaged Bacterial Minicells

Benjamin J Solomon, Jayesh Desai, Mark Rosenthal, Grant A McArthur, Scott T Pattison, Stacey L Pattison, Jennifer MacDiarmid, Himanshu Brahmbhatt, Andrew M Scott

Journal article  |  2015  |  PLOS ONE

First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma

James R Whittle, Jason D Lickliter, Hui K Gan, Andrew M Scott, John Simes, Benjamin J Solomon, Jennifer A MacDiarmid, Himanshu Brahmbhatt, Mark A Rosenthal

Journal article  |  2015  |  Journal of Clinical Neuroscience

Spleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy

Shu Wen Wen, Sarah J Everitt, Justin Bedo, Marine Chabrot, David L Ball, Benjamin Solomon, Michael MacManus, Rodney J Hicks, Andreas Moeller, Antoine Leimgruber

Journal article  |  2015  |  PLOS ONE

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs

Francis W Hunter, Richard J Young, Zvi Shalev, Ravi N Vellanki, Jingli Wang, Yongchuan Gu, Naveen Joshi, Sreevalsan Sreebhavan, Ilan Weinreb, David P Goldstein, Jason Moffat, Troy Ketela, Kevin R Brown, Marianne Koritzinsky, Benjamin Solomon, Danny Rischin, William R Wilson, Bradly G Wouters

Journal article  |  2015  |  Cancer Research

New Treatment Options for ALK-Rearranged Non-Small Cell Lung Cancer

Laird Cameron, Benjamin Solomon

Journal article  |  2015  |  Current Treatment Options in Oncology

Ceritinib in patients with advanced anaplastic lymphoma kinase-rearranged anaplastic large-cell lymphoma

Heike Richly, Tae Min Kim, Martin Schuler, Dong-Wan Kim, Simon J Harrison, Alice T Shaw, Anthony L Boral, Alejandro Yovine, Benjamin Solomon

Journal article  |  2015  |  Blood

Comprehensive genomic profiles of small cell lung cancer

Julie George, Jing Shan Lim, Se Jin Jang, Yupeng Cun, Luka Ozretic, Gu Kong, Frauke Leenders, Xin Lu, Lynnette Fernandez-Cuesta, Graziella Bosco, Christian Mueller, Ilona Dahmen, Nadine S Jahchan, Kwon-Sik Park, Dian Yang, Anthony N Karnezis, Dedeepya Vaka, Angela Torres, Maia Segura Wang, Jan O Korbel, et al.

Journal article  |  2015  |  Nature

Treatment of ALK-Rearranged Non-Small Cell Lung Cancer: Recent Progress and Future Directions

Laird Cameron, Benjamin Solomon

Journal article  |  2015  |  Drugs

Progression-Free and Overall Survival in ALK-Positive NSCLC Patients Treated with Sequential Crizotinib and Ceritinib

Justin F Gainor, Daniel SW Tan, Tomasso De Pas, Benjamin J Solomon, Aziah Ahmad, Chiara Lazzari, Filippo de Marinis, Gianluca Spitaleri, Katherine Schultz, Luc Friboulet, Beow Y Yeap, Jeffrey A Engelman, Alice T Shaw

Journal article  |  2015  |  Clinical Cancer Research

Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastases

Daniel B Costa, Alice T Shaw, Sai-Hong I Ou, Benjamin J Solomon, Gregory J Riely, Myung-Ju Ahn, Caicun Zhou, S Martin Shreeve, Paulina Selaru, Anna Polli, Patrick Schnell, Keith D Wilner, Robin Wiltshire, D Ross Camidge, Lucio Crino

Journal article  |  2015  |  Journal of Clinical Oncology

Complex renal cysts associated with crizotinib treatment

Patrick Schnell, Cynthia H Bartlett, Benjamin J Solomon, Vanessa Tassell, Alice T Shaw, Tommaso de Pas, Soo-Hyun Lee, Geon Kook Lee, Kaoru Tanaka, Weiwei Tan, Yiyun Tang, Keith D Wilner, Allan Safferman, Ji-Youn Han

Journal article  |  2015  |  Cancer Medicine

Rociletinib in EGFR-Mutated Non-Small-Cell Lung Cancer

LV Sequist, J-C Soria, JW Goldman, HA Wakelee, SM Gadgeel, A Varga, V Papadimitrakopoulou, BJ Solomon, GR Oxnard, R Dziadziuszko, DL Aisner, RC Doebele, C Galasso, EB Garon, RS Heist, J Logan, JW Neal, MA Mendenhall, S Nichols, Z Piotrowska, et al.

Journal article  |  2015  |  New England Journal of Medicine

Comparison of Methods in the Detection of ALK and ROS1 Rearrangements in Lung Cancer

Toni-Maree Rogers, Prudence A Russell, Gavin Wright, Zoe Wainer, Jia-Min Pang, Leigh A Henricksen, Shalini Singh, Stacey Stanislaw, James Grille, Esteban Roberts, Benjamin Solomon, Stephen B Fox

Journal article  |  2015  |  Journal of Thoracic Oncology

Validating ROS1 Rearrangements As a Therapeutic Target in Non-Small-Cell Lung Cancer

Benjamin Solomon

Journal article  |  2015  |  Journal of Clinical Oncology

Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma

RJ Young, D Urban, C Angel, J Corry, B Lyons, N Vallance, S Kleid, TA Iseli, B Solomon, D Rischin

Journal article  |  2015  |  British Journal of Cancer

MOLECULAR INSIGHTS INFLUENCING THE MANAGEMENT OF HEAD AND NECK CANCERS

Annette Lim, Benjamin Solomon, Danny Rischin

Journal article  |  2015  |  Cancer Forum

Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC

Michael Michael, Shane C White, Ehtesham Abdi, Louise Nott, Phillip Clingan, Allan Zimet, Peter Button, Daniel Gregory, Benjamin Solomon, Alexander Dobrovic, Hongdo Do, Stephen Clarke

Journal article  |  2015  |  Asia-Pacific Journal of Clinical Oncology

Abiraterone in Metastatic Salivary Duct Carcinoma

Damien Urban, Danny Rischin, Christopher Angel, Ieta D'Costa, Benjamin Solomon

Journal article  |  2015  |  Journal of the National Comprehensive Cancer Network

First-Line Crizotinib in ALK-Positive Lung Cancer REPLY

Benjamin J Solomon, Tony Mok

Journal article  |  2015  |  New England Journal of Medicine

Crizotinib in ROS1-Rearranged Non-Small-Cell Lung Cancer Reply

Alice T Shaw, Benjamin J Solomon

Journal article  |  2015  |  New England Journal of Medicine

Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data

Lynnette Fernandez-Cuesta, Ruping Sun, Roopika Menon, Julie George, Susanne Lorenz, Leonardo A Meza-Zepeda, Martin Peifer, Dennis Plenker, Johannes M Heuckmann, Frauke Leenders, Thomas Zander, Ilona Dahmen, Mirjam Koker, Jakob Schoettle, Roland T Ullrich, Janine Altmueller, Christian Becker, Peter Nuernberg, Henrik Seidel, Diana Boehm, et al.

Journal article  |  2015  |  Genome Biology

Editor in Chief: Response to Eyre et al. "ALK-positive anaplastic large cell lymphoma: current and future perspectives in adult and paediatric disease"

Rachel Conyers, Aparna Rao, Benjamin Solomon, John F Seymour

Journal article  |  2015  |  European Journal of Haematology

FGFR1 inhibition in lung squamous cell carcinoma: questions and controversies

CE Weeden, B Solomon, M-L Asselin-Labat

Journal article  |  2015  |  Cell Death Discovery

Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome

Annette M Lim, Ida LM Candiloro, Nicholas Wong, Marnie Collins, Hongdo Do, Elena A Takano, Christopher Angel, Richard J Young, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Danny Rischin, Benjamin Solomon, Alexander Dobrovic

Journal article  |  2014  |  Clinical Epigenetics

First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer

Benjamin J Solomon, Tony Mok, Dong-Wan Kim, Yi-Long Wu, Kazuhiko Nakagawa, Tarek Mekhail, Enriqueta Felip, Federico Cappuzzo, Jolanda Paolini, Tiziana Usari, Shrividya Iyer, Arlene Reisman, Keith D Wilner, Jennifer Tursi, Fiona Blackhall, M Boyer, V Ganju, B Hughes, N Pavlakis, B Solomon, et al.

Journal article  |  2014  |  New England Journal of Medicine

Prevalence, morphology, and natural history of FGFR1-amplified lung cancer, including squamous cell carcinoma, detected by FISH and SISH

Prudence A Russell, Yong Yu, Richard J Young, Matthew Conron, Zoe Wainer, Naveed Alam, Benjamin Solomon, Gavin M Wright

Journal article  |  2014  |  Modern Pathology

Crizotinib in ROS1-Rearranged Non-Small-Cell Lung Cancer

Alice T Shaw, Sai-Hong I Ou, Yung-Jue Bang, D Ross Camidge, Benjamin J Solomon, Ravi Salgia, Gregory J Riely, Marileila Varella-Garcia, Geoffrey I Shapiro, Daniel B Costa, Robert C Doebele, Phi Le Long, Zongli Zheng, Weiwei Tan, Patricia Stephenson, S Martin Shreeve, Lesley M Tye, James G Christensen, Keith D Wilner, Jeffrey W Clark, et al.

Journal article  |  2014  |  New England Journal of Medicine

Refining the Toxicity Profile of Crizotinib

Benjamin Solomon

Journal article  |  2014  |  Journal of Thoracic Oncology

Comment on 'Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization' Response

Wendy A Cooper, Benjamin Solomon

Journal article  |  2014  |  Modern Pathology

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozretic, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ansen, Sven Perner, Michael Brockmann, et al.

Journal article  |  2014  |  Nature Medicine

Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

Annette M Lim, Hongdo Do, Richard J Young, Stephen Q Wong, Christopher Angel, Marnie Collins, Elena A Takano, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Stephen B Fox, Danny Rischin, Alexander Dobrovic, Benjamin Solomon

Journal article  |  2014  |  International Journal of Cancer

Preoperative chemotherapy for non-small-cell lung cancer

Gerard G Hanna, Shankar Siva, Nikki Plumridge, Benjamin Solomon, David L Ball

Journal article  |  2014  |  The Lancet

Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by F-18-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer

Antoine Leimgruber, Andreas Moeller, Sarah J Everitt, Marine Chabrot, David L Ball, Ben Solomon, Michael MacManus, Rodney J Hicks

Journal article  |  2014  |  Journal of Nuclear Medicine

Thromboprophylaxis for lung cancer patients-multimodality assessment of clinician practices, perceptions and decision support tools

M Alexander, S Kirsa, M MacManus, D Ball, B Solomon, K Burbury

Journal article  |  2014  |  Supportive Care in Cancer

Outcomes of an Australian testing programme for epidermal growth factor receptor mutations in non-small cell lung cancer

MJ Peters, JJ Bowden, P Carpenter, J Lewis, B Solomon

Journal article  |  2014  |  Internal Medicine Journal

Thromboembolism in lung cancer - An area of urgent unmet need

M Alexander, S Kirsa, R Wolfe, M MacManus, D Ball, B Solomon, K Burbury

Journal article  |  2014  |  Lung Cancer

CD74-NRG1 Fusions in Lung Adenocarcinoma

Lynnette Fernandez-Cuesta, Dennis Plenker, Hirotaka Osada, Ruping Sun, Roopika Menon, Frauke Leenders, Sandra Ortiz-Cuaran, Martin Peifer, Marc Bos, Juliane Dassler, Florian Malchers, Jakob Schottle, Wenzel Vogel, Ilona Dahmen, Mirjam Koker, Roland T Ullrich, Gavin M Wright, Prudence A Russell, Zoe Wainer, Benjamin Solomon, et al.

Journal article  |  2014  |  Cancer Discovery

Ceritinib in ALK-Rearranged Non-Small-Cell Lung Cancer

Alice T Shaw, Dong-Wan Kim, Ranee Mehra, Daniel SW Tan, Enriqueta Felip, Laura QM Chow, D Ross Camidge, Johan Vansteenkiste, Sunil Sharma, Tommaso De Pas, Gregory J Riely, Benjamin J Solomon, Juergen Wolf, Michael Thomas, Martin Schuler, Geoffrey Liu, Armando Santoro, Yvonne Y Lau, Meredith Goldwasser, Anthony L Boral, et al.

Journal article  |  2014  |  New England Journal of Medicine

Psychiatric Morbidity in Patients With Lung Cancer Response

Damien Urban, Aparna Rao, Mathias Bressel, Dina Neiger, Benjamin Solomon, Linda Mileshkin

Journal article  |  2014  |  Chest

Randomised, double-blind trial of carboplatin and paclitaxel with daily oral cediranib or placebo in patients with advanced non-small cell lung cancer: NCIC Clinical Trials Group study BR29.

SA Laurie, BJ Solomon, L Seymour, PM Ellis, GD Goss, FA Shepherd, MJ Boyer, AM Arnold, P Clingan, F Laberge, D Fenton, V Hirsh, M Zukin, MR Stockler, CW Lee, EX Chen, A Montenegro, K Ding, PA Bradbury

Journal article  |  2014  |  European Journal of Cancer

INTRODUCTION: This randomised double-blind placebo-controlled study evaluated the addition of cediranib, an inhibitor of vascular ..

Absence of a Relationship between Tumor 18F-fluorodeoxyglucose Standardized Uptake Value and Survival in Patients Treated with Definitive Radiotherapy for Non-Small-Cell Lung Cancer

Ming-Yin Lin, Muzo Wu, Sinead Brennan, Marie-Pierre Campeau, David Sidney Binns, Michael MacManus, Benjamin Solomon, Rodney J Hicks, Richard John Fisher, David Lee Ball

Journal article  |  2014  |  Journal of Thoracic Oncology

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

Lynnette Fernandez-Cuesta, Martin Peifer, Xin Lu, Ruping Sun, Luka Ozretic, Danila Seidel, Thomas Zander, Frauke Leenders, Julie George, Christian Mueller, Ilona Dahmen, Berit Pinther, Graziella Bosco, Kathryn Konrad, Janine Altmueller, Peter Nuernberg, Viktor Achter, Ulrich Lang, Peter M Schneider, Magdalena Bogus, et al.

Journal article  |  2014  |  Nature Communications

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

Hongdo Do, Nicholas C Wong, Carmel Murone, Thomas John, Benjamin Solomon, Paul L Mitchell, Alexander Dobrovic

Journal article  |  2014  |  Scientific Reports

Co-targeting Deoxyribonucleic Acide-Dependent Protein Kinase and Poly(Adenosine Diphosphate-Ribose) Polymerase-1 Promotes Accelerated Senescence of Irradiated Cancer Cells

Arun Azad, Patricia Bukczynska, Susan Jackson, Ygal Haput, Carleen Cullinane, Grant A McArthur, Benjamin Solomon

Journal article  |  2014  |  International Journal of Radiation: Oncology - Biology - Physics

Correlation of p16 status, hypoxic imaging using [18F]-misonidazole positron emission tomography and outcome in patients with loco-regionally advanced head and neck cancer

Mateya E Trinkaus, Rodney J Hicks, Richard J Young, Lester J Peters, Ben Solomon, Mathias Bressel, June Corry, Richard Fisher, David Binns, Grant A McArthur, Danny Rischin

Journal article  |  2014  |  Journal of Medical Imaging and Radiation Oncology

Imaging of molecular target modulation in oncology: Challenges of early clinical trials

C Cullinane, B Solomon, RJ Hicks

Journal article  |  2014  |  Clinical and Translational Imaging

Current Status of Targeted Therapy for Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer

B Solomon, KD Wilner, AT Shaw

Journal article  |  2014  |  Clinical Pharmacology & Therapeutics

Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization

Christina I Selinger, Toni-Maree Rogers, Prudence A Russell, Sandra O'Toole, PoYee Yip, Gavin M Wright, Zoe Wainer, Lisa G Horvath, Michael Boyer, Brian McCaughan, Maija RJ Kohonen-Corish, Stephen Fox, Wendy A Cooper, Benjamin Solomon

Journal article  |  2013  |  Modern Pathology

Clinical Benefit From Pemetrexed Before and After Crizotinib Exposure and From Crizotinib Before and After Pemetrexed Exposure in Patients With Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer

Eamon M Berge, Xian Lu, Delee Maxson, Anna E Baron, Shirish M Gadgeel, Benjamin J Solomon, Robert C Doebele, Maria Varella-Garcia, D Ross Camidge

Journal article  |  2013  |  Clinical Lung Cancer

A Genomics-Based Classification of Human Lung Tumors

Danila Seidel, Thomas Zander, Lukas C Heukamp, Martin Peifer, Marc Bos, Lynnette Fernandez-Cuesta, Frauke Leenders, Xin Lu, Sascha Ansen, Masyar Gardizi, Chau Nguyen, Johannes Berg, Prudence Russell, Zoe Wainer, Hans-Ulrich Schildhaus, Toni-Maree Rogers, Benjamin Solomon, William Pao, Scott L Carter, Gad Getz, et al.

Journal article  |  2013  |  Science Translational Medicine

Suicide in Lung Cancer Who Is at Risk?

Damien Urban, Aparna Rao, Mathias Bressel, Dina Neiger, Benjamin Solomon, Linda Mileshkin

Journal article  |  2013  |  Chest

Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer

Peter Savas, Brett Hughes, Benjamin Solomon

Journal article  |  2013  |  Journal of Thoracic Disease

Patients Treated With Platinum-Doublet Chemotherapy for Advanced Non-Small-Cell Lung Cancer Have Inferior Outcomes If Previously Treated With Platinum-based Chemoradiation

Ashvin Paramanathan, Benjamin Solomon, Marnie Collins, Michael Franco, Sarah Kofoed, Heather Francis, David Ball, Linda Mileshkin

Journal article  |  2013  |  Clinical Lung Cancer

Lymph Node Ratio May Predict the Benefit of Postoperative Radiotherapy in Non-Small-Cell Lung Cancer

Damien Urban, Jair Bar, Benjamin Solomon, David Ball

Journal article  |  2013  |  Journal of Thoracic Oncology

Lung cancer beyond 2013: Many different diseases

N Pavlakis, B Solomon

Journal article  |  2013  |  Cancer Forum

Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

Alice T Shaw, Dong-Wan Kim, Kazuhiko Nakagawa, Takashi Seto, Lucio Crino, Myung-Ju Ahn, Tommaso De Pas, Benjamin Besse, Benjamin J Solomon, Fiona Blackhall, Yi-Long Wu, Michael Thomas, Kenneth J O'Byrne, Denis Moro-Sibilot, D Ross Camidge, Tony Mok, Vera Hirsh, Gregory J Riely, Shrividya Iyer, Vanessa Tassell, et al.

Journal article  |  2013  |  New England Journal of Medicine

Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome

Richard J Young, Annette M Lim, Christopher Angel, Marnie Collins, Siddhartha Deb, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Prudence A Russell, Gavin Wright, Grant A McArthur, Stephen B Fox, Danny Rischin, Benjamin Solomon

Journal article  |  2013  |  Oral Oncology

Treatment response in the neck: p16 versus p16-oropharyngeal cancer

Daisy Mak, Rodney J Hicks, Danny Rischin, Ben Solomon, Lester Peters, Mathias Bressel, Richard J Young, June Corry

Journal article  |  2013  |  Journal of Medical Imaging and Radiation Oncology

A phase II study of induction carboplatin and gemcitabine followed by chemoradiotherapy for the treatment of locally advanced nasopharyngeal carcinoma

Annette M Lim, June Corry, Marnie Collins, Lester Peters, Rodney J Hicks, Ieta D'Costa, Andrew Coleman, Margaret Chua, Benjamin Solomon, Danny Rischin

Journal article  |  2013  |  Oral Oncology

Pemetrexed-based chemotherapy in patients with advanced, ALK-positive non-small cell lung cancer

AT Shaw, AM Varghese, BJ Solomon, DB Costa, S Novello, M Mino-Kenudson, MM Awad, JA Engelman, GJ Riely, V Monica, BY Yeap, GV Scagliotti

Journal article  |  2013  |  Annals of Oncology

Sex and SUVmax: Sex-Dependent Prognostication in Early Non-Small Cell Lung Cancer

Zoe Wainer, Marissa G Daniels, Jason Callahan, David Binns, Rodney J Hicks, Phillip Antippa, Prudence A Russell, Naveed Z Alam, Matthew Conron, Benjamin Solomon, Gavin M Wright

Journal article  |  2012  |  Journal of Nuclear Medicine

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Martin Peifer, Lynnette Fernandez-Cuesta, Martin L Sos, Julie George, Danila Seidel, Lawryn H Kasper, Dennis Plenker, Frauke Leenders, Ruping Sun, Thomas Zander, Roopika Menon, Mirjam Koker, Ilona Dahmen, Christian Mueller, Vincenzo Di Cerbo, Hans-Ulrich Schildhaus, Janine Altmueller, Ingelore Baessmann, Christian Becker, Bram de Wilde, et al.

Journal article  |  2012  |  Nature Genetics

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

D Ross Camidge, Yung-Jue Bang, Eunice L Kwak, A John Iafrate, Marileila Varella-Garcia, Stephen B Fox, Gregory J Riely, Benjamin Solomon, Sai-Hong I Ou, Dong-Wan Kim, Ravi Salgia, Panagiotis Fidias, Jeffrey A Engelman, Leena Gandhi, Pasi A Jaenne, Daniel B Costa, Geoffrey I Shapiro, Patricia LoRusso, Katherine Ruffner, Patricia Stephenson, et al.

Journal article  |  2012  |  Lancet Oncology

Correlation of Ataxia-Telangiectasia-Mutated (ATM) gene loss with outcome in head and neck squamous cell carcinoma

Annette M Lim, Richard J Young, Marnie Collins, Stephen B Fox, Grant A McArthur, June Corry, Lester Peters, Danny Rischin, Benjamin Solomon

Journal article  |  2012  |  Oral Oncology

Molecular therapeutic advances in personalized therapy of melanoma and non-small cell lung cancer.

Fergal C Kelleher, Benjamin Solomon, Grant A McArthur

Journal article  |  2012  |  Journal of Personalized Medicine

The incorporation of individualized molecular therapeutics into routine clinical practice for both non-small cell lung cancer (NSC..

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Ryohei Katayama, Alice T Shaw, Tahsin M Khan, Mari Mino-Kenudson, Benjamin J Solomon, Balazs Halmos, Nicholas A Jessop, John C Wain, Alan Tien Yeo, Cyril Benes, Lisa Drew, Jamal Carlos Saeh, Katherine Crosby, Lecia V Sequist, A John Iafrate, Jeffrey A Engelman

Journal article  |  2012  |  Science Translational Medicine

Progress in Molecular Targeted Therapy for Thyroid Cancer: Vandetanib in Medullary Thyroid Cancer

Benjamin Solomon, Danny Rischin

Journal article  |  2012  |  Journal of Clinical Oncology

Are Anaplastic Lymphoma Kinase Gene Rearrangements in Non-small Cell Lung Cancer Prognostic, Predictive, or Both?

Benjamin Solomon, Alice T Shaw

Journal article  |  2012  |  Journal of Thoracic Oncology

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

Karen Sheppard, Kathryn M Kinross, Benjamin Solomon, Richard B Pearson, Wayne A Phillips

Journal article  |  2012  |  Critical Reviews in Oncogenesis

The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating cell growth, proliferation, metabolism, s..

MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib

Jochen K Lennerz, Eunice L Kwak, Allison Ackerman, Michael Michael, Stephen B Fox, Kristin Bergethon, Gregory Y Lauwers, James G Christensen, Keith D Wilner, Daniel A Haber, Ravi Salgia, Yung-Jue Bang, Jeffrey W Clark, Benjamin J Solomon, A John Iafrate

Journal article  |  2011  |  Journal of Clinical Oncology

Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer Cells

Arun Azad, Susan Jackson, Carleen Cullinane, Anthony Natoli, Paul M Neilsen, David F Callen, Sauveur-Michel Maira, Wolfgang Hackl, Grant A McArthur, Benjamin Solomon

Journal article  |  2011  |  Molecular Cancer Research

Everolimus in Combination with Pemetrexed in Patients with Advanced Non-small Cell Lung Cancer Previously Treated with Chemotherapy A Phase I Study Using a Novel, Adaptive Bayesian Dose-Escalation Model

Johan Vansteenkiste, Benjamin Solomon, Michael Boyer, Juergen Wolf, Neil Miller, Lilla Di Scala, Ilona Pylvaenaeinen, Katarina Petrovic, Sasa Dimitrijevic, Beatrijs Anrys, Eckart Laack

Journal article  |  2011  |  Journal of Thoracic Oncology

Crizotinib and Testing for ALK

Alice T Shaw, Benjamin Solomon, Mari Mino-Kenudson

Journal article  |  2011  |  Journal of the National Comprehensive Cancer Network

Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

Alice T Shaw, Beow Y Yeap, Benjamin J Solomon, Gregory J Riely, Justin Gainor, Jeffrey A Engelman, Geoffrey I Shapiro, Daniel B Costa, Sai-Hong I Ou, Mohit Butaney, Ravi Salgia, Robert G Maki, Marileila Varella-Garcia, Robert C Doebele, Yung-Jue Bang, Kimary Kulig, Paulina Selaru, Yiyun Tang, Keith D Wilner, Eunice L Kwak, et al.

Journal article  |  2011  |  The Lancet Oncology

The emerging era of personalized therapy in squamous cell carcinoma of the head and neck

David I Pryor, Benjamin Solomon, Sandro V Porceddu

Journal article  |  2011  |  Asia-Pacific Journal of Clinical Oncology

Differential F-18-FDG and 3 '-Deoxy-3 '-F-18-Fluorothymidine PET Responses to Pharmacologic Inhibition of the c-MET Receptor in Preclinical Tumor Models

Carleen Cullinane, Donna S Dorow, Susan Jackson, Benjamin Solomon, Ekaterina Bogatyreva, David Binns, Richard Young, Maria E Arango, James G Christensen, Grant A McArthur, Rodney J Hicks

Journal article  |  2011  |  Journal of Nuclear Medicine

Relationship between Epidermal Growth Factor Receptor Status, p16(INK4A), and Outcome in Head and Neck Squamous Cell Carcinoma

Richard J Young, Danny Rischin, Richard Fisher, Grant A McArthur, Stephen B Fox, Lester J Peters, June Corry, Annette Lim, Kelly Waldeck, Benjamin Solomon

Journal article  |  2011  |  Cancer Epidemiology, Biomarkers & Prevention

Changes in F-18-Fluorodeoxyglucose and F-18-Fluorodeoxythymidine Positron Emission Tomography Imaging in Patients with Non-Small Cell Lung Cancer Treated with Erlotinib

Linda Mileshkin, Rodney J Hicks, Brett GM Hughes, Paul LR Mitchell, Veena Charu, Barbara J Gitlitz, David Macfarlane, Benjamin Solomon, Lukas C Amler, Wei Yu, Andrea Pirzkall, Bernard M Fine

Journal article  |  2011  |  Clinical Cancer Research

Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification

Sai-Hong Ignatius Ou, Eunice L Kwak, Christina Siwak-Tapp, Joni Dy, Kristin Bergethon, Jeffrey W Clark, D Ross Camidge, Benjamin J Solomon, Robert G Maki, Yung-Jue Bang, Dong-Wan Kim, James Christensen, Weiwei Tan, Keith D Wilner, Ravi Salgia, A John Iafrate

Journal article  |  2011  |  Journal of Thoracic Oncology

Targeting Anaplastic Lymphoma Kinase in Lung Cancer

Alice T Shaw, Benjamin Solomon

Journal article  |  2011  |  Clinical Cancer Research

An Australian survey of clinical practices in management of neutropenic fever in adult cancer patients 2009

S Lingaratnam, MA Slavin, L Mileshkin, B Solomon, K Burbury, JF Seymour, R Sharma, B Koczwara, SW Kirsa, ID Davis, M Prince, J Szer, C Underhill, O Morrissey, KA Thursky

Journal article  |  2011  |  Internal Medicine Journal

Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.

Sai-Hong Ignatius Ou, Lyudmila Bazhenova, D Ross Camidge, Benjamin J Solomon, June Herman, Tatiana Kain, Yung-Jue Bang, Eunice L Kwak, Alice T Shaw, Ravi Salgia, Robert G Maki, Jeffrey W Clark, Keith D Wilner, A John Iafrate

Journal article  |  2010  |  Journal of Thoracic Oncology

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

Eunice L Kwak, Yung-Jue Bang, D Ross Camidge, Alice T Shaw, Benjamin Solomon, Robert G Maki, Sai-Hong I Ou, Bruce J Dezube, Pasi A Jänne, Daniel B Costa, Marileila Varella-Garcia, Woo-Ho Kim, Thomas J Lynch, Panos Fidias, Hannah Stubbs, Jeffrey A Engelman, Lecia V Sequist, WeiWei Tan, Leena Gandhi, Mari Mino-Kenudson, et al.

Journal article  |  2010  |  New England Journal of Medicine

BACKGROUND: Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non-small-..

An Open-Label, Single-Arm Phase Two Trial of Gefitinib in Patients With Advanced or Metastatic Castration-Resistant Prostate Cancer

Carmel Pezaro, Mark A Rosenthal, Howard Gurney, Ian D Davis, Craig Underhill, Michael J Boyer, Dusan Kotasek, Benjamin Solomon, Guy C Toner

Journal article  |  2009  |  American Journal of Clinical Oncology - Cancer Clinical Trials

The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve as a Target for Genetically Redirected T cells Despite the Presence of Soluble Antigen in Serum

Jennifer A Westwood, William K Murray, Melanie Trivett, Nicole M Haynes, Benjamin Solomon, Linda Mileshkin, David Ball, Michael Michael, Angela Burman, Preethi Mayura-Guru, Joseph A Trapani, Stefan Peinert, Dirk Honemann, H Miles Prince, Andrew M Scott, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2009  |  Journal of Immunotherapy

A phase I trial of high-dose palliative radiotherapy plus concurrent weekly Vinorelbine and Cisplatin in patients with locally advanced and metastatic NSCLC

M Michael, A Wirth, DL Ball, M MacManus, D Rischin, L Mileshkin, B Solomon, J McKendrick, AD Milner

Journal article  |  2005  |  British Journal of Cancer