Brendon Chua

TLR2-mediated innate immune priming boosts lung anti-viral immunity

Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T Reid, Punnam Chander Veerati, Chris L Grainge, Peter AB Wark, Darryl Knight, David Jackson, Christophe Demaison, Nathan W Bartlett

Journal article  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

BACKGROUND: We assessed whether Toll-like receptor (TLR)2 activation boosts the innate immune response to rhinovirus infection, as..

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki, et al.

Journal article  |  2021  |  VACCINE

Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud, et al.

Journal article  |  2021  |  IMMUNITY

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons

Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern

Journal article  |  2021  |  FASEB JOURNAL

Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..

High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshanski, William Heath, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

Journal article  |  2021

Although co-expression of CD38 and HLA-DR on CD8 + T cells reflects activation during influenza, SARS-CoV-2, Dengue, Ebola and HIV..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao, et al.

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model.

Pamela C Proud, Daphne Tsitoura, Robert J Watson, Brendon Y Chua, Marilyn J Aram, Kevin R Bewley, Breeze E Cavell, Rebecca Cobb, Stuart Dowall, Susan A Fotheringham, Catherine MK Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A Ryan, Gillian S Slack, Stephen Thomas, Nadina I Wand, Paul Yeates, Christophe Demaison, et al.

Journal article  |  2021  |  EBioMedicine

BACKGROUND: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respirator..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..