Brendon Chua

TLR2-mediated innate immune priming boosts lung anti-viral immunity.

Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T Reid, Punnam Chander Veerati, Chris L Grainge, Peter AB Wark, Darryl Knight, David Jackson, Christophe Demaison, Nathan W Bartlett

Journal article  |  2020  |  European Respiratory Journal

RESEARCH QUESTION: Assessment of whether TLR2 activation boosts the innate immune response to rhinovirus infection, as a treatment..

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model.

Pamela C Proud, Daphne Tsitoura, Robert J Watson, Brendon Y Chua, Marilyn J Aram, Kevin R Bewley, Breeze E Cavell, Rebecca Cobb, Stuart Dowall, Susan A Fotheringham, Catherine MK Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A Ryan, Gillian S Slack, Stephen Thomas, Nadina I Wand, Paul Yeates, Christophe Demaison, et al.

Journal article  |  2020  |  EBioMedicine

BACKGROUND: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respirator..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays

Marios Koutsakos, Toshiki Sekiya, Brendon Y Chua, Hoang Oanh Nguyen Thi, Adam K Wheatley, Jennifer A Juno, Marumi Ohno, Naoki Nomura, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Saori Suzuki, Hirohito Ishigaki, Misako Nakayama, Cong T Nguyen, Yasushi Itoh, Masashi Shingai, Kazumasa Ogasawara, Yoichiro Kino, Stephen J Kent, et al.

Journal article  |  2020  |  Immunology and Cell Biology

Influenza remains a significant global public health burden, despite substantial annual vaccination efforts against circulating vi..

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL _3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice

Kirstie M Mangas, Nicholas J Tobias, Estelle Marion, Jeremie Babonneau, Laurent Marsollier, Jessica L Porter, Sacha J Pidot, Chinn Yi Wong, David C Jackson, Brendon Y Chua, Timothy P Stinear

Journal article  |  2020  |  PeerJ

Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019

Karla J Helbig, Rowena A Bull, Rebecca Ambrose, Michael R Beard, Helen Blanchard, Till Bocking, Brendon Chua, Agathe MG Colmant, Keaton M Crosse, Damian FJ Purcell, Johanna Fraser, Joshua A Hayward, Stuart T Hamilton, Matloob Husain, Robin MacDiarmid, Jason M Mackenzie, Gregory W Moseley, Thi HO Nguyen, Miguel E Quinones-Mateu, Karl Robinson, et al.

Journal article  |  2020  |  Viruses

The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian r..

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  Infection and Immunity

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use in an out-bred population

Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, Chinn Yi Wong, Brendon Y Chua, David C Jackson

Journal article  |  2020  |  Vaccine

To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of eliciting antibody responses in an o..

Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses

Maria Auladell, Xiaoxiao Jia, Luca Hensen, Brandon Chua, Annette Fox, Thi HO Nguyen, Peter C Doherty, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response

Acep R Wijayadikusumah, Weiguang Zeng, Hayley A McQuilten, Chinn Yi Wong, David C Jackson, Brendon Y Chua

Journal article  |  2019  |  Molecular Pharmaceutics