Brendon Chua

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  Infection and Immunity

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use in an out-bred population

Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, Chinn Yi Wong, Brendon Y Chua, David C Jackson

Journal article  |  2020  |  Vaccine

To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of eliciting antibody responses in an o..

Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses

Maria Auladell, Xiaoxiao Jia, Luca Hensen, Brandon Chua, Annette Fox, Thi HO Nguyen, Peter C Doherty, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response

Acep R Wijayadikusumah, Weiguang Zeng, Hayley A McQuilten, Chinn Yi Wong, David C Jackson, Brendon Y Chua

Journal article  |  2019  |  Molecular Pharmaceutics

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  Nature Immunology

In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear

Journal article  |  2019  |  The American Journal of Tropical Medicine and Hygiene

Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..

The Toll-Like Receptor 2 agonist PEG-Pam(2)Cys as an immunochemoprophylactic and immunochemotherapeutic against the liver and transmission stages of malaria parasites

Medard Ernest, Carol Hunja, Yuka Arakura, Yohei Haraga, Hussein M Abkallo, Weiguang Zeng, David C Jackson, Brendon Chua, Richard Culleton

Journal article  |  2018  |  International Journal for Parasitology: Drugs and Drug Resistance

Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine

D Christiansen, L Earnest-Silveira, B Chua, P Meuleman, I Boo, B Grubor-Bauk, DC Jackson, ZY Keck, SKH Foung, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2018  |  Scientific Reports

Antibody Responses to a Quadrivalent Hepatitis C Viral-Like Particle Vaccine Adjuvanted with Toll-Like Receptor 2 Agonists

Dale Christiansen, Linda Earnest-Silveira, Brendon Chua, Irene Boo, Heidi E Drummer, Branka Grubor-Bauk, Eric J Gowans, David C Jackson, Joseph Torresi

Journal article  |  2018  |  Viral Immunology

Opinion: Making Inactivated and Subunit-Based Vaccines Work

Brendon Y Chua, Toshiki Sekiya, David C Jackson

Journal article  |  2018  |  Viral Immunology

Structure-function relationships of protein-lipopeptide complexes and influence on immunogenicity

Acep R Wijayadikusumah, Lucy C Sullivan, David C Jackson, Brendon Y Chua

Journal article  |  2017  |  Amino Acids

PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8( ) T cell responses

Toshiki Sekiya, Junya Yamagishi, John Henry V Gray, Paul G Whitney, Axel Martinelli, Weiguang Zeng, Chinn Yi Wong, Chihiro Sugimoto, David C Jackson, Brendon Y Chua

Journal article  |  2017  |  Biomaterials

Establishment of memory CD8( ) T cells with live attenuated influenza virus across different vaccination doses

Zhongfang Wang, Lukasz Kedzierski, Simone Nuessing, Brendon Yew Loong Chua, Sergio M Quiones-Parra, Victor C Huber, David C Jackson, Paul G Thomas, Katherine Kedzierska

Journal article  |  2016  |  Journal of General Virology

Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection

Matthew R Olson, Brendon Y Chua, Kim L Good-Jacobson, Peter C Doherty, David C Jackson, Stephen J Turner

Journal article  |  2016  |  Immunology and Cell Biology

Improving the immunogenicity of subunit-based vaccines using a TLR2-targeting Pam(2)Cys-based adjuvant

AR Wijayadikusumah, DC Jackson, N Nurainy, BY Chua

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line

L Earnest-Silveira, B Chua, R Chin, D Christiansen, D Johnson, S Herrmann, SA Ralph, K Vercauteren, A Mesalam, P Meuleman, S Das, I Boo, H Drummer, C-T Bock, EJ Gowans, DC Jackson, Joseph Torresi

Journal article  |  2016  |  Journal of General Virology

Reducing the impact of influenza-associated secondary pneumococcal infections

Edin J Mifsud, Amabel C Tan, Kirsty R Short, Lorena E Brown, Brendon Y Chua, David C Jackson

Journal article  |  2016  |  Immunology and Cell Biology

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

Brendon Y Chua, Chinn Yi Wong, Edin J Mifsud, Kathryn M Edenborough, Toshiki Sekiya, Amabel CL Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J Turner, Peter C Doherty, Anne Kelso, Lorena E Brown, David C Jackson

Journal article  |  2015  |  mBio

Establishment of functional influenza virus-specific CDS T cell memory pools after intramuscular immunization

Zhongfang Wang, Brendon Y Chua, Javier Vega Ramos, Sergio M Quinones Parra, Emily Fairmaid, Lorena E Brown, David C Jackson, Katherine Kedzierska

Journal article  |  2015  |  Vaccine

Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses

Nicola L Bird, Matthew R Olson, Aeron C Hurt, Christine M Oshansky, Ding Yuan Oh, Patrick C Reading, Brendon Y Chua, Yilun Sun, Li Tang, Andreas Handel, David C Jackson, Stephen J Turner, Paul G Thomas, Katherine Kedzierska

Journal article  |  2015  |  PLOS ONE

Generation of adaptive immune responses following influenza virus challenge is not compromised by pre-treatment with the TLR-2 agonist Pam(2)Cys

Edin Jessica Mifsud, Amabel CL Tan, Lorena Elizabeth Brown, Brendon Yew Loong Chua, David C Jackson

Journal article  |  2015  |  Frontiers in Immunology

A single dose biodegradable vaccine depot that induces persistently high levels of antibody over a year

Brendon Y Chua, Toshiki Sekiya, Mohammad Al Kobaisi, Kirsty R Short, David E Mainwaring, David C Jackson

Journal article  |  2015  |  Biomaterials

Considerations for the rapid deployment of vaccines against H7N9 influenza

Brendon Y Chua, Lorena E Brown, David C Jackson

Journal article  |  2014  |  Expert Review of Vaccines

The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses

Brendon Y Chua, Matthew R Olson, Sammy Bedoui, Toshiki Sekiya, Chinn Y Wong, Stephen J Turner, David C Jackson

Journal article  |  2014  |  Immunology and Cell Biology

HEPATITIS C VLPS DELIVERED TO DENDRITIC CELLS BY A TLR2 TARGETING LIPOPEPTIDE RESULTS IN ENHANCED NEUTRALIZING ANTIBODY AND CELL-MEDIATED RESPONSES

J Torresi, R Chin, B Chua, D Johnson, L Earnest-Sliveira, W Zeng, E Gowans, TC Bock, DC Jackson

Conference Proceedings  |  2013  |  Journal of Hepatology

Hepatitis C VLPs Delivered to Dendritic Cells by a TLR2 Targeting Lipopeptide Results in Enhanced Antibody and Cell-Mediated Responses

Brendon Y Chua, Douglas Johnson, Amabel Tan, Linda Earnest-Silveira, Toshiki Sekiya, Ruth Chin, Joseph Torresi, David C Jackson

Journal article  |  2012  |  PLoS One

Control of size dispersity of chitosan biopolymer microparticles and nanoparticles to influence vaccine trafficking and cell uptake

Mohammad Al Kobiasi, Brendon Y Chua, David Tonkin, David C Jackson, David E Mainwaring

Journal article  |  2012  |  Journal of Biomedical Materials Research

Chitosan-based particles as biocompatible delivery vehicles for peptide and protein-based vaccines

Brendon Y Chu, Mohammad Al Kobiasi, Weiguang Zeng, David Mainwaring, David C Jackson

Journal article  |  2012  |  Procedia in Vaccinology

Chitosan Microparticles and Nanoparticles as Biocompatible Delivery Vehicles for Peptide and Protein-Based Immunocontraceptive Vaccines

Brendon Y Chua, Mohammad Al Kobaisi, Weiguang Zeng, David Mainwaring, David C Jackson

Journal article  |  2012  |  Molecular Pharmaceutics

Electrostatic-mediated enhancement of protein antigen immunogenicity using charged TLR2-targeting lipopeptides

Brendon Y Chua, David Pejoski, Stephen J Turner, Weiguang Zeng, David C Jackson

Journal article  |  2012  |  Procedia in Vaccinology

Systemic and Mucosal Vaccination of Rabbits Using Envelope Glycoproteins Derived from HIV-1 Pre-Seroconversion Strains as Novel Immunogens

S Reddy, R Center, K Suzuki, B Chua, D Jackson, P Gorry, A Kelleher, D Purcell

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Soluble Proteins Induce Strong CD8( ) T Cell and Antibody Responses through Electrostatic Association with Simple Cationic or Anionic Lipopeptides That Target TLR2

Brendon Y Chua, David Pejoski, Stephen J Turner, Weiguang Zeng, David C Jackson

Journal article  |  2011  |  Journal of Immunology

NOVEL ADJUVANTS INCREASE HUMORAL NEUTRALISING ANTIBODY AND T CELL IMMUNE RESPONSES IN MHC CLASS I TRANSGENIC MICE TO RECOMBINANT MAMMALIAN CELL DERIVED HEPATITIS C VIRUS-LIKE-PARTICLES

D Johnson, B Chua, A Tan, R Chin, L Earnest-Silveira, T Bock, W Zeng, D Jackson, J Torresi

Conference Proceedings  |  2011  |  Journal of Hepatology

Role of Adjuvants in Enhancing the Immunogenicity of HIV-1 Envelope Glycoprotein based Vaccine Immunogens

S Reddy, B Chua, M Kramski, R Center, D Jackson, D Purcell

Conference Proceedings  |  2010  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals

Eric J Gowans, Stuart Roberts, Kathryn Jones, Irene Dinatale, Philippe A Latour, Brendan Chua, Emily MY Eriksson, Ruth Chin, Shuo Li, Dominic M Wall, Rosemary L Sparrow, Jude Moloney, Maureen Loudovaris, Rosemary Ffrench, H Miles Prince, Derek Hart, Weng Zeng, Joseph Torresi, Lorena E Brown, David C Jackson

Journal article  |  2010  |  Journal of Hepatology

Structural requirement for the agonist activity of the TLR2 ligand Pam2Cys

Weiguang Zeng, Emily Eriksson, Brendon Chua, Lara Grollo, David C Jackson

Journal article  |  2010  |  Amino Acids

RECOMBINANT MAMMALIAN CELL DERIVED HEPATITIS C VIRUS LIKE PARTICLES INDUCE NEUTRALISING ANTIBODY AND B CELL RESPONSES TO HEPATITIS C VIRUS

DF Johnson, B Chua, R Chin, L Earnest-Silveira, H Zentgraf, C-T Bock, W Zeng, DC Jacskon, J Torresi

Conference Proceedings  |  2010  |  Journal of Hepatology

Lipopeptide-Based Vaccines

David Jackson, Brendon Chua, Lorena Brown, Peter Moyle, Istvan Toth

Book Chapter  |  2009

RECOMBINANT MAMMALIAN CELL DERIVED HCV VIRUS LIKE PARTICLES TO INDUCE NEUTRALISING ANTIBODY RESPONSES TO HCV

D Johnson, R Chin, L Earnest-Silveira, H Zentgraf, C-T Bock, B Chua, D Jackson, J Torresi

Conference Proceedings  |  2009  |  Journal of Hepatology

A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection

Brendon Y Chua, Emily M Eriksson, Lorena E Brown, Weiguang Zeng, Eric J Gowans, Joseph Torresi, David C Jackson

Journal article  |  2008  |  Vaccine

Dendritic cell acquisition of epitope cargo mediated by simple cationic peptide structures

Brendon Y Chua, Emily M Eriksson, Daniel P Poole, Weiguang Zeng, David C Jackson

Journal article  |  2008  |  Peptides

Enhancing immunogenicity of HCV DNA vaccines by targeted delivery to dendritic cells (DC)

BY Chua, W Zeng, II Atmosukarto, J Torresi, DC Jackson

Conference Proceedings  |  2008  |  JOURNAL OF HEPATOLOGY

Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines.

Brendon Y Chua, Weiguang Zeng, David C Jackson

Journal article  |  2008  |  Methods in Molecular Biology

Effective Th1- and Th2-type immune responses that result in protective immunity against pathogens can be induced by self-adjuvanti..

Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines

BY Chua, W Zeng, DC Jackson

Journal article  |  2008  |  Methods in Molecular Biology

634 ENHANCING IMMUNOGENICITY OF HCV DNA VACCINES BY TARGETED DELIVERY TO DENDRITIC CELLS (DC)

BY Chua, W Zeng, II Atmosukarto, J Torresi, DC Jackson

Journal article  |  2008  |  Journal of Hepatology

Simple branched arginine-based structures can enhance the cellular uptake of peptide cargos

Brendon Y Chua, Weiguang Zeng, David C Jackson

Journal article  |  2007  |  International Journal of Peptide Research and Therapeutics

Comparison of lipopeptide-based immunocontraceptive vaccines containing different lipid groups

Brendon Y Chua, Weiguang Zeng, Yuk Fai Lau, David C Jackson

Journal article  |  2007  |  Vaccine

Totally synthetic peptide-based vaccines that target dendritic cells and induce potent antibody or CTL responses

DC Jackson, BY Chua, W Zeng

Journal article  |  2006  |  International Congress Series

Methods in Molecular Biology, Volume 295: IMMUNOCHEMICAL PROTOCOLS, 3rd edition

Lara Grollo, Brendon Chua, David C Jackson

Journal article  |  2005  |  Immunology and Cell Biology

An insect antibacterial peptide-based drug delivery system

Laszlo Otvo, Mare Curdic, Brendon Y Chua, Georgia Deliyannis, David C Jackson

Journal article  |  2004  |  Molecular Pharmaceutics

Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus

BY Chua, A Healy, PU Cameron, O Stock, M Rizkalla, WG Zeng, J Torresi, LE Brown, NL Fowler, EJ Gowans, DC Jackson

Journal article  |  2003  |  Immunology and Cell Biology