Sam Wormald

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..

Somatic mutation footprinting reveals a unique tetranucleotide signature associated with intron-exon boundaries in lung cancer

Samuel Wormald, Anita Lerch, Dmitri Mouradov, Liam O'Connor

Journal article  |  2018  |  CARCINOGENESIS

Cigarette smoke comprises a large number of carcinogenic substances that can increase DNA mutation load in epithelial cells of the..

An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.

Cynthia L Fisher, Hendrik Marks, Lily Ting-Yin Cho, Robert Andrews, Sam Wormald, Thomas Carroll, Vivek Iyer, Peri Tate, Barry Rosen, Hendrik G Stunnenberg, Amanda G Fisher, William C Skarnes

Journal article  |  2017  |  Nucleic Acids Res

Mouse embryonic stem (ES) cells are a popular model system to study biological processes, though uncovering recessive phenotypes r..

TGF-beta and IL-6 family signalling crosstalk: an integrated model

Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess

Journal article  |  2017  |  GROWTH FACTORS

Mathematical models for TGF-β and IL-6 signalling have been linked, providing a platform for analyzing the crosstalk between the s..

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.

Paula A Coelho, Leah Bury, Marta N Shahbazi, Kifayathullah Liakath-Ali, Peri H Tate, Sam Wormald, Christopher J Hindley, Meritxell Huch, Joy Archer, William C Skarnes, Magdalena Zernicka-Goetz, David M Glover

Journal article  |  2015  |  Open Biol

To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that per..

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

Dmitri Mouradov, Clare Sloggett, Robert N Jorissen, Christopher G Love, Shan Li, Antony W Burgess, Diego Arango, Robert L Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L Wilding, David Bicknell, Ian PM Tomlinson, Walter F Bodmer, John M Mariadason, Oliver M Sieber

Journal article  |  2014  |  CANCER RESEARCH

Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental therapy, and biomarkers. However, to..

edgeR: a versatile tool for the analysis of shRNA-seq and CRISPR-Cas9 genetic screens.

Zhiyin Dai, Julie M Sheridan, Linden J Gearing, Darcy L Moore, Shian Su, Sam Wormald, Stephen Wilcox, Liam O'Connor, Ross A Dickins, Marnie E Blewitt, Matthew E Ritchie

Journal article  |  2014  |  F1000Res

Pooled library sequencing screens that perturb gene function in a high-throughput manner are becoming increasingly popular in func..

Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells.

Anna N Melidoni, Michael R Dyson, Sam Wormald, John McCafferty

Journal article  |  2013  |  Proc Natl Acad Sci U S A

Antibodies that modulate receptor function have great untapped potential in the control of stem cell differentiation. In contrast ..

Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway

Samuel Wormald, Liz Milla, Liam O'Connor

Journal article  |  2013  |  BMC MEDICAL GENOMICS

BACKGROUND: Tumour growth in colorectal cancer and other solid cancers is frequently supported by activating mutations in the epid..

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

Ben A Croker, Lisa A Mielke, Sam Wormald, Donald Metcalf, Hiu Kiu, Warren S Alexander, Douglas J Hilton, Andrew W Roberts

Journal article  |  2008  |  EXPERIMENTAL HEMATOLOGY

Granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) play key roles in regulating emergency granulopoiesis and i..