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An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells an..
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associ..
Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of P..
Selecting antagonistic antibodies that control differentiation through inducible expressio..
Displaying the 14 most recent scholarly works by Sam Wormald.
An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.
Cynthia L Fisher, Hendrik Marks, Lily Ting-Yin Cho, Robert Andrews, Sam Wormald, Thomas Carroll, Vivek Iyer, Peri Tate, Barry Rosen, Hendrik G Stunnenberg, Amanda G Fisher, William C Skarnes
Journal article | 2017 | Nucleic Acids Research
Mouse embryonic stem (ES) cells are a popular model system to study biological processes, though uncovering recessive phenotypes r..
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
Paula A Coelho, Leah Bury, Marta N Shahbazi, Kifayathullah Liakath-Ali, Peri H Tate, Sam Wormald, Christopher J Hindley, Meritxell Huch, Joy Archer, William C Skarnes, Magdalena Zernicka-Goetz, David M Glover
Journal article | 2015 | Open Biology
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that per..
Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Dmitri Mouradov, Clare Sloggett, Robert N Jorissen, Christopher G Love, Shan Li, Antony W Burgess, Diego Arango, Robert L Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L Wilding, David Bicknell, Ian PM Tomlinson, Walter F Bodmer, John M Mariadason, Oliver M Sieber
Journal article | 2014 | Cancer Research
Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells.
Anna N Melidoni, Michael R Dyson, Sam Wormald, John McCafferty
Journal article | 2013 | Proceedings of the National Academy of Sciences
Antibodies that modulate receptor function have great untapped potential in the control of stem cell differentiation. In contrast ..
Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle.
Gregory R Steinberg, Angela C Smith, Sam Wormald, Patrick Malenfant, Cheryl Collier, David J Dyck
Journal article | 2004 | American Journal of Physiology-Endocrinology and Metabolism
Leptin acutely stimulates skeletal muscle fatty acid (FA) metabolism in lean rodents and humans. This stimulatory effect is elimin..