Sapna Devi

Runx3 drives a CD8( ) T cell tissue residency program that is absent in CD4( ) T cells

Raissa Fonseca, Thomas N Burn, Luke C Gandolfo, Sapna Devi, Simone L Park, Andreas Obers, Maximilien Evrard, Susan N Christo, Frank A Buquicchio, Caleb A Lareau, Keely M McDonald, Sarah K Sandford, Natasha M Zamudio, Nagela G Zanluqui, Ali Zaid, Terence P Speed, Ansuman T Satpathy, Scott N Mueller, Francis R Carbone, Laura K Mackay

Journal article  |  2022  |  NATURE IMMUNOLOGY

Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription fac..

Transfusion-Related Renal Dysfunction After Cardiac Surgery The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish EG McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A Villadangos, Karim Asehnoune

Journal article  |  2022  |  JACC-BASIC TO TRANSLATIONAL SCIENCE

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the co..

Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

Joon Keit Loi, Yannick O Alexandre, Kirthana Senthil, Dominik Schienstock, Sarah Sandford, Sapna Devi, Susan N Christo, Laura K Mackay, Holly R Chinnery, Peregrine B Osborne, Laura E Downie, Erica K Sloan, Scott N Mueller

Journal article  |  2022  |  CELL REPORTS

The eye is considered immune privileged such that immune responses are dampened to protect vision. As the most anterior compartmen..

Differential location of NKT and MAIT cells within lymphoid tissue

Darryl N Johnson, Zheng Ruan, Emma Petley, Sapna Devi, Lauren E Holz, Adam P Uldrich, Jeffrey YW Mak, Jyh Liang Hor, Scott N Mueller, James McCluskey, David P Fairlie, Phillip K Darcy, Paul A Beavis, William R Heath, Dale Godfrey

Journal article  |  2022  |  SCIENTIFIC REPORTS

Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant α..

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

Yannick O Alexandre, Dominik Schienstock, Hyun Jae Lee, Luke C Gandolfo, Cameron G Williams, Sapna Devi, Bhupinder Pal, Joanna R Groom, Wang Cao, Susan N Christo, Claire L Gordon, Graham Starkey, Rohit D'Costa, Laura K Mackay, Ashraful Haque, Burkhard Ludewig, Gabrielle T Belz, Scott N Mueller

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine ..

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes

Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, Yu Kato, Susan N Christo, Raissa Fonseca, Simone L Park, Thomas N Burn, Maleika Osman, Sapna Devi, Jerold Chun, Scott N Mueller, George Kannourakis, Stuart P Berzins, Daniel G Pellicci, William R Heath, Stephen C Jameson, Laura K Mackay

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the key events controlling TRM cell developmen..

CD8( ) and CD4( ) T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infection and Form Long-Term Resident Memory

Nazanin Ghazanfari, Julia L Gregory, Sapna Devi, Daniel Fernandez-Ruiz, Lynette Beattie, Scott N Mueller, William R Heath

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8+ T cells and infected RBCs in the brain promotes the de..

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

Sapna Devi, Yannick O Alexandre, Joon Keit Loi, Ryan Gillis, Nazanin Ghazanfari, Sarah J Creed, Lauren E Holz, David Shackleford, Laura K Mackay, William R Heath, Erica K Sloan, Scott N Mueller

Journal article  |  2021  |  IMMUNITY

The sympathetic nervous system (SNS) controls various physiological functions via the neurotransmitter noradrenaline. Activation o..

Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration

Cameron R Bastow, Mark D Bunting, Ervin E Kara, Duncan R McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N Mueller, Ian H Frazer, Natasha Harvey, Mark R Condina, Clifford Young, Peter Hoffmann, Shaun R McColl, Iain Comerford

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocyte homing driven by the chemokine CCL21 is pivotal for adaptive immunity because it controls dendritic cell (DC) and T cell..

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

Yannick O Alexandre, Sapna Devi, Simone L Park, Laura K Mackay, William R Heath, Scott N Mueller

Journal article  |  2020  |  CELL REPORTS

Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered..