Gordon Dougan

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

Stephan Brouwer, Timothy C Barnett, Diane Ly, Katherine J Kasper, David MP De Oliveira, Tania Rivera-Hernandez, Amanda J Cork, Liam McIntyre, Magnus G Jespersen, Johanna Richter, Benjamin L Schulz, Gordon Dougan, Victor Nizet, Kwok-Yung Yuen, Yuanhai You, John K McCormick, Martina L Sanderson-Smith, Mark R Davies, Mark J Walker

Journal article  |  2020  |  Nature Communications

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) S..

Tenacious Endemic Typhoid Fever in Samoa

Michael J Sikorski, Sachin N Desai, Siaosi Tupua, Robert E Thomsen, Jane Han, Savitra Rambocus, Susana Nimarota-Brown, Linatupu Punimata, Salesa Tusitala, Michelle Sialeipata, Seth A Hoffman, J Kathleen Tracy, Ellen E Higginson, Sharon M Tennant, Jillian S Gauld, Daniel J Klein, Susan A Ballard, Roy M Robins-Browne, Gordon Dougan, Eric J Nilles, et al.

Journal article  |  2020  |  Clinical Infectious Diseases

BACKGROUND: Typhoid fever has been endemic on the island nation of Samoa (2016 population, 195 979) since the 1960s and has persis..

Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata.

Justin Im, Md Taufiqul Islam, Deok Ryun Kim, Faisal Ahmmed, Yun Chon, K Zaman, Ashraful Islam Khan, Mohammad Ali, Dipika Sur, Suman Kanungo, Shanta Dutta, Sujit K Bhattacharya, Gordon Dougan, Kathryn E Holt, Florian Marks, Jerome H Kim, Firdausi Qadri, John D Clemens

Journal article  |  2020  |  PLoS Neglected Tropical Diseases

We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fev..

Pathogen genomic surveillance of typhoidalSalmonellainfection in adults and children reveals no association between clinical outcomes and infecting genotypes

Carl D Britto, Sitarah Mathias, Ashish Bosco, Zoe A Dyson, Gordon Dougan, Savitha Raveendran, VL Abin, Sanju Jose, Savitha Nagaraj, Kathryn E Holt, Andrew J Pollard

Journal article  |  2020  |  Tropical Medicine and Health

Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent

Carl D Britto, Zoe A Dyson, Sitarah Mathias, Ashish Bosco, Gordon Dougan, Sanju Jose, Savitha Nagaraj, Kathryn E Holt, Andrew J Pollard

Journal article  |  2020  |  Journal of Antimicrobial Chemotherapy

BACKGROUND: The molecular structure of circulating enteric fever pathogens was studied using hospital-based genomic surveillance i..

Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei.

Claire Chewapreecha, Alison E Mather, Simon R Harris, Martin Hunt, Matthew TG Holden, Chutima Chaichana, Vanaporn Wuthiekanun, Gordon Dougan, Nicholas PJ Day, Direk Limmathurotsakul, Julian Parkhill, Sharon J Peacock

Journal article  |  2019  |  Communications Biology

The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-t..

The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre

Rhys A Dunstan, Derek Pickard, Sam Dougan, David Goulding, Claire Cormie, Joshua Hardy, Fuyi Li, Rhys Grinter, Katherine Harcourt, Lu Yu, Jiangning Song, Fernanda Schreiber, Jyoti Choudhary, Simon Clare, Fasseli Coulibaly, Richard A Strugnell, Gordon Dougan, Trevor Lithgow

Journal article  |  2019  |  Molecular Microbiology

Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center.

Matthew J Ellington, Eva Heinz, Alexander M Wailan, Matthew J Dorman, Marcus de Goffau, Amy K Cain, Sonal P Henson, Nicholas Gleadall, Christine J Boinett, Gordon Dougan, Nicholas M Brown, Neil Woodford, Julian Parkhill, M Estée Török, Sharon J Peacock, Nicholas R Thomson

Journal article  |  2019  |  Genome Biology

BACKGROUND: Two of the most important pathogens contributing to the global rise in antimicrobial resistance (AMR) are Klebsiella p..

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastian Duchene, Pierre R Smeesters, Hannah R Frost, David J Price, Matthew TG Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, et al.

Journal article  |  2019  |  Nature Genetics

Antibiotic Resistance and Typhoid

Zoe A Dyson, Elizabeth J Klemm, Sophie Palmer, Gordon Dougan

Journal article  |  2019  |  Clinical Infectious Diseases