Gordon Dougan

Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent

Carl D Britto, Zoe A Dyson, Sitarah Mathias, Ashish Bosco, Gordon Dougan, Sanju Jose, Savitha Nagaraj, Kathryn E Holt, Andrew J Pollard

Journal article  |  2020  |  Journal of Antimicrobial Chemotherapy

BACKGROUND: The molecular structure of circulating enteric fever pathogens was studied using hospital-based genomic surveillance i..

Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei.

Claire Chewapreecha, Alison E Mather, Simon R Harris, Martin Hunt, Matthew TG Holden, Chutima Chaichana, Vanaporn Wuthiekanun, Gordon Dougan, Nicholas PJ Day, Direk Limmathurotsakul, Julian Parkhill, Sharon J Peacock

Journal article  |  2019  |  Communications Biology

The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-t..

The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre

Rhys A Dunstan, Derek Pickard, Sam Dougan, David Goulding, Claire Cormie, Joshua Hardy, Fuyi Li, Rhys Grinter, Katherine Harcourt, Lu Yu, Jiangning Song, Fernanda Schreiber, Jyoti Choudhary, Simon Clare, Fasseli Coulibaly, Richard A Strugnell, Gordon Dougan, Trevor Lithgow

Journal article  |  2019  |  Molecular Microbiology

Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center.

Matthew J Ellington, Eva Heinz, Alexander M Wailan, Matthew J Dorman, Marcus de Goffau, Amy K Cain, Sonal P Henson, Nicholas Gleadall, Christine J Boinett, Gordon Dougan, Nicholas M Brown, Neil Woodford, Julian Parkhill, M Estée Török, Sharon J Peacock, Nicholas R Thomson

Journal article  |  2019  |  Genome Biology

BACKGROUND: Two of the most important pathogens contributing to the global rise in antimicrobial resistance (AMR) are Klebsiella p..

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastian Duchene, Pierre R Smeesters, Hannah R Frost, David J Price, Matthew TG Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, et al.

Journal article  |  2019  |  Nature Genetics

Antibiotic Resistance and Typhoid

Zoe A Dyson, Elizabeth J Klemm, Sophie Palmer, Gordon Dougan

Journal article  |  2019  |  Clinical Infectious Diseases

Wave 2 strains of atypical Vibrio cholerae El Tor caused the 2009-2011 cholera outbreak in Papua New Guinea

Andrew R Greenhill, Ankur Mutreja, Dieter Bulach, Matthew J Belousoff, Marinjho H Jonduo, Deirdre A Collins, Monalisa P Kas, Johanna Wapling, Torsten Seemann, Alice Lafana, Gordon Dougan, Mark Brown, Paul F Horwood

Journal article  |  2019  |  Microbial Genomics

Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1

Eva Heinz, Hasan Ejaz, Josefin Bartholdson Scott, Nancy Wang, Shruti Gujaran, Derek Pickard, Jonathan Wilksch, Hanwei Cao, Ikram-ul Haq, Gordon Dougan, Richard A Strugnell

Journal article  |  2019  |  Scientific Reports

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Laura Gomez-Valero, Christophe Rusniok, Danielle Carson, Sonia Mondino, Ana Elena Perez-Cobas, Monica Rolando, Shivani Pasricha, Sandra Reuter, Jasmin Demirtas, Johannes Crumbach, Stephane Descorps-Declere, Elizabeth L Hartland, Sophie Jarraud, Gordon Dougan, Gunnar N Schroeder, Gad Frankel, Carmen Buchrieser

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

María A Duque-Correa, Natasha A Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P Jenkins, Adam J Reid, Emma L Cambridge, Carmen Ballesteros Reviriego, undefined Sanger Mouse Genetics Project, undefined 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K Grencis, Matthew Berriman

Journal article  |  2019  |  PLOS Pathogens

The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of ..

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.

Judith Kraiczy, Komal M Nayak, Kate J Howell, Alexander Ross, Jessica Forbester, Camilla Salvestrini, Roxana Mustata, Sally Perkins, Amanda Andersson-Rolf, Esther Leenen, Anke Liebert, Ludovic Vallier, Philip C Rosenstiel, Oliver Stegle, Gordon Dougan, Robert Heuschkel, Bon-Kyoung Koo, Matthias Zilbauer

Journal article  |  2019  |  Gut

OBJECTIVE: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational rese..

Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

Jessica L Forbester, Nicholas Hannan, Ludovic Vallier, Gordon Dougan

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Intestinal human organoids (iHOs) provide an effective system for studying the intestinal epithelium and its interaction with vari..

Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing

Elizabeth J Klemm, Vanessa K Wong, Gordon Dougan

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

Se Eun Park, Thanh Pham Duy, Christine Boinett, Vanessa K Wong, Gi Deok Pak, Ursula Panzner, Ligia Maria Cruz Espinoza, Vera von Kalckreuth, Justin Im, Heidi Schuett-Gerowitt, John A Crump, Robert F Breiman, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, Raphael Rakotozandrindrainy, Abdramane Bassiahi Soura, Abraham Aseffa, Nagla Gasmelseed, Karen H Keddy, Juergen May, et al.

Journal article  |  2018  |  Nature Communications

Functional analysis of Salmonella Typhi adaptation to survival in water

Robert A Kingsley, Gemma Langridge, Sarah E Smith, Carine Makendi, Maria Fookes, Tom M Wileman, Moataz Abd El Ghany, A Keith Turner, Zoe A Dyson, Sushmita Sridhar, Derek Pickard, Sally Kay, Nicholas Feasey, Vanessa Wong, Lars Barquist, Gordon Dougan

Journal article  |  2018  |  Environmental Microbiology

Chemical Synergy between lonophore PBT2 and Zinc Reverses Antibiotic Resistance

Lisa Bohlmann, David MP De Oliveira, Ibrahim M El-Deeb, Erin B Brazel, Nichaela Harbison-Price, Cheryl-Iynn Y Ong, Tania Rivera-Hernandez, Scott A Ferguson, Amanda J Cork, Phan Minh-Duy, Amelia T Soderholm, Mark R Davies, Graeme R Nimmo, Gordon Dougan, Mark A Schembri, Gregory M Cook, Alastair G McEwan, Mark von Itzstein, Christopher A McDevitt, Mark J Walker

Journal article  |  2018  |  mBio

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

Jessica L Forbester, Emily A Lees, David Goulding, Sally Forrest, Amy Yeung, Anneliese Speak, Simon Clare, Eve L Coomber, Subhankar Mukhopadhyay, Judith Kraiczy, Fernanda Schreiber, Trevor D Lawley, Robert EW Hancock, Holm H Uhlig, Matthias Zilbauer, Fiona Powrie, Gordon Dougan

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Identification of novel adenovirus genotype 90 in children from Bangladesh

Charlotte J Houldcroft, Mathew A Beale, Md Abu Sayeed, Firdausi Qadri, Gordon Dougan, Ankur Mutreja

Journal article  |  2018  |  Microbial Genomics

A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.

Carl D Britto, Vanessa K Wong, Gordan Dougan, Andrew J Pollard

Journal article  |  2018  |  PLOS Neglected Tropical Diseases

BACKGROUND: The temporal and spatial change in trends of antimicrobial resistance (AMR) in typhoid have not been systematically st..

New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam

Alison E Mather, Le Thi Phuong Tu, Yunfeng Gao, Simon Clare, Subhankar Mukhopadhyay, David A Goulding, Tran Do Hoang Nhu, Thanh Tuyen Ha, Phu Huong Lan Nguyen, Corinne N Thompson, Hoang Thu Trang Nguyen, Juan Carrique-Mas, Tri Tue Ngo, James I Campbell, Maia A Rabaa, Pham Thanh Duy, Katherine Harcourt, Thi Hoa Ngo, Vinh Trung Nguyen, Constance Schultsz, et al.

Journal article  |  2018  |  mBio

An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis

Von Vergel L Torres, Eva Heinz, Christopher J Stubenrauch, Jonathan J Wilksch, Hanwei Cao, Ji Yang, Abigail Clements, Rhys A Dunstan, Felicity Alcock, Chaille T Webb, Gordon Dougan, Richard A Strugnell, Iain D Hay, Trevor Lithgow

Journal article  |  2018  |  Molecular Microbiology

Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.

HJ Wilson, F Khokhar, DA Enoch, NM Brown, J Ahluwalia, G Dougan, ME Török

Journal article  |  2018  |  Journal of Hospital Infection

Infections with carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) are associated with in..

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants

Rhys Grinter, Iain D Hay, Jiangning Song, Jiawei Wang, Don Teng, Vijay Dhanesakaran, Jonathan J Wilksch, Mark R Davies, Dene Littler, Simone A Beckham, Ian R Henderson, Richard A Strugnell, Gordon Dougan, Trevor Lithgow

Journal article  |  2018  |  PLOS Biology

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

Giorgio Napolitani, Prathiba Kurupati, Karen Wei Weng Teng, Malick M Gibani, Margarida Rei, Anna Aulicino, Lorena Preciado-Llanes, Michael Thomas Wong, Etienne Becht, Lauren Howson, Paola de Haas, Mariolina Salio, Christoph J Blohmke, Lars Ronn Olsen, David Miguel Susano Pinto, Laura Scifo, Claire Jones, Hazel Dobinson, Danielle Campbell, Helene B Juel, et al.

Journal article  |  2018  |  Nature Immunology

Farewell Stan Stanley Falkow: 1934-2018.

FC Cabello, SN Cohen, R Curtiss, G Dougan, J van Embden, BB Finlay, F Heffron, D Helinski, R Hull, S Hull, R Isberg, DJ Kopecko, S Levy, J Mekalanos, JM Ortiz, R Rappuoli, MC Roberts, M So, KN Timmis

Journal article  |  2018  |  Environmental Microbiology

Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC) (vol 7, 2017)

Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Asa Sjoling, Ann-Mari Svennerholm

Journal article  |  2018  |  Scientific Reports

Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy

Carl D Britto, Zoe A Dyson, Sebastian Duchene, Michael J Carter, Meeru Gurung, Dominic F Kelly, David R Murdoch, Imran Ansari, Stephen Thorson, Shrijana Shrestha, Neelam Adhikari, Gordon Dougan, Kathryn E Holt, Andrew J Pollard

Journal article  |  2018  |  PLOS Neglected Tropical Diseases

PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data

Andrew J Page, Alexander Wailan, Yan Shao, Kim Judge, Gordon Dougan, Elizabeth J Klemm, Nicholas R Thomson, Jacqueline A Keane

Journal article  |  2018  |  Microbial Genomics

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, Andrew J Knights, Alice L Mann, Kousik Kundu, Christine Hale, Gordon Dougan, Daniel J Gaffney

Journal article  |  2018  |  Nature Genetics

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile

Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel

Journal article  |  2018  |  Infection and Immunity

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

Pankaj Deo, Seong H Chow, Iain D Hay, Oded Kleifeld, Adam Costin, Kirstin D Elgass, Jhih-Hang Jiang, Georg Ramm, Kipros Gabriel, Gordon Dougan, Trevor Lithgow, Eva Heinz, Thomas Naderer

Journal article  |  2018  |  PLOS Pathogens

Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins

Elizabeth J Klemm, Sadia Shakoor, Andrew J Page, Farah Naz Qamar, Kim Judge, Dania K Saeed, Vanessa K Wong, Timothy J Dallman, Satheesh Nair, Stephen Baker, Ghazala Shaheen, Shahida Qureshi, Mohammad Tahir Yousafzai, Muhammad Khalid Saleem, Zahra Hasan, Gordon Dougan, Rumina Hasan

Journal article  |  2018  |  mBio

Integrated view of Vibrio cholerae in the Americas

Daryl Domman, Marie-Laure Quilici, Matthew J Dorman, Elisabeth Njamkepo, Ankur Mutreja, Alison E Mather, Gabriella Delgado, Rosario Morales-Espinosa, Patrick AD Grimont, Marcial Leonardo Lizarraga-Partida, Christiane Bouchier, David M Aanensen, Pablo Kuri-Morales, Cheryl L Tarr, Gordon Dougan, Julian Parkhill, Josefina Campos, Alejandro Cravioto, Francois-Xavier Weill, Nicholas R Thomson

Journal article  |  2017  |  Science

Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function

Christopher J Stubenrauch, Gordon Dougan, Trevor Lithgow, Eva Heinz

Journal article  |  2017  |  Open Biology

Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan

Hasan Ejaz, Nancy Wang, Jonathan J Wilksch, Andrew J Page, Hanwei Cao, Shruti Gujaran, Jacqueline A Keane, Trevor Lithgow, Ikram ul-Haq, Gordon Dougan, Richard A Strugnell, Eva Heinz

Journal article  |  2017  |  Emerging Infectious Diseases

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever

Christoph J Blohmke, Jennifer Hill, Thomas C Darton, Matheus Carvalho-Burger, Andrew Eustace, Claire Jones, Fernanda Schreiber, Martin R Goodier, Gordon Dougan, Helder I Nakaya, Andrew J Pollard

Journal article  |  2017  |  Frontiers in Immunology

Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC)

Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Asa Sjoling, Ann-Mari Svennerholm

Journal article  |  2017  |  Scientific Reports

Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391

Matthew J Sullivan, Brian M Forde, Darren W Prince, Deepak S Ipe, Nouri L Ben Zakour, Mark R Davies, Gordon Dougan, Scott A Beatson, Glen C Ulett

Journal article  |  2017  |  Genome Announcements

Salmonella enterica serovar Typhi Producing CTX-M-15 Extended Spectrum beta-Lactamase in the Democratic Republic of the Congo

Marie-France Phoba, Barbara Barbe, Octavie Lunguya, Lysette Masendu, Deo Lulengwa, Gordon Dougan, Vanessa K Wong, Sophie Bertrand, Pieter-Jan Ceyssens, Jan Jacobs, Sandra Van Puyvelde, Stijn Deborggraeve

Journal article  |  2017  |  Clinical Infectious Diseases

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights

Raymond Kiu, Shabhonam Caim, Cristina Alcon-Giner, Gusztav Belteki, Paul Clarke, Derek Pickard, Gordon Dougan, Lindsay J Hall

Journal article  |  2017  |  Genome Biology and Evolution

The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK

James E Meiring, Malick Gibani, Buddha Basnyat, Adwoa D Bentsi-Enchill, John Clemens, Thomas C Darton, Kashmira Date, Gordon Dougan, Denise Garrett, Bradford D Gessner, Melita A Gordon, Robert S Heyderman, Joachim Hombach, Karen L Kotloff, Myron M Levine, Stephen P Luby, Vadrevu Krishna Mohan, Anthony A Marfin, Kim Mulholland, Kathleen Neuzil, et al.

Journal article  |  2017  |  Vaccine

Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium

Edna M Ondari, Jennifer N Heath, Elizabeth J Klemm, Gemma Langridge, Lars Barquist, David A Goulding, Simon Clare, Gordon Dougan, Robert A Kingsley, Calman A MacLennan

Journal article  |  2017  |  Infection and Immunity

NBEAL2 is required for neutrophil and NK cell function and pathogen defense

John M Sowerby, David C Thomas, Simon Clare, Marion Espeli, Jose A Guerrero, Kim Hoenderdos, Katherine Harcourt, Morgan Marsden, Juneid Abdul-Karim, Mathew Clement, Robin Antrobus, Yagnesh Umrania, Philippa R Barton, Shaun M Flint, Jatinder K Juss, Alison M Condliffe, Paul A Lyons, Ian R Humphreys, Edwin R Chilvers, Willem H Ouwehand, et al.

Journal article  |  2017  |  Journal of Clinical Investigation

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever

Tran Vu Thieu Nga, Trinh Van Tan, Tran Tuan Anh, Elizabeth J Klemm, Nguyen Ngoc Minh Chau, Voong Vinh Phat, Pham Thanh Duy, Ho Ngoc Dan Thanh, Pham Duc Trung, Pinky Langat, Laura B Martin, Jorge Galan, Li Liang, Philip L Felgner, D Huw Davies, Hanna K de Jong, Rapeephan R Maude, Masako Fukushima, Lalith Wijedoru, Aniruddha Ghose, et al.

Journal article  |  2017  |  Journal of Infection

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2

Iva A Tchasovnikarova, Richard T Timms, Christopher H Douse, Rhys C Roberts, Gordon Dougan, Robert E Kingston, Yorgo Modis, Paul J Lehner

Journal article  |  2017  |  Nature Genetics

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency

Taco W Kuijpers, Anton TJ Tool, Ivo van der Bijl, Martin de Boer, Michel van Houdt, Iris M de Cuyper, Dirk Roos, Floris van Alphen, Karin van Leeuwen, Emma L Cambridge, Mark J Arends, Gordon Dougan, Simon Clare, Ramiro Ramirez-Solis, Steven T Pals, David J Adams, Alexander B Meijer, Timo K van den Berg

Journal article  |  2017  |  Journal of Allergy and Clinical Immunology

The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys

Thomas C Darton, James E Meiring, Susan Tonks, Md Arifuzzaman Khan, Farhana Khanam, Mila Shakya, Deus Thindwa, Stephen Baker, Buddha Basnyat, John D Clemens, Gordon Dougan, Christiane Dolecek, Sarah J Dunstan, Melita A Gordon, Robert S Heyderman, Kathryn E Holt, Virginia E Pitzer, Firdausi Qadri, K Zaman, Andrew J Pollard

Journal article  |  2017  |  BMJ Open

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

Amy TY Yeung, Christine Hale, Amy H Lee, Erin E Gill, Wendy Bushell, David Parry-Smith, David Goulding, Derek Pickard, Theodoros Roumeliotis, Jyoti Choudhary, Nick Thomson, William C Skarnes, Gordon Dougan, Robert EW Hancock

Journal article  |  2017  |  Nature Communications

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

David C Thomas, Simon Clare, John M Sowerby, Mercedes Pardo, Jatinder K Juss, David A Goulding, Louise van der Weyden, Daniel Storisteanu, Ananth Prakash, Marion Espeli, Shaun Flint, James C Lee, Kim Hoenderdos, Leanne Kane, Katherine Harcourt, Subhankar Mukhopadhyay, Yagnesh Umrania, Robin Antrobus, James A Nathan, David J Adams, et al.

Journal article  |  2017  |  Journal of Experimental Medicine

Global and regional dissemination and evolution of Burkholderia pseudomallei

Claire Chewapreecha, Matthew TG Holden, Minna Vehkala, Niko Valimaki, Zhirong Yang, Simon R Harris, Alison E Mather, Apichai Tuanyok, Birgit De Smet, Simon Le Hello, Chantal Bizet, Mark Mayo, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Rattanaphone Phetsouvanh, Brian G Spratt, Jukka Corander, Paul Keim, Gordon Dougan, David AB Dance, et al.

Journal article  |  2017  |  Nature Microbiology

Typhoid in Africa and vaccine deployment

Gordon Dougan

Journal article  |  2017  |  The Lancet Global Health

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi

Rebecca Johnson, Alexander Byrne, Cedric N Berger, Elizabeth Klemm, Valerie F Crepin, Gordon Dougan, Gad Frankel

Journal article  |  2017  |  Journal of Bacteriology

Antimicrobial resistance in human populations: challenges and opportunities.

S Allcock, EH Young, M Holmes, D Gurdasani, G Dougan, MS Sandhu, L Solomon, ME Török

Journal article  |  2017  |  Global Health, Epidemiology and Genomics

Antimicrobial resistance (AMR) is a global public health threat. Emergence of AMR occurs naturally, but can also be selected for b..

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1 alpha Stability in Aerobic Conditions

Stephen P Burr, Ana SH Costa, Guinevere L Grice, Richard T Timms, Ian T Lobb, Peter Freisinger, Roger B Dodd, Gordon Dougan, Paul J Lehner, Christian Frezza, James A Nathan

Journal article  |  2016  |  Cell Metabolism

Single-cell RNA-seq identifies a PD-1(hi) ILC progenitor and defines its development pathway

Yong Yu, Jason CH Tsang, Cui Wang, Simon Clare, Juexuan Wang, Xi Chen, Cordelia Brandt, Leanne Kane, Lia S Campos, Liming Lu, Gabrielle T Belz, Andrew NJ McKenzie, Sarah A Teichmann, Gordon Dougan, Pentao Liu

Journal article  |  2016  |  Nature

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

Richard T Timms, Iva A Tchasovnikarova, Robin Antrobus, Gordon Dougan, Paul J Lehner

Journal article  |  2016  |  Cell Reports

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Vanessa K Wong, Stephen Baker, Thomas R Connor, Derek Pickard, Andrew J Page, Jayshree Dave, Niamh Murphy, Richard Holliman, Armine Sefton, Michael Millar, Zoe A Dyson, Gordon Dougan, Kathryn E Holt

Journal article  |  2016  |  Nature Communi

Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process

Stefan L Karlsson, Nicholas Thomson, Ankur Mutreja, Thomas Connor, Dipika Sur, Mohammad Ali, John Clemens, Gordon Dougan, Jan Holmgren, Michael Lebens

Journal article  |  2016  |  PLOS Neglected Tropical Diseases

Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa

Vanessa K Wong, Kathryn E Holt, Chinyere Okoro, Stephen Baker, Derek J Pickard, Florian Marks, Andrew J Page, Grace Olanipekun, Huda Munir, Roxanne Alter, Paul D Fey, Nicholas A Feasey, Francois-Xavier Weill, Simon Le Hello, Peter J Hart, Samuel Kariuki, Robert F Breiman, Melita A Gordon, Robert S Heyderman, Jan Jacobs, et al.

Journal article  |  2016  |  PLOS Neglected Tropical Diseases

Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence

Nitin Kumar, Fabio Miyajima, Miao He, Paul Roberts, Andrew Swale, Louise Ellison, Derek Pickard, Godfrey Smith, Rebecca Molyneux, Gordon Dougan, Julian Parkhill, Brendan W Wren, Christopher M Parry, Munir Pirmohamed, Trevor D Lawley

Journal article  |  2016  |  Clinical Infectious Diseases

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

Elizabeth J Klemm, Effrossyni Gkrania-Klotsas, James Hadfield, Jessica L Forbester, Simon R Harris, Christine Hale, Jennifer N Heath, Thomas Wileman, Simon Clare, Leanne Kane, David Goulding, Thomas D Otto, Sally Kay, Rainer Doffinger, Fiona J Cooke, Andrew Carmichael, Andrew Ml Lever, Julian Parkhill, Calman A MacLennan, Dinakantha Kumararatne, et al.

Journal article  |  2016  |  Nature microbiology

Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are ..

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host

Elizabeth J Klemm, Effrossyni Gkrania-Klotsas, James Hadfield, Jessica L Forbester, Simon R Harris, Christine Hale, Jennifer N Heath, Thomas Wileman, Simon Clare, Leanne Kane, David Goulding, Thomas D Otto, Sally Kay, Rainer Doffinger, Fiona J Cooke, Andrew Carmichael, Andrew ML Lever, Julian Parkhill, Calman A MacLennan, Dinakantha Kumararatne, et al.

Journal article  |  2016  |  Nature Microbiology

Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants

Danielle J Ingle, Marija Tauschek, David J Edwards, Dianna M Hocking, Derek J Pickard, Kristy I Azzopardi, Thakshila Amarasena, Vicki Bennett-Wood, Jaclyn S Pearson, Boubou Tamboura, Martin Antonio, John B Ochieng, Joseph Oundo, Inacio Mandomando, Shahida Qureshi, Thandavarayan Ramamurthy, Anowar Hossain, Karen L Kotloff, James P Nataro, Gordon Dougan, et al.

Journal article  |  2016  |  Nature Microbiology

Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1

Kathryn Holt, Johanna J Kenyon, Mohammad Hamidian, Mark B Schultz, Derek J Pickard, Gordon Dougan, Ruth Hall

Journal article  |  2016  |  Microbial Genomics

Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae

Deepak S Ipe, Nouri L Ben Zakour, Matthew J Sullivan, Scott A Beatson, Kimberly B Ulett, William H Benjamin, Mark R Davies, Samantha J Dando, Nathan P King, Allan W Cripps, Mark A Schembri, Gordon Dougan, Glen C Ulett

Journal article  |  2016  |  Infection and Immunity

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

Nouri L Ben Zakour, Mark R Davies, Yuanhai You, Jonathan HK Chen, Brian M Forde, Mitchell Stanton-Cook, Ruifu Yang, Yujun Cui, Timothy C Barnett, Carola Venturini, Cheryl-Iynn Y Ong, Herman Tse, Gordon Dougan, Jianzhong Zhang, Kwok-Yung Yuen, Scott A Beatson, Mark J Walker

Journal article  |  2015  |  Scientific Reports

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

Kaur Alasoo, Fernando O Martinez, Christine Hale, Siamon Gordon, Fiona Powrie, Gordon Dougan, Subhankar Mukhopadhyay, Daniel J Gaffney

Journal article  |  2015  |  Scientific Reports

Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells

Jessica L Forbester, David Goulding, Ludovic Vallier, Nicholas Hannan, Christine Hale, Derek Pickard, Subhankar Mukhopadhyay, Gordon Dougan

Journal article  |  2015  |  Infection and Immunity

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Iva A Tchasovnikarova, Richard T Timms, Nicholas J Matheson, Kim Wals, Robin Antrobus, Berthold Goettgens, Gordon Dougan, Mark A Dawson, Paul J Lehner

Journal article  |  2015  |  Science

Correction to:Signatures of Adaptation in Human Invasive Salmonella Typhimurium ST313 Populations from Sub-Saharan Africa (PLoS Negl Trop Dis, 9, 6, (2015))

CK Okoro, L Barquist, TR Connor, SR Harris, C Simon, MP Stevens, MJ Arends, C Hale, L Kane, DJ Pickard, J Hill, K Harcourt, J Parkhill, G Dougan, RA Kingsley

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

Yong Yu, Cui Wang, Simon Clare, Juexuan Wang, Song-Choon Lee, Cordelia Brandt, Shannon Burke, Liming Lu, Daqian He, Nancy A Jenkins, Neal G Copeland, Gordon Dougan, Pentao Liu

Journal article  |  2015  |  Journal of Experimental Medicine

Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Vanessa K Wong, Stephen Baker, Derek J Pickard, Julian Parkhill, Andrew J Page, Nicholas A Feasey, Robert A Kingsley, Nicholas R Thomson, Jacqueline A Keanel, Francois-Xavier Weill, David J Edwards, Jane Hawkey, Simon R Harris, Alison E Mather, Amy K Cain, James Hadfield, Peter J Hart, Tran Vu Thieu Nga, Elizabeth J Klemm, Dafni A Glinos, et al.

Journal article  |  2015  |  Nature Genetics

Non-typhoidal Salmonella Typhimurium ST313 isolates that cause bacteremia in humans stimulate less inflammasome activation than ST19 isolates associated with gastroenteritis

Sarah Carden, Chinyere Okoro, Gordon Dougan, Denise Monack

Journal article  |  2015  |  Pathogens and Disease

Ceftriaxone-Resistant Salmonella enterica Serotype Typhimurium Sequence Type 313 from Kenyan Patients Is Associated with the bla(CTX-M-15) Gene on a Novel IncHI2 Plasmid

Samuel Kariuki, Chinyere Okoro, John Kiiru, Samuel Njoroge, Geoffrey Omuse, Gemma Langridge, Robert A Kingsley, Gordon Dougan, Gunturu Reyathi

Journal article  |  2015  |  Antimicrobial Agents and Chemotherapy

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

Franklin R Toapanta, Paula J Bernal, Stephanie Fresnay, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

Induced Pluripotent Stem Cell Derived Macrophages as a Cellular System to Study Salmonella and Other Pathogens

Christine Hale, Amy Yeung, David Goulding, Derek Pickard, Kaur Alasoo, Fiona Powrie, Gordon Dougan, Subhankar Mukhopadhyay

Journal article  |  2015  |  PLOS ONE

Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model

Monica A McArthur, Stephanie Fresnay, Laurence S Magder, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein

Journal article  |  2015  |  PLOS Pathogens

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Glen P Carter, Anjana Chakravorty, Anh Pham Nguyen Tu, Steven Mileto, Fernanda Schreiber, Lucy Li, Pauline Howarth, Simon Clare, Bliss Cunningham, Susan P Sambol, Adam Cheknis, Iris Figueroa, Stuart Johnson, Dale Gerding, Julian I Rood, Gordon Dougan, Trevor D Lawley, Dena Lyras

Journal article  |  2015  |  mBio

Rapid Emergence of Multidrug Resistant, H58-Lineage Salmonella Typhi in Blantyre, Malawi

Nicholas A Feasey, Katherine Gaskell, Vanessa Wong, Chisomo Msefula, George Selemani, Save Kumwenda, Theresa J Allain, Jane Mallewa, Neil Kennedy, Aisleen Bennett, Joram O Nyirongo, Patience A Nyondo, Madalitso D Zulu, Julian Parkhill, Gordon Dougan, Melita A Gordon, Robert S Heyderman

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

Multidrug-Resistant Salmonella enterica, Serotype Typhi, Gulf of Guinea Region, Africa

Murielle Baltazar, Antoinette Ngandjio, Kathryn Elizabeth Holt, Elodie Lepillet, Maria Pardos de la Gandara, Jean-Marc Collard, Raymond Bercion, Ariane Nzouankeu, Simon Le Hello, Gordon Dougan, Marie-Christine Fonkoua, Francois-Xavier Weill

Journal article  |  2015  |  Emerging infectious diseases

Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.

ATY Yeung, C Hale, J Xia, PH Tate, D Goulding, JA Keane, S Mukhopadhyay, L Forrester, O Billker, WC Skarnes, REW Hancock, G Dougan

Journal article  |  2015  |  Scientific Reports

The ability to differentiate genetically modified mouse embryonic stem (ES) cells into functional macrophages provides a potential..

Signatures of Adaptation in Human Invasive Salmonella Typhimurium ST313 Populations from Sub-Saharan Africa

Chinyere K Okoro, Lars Barquist, Thomas R Connor, Simon R Harris, Simon Clare, Mark P Stevens, Mark J Arends, Christine Hale, Leanne Kane, Derek J Pickard, Jennifer Hill, Katherine Harcourt, Julian Parkhill, Gordon Dougan, Robert A Kingsley

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

An O Antigen Capsule Modulates Bacterial Pathogenesis in Shigella sonnei

Mariaelena Caboni, Thierry Pedron, Omar Rossi, David Goulding, Derek Pickard, Francesco Citiulo, Calman A MacLennan, Gordon Dougan, Nicholas R Thomson, Allan Saul, Philippe J Sansonetti, Christiane Gerke

Journal article  |  2015  |  PLOS Pathogens

The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions

Fernanda Schreiber, Sally Kay, Gad Frankel, Simon Clare, David Goulding, Esther van de Vosse, Jaap T van Dissel, Richard Strugnell, Guy Thwaites, Robert A Kingsley, Gordon Dougan, Stephen Baker

Journal article  |  2015  |  Scientific Reports

Allele Variants of Enterotoxigenic Escherichia coli Heat-Labile Toxin Are Globally Transmitted and Associated with Colonization Factors

Enrique Joffre, Astrid von Mentzer, Moataz Abd El Ghany, Numan Oezguen, Tor Savidge, Gordon Dougan, Ann-Mari Svennerholm, Asa Sjoling

Journal article  |  2015  |  Journal of Bacteriology

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

Mark R Davies, Matthew T Holden, Paul Coupland, Jonathan HK Chen, Carola Venturini, Timothy C Barnett, Nouri L Ben Zakour, Herman Tse, Gordon Dougan, Kwok-Yung Yuen, Mark J Walker

Journal article  |  2015  |  Nature Genetics

Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

Astrid von Mentzer, Thomas R Connor, Lothar H Wieler, Torsten Semmler, Atsushi Iguchi, Nicholas R Thomson, David A Rasko, Enrique Joffre, Jukka Corander, Derek Pickard, Gudrun Wiklund, Ann-Mari Svennerholm, Asa Sjoling, Gordon Dougan

Journal article  |  2014  |  Nature Genetics

Drug Resistance in Salmonella enterica ser. Typhimurium Bloodstream Infection, Malawi

Nicholas A Feasey, Amy K Cain, Chisomo L Msefula, Derek Pickard, Maaike Alaerts, Martin Aslett, Dean B Everett, Theresa J Allain, Gordon Dougan, Melita A Gordon, Robert S Heyderman, Robert A Kingsley

Journal article  |  2014  |  Emerging Infectious Diseases

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

Michelle A Linterman, Alice E Denton, Devina P Divekar, Ilona Zvetkova, Leanne Kane, Cristina Ferreira, Marc Veldhoen, Simon Clare, Gordon Dougan, Marion Espeli, Kenneth GC Smith

Journal article  |  2014  |  eLife

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

Tu Anh N Pham, Simon Clare, David Goulding, Julia M Arasteh, Mark D Stares, Hilary P Browne, Jacqueline A Keane, Andrew J Page, Natsuhiko Kumasaka, Leanne Kane, Lynda Mottram, Katherine Harcourt, Christine Hale, Mark J Arends, Daniel J Gaffney, Gordon Dougan, Trevor D Lawley

Journal article  |  2014  |  Cell Host & Microbe

Typhoid fever in Fiji: a reversible plague?

Corinne N Thompson, Mike Kama, Shrish Acharya, Una Bera, John Clemens, John A Crump, Aggie Dawainavesi, Gordon Dougan, W John Edmunds, Kimberley Fox, Kylie Jenkins, M Imran Khan, Josefa Koroivueta, Myron M Levine, Laura B Martin, Eric Nilles, Virginia E Pitzer, Shalini Singh, Ratu Vereniki Raiwalu, Stephen Baker, et al.

Journal article  |  2014  |  Tropical Medicine & International Health

Emergence of a New Epidemic Neisseria meningitidis Serogroup A Clone in the African Meningitis Belt: High-Resolution Picture of Genomic Changes That Mediate Immune Evasion

Araceli Lamelas, Simon R Harris, Katharina Roeltgen, Jean-Pierre Dangy, Julia Hauser, Robert A Kingsley, Thomas R Connor, Ali Sie, Abraham Hodgson, Gordon Dougan, Julian Parkhill, Stephen D Bentley, Gerd Pluschke

Journal article  |  2014  |  mBio

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

Dick JH van den Boomen, Richard T Timms, Guinevere L Grice, Helen R Stagg, Karsten Skodt, Gordon Dougan, James A Nathan, Paul J Lehner

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Violette Da Cunha, Mark R Davies, Pierre-Emmanuel Douarre, Isabelle Rosinski-Chupin, Immaculada Margarit, Sebastien Spinali, Tim Perkins, Pierre Lechat, Nicolas Dmytruk, Elisabeth Sauvage, Laurence Ma, Benedetta Romi, Magali Tichit, Maria-Jose Lopez-Sanchez, Stephane Descorps-Declere, Erika Souche, Carmen Buchrieser, Patrick Trieu-Cuot, Ivan Moszer, Dominique Clermont, et al.

Journal article  |  2014  |  Nature Communications

The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India

Moataz Abd El Ghany, Jagadish Chander, Ankur Mutreja, Mamoon Rashid, Grant A Hill-Cawthorne, Shahjahan Ali, Raeece Naeem, Nicholas R Thomson, Gordon Dougan, Arnab Pain

Journal article  |  2014  |  PLoS Neglected Tropical Diseases

Vitamin B-12-dependent taurine synthesis regulates growth and bone mass

Pablo Roman-Garcia, Isabel Quiros-Gonzalez, Lynda Mottram, Liesbet Lieben, Kunal Sharan, Arporn Wangwiwatsin, Jose Tubio, Kirsty Lewis, Debbie Wilkinson, Balaji Santhanam, Nazan Sarper, Simon Clare, George S Vassiliou, Vidya R Velagapudi, Gordon Dougan, Vijay K Yadav

Journal article  |  2014  |  Journal of Clinical Investigation

Insertions in the OCL1 locus of Acinetobacter baumannii lead to shortened lipooligosaccharides

Johanna J Kenyon, Kathryn E Holt, Derek Pickard, Gordon Dougan, Ruth M Hall

Journal article  |  2014  |  Research in microbiology

The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design

Nina M van Sorge, Jason N Cole, Kirsten Kuipers, Anna Henningham, Ramy K Aziz, Ana Kasirer-Friede, Leo Lin, Evelien TM Berends, Mark R Davies, Gordon Dougan, Fan Zhang, Samira Dahesh, Laura Shaw, Jennifer Gin, Madeleine Cunningham, Joseph A Merriman, Julia Huetter, Bernd Lepenies, Suzan HM Rooijakkers, Richard Malley, et al.

Journal article  |  2014  |  Cell Host & Microbe

Complete Genome Sequences of Two Citrobacter rodentium Bacteriophages, CR8 and CR44b.

Ana Luisa Toribio, Derek Pickard, Ana M Cerdeño-Tárraga, Nicola K Petty, Nicholas Thomson, George Salmond, Gordon Dougan

Journal article  |  2014  |  Genome Announcements

The complete genomes of two virulent phages infecting Citrobacter rodentium are reported here for the first time. Both bacteriopha..

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

Claire S Waddington, Thomas C Darton, Claire Jones, Kathryn Haworth, Anna Peters, Tessa John, Ben AV Thompson, Simon A Kerridge, Robert A Kingsley, Liqing Zhou, Kathryn E Holt, Ly-Mee Yu, Stephen Lockhart, Jeremy J Farrar, Marcelo B Sztein, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard

Journal article  |  2014  |  Clinical Infectious Diseases

Global dissemination of a multidrug resistant Escherichia coli clone

Nicola K Petty, Nouri L Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M Forde, Phan Minh-Duy, Danilo Gomes Moriel, Kate M Peters, Mark Davies, Benjamin A Rogers, Gordon Dougan, Jesus Rodriguez-Bano, Alvaro Pascual, Johann DD Pitout, Mathew Upton, David L Paterson, Timothy R Walsh, Mark A Schembri, Scott A Beatson

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Neutrophils Recruited by IL-22 in Peripheral Tissues Function as TRAIL-Dependent Antiviral Effectors against MCMV

Maria A Stacey, Morgan Marsden, Tu Anh N Pham, Simon Clare, Garry Dolton, Gabrielle Stack, Emma Jones, Paul Klenerman, Awen M Gallimore, Philip R Taylor, Robert J Snelgrove, Trevor D Lawley, Gordon Dougan, Chris A Benedict, Simon A Jones, Gavin WG Wilkinson, Ian R Humphreys

Journal article  |  2014  |  Cell Host & Microbe

Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure

Matteo De Chiara, Derek Hood, Alessandro Muzzi, Derek J Pickard, Tim Perkins, Mariagrazia Pizza, Gordon Dougan, Rino Rappuoli, E Richard Moxon, Marco Soriani, Claudio Donati

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

A GC1 Acinetobacter baumannii isolate carrying AbaR3 and the aminoglycoside resistance transposon TnaphA6 in a conjugative plasmid

Mohammad Hamidian, Kathryn E Holt, Derek Pickard, Gordon Dougan, Ruth M Hall

Journal article  |  2014  |  Journal of Antimicrobial Chemotherapy

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism

Laura J Pettit, Hilary P Browne, Lu Yu, Wiep Klaas Smits, Robert P Fagan, Lars Barquist, Melissa J Martin, David Goulding, Sylvia H Duncan, Harry J Flint, Gordon Dougan, Jyoti S Choudhary, Trevor D Lawley

Journal article  |  2014  |  BMC Genomics

Identification of a marker for two lineages within the GC1 clone of Acinetobacter baumannii

Mohammad Hamidian, Matthew Wynn, Kathryn E Holt, Derek Pickard, Gordon Dougan, Ruth M Hall

Journal article  |  2014  |  Journal of Antimicrobial Chemotherapy

Salmonella enterica Serovar Typhi and the Pathogenesis of Typhoid Fever

Gordon Dougan, Stephen Baker

Journal article  |  2014  |  Annual Review of Microbiology

Draft genome sequence of highly nematicidal Bacillus thuringiensis DB27

I Iatsenko, C Corton, DJ Pickard, G Dougan, RJ Sommer

Journal article  |  2014  |  Genome Announcements

Antibacterial resistance in sub-Saharan Africa: an underestimated emergency

Samuel Kariuki, Gordon Dougan

Journal article  |  2014  |  Annals of the New York Academy of Sciences

Genomic Epidemiology of Vibrio cholerae O1 Associated with Floods, Pakistan, 2010

Muhammad Ali Shah, Ankur Mutreja, Nicholas Thomson, Stephen Baker, Julian Parkhill, Gordon Dougan, Habib Bokhari, Brendan W Wren

Journal article  |  2014  |  Emerging Infectious Diseases

Characterization of the yehUT Two-Component Regulatory System of Salmonella enterica Serovar Typhi and Typhimurium

Vanessa K Wong, Derek J Pickard, Lars Barquist, Karthikeyan Sivaraman, Andrew J Page, Peter J Hart, Mark J Arends, Kathryn E Holt, Leanne Kane, Lynda F Mottram, Louise Ellison, Ruben Bautista, Chris J McGee, Sally J Kay, Thomas M Wileman, Linda J Kenney, Calman A MacLennan, Robert A Kingsley, Gordon Dougan

Journal article  |  2013  |  PLoS One

RocA Truncation Underpins Hyper-Encapsulation, Carriage Longevity and Transmissibility of Serotype M18 Group A Streptococci

Nicola N Lynskey, David Goulding, Magdalena Gierula, Claire E Turner, Gordon Dougan, Robert J Edwards, Shiranee Sriskandan

Journal article  |  2013  |  PLoS Pathogens

RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp ATCC 39006

Nabil M Wilf, Adam J Reid, Joshua P Ramsay, Neil R Williamson, Nicholas J Croucher, Laurent Gatto, Svenja S Hester, David Goulding, Lars Barquist, Kathryn S Lilley, Robert A Kingsley, Gordon Dougan, George PC Salmond

Journal article  |  2013  |  BMC Genomics

Defining the Range of Pathogens Susceptible to Ifitm3 Restriction Using a Knockout Mouse Model

Aaron R Everitt, Simon Clare, Jacqueline U McDonald, Leanne Kane, Katherine Harcourt, Malika Ahras, Amar Lall, Christine Hale, Angela Rodgers, Douglas B Young, Ashraful Haque, Oliver Billker, John S Tregoning, Gordon Dougan, Paul Kellam

Journal article  |  2013  |  PLoS ONE

Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

Richard T Timms, Lidia M Duncan, Iva A Tchasovnikarova, Robin Antrobus, Duncan L Smith, Gordon Dougan, Michael P Weekes, Paul J Lehner

Journal article  |  2013  |  PLoS Pathogens

Tracking the establishment of local endemic populations of an emergent enteric pathogen

Kathryn E Holt, Vu Thieu Nga Tran, Pham Thanh Duy, Vinh Ha, Dong Wook Kim, Phan Vu Tra My, James I Campbell, Van Minh Hoang Nguyen, Thanh Vinh Nguyen, Van Minh Pham, Thu Thuy Cao, Thi Thu Nga Tran, Corinne Thompson, Thi Ngoc Dung Tran, Thi Khanh Nhu Nguyen, Voong Vinh Phat, Thi Ngoc Tuyet Pham, Le Phuc Hoang, Thi Nam Lien Nguyen, Duc Phu Bui, et al.

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Extensive Diversity of Streptococcus pyogenes in a Remote Human Population Reflects Global-Scale Transmission Rather than Localised Diversification

Rebecca J Towers, Jonathan R Carapetis, Bart J Currie, Mark R Davies, Mark J Walker, Gordon Dougan, Philip M Giffard

Journal article  |  2013  |  PLoS ONE

A Study on the Geophylogeny of Clinical and Environmental Vibrio cholerae in Kenya

John Kiiru, Ankur Mutreja, Ahmed Abade Mohamed, Racheal W Kimani, Joyce Mwituria, Robert Onsare Sanaya, Jane Muyodi, Gunturu Revathi, Julian Parkhill, Nicholas Thomson, Gordon Dougan, Samuel Kariuki

Journal article  |  2013  |  PLoS ONE

Genome and Transcriptome Adaptation Accompanying Emergence of the Definitive Type 2 Host-Restricted Salmonella enterica Serovar Typhimurium Pathovar

Robert A Kingsley, Sally Kay, Thomas Connor, Lars Barquist, Leanne Sait, Kathryn E Holt, Karthi Sivaraman, Thomas Wileman, David Goulding, Simon Clare, Christine Hale, Aswin Seshasayee, Simon Harris, Nicholas R Thomson, Paul Gardner, Wolfgang Rabsch, Paul Wigley, Tom Humphrey, Julian Parkhill, Gordon Dougan

Journal article  |  2013  |  MBIO

Identification of Salmonella enterica Serovar Typhi Genotypes by Use of Rapid Multiplex Ligation-Dependent Probe Amplification

Pham Thanh Duy, Tran Vu Thieu Nga, Tran Thuy Chau, Martin Loden, Kiki Tuin, James I Campbell, Van Minh Hoang Nguyen, Voong Vinh Phat, Jeremy J Farrar, Kathryn E Holt, Gordon Dougan, Stephen Baker

Journal article  |  2013  |  Journal of Clinical Microbiology

The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027

Melissa J Martin, Simon Clare, David Goulding, Alexandra Faulds-Pain, Lars Barquist, Hilary P Browne, Laura Pettit, Gordon Dougan, Trevor D Lawley, Brendan W Wren

Journal article  |  2013  |  Journal of Bacteriology

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Jacqueline K White, Anna-Karin Gerdin, Natasha A Karp, Ed Ryder, Marija Buljan, James N Bussell, Jennifer Salisbury, Simon Clare, Neil J Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R Bottomley, David G Melvin, David Sunter, Niels C Adams, David Tannahill, Darren W Logan, Daniel G MacArthur, Jonathan Flint, et al.

Journal article  |  2013  |  Cell

Correction: Mcph1-deficient mice reveal a role for MCPH1 in otitis media (PLoS ONE)

J Chen, N Ingham, S Clare, C Raisen, VE Vancollie, O Ismail, RE McIntyre, SH Tsang, VB Mahajan, G Dougan, DJ Adams, JK White, KP Steel

Journal article  |  2013  |  PLoS ONE

Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media

Jing Chen, Neil Ingham, Simon Clare, Claire Raisen, Valerie E Vancollie, Ozama Ismail, Rebecca E McIntyre, Stephen H Tsang, Vinit B Mahajan, Gordon Dougan, David J Adams, Jacqueline K White, Karen P Steel

Journal article  |  2013  |  PLoS ONE

A Genomewide Mutagenesis Screen Identifies Multiple Genes Contributing to Vi Capsular Expression in Salmonella enterica Serovar Typhi

Derek Pickard, Robert A Kingsley, Christine Hale, Keith Turner, Karthikeyan Sivaraman, Michael Wetter, Gemma Langridge, Gordon Dougan

Journal article  |  2013  |  Journal of Bacteriology

Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice

Simon Clare, Victoria John, Alan W Walker, Jennifer L Hill, Cei Abreu-Goodger, Christine Hale, David Goulding, Trevor D Lawley, Pietro Mastroeni, Gadi Frankel, Anton J Enright, Elena Vigorito, Gordon Dougan

Journal article  |  2013  |  Infection and Immunity

Sequencing and Functional Annotation of Avian Pathogenic Escherichia coli Serogroup O78 Strains Reveal the Evolution of E. coli Lineages Pathogenic for Poultry via Distinct Mechanisms

Francis Dziva, Heidi Hauser, Thomas R Connor, Pauline M van Diemen, Graham Prescott, Gemma C Langridge, Sabine Eckert, Roy R Chaudhuri, Christa Ewers, Melha Mellata, Suman Mukhopadhyay, Roy Curtiss, Gordon Dougan, Lothar H Wieler, Nicholas R Thomson, Derek J Pickard, Mark P Stevens

Journal article  |  2013  |  Infection and Immunity

ChIP-seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization

Timothy T Perkins, Mark R Davies, Elizabeth J Klemm, Gary Rowley, Thomas Wileman, Keith James, Thomas Keane, Duncan Maskell, Jay CD Hinton, Gordon Dougan, Robert A Kingsley

Journal article  |  2013  |  Molecular Microbiology

Host Responses to Melioidosis and Tuberculosis Are Both Dominated by Interferon-Mediated Signaling

Gavin CKW Koh, M Fernanda Schreiber, Ruben Bautista, Rapeephan R Maude, Susanna Dunachie, Direk Limmathurotsakul, Nicholas PJ Day, Gordon Dougan, Sharon J Peacock

Journal article  |  2013  |  PLoS ONE

Genome sequence of porcine Escherichia coli strain IMT8073, an atypical enteropathogenic E. coli strain isolated from a piglet with diarrhea

T Semmler, I Eichhorn, A Bethe, R Bauerfeind, D Pickard, RA Kingsley, G Dougan, LH Wieler

Journal article  |  2013  |  Genome Announcements

Public Health Value of Next-Generation DNA Sequencing of Enterohemorrhagic Escherichia coli Isolates from an Outbreak

Anthony P Underwood, Tim Dallman, Nicholas R Thomson, Michaela Williams, Katy Harker, Neil Perry, Bob Adak, Geraldine Willshaw, Tom Cheasty, Jonathan Green, Gordon Dougan, Julian Parkhill, John Wain

Journal article  |  2013  |  Journal of Clinical Microbiology

Emergence and global spread of epidemic healthcare-associated Clostridium difficile

Miao He, Fabio Miyajima, Paul Roberts, Louise Ellison, Derek J Pickard, Melissa J Martin, Thomas R Connor, Simon R Harris, Derek Fairley, Kathleen B Bamford, Stephanie D'Arc, Jon Brazier, Derek Brown, John E Coia, Gill Douce, Dale Gerding, Hee Jung Kim, Tse Hsien Koh, Haru Kato, Mitsutoshi Senoh, et al.

Journal article  |  2013  |  Nature Genetics

Interaction of Salmonella Typhimurium with Dendritic Cells Derived from Pluripotent Embryonic Stem Cells

Raffaella Rossi, Christine Hale, David Goulding, Robert Andrews, Zarah Abdellah, Paul J Fairchild, Gordon Dougan

Journal article  |  2012  |  PLoS ONE

The Capsular Polysaccharide Vi from Salmonella Typhi Is a B1b Antigen

Jennifer L Marshall, Adriana Flores-Langarica, Robert A Kingsley, Jessica R Hitchcock, Ewan A Ross, Constantino Lopez-Macias, Jeremy Lakey, Laura B Martin, Kai-Michael Toellner, Calman A MacLennan, Ian C MacLennan, Ian R Henderson, Gordon Dougan, Adam F Cunningham

Journal article  |  2012  |  The Journal of Immunology

Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa

Chinyere K Okoro, Robert A Kingsley, Thomas R Connor, Simon R Harris, Christopher M Parry, Manar N Al-Mashhadani, Samuel Kariuki, Chisomo L Msefula, Melita A Gordon, Elizabeth de Pinna, John Wain, Robert S Heyderman, Stephen Obaro, Pedro L Alonso, Inacio Mandomando, Calman A MacLennan, Milagritos D Tapia, Myron M Levine, Sharon M Tennant, Julian Parkhill, et al.

Journal article  |  2012  |  Nature Genetics

The Microbiological and Clinical Characteristics of Invasive Salmonella in Gallbladders from Cholecystectomy Patients in Kathmandu, Nepal

Sabina Dongol, Corinne N Thompson, Simon Clare, Vu Thieu Nga Tran, Thanh Duy Pham, Abhilasha Karkey, Amit Arjyal, Samir Koirala, Nely Shrestha Khatri, Pukar Maskey, Sanjay Poudel, Vijay Kumar Jaiswal, Sujan Vaidya, Gordon Dougan, Jeremy J Farrar, Christiane Dolecek, Buddha Basnyat, Stephen Baker

Journal article  |  2012  |  PLoS ONE

Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice

Trevor D Lawley, Simon Clare, Alan W Walker, Mark D Stares, Thomas R Connor, Claire Raisen, David Goulding, Roland Rad, Fernanda Schreiber, Cordelia Brandt, Laura J Deakin, Derek J Pickard, Sylvia H Duncan, Harry J Flint, Taane G Clark, Julian Parkhill, Gordon Dougan

Journal article  |  2012  |  PLoS Pathogens

Molecular Characterization of the viaB Locus Encoding the Biosynthetic Machinery for Vi Capsule Formation in Salmonella Typhi

Michael Wetter, David Goulding, Derek Pickard, Michael Kowarik, Charles J Waechter, Gordon Dougan, Michael Wacker

Journal article  |  2012  |  PLoS ONE

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe

Kathryn E Holt, Stephen Baker, Francois-Xavier Weill, Edward C Holmes, Andrew Kitchen, Jun Yu, Vartul Sangal, Derek J Brown, John E Coia, Dong Wook Kim, Seon Young Choi, Su Hee Kim, Wanderley D da Silveira, Derek J Pickard, Jeremy J Farrar, Julian Parkhill, Gordon Dougan, Nicholas R Thomson

Journal article  |  2012  |  Nature Genetics

Routine Use of Microbial Whole Genome Sequencing in Diagnostic and Public Health Microbiology

Claudio U Koeser, Matthew J Ellington, Edward JP Cartwright, Stephen H Gillespie, Nicholas M Brown, Mark Farrington, Matthew TG Holden, Gordon Dougan, Stephen D Bentley, Julian Parkhill, Sharon J Peacock

Journal article  |  2012  |  PLoS Pathogens

The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor

Laura J Deakin, Simon Clare, Robert P Fagan, Lisa F Dawson, Derek J Pickard, Michael R West, Brendan W Wren, Neil F Fairweather, Gordon Dougan, Trevor D Lawley

Journal article  |  2012  |  Infection and Immunity

Molecular Characterization of the 2011 Hong Kong Scarlet Fever Outbreak

Herman Tse, Jessie YJ Bao, Mark R Davies, Peter Maamary, Hoi-Wah Tsoi, Amy HY Tong, Tom CC Ho, Chi-Ho Lin, Christine M Gillen, Timothy C Barnett, Jonathan HK Chen, Mianne Lee, Wing-Cheong Yam, Chi-Kin Wong, Cheryl-lynn Y Ong, Yee-Wai Chan, Cheng-Wei Wu, Tony Ng, Wilina WL Lim, Thomas HF Tsang, et al.

Journal article  |  2012  |  Journal of Infectious Diseases

Genotypic Homogeneity of Multidrug Resistant S. Typhimurium Infecting Distinct Adult and Childhood Susceptibility Groups in Blantyre, Malawi

Chisomo L Msefula, Robert A Kingsley, Melita A Gordon, Elizabeth Molyneux, Malcolm E Molyneux, Calman A MacLennan, Gordon Dougan, Robert S Heyderman

Journal article  |  2012  |  PLoS ONE

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function

Anastasia Nijnik, Simon Clare, Christine Hale, Jing Chen, Claire Raisen, Lynda Mottram, Mark Lucas, Jeanne Estabel, Edward Ryder, Hibret Adissu, Niels C Adams, Ramiro Ramirez-Solis, Jacqueline K White, Karen P Steel, Gordon Dougan, Robert EW Hancock

Journal article  |  2012  |  The Journal of Immunology

Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa

Nicholas A Feasey, Gordon Dougan, Robert A Kingsley, Robert S Heyderman, Melita A Gordon

Journal article  |  2012  |  The Lancet

Fluorescence-Based Phenotypic Selection Allows Forward Genetic Screens in Haploid Human Cells

Lidia M Duncan, Richard T Timms, Eszter Zavodszky, Florencia Cano, Gordon Dougan, Felix Randow, Paul J Lehner

Journal article  |  2012  |  PLoS ONE

Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak

Claudio U Koeser, Matthew TG Holden, Matthew J Ellington, Edward JP Cartwright, Nicholas M Brown, Amanda L Ogilvy-Stuart, Li Yang Hsu, Claire Chewapreecha, Nicholas J Croucher, Simon R Harris, Mandy Sanders, Mark C Enright, Gordon Dougan, Stephen D Bentley, Julian Parkhill, Louise J Fraser, Jason R Betley, Ole B Schulz-Trieglaff, Geoffrey P Smith, Sharon J Peacock

Journal article  |  2012  |  New England Journal of Medicine

Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica

Mark Achtman, John Wain, Francois-Xavier Weill, Satheesh Nair, Zhemin Zhou, Vartul Sangal, Mary G Krauland, James L Hale, Heather Harbottle, Alexandra Uesbeck, Gordon Dougan, Lee H Harrison, Sylvain Brisse

Journal article  |  2012  |  PLoS Pathogens

IFITM3 restricts the morbidity and mortality associated with influenza

Aaron R Everitt, Simon Clare, Thomas Pertel, Sinu P John, Rachael S Wash, Sarah E Smith, Christopher R Chin, Eric M Feeley, Jennifer S Sims, David J Adams, Helen M Wise, Leanne Kane, David Goulding, Paul Digard, Verneri Anttila, J Kenneth Baillie, Tim S Walsh, David A Hume, Aarno Palotie, Yali Xue, et al.

Journal article  |  2012  |  Nature

High-Resolution Single Nucleotide Polymorphism Analysis Distinguishes Recrudescence and Reinfection in Recurrent Invasive Nontyphoidal Salmonella Typhimurium Disease

Chinyere K Okoro, Robert A Kingsley, Michael A Quail, Anstead M Kankwatira, Nicholas A Feasey, Julian Parkhill, Gordon Dougan, Melita A Gordon

Journal article  |  2012  |  Clinical Infectious Diseases

Structure, Diversity, and Mobility of the Salmonella Pathogenicity Island 7 Family of Integrative and Conjugative Elements within Enterobacteriaceae

Helena MB Seth-Smith, Maria C Fookes, Chinyere K Okoro, Stephen Baker, Simon R Harris, Paul Scott, Derek Pickard, Michael A Quail, Carol Churcher, Mandy Sanders, Johan Harmse, Gordon Dougan, Julian Parkhill, Nicholas R Thomson

Journal article  |  2012  |  Journal of Bacteriology

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation

Anastasia Nijnik, Simon Clare, Christine Hale, Claire Raisen, Rebecca E McIntyre, Kosuke Yusa, Aaron R Everitt, Lynda Mottram, Christine Podrini, Mark Lucas, Jeanne Estabel, David Goulding, Niels Adams, Ramiro Ramirez-Solis, Jacqui K White, David J Adams, Robert EW Hancock, Gordon Dougan

Journal article  |  2012  |  Blood

Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection

Saranna Fanning, Lindsay J Hall, Michelle Cronin, Aldert Zomer, John MacSharry, David Goulding, Mary O'Connell Motherway, Fergus Shanahan, Kenneth Nally, Gordon Dougan, Douwe van Sinderen

Journal article  |  2012  |  Proceedings of the National Academy of Sciences

High-Resolution Genotyping of the Endemic Salmonella Typhi Population during a Vi (Typhoid) Vaccination Trial in Kolkata

Kathryn E Holt, Shanta Dutta, Byomkesh Manna, Sujit K Bhattacharya, Barnali Bhaduri, Derek J Pickard, R Leon Ochiai, Mohammad Ali, John D Clemens, Gordon Dougan

Journal article  |  2012  |  PLoS Neglected Tropical Diseases

Sequence-Based Analysis Uncovers an Abundance of Non-Coding RNA in the Total Transcriptome of Mycobacterium tuberculosis

Kristine B Arnvig, Inaki Comas, Nicholas R Thomson, Joanna Houghton, Helena I Boshoff, Nicholas J Croucher, Graham Rose, Timothy T Perkins, Julian Parkhill, Gordon Dougan, Douglas B Young

Journal article  |  2011  |  PLoS Pathogens

The Human Transcriptome During Nontyphoid Salmonella and HIV Coinfection Reveals Attenuated NF kappa B-Mediated Inflammation and Persistent Cell Cycle Disruption

Fernanda Schreiber, David J Lynn, Angela Houston, Joanna Peters, Gershom Mwafulirwa, Brett B Finlay, Fiona SL Brinkman, Robert EW Hancock, Robert S Heyderman, Gordon Dougan, Melita A Gordon

Journal article  |  2011  |  The Journal of Infectious Diseases

Ileal Pouch Microbial Diversity Reply

Simon D McLaughlin, Alan W Walker, Carol Churcher, Susan K Clark, Paris P Tekkis, Matthew W Johnson, Julian Parkhill, Paul J Ciclitira, Gordon Dougan, R John Nicholls, Liljana Petrovska

Journal article  |  2011  |  Annals of Surgery

Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission

Stephen Baker, Kathryn E Holt, Archie CA Clements, Abhilasha Karkey, Amit Arjyal, Maciej F Boni, Sabina Dongol, Naomi Hammond, Samir Koirala, Thanh Duy Pham, Vu Thieu Nga Tran, James I Campbell, Christiane Dolecek, Buddha Basnyat, Gordon Dougan, Jeremy J Farrar

Journal article  |  2011  |  Open biology

Evidence for several waves of global transmission in the seventh cholera pandemic

Ankur Mutreja, Dong Wook Kim, Nicholas R Thomson, Thomas R Connor, Je Hee Lee, Samuel Kariuki, Nicholas J Croucher, Seon Young Choi, Simon R Harris, Michael Lebens, Swapan Kumar Niyogi, Eun Jin Kim, T Ramamurthy, Jongsik Chun, James LN Wood, John D Clemens, Cecil Czerkinsky, G Balakrish Nair, Jan Holmgren, Julian Parkhill, et al.

Journal article  |  2011  |  Nature

Mannosidase 2, alpha 1 Deficiency Is Associated with Ricin Resistance in Embryonic Stem (ES) Cells

Wei Wang, Christine Hale, Dave Goulding, Stuart M Haslam, Berangere Tissot, Christopher Lindsay, Stephen Michell, Rick Titball, Jun Yu, Ana Luisa Toribio, Raffaella Rossi, Anne Dell, Allan Bradley, Gordon Dougan

Journal article  |  2011  |  PLoS ONE

Salmonella bongori Provides Insights into the Evolution of the Salmonellae

Maria Fookes, Gunnar N Schroeder, Gemma C Langridge, Carlos J Blondel, Caterina Mammina, Thomas R Connor, Helena Seth-Smith, Georgios S Vernikos, Keith S Robinson, Mandy Sanders, Nicola K Petty, Robert A Kingsley, Andreas J Baeumler, Sean-Paul Nuccio, Ines Contreras, Carlos A Santiviago, Duncan Maskell, Paul Barrow, Tom Humphrey, Antonino Nastasi, et al.

Journal article  |  2011  |  PLoS Pathogens

A Salmonella Typhimurium-Typhi Genomic Chimera: A Model to Study Vi Polysaccharide Capsule Function In Vivo

Angela M Jansen, Lindsay J Hall, Simon Clare, David Goulding, Kathryn E Holt, Andrew J Grant, Piero Mastroeni, Gordon Dougan, Robert A Kingsley

Journal article  |  2011  |  PLoS pathogens

Emergence of a Globally Dominant IncHI1 Plasmid Type Associated with Multiple Drug Resistant Typhoid

Kathryn E Holt, Duy Phan Minh, Stephen Baker, Thanh Duy Pham, Vu Thieu Nga Tran, Satheesh Nair, A Keith Turner, Ciara Walsh, Seamus Fanning, Sinead Farrell-Ward, Shanta Dutta, Sam Kariuki, Francois-Xavier Weill, Julian Parkhill, Gordon Dougan, John Wain

Journal article  |  2011  |  PLoS Neglected Tropical Diseases

Effects of Chronic Ascariasis and Trichuriasis on Cytokine Production and Gene Expression in Human Blood: A Cross-Sectional Study

Miguel Reina Ortiz, Fernanda Schreiber, Susana Benitez, Nely Broncano, Martha E Chico, Maritza Vaca, Neal Alexander, David J Lewis, Gordon Dougan, Philip J Cooper

Journal article  |  2011  |  PLoS Neglected Tropical Diseases

In Vivo Regulation of the Vi Antigen in Salmonella and Induction of Immune Responses with an In Vivo-Inducible Promoter

Carole Janis, Andrew J Grant, Trevelyan J McKinley, Fiona JE Morgan, Victoria F John, Jenny Houghton, Robert A Kingsley, Gordon Dougan, Pietro Mastroeni

Journal article  |  2011  |  Infection and Immunity

Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection

Saeeda Bobat, Adriana Flores-Langarica, Jessica Hitchcock, Jennifer L Marshall, Robert A Kingsley, Margaret Goodall, Cristina Gil-Cruz, Karine Serre, Denisse L Leyton, Shirdi E Letran, Fabrina Gaspal, Rebecca Chester, Jayne L Chamberlain, Gordon Dougan, Constantino Lopez-Macias, Ian R Henderson, James Alexander, Ian CM MacLennan, Adam F Cunningham

Journal article  |  2011  |  European Journal of Immunology

Citrobacter rodentium is an Unstable Pathogen Showing Evidence of Significant Genomic Flux

Nicola K Petty, Theresa Feltwell, Derek Pickard, Simon Clare, Ana L Toribio, Maria Fookes, Kevin Roberts, Rita Monson, Satheesh Nair, Robert A Kingsley, Richard Bulgin, Siouxsie Wiles, David Goulding, Thomas Keane, Craig Corton, Nicola Lennard, David Harris, David Willey, Richard Rance, Lu Yu, et al.

Journal article  |  2011  |  PLoS Pathogens

Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis

Gavin CKW Koh, Rapeephan R Maude, M Fernanda Schreiber, Direk Limmathurotsakul, W Joost Wiersinga, Vanaporn Wuthiekanun, Sue J Lee, Weera Mahavanakul, Wipada Chaowagul, Wirongrong Chierakul, Nicholas J White, Tom van der Poll, Nicholas PJ Day, Gordon Dougan, Sharon J Peacock

Journal article  |  2011  |  Clinical Infectious Diseases

Immunity to salmonellosis

Gordon Dougan, Victoria John, Sophie Palmer, Pietro Mastroeni

Journal article  |  2011  |  Immunological Reviews

Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E

Michail H Karavolos, DavidM Bulmer, Hannah Spencer, Giordano Rampioni, Ira Schmalen, Stephen Baker, Derek Pickard, Joe Gray, Maria Fookes, Klaus Winzer, Alasdair Ivens, Gordon Dougan, Paul Williams, CM Anjam Khan

Journal article  |  2011  |  EMBO reports

Rapid Pneumococcal Evolution in Response to Clinical Interventions

Nicholas J Croucher, Simon R Harris, Christophe Fraser, Michael A Quail, John Burton, Mark van der Linden, Lesley McGee, Anne von Gottberg, Jae Hoon Song, Kwan Soo Ko, Bruno Pichon, Stephen Baker, Christopher M Parry, Lotte M Lambertsen, Dea Shahinas, Dylan R Pillai, Timothy J Mitchell, Gordon Dougan, Alexander Tomasz, Keith P Klugman, et al.

Journal article  |  2011  |  Science

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

Alan W Walker, Jeremy D Sanderson, Carol Churcher, Gareth C Parkes, Barry N Hudspith, Neil Rayment, Jonathan Brostoff, Julian Parkhill, Gordon Dougan, Liljana Petrovska

Journal article  |  2011  |  BMC Microbiology

Comparative Whole Genome Sequence Analysis of the Carcinogenic Bacterial Model Pathogen Helicobacter felis

Isabelle C Arnold, Zuzana Zigova, Matthew Holden, Trevor D Lawley, Roland Rad, Gordon Dougan, Stanley Falkow, Stephen D Bentley, Anne Mueller

Journal article  |  2011  |  Genome Biology and Evolution

Temporal Fluctuation of Multidrug Resistant Salmonella Typhi Haplotypes in the Mekong River Delta Region of Vietnam

Kathryn E Holt, Christiane Dolecek, Thuy Chau Tran, Thanh Duy Pham, Thi Phi La Tran, Van Minh Hoang Nguyen, Vu Thieu Nga Tran, James I Campbell, Huu Manh Bui, Van Vinh Chau Nguyen, Tinh Hien Tran, Jeremy Farrar, Gordon Dougan, Stephen Baker

Journal article  |  2011  |  PLoS Neglected Tropical Diseases

Live Vaccines and Their Role in Modern Vaccinology

Gordon Dougan, David Goulding, Lindsay J Hall

Journal article  |  2011  |  Birkhauser Advances in Infectious Diseases

The Burden and Characteristics of Enteric Fever at a Healthcare Facility in a Densely Populated Area of Kathmandu

Abhilasha Karkey, Amit Arjyal, Katherine L Anders, Maciej F Boni, Sabina Dongol, Samir Koirala, Vu Tra My Phan, Vu Thieu Nga Tran, Archie CA Clements, Kathryn E Holt, Thanh Duy Pham, Jeremy N Day, James I Campbell, Gordon Dougan, Christiane Dolecek, Jeremy Farrar, Buddha Basnyat, Stephen Baker

Journal article  |  2010  |  PLoS One

A Conserved Acetyl Esterase Domain Targets Diverse Bacteriophages to the Vi Capsular Receptor of Salmonella enterica Serovar Typhi

Derek Pickard, Ana Luisa Toribio, Nicola K Petty, Andries van Tonder, Lu Yu, David Goulding, Bart Barrell, Richard Rance, David Harris, Michael Wetter, John Wain, Jyoti Choudhary, Nicholas Thomson, Gordon Dougan

Journal article  |  2010  |  Journal of Bacteriology

Legionella pneumophila Strain 130b Possesses a Unique Combination of Type IV Secretion Systems and Novel Dot/Icm Secretion System Effector Proteins

Gunnar N Schroeder, Nicola K Petty, Aurelie Mousnier, Clare R Harding, Adam J Vogrin, Bryan Wee, Norman K Fry, Timothy G Harrison, Hayley J Newton, Nicholas R Thomson, Scott A Beatson, Gordon Dougan, Elizabeth L Hartland, Gad Frankel

Journal article  |  2010  |  Journal of Bacteriology

A new era in the genomics of bacteria

Gordon Dougan, George M Weinstock

Journal article  |  2010  |  Current Opinion in Microbiology

Use of Purified Clostridium difficile Spores To Facilitate Evaluation of Health Care Disinfection Regimens

Trevor D Lawley, Simon Clare, Laura J Deakin, David Goulding, Jennifer L Yen, Claire Raisen, Cordelia Brandt, Jon Lovell, Fiona Cooke, Taane G Clark, Gordon Dougan

Journal article  |  2010  |  Applied and Environmental Microbiology

Molecular and physiological analysis of three Pseudomonas aeruginosa phages belonging to the "N4-like viruses"

Pieter-Jan Ceyssens, Andrew Brabban, Larissa Rogge, Matthew Spooner Lewis, Derek Pickard, David Goulding, Gordon Dougan, Jean-Paul Noben, Andrew Kropinski, Elizabeth Kutter, Rob Lavigne

Journal article  |  2010  |  Virology

Probing local innate immune responses after mucosal immunisation.

Lindsay J Hall, Simon Clare, Gordon Dougan

Journal article  |  2010  |  Journal of Immune Based Therapies and Vaccines

BACKGROUND: Intranasal immunisation is potentially a very effective route for inducing both mucosal and systemic immunity to an in..

An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guerin

Fernanda Schreiber, Zhiming Huo, Rafaela Giemza, Maria Woodrow, Nicola Fenner, Zoe Stevens, Gordon Dougan, Steven Prideaux, Luiz RR Castello-Branco, David JM Lewis

Journal article  |  2010  |  Vaccine

A Randomised Trial Evaluating the Safety and Immunogenicity of the Novel Single Oral Dose Typhoid Vaccine M01ZH09 in Healthy Vietnamese Children

Tinh Hien Tran, Thi Dung Nguyen, Thanh Truong Nguyen, Thi Thanh Van Ninh, Nguyen Bich Chau Tran, Van Minh Hoang Nguyen, Thi Thu Nga Tran, Thu Thuy Cao, Van Minh Pham, Thi Cam Binh Nguyen, Thi Diem Ha Tran, Van Toi Pham, Song Diep To, James I Campbell, Elaine Stockwell, Constance Schultsz, Cameron P Simmons, Clare Glover, Winnie Lam, Filipe Marques, et al.

Journal article  |  2010  |  PLoS One

Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion

Peng Li, Shannon Burke, Juexuan Wang, Xiongfeng Chen, Mariaestela Ortiz, Song-Choon Lee, Dong Lu, Lia Campos, David Goulding, Bee Ling Ng, Gordon Dougan, Brian Huntly, Bertie Gottgens, Nancy A Jenkins, Neal G Copeland, Francesco Colucci, Pentao Liu

Journal article  |  2010  |  Science

The Bacteriology of Pouchitis A Molecular Phylogenetic Analysis Using 16S rRNA Gene Cloning and Sequencing

Simon D McLaughlin, Alan W Walker, Carol Churcher, Susan K Clark, Paris P Tekkis, Matthew W Johnson, Julian Parkhill, Paul J Ciclitira, Gordon Dougan, Ralph John Nicholls, Liljana Petrovska

Journal article  |  2010  |  Annals of Surgery

Intra- and Interhost Evolutionary Dynamics of Equine Influenza Virus

Pablo R Murcia, Gregory J Baillie, Janet Daly, Debra Elton, Carley Jervis, Jennifer A Mumford, Richard Newton, Colin R Parrish, Karin Hoelzer, Gordon Dougan, Julian Parkhill, Nicola Lennard, Doug Ormond, Sharon Moule, Andrew Whitwham, John W McCauley, Trevelyan J McKinley, Edward C Holmes, Bryan T Grenfell, James LN Wood

Journal article  |  2010  |  Journal of Virology

Typhoid in Kenya Is Associated with a Dominant Multidrug-Resistant Salmonella enterica Serovar Typhi Haplotype That Is Also Widespread in Southeast Asia

Samuel Kariuki, Gunturu Revathi, John Kiiru, Doris M Mengo, Joyce Mwituria, Jane Muyodi, Agnes Munyalo, Yik Y Teo, Kathryn E Holt, Robert A Kingsley, Gordon Dougan

Journal article  |  2010  |  Journal of clinical microbiology

High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children

Kathryn E Holt, Stephen Baker, Sabina Dongol, Buddha Basnyat, Neelam Adhikari, Stephen Thorson, Anoop S Pulickal, Yajun Song, Julian Parkhill, Jeremy J Farrar, David R Murdoch, Dominic F Kelly, Andrew J Pollard, Gordon Dougan

Journal article  |  2010  |  BMC Infectious Diseases

Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli

Danilo Gomes Moriel, Isabella Bertoldi, Angela Spagnuolo, Sara Marchi, Roberto Rosini, Barbara Nesta, Ilaria Pastorello, Vanja A Mariani Corea, Giulia Torricelli, Elena Cartocci, Silvana Savino, Maria Scarselli, Ulrich Dobrindt, Joerg Hacker, Herve Tettelin, Luke J Tallon, Steven Sullivan, Lothar H Wieler, Christa Ewers, Derek Pickard, et al.

Journal article  |  2010  |  Proceedings of the National Academy of Sciences

Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults

Calman A MacLennan, James J Gilchrist, Melita A Gordon, Adam F Cunningham, Mark Cobbold, Margaret Goodall, Robert A Kingsley, Joep JG van Oosterhout, Chisomo L Msefula, Wilson L Mandala, Denisse L Leyton, Jennifer L Marshall, Esther N Gondwe, Saeeda Bobat, Constantino Lopez-Macias, Rainer Doffinger, Ian R Henderson, Eduard E Zijlstra, Gordon Dougan, Mark T Drayson, et al.

Journal article  |  2010  |  Science

Evolutionary dynamics of Clostridium difficile over short and long time scales

Miao He, Mohammed Sebaihia, Trevor D Lawley, Richard A Stabler, Lisa F Dawson, Melissa J Martin, Kathryn E Holt, Helena MB Seth-Smith, Michael A Quail, Richard Rance, Karen Brooks, Carol Churcher, David Harris, Stephen D Bentley, Christine Burrows, Louise Clark, Craig Corton, Vicky Murray, Graham Rose, Scott Thurston, et al.

Journal article  |  2010  |  Proceedings of the National Academy of Sciences

NK Cells Influence Both Innate and Adaptive Immune Responses after Mucosal Immunization with Antigen and Mucosal Adjuvant

Lindsay J Hall, Simon Clare, Gordon Dougan

Journal article  |  2010  |  The Journal of Immunology

Searching for the elusive typhoid diagnostic

Stephen Baker, Michael Favorov, Gordon Dougan

Journal article  |  2010  |  BMC Infectious Diseases

The Citrobacter rodentium Genome Sequence Reveals Convergent Evolution with Human Pathogenic Escherichia coli

Nicola K Petty, Richard Bulgin, Valerie F Crepin, Ana M Cerdeno-Tarraga, Gunnar N Schroeder, Michael A Quail, Nicola Lennard, Craig Corton, Andrew Barron, Louise Clark, Ana L Toribio, Julian Parkhill, Gordon Dougan, Gad Frankel, Nicholas R Thomson

Journal article  |  2010  |  Journal of Bacteriology

Ten years experience of Salmonella infections in Cambridge, UK

Nicholas Matheson, Robert A Kingsley, Katherine Sturgess, Sani H Aliyu, John Wain, Gordon Dougan, Fiona J Cooke

Journal article  |  2010  |  Journal of Infection

Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi

Lucinda J Thompson, Sarah J Dunstan, Christiane Dolecek, Tim Perkins, Deborah House, Gordon Dougan, Thi Hue Nguyen, Thi Phi La Tran, Doan Cong Du, Thi Phuong Le, Thi Dung Nguyen, Tinh Hien Tran, Jeremy J Farrar, Denise Monack, David J Lynn, Stephen J Popper, Stanley Falkow

Journal article  |  2009  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

Clara Amid, Linda M Rehaume, Kelly L Brown, James GR Gilbert, Gordon Dougan, Robert EW Hancock, Jennifer L Harrow

Journal article  |  2009  |  BMC Genomics

Distinctive Profiles of Infection and Pathology in Hamsters Infected with Clostridium difficile Strains 630 and B1

David Goulding, Harold Thompson, Jenny Emerson, Neil F Fairweather, Gordon Dougan, Gill R Douce

Journal article  |  2009  |  Infection and Immunity

Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants

Gemma C Langridge, Minh-Duy Phan, Daniel J Turner, Timothy T Perkins, Leopold Parts, Jana Haase, Ian Charles, Duncan J Maskell, Sarah E Peters, Gordon Dougan, John Wain, Julian Parkhill, A Keith Turner

Journal article  |  2009  |  Genome Research

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

Robert A Kingsley, Chisomo L Msefula, Nicholas R Thomson, Samuel Kariuki, Kathryn E Holt, Melita A Gordon, David Harris, Louise Clarke, Sally Whitehead, Vartul Sangal, Kevin Marsh, Mark Achtman, MalcolmE Molyneux, Martin Cormican, Julian Parkhill, Calman A MacLennan, Robert S Heyderman, Gordon Dougan

Journal article  |  2009  |  Genome research

The T3SS Effector EspT Defines a New Category of Invasive Enteropathogenic E. coli (EPEC) Which Form Intracellular Actin Pedestals

Richard Bulgin, Ana Arbeloa, David Goulding, Gordon Dougan, Valerie F Crepin, Benoit Raymond, Gad Frankel

Conference Proceedings  |  2009  |  PLoS Pathogens

A simple method for directional transcriptome sequencing using Illumina technology

Nicholas J Croucher, Maria C Fookes, Timothy T Perkins, Daniel J Turner, Samuel B Marguerat, Thomas Keane, Michael A Quail, Miao He, Sammey Assefa, Juerg Baehler, Robert A Kingsley, Julian Parkhill, Stephen D Bentley, Gordon Dougan, Nicholas R Thomson

Journal article  |  2009  |  Nucleic Acids Research

Genomic and phenotypic variation in epidemic-spanning Salmonella enterica serovar Enteritidis isolates

Laura Betancor, Lucia Yim, Maria Fookes, Araci Martinez, Nicholas R Thomson, Alasdair Ivens, Sarah Peters, Clare Bryant, Gabriela Algorta, Samuel Kariuki, Felipe Schelotto, Duncan Maskell, Gordon Dougan, Jose A Chabalgoity

Journal article  |  2009  |  BMC Microbiology

Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B-ESAT6 fusion protein

Lindsay J Hall, Simon Clare, Derek Pickard, Simon O Clark, Dominic LF Kelly, Moataz Abd El Ghany, Christine Hale, Jes Dietrich, Peter Andersen, Philip D Marsh, Gordon Dougan

Journal article  |  2009  |  Vaccine

The Key Role of Genomics in Modern Vaccine and Drug Design for Emerging Infectious Diseases

Kate L Seib, Gordon Dougan, Rino Rappuoli

Journal article  |  2009  |  PLoS Genetics

Proteomic and Genomic Characterization of Highly Infectious Clostridium difficile 630 Spores

Trevor D Lawley, Nicholas J Croucher, Lu Yu, Simon Clare, Mohammed Sebaihia, David Goulding, Derek J Pickard, Julian Parkhill, Jyoti Choudhary, Gordon Dougan

Journal article  |  2009  |  Journal of Bacteriology

Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts

Trevor D Lawley, Simon Clare, Alan W Walker, David Goulding, Richard A Stabler, Nicholas Croucher, Piero Mastroeni, Paul Scott, Claire Raisen, Lynda Mottram, Neil F Fairweather, Brendan W Wren, Julian Parkhill, Gordon Dougan

Journal article  |  2009  |  Infection and Immunity

Detecting SNPs and estimating allele frequencies in clonal bacterial populations by sequencing pooled DNA

Kathryn E Holt, Yik Y Teo, Heng Li, Satheesh Nair, Gordon Dougan, John Wain, Julian Parkhill

Journal article  |  2009  |  Bioinformatics

Paternal Effect of the Nuclear Formin-like Protein MISFIT on Plasmodium Development in the Mosquito Vector

Ellen SC Bushell, Andrea Ecker, Timm Schlegelmilch, David Goulding, Gordon Dougan, Robert E Sinden, George K Christophides, Fotis C Kafatos, Dina Vlachou

Journal article  |  2009  |  PLoS Pathogens

A Strand-Specific RNA-Seq Analysis of the Transcriptome of the Typhoid Bacillus Salmonella Typhi

Timothy T Perkins, Robert A Kingsley, Maria C Fookes, Paul P Gardner, Keith D James, Lu Yu, Samuel A Assefa, Miao He, Nicholas J Croucher, Derek J Pickard, Duncan J Maskell, Julian Parkhill, Jyoti Choudhary, Nicholas R Thomson, Gordon Dougan

Journal article  |  2009  |  PLoS Genetics

The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

Cristina Gil-Cruz, Saeeda Bobat, Jennifer L Marshall, Robert A Kingsley, Ewan A Ross, Ian R Henderson, Denisse L Leyton, Ruth E Coughlan, Mahmood Khan, Karina T Jensen, Christopher D Buckley, Gordon Dougan, Ian CM MacLennan, Constantino Lopez-Macias, Adam F Cunningham

Journal article  |  2009  |  Proceedings of the National Academy of Sciences

The Cholera Crisis in Africa

S Bhattacharya, R Black, L Bourgeois, J Clemens, A Cravioto, JL Deen, Gordon Dougan, R Glass, RF Grais, M Greco, I Gust, J Holmgren, S Kariuki, P-H Lambert, MA Liu, I Longini, GB Nair, R Norrby, GJV Nossal, P Ogra, et al.

Journal article  |  2009  |  Science

Interaction of Enteric Bacterial Pathogens with Murine Embryonic Stem Cells (vol 77, pg 585, 2009)

Jun Yu, Raffaella Rossi, Christine Hale, David Goulding, Gordon Dougan

Journal article  |  2009  |  Infection and Immunity

Interaction of Salmonella enterica with basil and other salad leaves

Cedric N Berger, Robert K Shaw, Derek J Brown, Henry Mather, Simon Clare, Gordon Dougan, Mark J Pallen, Gad Frankel

Journal article  |  2009  |  The ISME Journal

Interaction of Enteric Bacterial Pathogens with Murine Embryonic Stem Cells

Jun Yu, Raffaella Rossi, Christine Hale, David Goulding, Gordon Dougan

Journal article  |  2009  |  Infection and Immunity

Variation in Salmonella enterica Serovar Typhi IncHI1 Plasmids during the Global Spread of Resistant Typhoid Fever

Minh-Duy Phan, Claire Kidgell, Satheesh Nair, Kathryn E Holt, Arthur K Turner, Jason Hinds, Philip Butcher, Fiona J Cooke, Nicholas R Thomson, Richard Titball, Zulfiqar A Bhutta, Rumina Hasan, Gordon Dougan, John Wain

Journal article  |  2009  |  Antimicrobial agents and chemotherapy

Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi

Kathryn E Holt, Nicholas R Thomson, John Wain, Gemma C Langridge, Rumina Hasan, Zulfiqar A Bhutta, Michael A Quail, Halina Norbertczak, Danielle Walker, Mark Simmonds, Brian White, Nathalie Bason, Karen Mungall, Gordon Dougan, Julian Parkhill

Journal article  |  2009  |  BMC genomics

Typhoid Fever

Robert A Kingsley, Gordon Dougan

Book Chapter  |  2009

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

Richard A Stabler, Miao He, Lisa Dawson, Melissa Martin, Esmeralda Valiente, Craig Corton, Trevor D Lawley, Mohammed Sebaihia, Michael A Quail, Graham Rose, Dale N Gerding, Maryse Gibert, Michel R Popoff, Julian Parkhill, Gordon Dougan, Brendan W Wren

Journal article  |  2009  |  Genome Biology

Does the Trojan Horse Have an Achilles' Heel?

Gordon Dougan

Journal article  |  2009  |  New England Journal of Medicine

Complete Genome Sequence and Comparative Genome Analysis of Enteropathogenic Escherichia coli O127:H6 Strain E2348/69

Atsushi Iguchi, Nicholas R Thomson, Yoshitoshi Ogura, David Saunders, Tadasuke Ooka, Ian R Henderson, David Harris, M Asadulghani, Ken Kurokawa, Paul Dean, Brendan Kenny, Michael A Quail, Scott Thurston, Gordon Dougan, Tetsuya Hayashi, Julian Parkhill, Gad Frankel

Journal article  |  2009  |  Journal of Bacteriology

Characterization of the Genomes of a Diverse Collection of Salmonella enterica Serovar Typhimurium Definitive Phage Type 104

Fiona J Cooke, Derek J Brown, Maria Fookes, Derek Pickard, Alasdair Ivens, John Wain, Mark Roberts, Robert A Kingsley, Nicholas R Thomson, Gordon Dougan

Journal article  |  2008  |  Journal of Bacteriology

Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways

Nicholas R Thomson, Debra J Clayton, Daniel Windhorst, Georgios Vernikos, Susanne Davidson, Carol Churcher, Michael A Quail, Mark Stevens, Michael A Jones, Michael Watson, Andy Barron, Abigail Layton, Derek Pickard, Robert A Kingsley, Alex Bignell, Louise Clark, Barbara Harris, Doug Ormond, Zahra Abdellah, Karen Brooks, et al.

Journal article  |  2008  |  Genome Research

High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi

Kathryn E Holt, Julian Parkhill, Camila J Mazzoni, Philippe Roumagnac, Francois-Xavier Weill, Ian Goodhead, Richard Rance, Stephen Baker, Duncan J Maskell, John Wain, Christiane Dolecek, Mark Achtman, Gordon Dougan

Journal article  |  2008  |  Nature genetics

Antibodies to the Vi capsule of Salmonella Typhi in the serum of typhoid patients and healthy control subjects from a typhoid endemic region

Deborah House, Vo A Ho, To S Diep, Nguyen T Chinh, Phan V Bay, Vinh Ha, Duc Minh, Christopher M Parry, Gordon Dougan, Nicholas J White, Jeremy J Farrar, Tinh Hien Tran, John Wain

Journal article  |  2008  |  The Journal of Infection in Developing Countries

Interaction of Salmonella enterica serovar Typhi with cultured epithelial cells: roles of surface structures in adhesion and invasion

Anne Bishop, Deborah House, Timothy Perkins, Stephen Baker, Robert A Kingsley, Gordon Dougan

Journal article  |  2008  |  Microbiology

Mobilization of the incQ plasmid R300B with a chromosomal conjugation system in Salmonella enterica serovar Typhi

Stephen Baker, Derek Pickard, Sally Whitehead, Jeremy Farrar, Gordon Dougan

Journal article  |  2008  |  Journal of Bacteriology

High-throughput genotyping of Salmonella enterica serovar typhi allowing geographical assignment of Haplotypes and pathotypes within an urban district of Jakarta, Indonesia

Stephen Baker, Kathryn Holt, Esther van de Vosse, Philippe Roumagnac, Sally Whitehead, Emma King, Philip Ewels, Andrew Keniry, Francois-Xavier Weill, Diane Lightfoot, Jaap T van Dissel, Kenneth E Sanderson, Jeremy Farrar, Mark Achtman, Panagiotis Deloukas, Gordon Dougan

Journal article  |  2008  |  Journal of Clinical Microbiology

Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1

Derek Pickard, Nicholas R Thomson, Stephen Baker, John Wain, Mercedes Pardo, David Goulding, Nancy Hamlin, Jyoti Choudhary, John Threfall, Gordon Dougan

Journal article  |  2008  |  Journal of Bacteriology

The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children

Calman A MacLennan, Esther N Gondwe, Chisomo L Msefula, Robert A Kingsley, Nicholas R Thomson, Sarah A White, Margaret Goodall, Derek J Pickard, Stephen M Grahami, Gordon Dougan, C Anthony Hart, Malcolm E Molyneux, Mark T Drayson

Journal article  |  2008  |  Journal of Clinical Investigation

Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.

Tran Thuy Chau, James Ian Campbell, Claudia M Galindo, Nguyen Van Minh Hoang, To Song Diep, Tran Thu Thi Nga, Nguyen Van Vinh Chau, Phung Quoc Tuan, Anne Laure Page, R Leon Ochiai, Constance Schultsz, John Wain, Zulfiqar A Bhutta, Christopher M Parry, Sujit K Bhattacharya, Shanta Dutta, Magdarina Agtini, Baiqing Dong, Yang Honghui, Dang Duc Anh, et al.

Journal article  |  2007  |  Antimicrobial Agents and Chemotherapy

This study describes the pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated acro..

A linear plasmid truncation induces unidirectional flagellar phase change in H : z66 positive Salmonella Typhi

Stephen Baker, Kathryn Holt, Sally Whitehead, Ian Goodhead, Tim Perkins, Bruce Stocker, Jonathan Hardy, Gordon Dougan

Journal article  |  2007  |  Molecular microbiology

Multilocus sequence typing analysis of Shigella flexneri isolates collected in Asian countries

Seon Young Choi, Yoon-Seong Jeon, Je Hee Lee, Boram Choi, Sun Hwa Moon, Lorenz von Seidlein, John D Clemens, Gordon Dougan, John Wain, Jun Yu, Je Chul Lee, Sung Yong Seol, Bok Kwon Lee, Jae-Hoon Song, Manki Song, Cecil Czerkinsky, Jongsik Chun, Dong Wook Kim

Journal article  |  2007  |  Journal of Medical Microbiology

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

Baerbel Stecher, Riccardo Robbiani, Alan W Walker, Astrid M Westendorf, Manja Barthel, Marcus Kremer, Samuel Chaffron, Andrew J Macpherson, Jan Buer, Julian Parkhill, Gordon Dougan, Christian von Mering, Wolf-Dietrich Hardt

Journal article  |  2007  |  PLoS Biology

A generalized transducing phage for the murine pathogen Citrobacter rodentium

Nicola K Petty, Ana L Toribi, David Goulding, Ian Foulds, Nicholas Thomson, Gordon Dougan, George PC Salmond

Journal article  |  2007  |  Microbiology

Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium

Anne L Bishop, Siouxsie Wiles, Gordon Dougan, Gad Frankel

Journal article  |  2007  |  Microbes and Infection

Prophage sequences defining hot spots of genome variation in Salmonella enterica serovar typhimurium can be used to discriminate between field isolates

Fiona J Cooke, John Wain, Maria Fookes, Alasdair Ivens, Nicholas Thomson, Derek J Brown, E John Threlfall, George Gunn, Geoffrey Foster, Gordon Dougan

Journal article  |  2007  |  Journal of Clinical Microbiology

A TNF region haplotype offers protection from typhoid fever in Vietnamese patients

Sarah J Dunstan, Nguyen Thi Hue, Kirk Rockett, Julian Forton, Andrew P Morris, P MorrisMahamadou Diakite, Mai Ngoc Lanh, Le Thi Phuong, Deborah House, Christopher M Parry, Ha Vinh, Nguyen T Hieu, Gordon Dougan, Tran Tinh Hien, Dominic Kwiatowski, Jeremy J Farrar

Journal article  |  2007  |  Human Genetics

The genome of Salmonella enterica serovar typhi

Stephen Baker, Gordon Dougan

Journal article  |  2007  |  Clinical Infectious Diseases

Erratum: Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection (Infection and Immunity (2004) 72, 4, (2288-2302)

R Mundy, L Petrovska, K Smollett, N Simpson, RK Wilson, J Yu, X Tu, I Rosenshine, S Clare, G Dougan, G Frankel

Journal article  |  2007  |  Infection and Immunity

Quorum sensing has an unexpected role in virulence in the model pathogen Citrobacter rodentium

Sarah J Coulthurst, Simon Clare, Terry J Evans, Ian J Foulds, Kevin J Roberts, Martin Welch, Gordon Dougan, George PC Salmond

Journal article  |  2007  |  EMBO reports

Multidrug-resistant Salmonella enterica serovar Paratyphi A harbors IncHI1 plasmids similar to those found in serovar Typhi

Kathryn E Holt, Nicholas R Thomson, John Wain, Minh Duy Phan, Satheesh Nair, Rumina Hasan, Zulfiqar A Bhutta, Michael A Quail, Halina Norbertczak, Danielle Walker, Gordon Dougan, Julian Parkhill

Journal article  |  2007  |  Journal of bacteriology

Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.

S Khan, S Chatfield, R Stratford, J Bedwell, M Bentley, S Sulsh, R Giemza, S Smith, E Bongard, CA Cosgrove, J Johnson, G Dougan, GE Griffin, J Makin, DJM Lewis

Journal article  |  2007  |  Vaccine

We have evaluated an oral vaccine based on an Salmonella enteric serovar typhi (S. typhi) Ty2 derivative TSB7 harboring deletion m..

A novel linear plasmid mediates flagellar variation in Salmonella Typhi

Stephen Baker, Jonathan Hardy, Kenneth E Sanderson, Michael Quail, Ian Goodhead, Robert A Kingsley, Julian Parkhill, Bruce Stocker, Gordon Dougan

Journal article  |  2007  |  PLoS Pathogens

Functional cell permeable motifs within medically relevant proteins

Walter Low, Alison Mortlock, Liljana Petrovska, Tania Dottorini, Gordon Dougan, Andrea Crisanti

Journal article  |  2007  |  Journal of Biotechnology

Requirement of bic/microRNA-155 for normal immune function

Antony Rodriguez, Elena Vigorito, Simon Clare, Madhuri V Warren, Philippe Couttet, Dalya R Soond, Stijn van Dongen, Russell J Grocock, Partha P Das, Eric A Miska, David Vetrie, Klaus Okkenhaug, Anton J Enright, Gordon Dougan, Martin Turner, Allan Bradley

Journal article  |  2007  |  Science

Candidate live, attenuated Salmonella enterica serotype typhimurium vaccines with reduced fecal shedding are immunogenic and effective oral vaccines

Moataz Abd El Ghany, Angela Jansen, Simon Clare, Lindsay Hall, Derek Pickard, Robert A Kingsley, Gordon Dougan

Journal article  |  2007  |  Infection and Immunity

Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or O26:H-.

PM van Diemen, F Dziva, A Abu-Median, TS Wallis, H van den Bosch, G Dougan, N Chanter, G Frankel, MP Stevens

Journal article  |  2007  |  Veterinary Immunology and Immunopathology

Enterohaemorrhagic Escherichia coli (EHEC) infections in humans are an important public health concern and are commonly acquired v..

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081

Nicholas R Thomson, Sarah Howard, Brendan W Wren, Matthew TG Holden, Lisa Crossman, Gregory L Challis, Carol Churcher, Karen Mungall, Karen Brooks, Tracey Chillingworth, Theresa Feltwell, Zahra Abdellah, Heidi Hauser, Kay Jagels, Mark Maddison, Sharon Moule, Mandy Sanders, Sally Whitehead, Michael A Quail, Gordon Dougan, et al.

Journal article  |  2006  |  PLoS Genetics

Evolutionary history of Salmonella Typhi

Philippe Roumagnac, Francois-Xavier Weill, Christiane Dolecek, Stephen Baker, Sylvain Brisse, Nguyen Tran Chinh, Thi Anh Hong Le, Camilo J Acosta, Jeremy Farrar, Gordon Dougan, Mark Achtman

Journal article  |  2006  |  Science

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

Mohammed Sebaihia, Brendan W Wren, Peter Mullany, Neil F Fairweather, Nigel Minton, Richard Stabler, Nicholas R Thomson, Adam P Roberts, Ana M Cerdeno-Tarrraga, Hongmei Wang, Matthew TG Holden, Anne Wright, Carol Churcher, Michael A Quail, Stephen Baker, Nathalie Bason, Karen Brooks, Tracey Chillingworth, Ann Cronin, Paul Davis, et al.

Journal article  |  2006  |  Nature Genetics

Immunization with the iron uptake ABC transporter proteins PiaA and PiuA prevents respiratory infection with Streptococcus pneumoniae

Maha Jomaa, Stephen Terry, Chris Hale, Christopher Jones, Gordon Dougan, Jeremy Brown

Journal article  |  2006  |  Vaccine

Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis.

Christine Hale, Frances Bowe, Derek Pickard, Simon Clare, Jean-Francois Haeuw, Ultan Powers, Nathalie Menager, Pietro Mastroeni, Gordon Dougan

Journal article  |  2006  |  Vaccine

Immunisation of BALB/c mice with a vaccine containing Vi polysaccharide conjugated to the Klebsiella pneumoniae outer membrane 40 ..

How bacteria and their products provide clues to vaccine and adjuvant development.

Gordon Dougan, Carlos Hormaeche

Journal article  |  2006  |  Vaccine

Evidence has emerged that both vertebrates and invertebrates share innate immune pathways involved in the recognition of and the r..

Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.

Catherine A Cosgrove, Luiz RR Castello-Branco, Tracy Hussell, Amy Sexton, Rafaela Giemza, Richard Phillips, Andrew Williams, George E Griffin, Gordon Dougan, David JM Lewis

Journal article  |  2006  |  Infection and Immunity

Oral immunization of healthy adults with 10(7) CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma in..

Helicobacter pylori has stimulatory effects on naive T cells.

Anna Maria Malfitano, Rachel Cahill, Peter Mitchell, Gad Frankel, Gordon Dougan, Maurizio Bifulco, Giovanna Lombardi, Robert I Lechler, Kathleen B Bamford

Journal article  |  2006  |  Helicobacter

BACKGROUND: Despite an apparently active host response, Helicobacter pylori infection can persist for life. Unexpectedly, T cells ..

Citrobacter rodentium of mice and man.

Rosanna Mundy, Thomas T MacDonald, Gordon Dougan, Gad Frankel, Siouxsie Wiles

Journal article  |  2005  |  Cellular Microbiology

The major classes of enteric bacteria harbour a conserved core genomic structure, common to both commensal and pathogenic strains,..

Identification of core and variable components of the Salmonella enterica subspecies I genome by microarray.

Muna F Anjum, Chris Marooney, Maria Fookes, Stephen Baker, Gordon Dougan, Al Ivens, Martin J Woodward

Journal article  |  2005  |  Infection and Immunity

We have performed microarray hybridization studies on 40 clinical isolates from 12 common serovars within Salmonella enterica subs..

Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae.

Maha Jomaa, Jose Yuste, James C Paton, Christopher Jones, Gordon Dougan, Jeremy S Brown

Journal article  |  2005  |  Infection and Immunity

PiaA and PiuA are the lipoprotein components of the Pia and Piu Streptococcus pneumoniae iron uptake ABC transporters and are requ..

The lrp gene and its role in type I fimbriation in Citrobacter rodentium.

Angela Cordone, Emilia MF Mauriello, Derek J Pickard, Gordon Dougan, Maurilio De Felice, Ezio Ricca

Journal article  |  2005  |  Journal of Bacteriology

Citrobacter rodentium is a murine pathogen that is now widely used as an in vivo model for gastrointestinal infections due to its ..

Universal DNA primers amplify bacterial DNA from human fetal membranes and link Fusobacterium nucleatum with prolonged preterm membrane rupture.

RJ Cahill, S Tan, G Dougan, P O'Gaora, D Pickard, N Kennea, MHF Sullivan, RG Feldman, AD Edwards

Journal article  |  2005  |  Molecular Human Reproduction

A large number of bacterial species have been identified in fetal membranes after preterm labour (PTL) associated with intrauterin..

Detection of Vi-negative Salmonella enterica serovar typhi in the peripheral blood of patients with typhoid fever in the Faisalabad region of Pakistan.

Stephen Baker, Yasra Sarwar, Hafsa Aziz, Asma Haque, Aamir Ali, Gordon Dougan, John Wain, Abdul Haque

Journal article  |  2005  |  Journal of Clinical Microbiology

The synthesis and transportation proteins of the Vi capsular polysaccharide of Salmonella enterica serovar Typhi (serovar Typhi) a..

Use of paired serum samples for serodiagnosis of typhoid fever.

Deborah House, Nguyen T Chinh, To S Diep, Christopher M Parry, John Wain, Gordon Dougan, Nicholas J White, Tran Tinh Hien, Jeremy J Farrar

Journal article  |  2005  |  Journal of Clinical Microbiology

Using an enzyme-linked immunosorbent assay we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serolog..

Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract.

Siouxsie Wiles, Gordon Dougan, Gad Frankel

Journal article  |  2005  |  Cellular Microbiology

Citrobacter rodentium belongs to a family of human and animal enteric pathogens that includes the clinically significant enterohae..

Non-clinical safety evaluation of novel vaccines and adjuvants: new products, new strategies.

Frank R Brennan, Gordon Dougan

Journal article  |  2005  |  Vaccine

Advances in molecular biology and biotechnology, coupled with an increased understanding of disease processes and mechanisms of pr..

Cancer immunotherapy based on killing of Salmonella-infected tumor cells.

Francesca Avogadri, Chiara Martinoli, Liljana Petrovska, Claudia Chiodoni, Pietro Transidico, Vincenzo Bronte, Renato Longhi, Mario P Colombo, Gordon Dougan, Maria Rescigno

Journal article  |  2005  |  Cancer Research

A major obstacle for the development of effective immunotherapy is the ability of tumors to escape the immune system. The possibil..

Analysis of the hypervariable region of the Salmonella enterica genome associated with tRNA(leuX).

Anne L Bishop, Stephen Baker, Sara Jenks, Maria Fookes, Peadar O Gaora, Derek Pickard, Muna Anjum, Jeremy Farrar, Tran T Hien, Al Ivens, Gordon Dougan

Journal article  |  2005  |  Journal of Bacteriology

The divergence of Salmonella enterica and Escherichia coli is estimated to have occurred approximately 140 million years ago. Desp..

Protection against tetanus toxin using a plant-based vaccine.

John S Tregoning, Simon Clare, Frances Bowe, Lorna Edwards, Neil Fairweather, Omar Qazi, Peter J Nixon, Pal Maliga, Gordon Dougan, Tracy Hussell

Journal article  |  2005  |  European Journal of Immunology

Plant-expressed vaccines may provide a unique opportunity for generating anti-pathogen immunity, especially in countries where col..

Erratum: Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium (Cellular Microbiology (2004))

S Wiles, S Clare, J Harker, A Huett, D Young, G Dougan, G Frankel

Journal article  |  2005  |  Cellular Microbiology

Vi antigen expression in Salmonella enterica serovar Typhi clinical isolates from Pakistan.

John Wain, Deborah House, Afia Zafar, Stephen Baker, Satheesh Nair, Claire Kidgell, Zulfiqar Bhutta, Gordon Dougan, Rumina Hasan

Journal article  |  2005  |  Journal of Clinical Microbiology

The accurate identification of Salmonella enterica subsp. enterica serovar Typhi variants that fail to express the capsular polysa..

Optimization of Salmonella enterica serovar typhi DeltaaroC DeltassaV derivatives as vehicles for delivering heterologous antigens by chromosomal integration and in vivo inducible promoters.

Richard Stratford, Nicola D McKelvie, Nicky J Hughes, Emma Aldred, Claire Wiseman, Johanna Curtis, Trevor Bellaby, Matt Bentley, Zoë Hindle, Frank R Brennan, Steven N Chatfield, Gordon Dougan, Shahid A Khan

Journal article  |  2005  |  Infection and Immunity

Novel candidate live oral vaccines based on a Salmonella enterica serovar Typhi ZH9 (Ty2 DeltaaroC DeltassaV) derivative that dire..

Shedding patterns of verocytotoxin-producing Escherichia coli strains in a cohort of calves and their dams on a Scottish beef farm.

DJ Shaw, C Jenkins, MC Pearce, T Cheasty, GJ Gunn, G Dougan, HR Smith, MEJ Woolhouse, G Frankel

Journal article  |  2004  |  Applied and Environmental Microbiology

Rectal fecal samples were taken once a week from 49 calves on the same farm. In addition, the dams of the calves were sampled at t..

Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene

L Petrovska, RJ Aspinall, L Barber, S Clare, CP Simmons, R Stratford, SA Khan, NR Lemoine, G Frankel, DW Holden, G Dougan

Journal article  |  2004  |  Cellular Microbiology

Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.

Chris KF Li, Sylvia LF Pender, Karen M Pickard, Victoria Chance, Judith A Holloway, Alan Huett, Nathalie S Gonçalves, John S Mudgett, Gordon Dougan, Gad Frankel, Thomas T MacDonald

Journal article  |  2004  |  The Journal of Immunology

Infection of mice with the intestinal bacterial pathogen Citrobacter rodentium results in colonic mucosal hyperplasia and a local ..

Early interactions of Salmonella enterica serovar typhimurium with human small intestinal epithelial explants

A Haque, F Bowe, RJ Fitzhenry, G Frankel, M Thomson, R Heuschkel, S Murch, MP Stevens, TS Wallis, AD Phillips, G Dougan

Journal article  |  2004  |  Gut

BACKGROUND: Salmonella enterica serovar typhimurium (S typhimurium) causes invasive gastroenteritis in humans, a disease involving..

Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

Siouxsie Wiles, Simon Clare, James Harker, Alan Huett, Douglas Young, Gordon Dougan, Gad Frankel

Journal article  |  2004  |  Cellular Microbiology

Citrobacter rodentium belongs to a family of human and animal enteric pathogens that includes the clinically significant enterohae..

Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines.

Christine Hale, Ian R Humphreys, Tracy Hussell, Frances Bowe, Simon Clare, Derek Pickard, Andrew Preston, Giuseppe Del Giudice, Gordon Dougan

Journal article  |  2004  |  Vaccine

Groups of neonatal mice were immunised with different mucosal vaccines based on acellular (Pertactin antigen) or whole cell (inact..

Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG.

Nicola D McKelvie, Richard Stratford, Tao Wu, Trevor Bellaby, Emma Aldred, Nicky J Hughes, Steven N Chatfield, Derek Pickard, Christine Hale, Gordon Dougan, Shahid A Khan

Journal article  |  2004  |  Vaccine

DNA derived from regions upstream of the Salmonella enterica serovar Typhimurium ssaG gene were used to drive expression of differ..

Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes.

Sivan Dahan, Stuart Knutton, Robert K Shaw, Valerie F Crepin, Gordon Dougan, Gad Frankel

Journal article  |  2004  |  Infection and Immunity

Using a DNA microarray, we determined changes in enterohemorrhagic Escherichia coli O157:H7 gene expression during binding to plas..

Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.

Frances Bowe, Ed C Lavelle, Edel A McNeela, Christine Hale, Simon Clare, Beatrice Arico, Marzia M Giuliani, Aaron Rae, Alan Huett, Rino Rappuoli, Gordon Dougan, Kingston HG Mills

Journal article  |  2004  |  Infection and Immunity

Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup..

A clinical, microbiological, and pathological study of intestinal perforation associated with typhoid fever.

Quoc Chanh Nguyen, Paul Everest, Tan Khoa Tran, Deborah House, Simon Murch, Christopher Parry, Phillippa Connerton, Van Bay Phan, Song Diep To, Pietro Mastroeni, Nicholas J White, T Hien Tran, Van Ho Vo, Gordon Dougan, Jeremy J Farrar, John Wain

Journal article  |  2004  |  Clinical Infectious Diseases

One of the most serious complications of typhoid fever is intestinal perforation. Of 27 patients admitted to a provincial hospital..

The role of prophage-like elements in the diversity of Salmonella enterica serovars.

Nicholas Thomson, Stephen Baker, Derek Pickard, Maria Fookes, Muna Anjum, Nancy Hamlin, John Wain, Deborah House, Zulfiqar Bhutta, Kaman Chan, Stanley Falkow, Julian Parkhill, Martin Woodward, Al Ivens, Gordon Dougan

Journal article  |  2004  |  Journal of Molecular Biology

The Salmonella enterica serovar Typhi CT18 (S.Typhi) chromosome harbours seven distinct prophage-like elements, some of which may ..

Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection.

Rosanna Mundy, Liljana Petrovska, Katherine Smollett, Nandi Simpson, Rebecca K Wilson, Jun Yu, Xuanlin Tu, Ilan Rosenshine, Simon Clare, Gordon Dougan, Gad Frankel

Journal article  |  2004  |  Infection and Immunity

Citrobacter rodentium is a member of a group of pathogens that colonize the lumen of the host gastrointestinal tract via attaching..

New advances in the production of edible plant vaccines: chloroplast expression of a tetanus vaccine antigen, TetC.

John Tregoning, Pal Maliga, Gordon Dougan, Peter J Nixon

Journal article  |  2004  |  Phytochemistry

Vaccines are a proven method of controlling disease. However there are issues with the delivery and administration of vaccines. A ..

Live Salmonella enterica serovar Typhimurium (S. Typhimurium) elicit dendritic cell responses that differ from those induced by killed S. Typhimurium.

Mari Norimatsu, Victoria Chance, Gordon Dougan, Christopher J Howard, Bernardo Villarreal-Ramos

Journal article  |  2004  |  Veterinary Immunology and Immunopathology

The immune response of bovine monocytes-derived dendritic cells (DC) exposed to either live or killed Salmonella enterica serovar ..

Subtyping of virulence genes in verocytotoxin-producing Escherichia coli (VTEC) other than serogroup O157 associated with disease in the United Kingdom.

C Jenkins, GA Willshaw, J Evans, T Cheasty, H Chart, DJ Shaw, G Dougan, G Frankel, HR Smith

Journal article  |  2003  |  Journal of Medical Microbiology

Verocytotoxin-producing Escherichia coli (VTEC) causes a wide spectrum of disease in humans, from mild diarrhoea to haemolytic ura..

Intracellular adhesion molecule 1 plays a key role in acquired immunity to Salmonellosis

S Clare, R Goldin, C Hale, R Aspinall, C Simmons, P Mastroeni, G Dougan

Journal article  |  2003  |  Infection and Immunity

Foreword

G Dougan

Book  |  2003

Molecular analysis of incHI1 antimicrobial resistance plasmids from Salmonella serovar Typhi strains associated with typhoid fever.

John Wain, LT Diem Nga, Claire Kidgell, Keith James, Sarah Fortune, To Song Diep, Tahir Ali, Peadar O Gaora, Christopher Parry, Julian Parkhill, Jeremy Farrar, Nicholas J White, Gordon Dougan

Journal article  |  2003  |  Antimicrobial Agents and Chemotherapy

The first outbreak of multidrug-resistant (MDR) typhoid fever in Vietnam was in 1993, and by 1995 nearly 90% of cases were MDR. Pl..

Composition, acquisition, and distribution of the Vi exopolysaccharide-encoding Salmonella enterica pathogenicity island SPI-7.

Derek Pickard, John Wain, Stephen Baker, Alexandra Line, Sonia Chohan, Maria Fookes, Andrew Barron, Peadar O Gaora, José A Chabalgoity, Niren Thanky, Christoph Scholes, Nicholas Thomson, Michael Quail, Julian Parkhill, Gordon Dougan

Journal article  |  2003  |  Journal of Bacteriology

Vi capsular polysaccharide production is encoded by the viaB locus, which has a limited distribution in Salmonella enterica serova..

Central role for B lymphocytes and CD4( ) T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium

CP Simmons, S Clare, M Ghaem-Maghami, TK Uren, J Rankin, A Huett, R Goldin, DJ Lewis, TT MacDonald, RA Strugnell, G Frankel, G Dougan

Journal article  |  2003  |  Infection and Immunity

Subtyping intimin genes from enteropathogenic Escherichia coli associated with outbreaks and sporadic cases in the United Kingdom and Eire.

C Jenkins, AJ Lawson, T Cheasty, GA Willshaw, P Wright, G Dougan, G Frankel, HR Smith

Journal article  |  2003  |  Molecular and Cellular Probes

PCR-RFLP methods for subtyping the intimin gene from strains of typical and atypical enteropathogenic Escherichia coli (EPEC) and ..

OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia.

Ian R Humphreys, Lorna Edwards, Gerhard Walzl, Aaron J Rae, Gordon Dougan, Sue Hill, Tracy Hussell

Journal article  |  2003  |  The Journal of Immunology

Pulmonary eosinophilia induced in C57BL/6 mice after Cryptococcus neoformans infection is driven by CD4(+) Th2 cells. The immunolo..

Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences.

Nathalie S Gonçalves, Christine Hale, Gordon Dougan, Gad Frankel, Thomas T MacDonald

Journal article  |  2003  |  Infection and Immunity

Intimin-conjugated fluorescent beads bind to spleen CD4 T cells and Peyer's patch, mesenteric lymph node, and cecal follicle lymph..

Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium