Pablo Casillas Espinosa

Early life adversity accelerates epileptogenesis and enhances depression-like behaviors in rats.

Rayiky Rupasinghe, Gabi Dezsi, Ezgi Ozturk, Simone Carron, Matthew R Hudson, Pablo M Casillas-Espinosa, Nigel C Jones

Journal article  |  2022  |  Exp Neurol

OBJECTIVE: Early life stressors are well-established risk factors for psychiatric disorders, and evidence also suggests that these..

An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy

Anna Harutyunyan, Debbie Chong, Rui Li, Anup D Shah, Zahra Ali, Cheng Huang, Christopher K Barlow, Piero Perucca, Terence J O'Brien, Nigel C Jones, Ralf B Schittenhelm, Alison Anderson, Pablo M Casillas-Espinosa

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, al..

Pediatric traumatic brain injury and a subsequent transient immune challenge independently influenced chronic outcomes in male mice

Rishabh Sharma, Pablo M Casillas-Espinosa, Larissa K Dill, Sarah SJ Rewell, Matthew R Hudson, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal article  |  2021  |  BRAIN BEHAVIOR AND IMMUNITY

Traumatic brain injury (TBI) is a major contributor to death and disability worldwide. Children are at particularly high risk of b..

Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy

Kim L Powell, Zining Liu, Claire L Curl, Antonia JA Raaijmakers, Pragati Sharma, Emma L Braine, Flavia M Gomes, Shobi Sivathamboo, Vaughan G Macefield, Pablo M Casillas-Espinosa, Nigel C Jones, Lea M Delbridge, Terence J O'Brien

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

OBJECTIVE: This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilept..

Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still m..

Experimental traumatic brain injury does not lead to lung infection

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie HY Wong, Sandy R Shultz, Stuart J McDonald

Journal article  |  2020  |  JOURNAL OF NEUROIMMUNOLOGY

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is a..

Neurodegenerative pathways as targets for acquired epilepsy therapy development

Pablo M Casillas-Espinosa, Idrish Ali, Terence J O'Brien

Journal article  |  2020  |  Epilepsia Open

There is a growing body of clinical and experimental evidence that neurodegenerative diseases and epileptogenesis after an acquire..

A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes Agoston, Peter VS Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz

Journal article  |  2020  |  BONE

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to inju..

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  PROGRESS IN NEUROBIOLOGY

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets

Rishabh Sharma, Wai Lam Leung, Akram Zamani, Terence J O'Brien, Pablo M Casillas Espinosa, Bridgette D Semple

Journal article  |  2019  |  BRAIN SCIENCES

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for su..