Alan Cowman

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.

Brodie L Bailey, William Nguyen, Anna Ngo, Christopher D Goodman, Maria R Gancheva, Paola Favuzza, Laura M Sanz, Francisco-Javier Gamo, Kym N Lowes, Geoffrey I McFadden, Danny W Wilson, Benoît Laleu, Stephen Brand, Paul F Jackson, Alan F Cowman, Brad E Sleebs

Journal article  |  2021  |  Bioorg Chem

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported..

High-dimensional mass cytomet identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria

Lisa J Ioannidis, Halina M Pietrzak, Ann Ly, Retno As Utami, Emily M Eriksson, Stephanie Studniberg, Waruni Abeysekera, Connie SN Li-Wai-Suen, Dylan Sheerin, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah N Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Leily Trianty, et al.

Journal article  |  2021  |  JCI INSIGHT

IFN-γ-driven responses to malaria have been shown to modulate the development and function of T follicular helper (TFH) cells and ..

4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation

Niall D Geoghegan, Cindy Evelyn, Lachlan W Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S Marapana, Daryan Kempe, Jennifer K Thompson, Michael J Mlodzianoski, Julie Healer, Mate Biro, Alan F Cowman, Kelly L Rogers

Journal article  |  2021  |  NATURE COMMUNICATIONS

Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry i..

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

Brad E Sleebs, Kate E Jarman, Sonja Frolich, Wilson Wong, Julie Healer, Weiwen Dai, Isabelle S Lucet, Danny W Wilson, Alan F Cowman

Journal article  |  2020  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

The P. falciparum parasite, responsible for the disease in humans known as malaria, must invade erythrocytes to provide an environ..

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Gregory M LaMonte, Frances Rocamora, Danushka S Marapana, Nina F Gnadig, Sabine Ottilie, Madeline R Luth, Tilla S Worgall, Gregory M Goldgof, Roxanne Mohunlal, TR Santha Kumar, Jennifer K Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M Williams, Bing Yu Zou, Andrea L Cheung, Prianka Kumar, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplaci..

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Paola Favuzza, Manuel de Lera Ruiz, Jennifer K Thompson, Tony Triglia, Anna Ngo, Ryan WJ Steel, Marissa Vavrek, Janni Christensen, Julie Healer, Christopher Boyce, Zhuyan Guo, Mengwei Hu, Tanweer Khan, Nicholas Murgolo, Lianyun Zhao, Jocelyn Sietsma Penington, Kitsanapong Reaksudsan, Kate Jarman, Melanie H Dietrich, Lachlan Richardson, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmo..

Uncovering the ART of antimalarial resistance

Danushka Marapana, Alan F Cowman

Journal article  |  2020  |  SCIENCE

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

Charlie Jennison, Leonardo Lucantoni, Matthew T O'Neill, Robyn McConville, Sara M Erickson, Alan F Cowman, Brad E Sleebs, Vicky M Avery, Justin A Boddey

Journal article  |  2019  |  CELL REPORTS

Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block tra..

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Matthew WA Dixon, Alan F Cowman, Spencer J Williams, Leann Tilley, Malcolm J McConville, Simon A Cobbold

Journal article  |  2019  |  MBIO

Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathway..

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes

Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K Thompson, Alexei A Kouzmitchev, Hayley E Bullen, Paul R Gilson, Alan F Cowman, Christopher J Tonkin

Journal article  |  2019  |  MBIO

Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial ..