Prof Alan Cowman

www.wehi.edu.au/people/alan-cowman

My laboratory studies malaria, a disease that is responsible for more than 400,000 deaths each year globally.

We aim to advance the understanding of this important disease and develop a vaccine and new treatments.

Find out more about Alan Cowman's experience

Alan Cowman's highlights

FEATURED Journal article

Uncovering the ART of antimalarial resistance

Alan Cowman's selected work

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Tra..

Journal article

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabol..

Journal article

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocyte..

Journal article

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodiu..

Journal article

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Pl..

Journal article

Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites

Journal article

Scholarly Works

Displaying the 396 most recent scholarly works by Alan Cowman.

Uncovering the ART of antimalarial resistance

Danushka Marapana, Alan F Cowman

Journal article | 2020 | Science

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

Charlie Jennison, Leonardo Lucantoni, Matthew T O'Neill, Robyn McConville, Sara M Erickson, Alan F Cowman, Brad E Sleebs, Vicky M Avery, Justin A Boddey

Journal article | 2019 | Cell Reports

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.

Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Matthew WA Dixon, Alan F Cowman, Spencer J Williams, Leann Tilley, Malcolm J McConville, Simon A Cobbold

Journal article | 2019 | mBio

Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathway..

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes

Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K Thompson, Alexei A Kouzmitchev, Hayley E Bullen, Paul R Gilson, Alan F Cowman, Christopher J Tonkin

Journal article | 2019 | mBio

Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial ..

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

Paul R Gilson, Rasika Kumarasingha, Jennifer Thompson, Xinxin Zhang, Jocelyn Sietsma Penington, Robabeh Kalhor, Hayley E Bullen, Adele M Lehane, Madeline G Dans, Tania F de Koning-Ward, Jessica K Holien, Tatiana P Soares da Costa, Mark D Hulett, Melissa J Buskes, Brendan S Crabb, Kiaran Kirk, Anthony T Papenfuss, Alan F Cowman, Belinda M Abbott

Journal article | 2019 | Scientific Reports

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

Julie Healer, Wilson Wong, Jennifer K Thompson, Wengqiang He, Richard W Birkinshaw, Kazutoyo Miura, Carol A Long, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Willem A de Jongh, Christopher Weir, Ella Svahn, Peter E Czabotar, Wai-Hong Tham, Ivo Mueller, Paul N Barlow, Alan F Cowman

Journal article | 2019 | Cellular Microbiology

Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites

Jan-Gero Schloetel, Joern Heine, Alan F Cowman, Michal Pasternak

Journal article | 2019 | Scientific Reports

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2R gamma(null) Mouse Model of Malaria

Paul R Gilson, William Nguyen, William A Poole, Jose E Teixeira, Jennifer K Thompson, Kaiyuan Guo, Rebecca J Stewart, Trent D Ashton, Karen L White, Laura M Sanz, Francisco-Javier Gamo, Susan A Charman, Sergio Wittlin, James Duffy, Christopher J Tonkin, Wai-Hong Tham, Brendan S Crabb, Brian M Cooke, Christopher D Huston, Alan F Cowman, et al.

Journal article | 2019 | Antimicrobial Agents and Chemotherapy

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria

Wen-Qiang He, Ahmad Rushdi Shakri, Rukmini Bhardwaj, Camila T Franca, Danielle I Stanisic, Julie Healer, Benson Kiniboro, Leanne J Robinson, Micheline Guillotte-Blisnick, Christele Huon, Peter Siba, Alan Cowman, Christopher L King, Wai-Hong Tham, Chetan E Chitnis, Ivo Mueller

Journal article | 2019 | PLOS Neglected Tropical Diseases

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article | 2019 | Nature

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

Danushka S Marapana, Laura F Dagley, Jarrod J Sandow, Thomas Nebl, Tony Triglia, Michal Pasternak, Benjamin K Dickerman, Brendan S Crabb, Paul R Gilson, Andrew Webb, Justin A Boddey, Alan F Cowman

Journal article | 2018 | Nature Microbiology

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

Rebecca Pawliw, Rebecca Farrow, Silvana Sekuloski, Helen Jennings, Julie Healer, Phuong Thuan, Pri Sathe, Cielo Pasay, Krystal Evans, Alan F Cowman, Louis Schofield, Nanhua Chen, James McCarthy, Katharine Trenholme

Journal article | 2018 | Malaria Journal

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Jakub Gruszczyk, Rick K Huang, Li-Jin Chan, Sebastien Menant, Chuan Hong, James M Murphy, Yee-Foong Mok, Michael DW Griffin, Richard D Pearson, Wilson Wong, Alan F Cowman, Zhiheng Yu, Tham Wai-Hong

Journal article | 2018 | Nature

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article | 2018 | European Journal of Medicinal Chemistry

Evidence that the &ITPlasmodium falciparum&IT Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries

Stephanie Hallee, Justin A Boddey, Alan F Cowman, Dave Richard

Journal article | 2018 | MSPHERE

Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries.

Stéphanie Hallée, Justin A Boddey, Alan F Cowman, Dave Richard

Journal article | 2018 | mSphere

The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their ..

Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Grace E Weber, Michael T White, Anna Babakhanyan, Peter Odada Sumba, John Vulule, Dylan Ely, Chandy John, Evelina Angov, David Lanar, Sheetij Dutta, David L Narum, Toshihiro Horii, Alan Cowman, James Beeson, Joseph Smith, James W Kazura, Arlene E Dent

Journal article | 2017 | Scientific Reports

Plasmepsins on the antimalarial hit list Two studies identify plasmepsins IX and X as new antimalarial drug targets

Justin A Boddey

Journal article | 2017 | Science

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Camila Tenorio Franca, Michael T White, Wen-Qiang He, Jessica B Hostetler, Jessica Brewster, Gabriel Frato, Indu Malhotra, Jakub Gruszczyk, Christele Huon, Enmoore Lin, Benson Kiniboro, Anjali Yadava, Peter Siba, Mary R Galinski, Julie Healer, Chetan Chitnis, Alan F Cowman, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, et al.

Journal article | 2017 | eLife

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

Sash Lopaticki, Annie SP Yang, Alan John, Nichollas E Scott, James P Lingford, Matthew T O'Neill, Sara M Erickson, Nicole C McKenzie, Charlie Jennison, Lachlan W Whitehead, Donna N Douglas, Norman M Kneteman, Ethan D Goddard-Borger, Justin A Boddey

Journal article | 2017 | Nature Communications

Vaccines to Accelerate Malaria Elimination and Eventual Eradication

Julie Healer, Alan F Cowman, David C Kaslow, Ashley J Birkett

Journal article | 2017 | Cold Spring Harbor Perspectives in Medicine

AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver

Annie SP Yang, Sash Lopaticki, Matthew T O'Neill, Sara M Erickson, Donna N Douglas, Norman M Kneteman, Justin A Boddey

Journal article | 2017 | Cellular Microbiology

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

Alan F Cowman, Christopher J Tonkin, Wai-Hong Tham, Manoj T Duraisingh

Journal article | 2017 | Cell Host & Microbe

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites

Alexander T Kennedy, Lakshmi C Wijeyewickrema, Alisee Huglo, Clara Lin, Robert Pike, Alan F Cowman, Wai-Hong Tham

Journal article | 2017 | The Journal of Immunology

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Wilson Wong, Xiao-Chen Bai, Brad E Sleebs, Tony Triglia, Alan Brown, Jennifer K Thompson, Katherine E Jackson, Eric Hanssen, Danushka S Marapana, Israel S Fernandez, Stuart A Ralph, Alan F Cowman, Sjors HW Scheres, Jake Baum

Journal article | 2017 | Nature Microbiology

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Annie SP Yang, Matthew T O'Neill, Charlie Jennison, Sash Lopaticki, Cody C Allison, Jennifer S Armistead, Sara M Erickson, Kelly L Rogers, Andrew M Ellisdon, James C Whisstock, Rebecca E Tweedell, Rhoel R Dinglasan, Donna N Douglas, Norman M Kneteman, Justin A Boddey

Journal article | 2017 | Cell Reports

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

Xavier Sisquella, Thomas Nebr, Jennifer K Thompson, Lachlan Whitehead, Brian M Malpede, Nichole D Salinas, Kelly Rogers, Niraj H Tolia, Andrea Fleig, Joseph O'Neill, Wai-Hong Timm, F David Horgen, Alan F Cowman

Journal article | 2017 | eLife

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

X Sisquella, T Nebl, JK Thompson, L Whitehead, BM Malpede, ND Salinas, K Rogers, NH Tolia, A Fleig, J O’Neill, WH Tham, FD Horgen, AF Cowman

Journal article | 2017 | eLife

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article | 2017 | eLife

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis, William Nguyen, Adrian E Di Rago, Hayley E Bullen, Boris Prinz, Sandra Duffy, Jonathan B Baell, Craig A Hutton, Helene Jousset Subroux, Brendan S Crabb, Vicky M Avery, Alan F Cowman, Brad E Sleebs

Journal article | 2017 | Journal of Medicinal Chemistry

Molecular mechanisms of host cell traversal by malaria sporozoites

Annie SP Yang, Justin A Boddey

Journal article | 2017 | International Journal for Parasitology

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes

Daniel Y Bargieri, Sabine Thiberge, Chwen L Tay, Alison F Carey, Alice Rantz, Florian Hischen, Audrey Lorthiois, Ursula Straschil, Pallavi Singh, Shailja Singh, Tony Triglia, Takafumi Tsuboi, Alan Cowman, Chetan Chitnis, Pietro Alano, Jake Baum, Gabriele Pradel, Catherine Lavazec, Robert Menard

Journal article | 2016 | Cell Host & Microbe

Malaria: Biology and Disease

Alan F Cowman, Julie Healer, Danushka Marapana, Kevin Marsh

Journal article | 2016 | Cell

Role of the ER and Golgi in protein export by Apicomplexa

Michael J Coffey, Charlie Jennison, Christopher J Tonkin, Justin A Boddey

Journal article | 2016 | Current Opinion in Cell Biology

Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity

Danika L Hill, Danny W Wilson, Natalia G Sampaio, Emily M Eriksson, Victoria Ryg-Cornejo, GL Abby Harrison, Alessandro D Uboldi, Leanne J Robinson, James G Beeson, Peter Siba, Alan F Cowman, Diana S Hansen, Ivo Mueller, Louis Schofield

Journal article | 2016 | Infection and Immunity

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

Jennifer C Volz, Alan Yap, Xavier Sisquella, Jenn K Thompson, Nicholas TY Lim, Lachlan W Whitehead, Lin Chen, Marko Lampe, Wai-Hong Tham, Danny Wilson, Thomas Nebl, Danushka Marapana, Tony Triglia, Wilson Wong, Kelly L Rogers, Alan F Cowman

Journal article | 2016 | Cell Host & Microbe

Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy

Chris Y Chiu, Michael T White, Julie Healer, Jenny K Thompson, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article | 2016 | Journal of Infectious Diseases

Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article | 2016 | Bioorganic & Medicinal Chemistry

Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes

Clara S Lin, Alessandro D Uboldi, Christian Epp, Hermann Bujard, Takafumi Tsuboi, Peter E Czabotar, Alan F Cowman

Journal article | 2016 | Journal of Biological Chemistry

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

Alexander T Kennedy, Christoph Q Schmidt, Jennifer K Thompson, Greta E Weiss, Tana Taechalertpaisarn, Paul R Gilson, Paul N Barlow, Brendan S Crabb, Alan F Cowman, Wai-Hong Tham

Journal article | 2016 | The Journal of Immunology

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Justin A Boddey, Matthew T O'Neill, Sash Lopaticki, Teresa G Carvalho, Anthony N Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J Babon, Alan F Cowman

Journal article | 2016 | Nature Communications

Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort

Arlene E Dent, Indu Malhotra, Xuelie Wang, Denise Babineau, Kee Thai Yeo, Timothy Anderson, Rhonda J Kimmel, Evelina Angov, David E Lanar, David Narum, Sheetij Dutta, Jack Richards, James G Beeson, Brendan S Crabb, Alan F Cowman, Toshihiro Horii, Eric Muchiri, Peter L Mungai, Christopher L King, James W Kazura

Journal article | 2016 | Clinical and Vaccine Immunology

Vaccine development

J Healer, AF Cowman

Book Chapter | 2016

Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion

David T Riglar, Lachlan Whitehead, Alan F Cowman, Kelly L Rogers, Jake Baum

Journal article | 2016 | Journal of Cell Science

Editorial, launch of Parasite Epidemiology and Control

J Kurtzhals, A Cowman

Journal article | 2016 | Parasite Epidemiology and Control

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes

Wai-Hong Tham, Nicholas TY Lim, Greta E Weiss, Sash Lopaticki, Brendan RE Ansell, Megan Bird, Isabelle Lucet, Dominique Dorin-Semblat, Christian Doerig, Paul R Gilson, Brendan S Crabb, Alan F Cowman

Journal article | 2015 | PLOS Pathogens

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin

Journal article | 2015 | eLife

Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1

Nicholas TY Lim, Markus J Harder, Alexander T Kennedy, Clara S Lin, Christopher Weir, Alan F Cowman, Melissa J Call, Christoph Q Schmidt, Wai-Hong Tham

Journal article | 2015 | Journal of Biological Chemistry

Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes

Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman

Journal article | 2015 | Nature Structural & Molecular Biology

Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria

Chris YH Chiu, Anthony N Hodder, Clara S Lin, Danika L Hill, Connie SN Li Wai Suen, Louis Schofield, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article | 2015 | Journal of Infectious Diseases

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

Greta E Weiss, Paul R Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke WM de Jong, Katherine L Harvey, Freya JI Fowkes, Paul N Barlow, Julian C Rayner, Gavin J Wright, Alan F Cowman, Brendan S Crabb

Journal article | 2015 | PLOS Pathogens

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Matthew T O'Neill, Sash Lopaticki, Kym N Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article | 2015 | MedChemComm

Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton

Melanie Rug, Marek Cyrklaff, Antti Mikkonen, Leandro Lemgruber, Simone Kuelzer, Cecilia P Sanchez, Jennifer Thompson, Eric Hanssen, Matthew O'Neill, Christine Langer, Michael Lanzer, Friedrich Frischknecht, Alexander G Maier, Alan F Cowman

Journal article | 2014 | Blood

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1

Katherine L Harvey, Alan Yap, Paul R Gilson, Alan F Cowman, Brendan S Crabb

Journal article | 2014 | International Journal for Parasitology

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article | 2014 | eLife

Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax

Brad E Sleebs, Michelle Gazdik, Matthew T O'Neill, Pravin Rajasekaran, Sash Lopaticki, Kurt Lackovic, Kym Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey

Journal article | 2014 | Journal of Medicinal Chemistry

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes by Plasmodium falciparum

Clara S Lin, Alessandro D Uboldi, Danushka Marapana, Peter E Czabotar, Christian Epp, Hermann Bujard, Nicole L Taylor, Matthew A Perugini, Anthony N Hodder, Alan F Cowman

Journal article | 2014 | Journal of Biological Chemistry

A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

Sebastian A Mikolajczak, Viswanathan Lakshmanan, Matthew Fishbaugher, Nelly Camargo, Anke Harupa, Alexis Kaushansky, Alyse N Douglass, Michael Baldwin, Julie Healer, Matthew O'Neill, Phuong Thuan, Alan Cowman, Stefan HI Kappe

Journal article | 2014 | Molecular Therapy

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Guenther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey

Journal article | 2014 | PLoS Biology

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article | 2014 | Frontiers in Microbiology

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites

Alan Yap, Mauro F Azevedo, Paul R Gilson, Greta E Weiss, Matthew T O'Neill, Danny W Wilson, Brendan S Crabb, Alan F Cowman

Journal article | 2014 | Cellular Microbiology

The Acute Transcriptomic and Proteomic Response of HC-04 Hepatoma Cells to Hepatocyte Growth Factor and its Implications for Plasmodium falciparum Sporozoite Invasion

Dingyin Tao, Jonas G King, Rebecca E Tweedell, Philipp J Jost, Justin A Boddey, Rhoel R Dinglasan

Journal article | 2014 | Molecular and Cellular Proteomics

Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor

Hyon Ju Park, Mara Guariento, Mateusz Maciejewski, Richard Hauhart, Wai-Hong Tham, Alan F Cowman, Christoph Q Schmidt, Haydyn DT Mertens, M Kathryn Liszewski, Dennis E Hourcade, Paul N Barlow, John P Atkinson

Journal article | 2014 | Journal of Biological Chemistry

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

Michele Spring, Jittawadee Murphy, Robin Nielse, Megan Dowler, Jason W Bennett, Stasya Zarling, Jack Williams, Patricia de la Vega, Lisa Ware, Jack Komisar, Mark Polhemus, Thomas L Richie, Judy Epstein, Cindy Tamminga, Ilin Chuang, Nancy Richie, Michael O'Neil, D Gray Heppner, Julie Healer, Matthew O'Neill, et al.

Journal article | 2013 | Vaccine

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article | 2013 | PLoS One

Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion

Eric Hanssen, Chaitali Dekiwadia, David T Riglar, Melanie Rug, Leandro Lemgruber, Alan F Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum, Stuart A Ralph

Journal article | 2013 | Cellular Microbiology

Erythrocyte-Binding Antigens of Plasmodium falciparum Are Targets of Human Inhibitory Antibodies and Function To Evade Naturally Acquired Immunity

Kristina EM Persson, Freya JI Fowkes, Fiona J McCallum, Nimmo Gicheru, Linda Reiling, Jack S Richards, Danny W Wilson, Sash Lopaticki, Alan F Cowman, Kevin Marsh, James G Beeson

Journal article | 2013 | J. Immunol.

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

Jack S Richards, Thangavelu U Arumugam, Linda Reiling, Julie Healer, Anthony N Hodder, Freya JI Fowkes, Nadia Cross, Christine Langer, Satoru Takeo, Alex D Uboldi, Jennifer K Thompson, Paul R Gilson, Ross L Coppel, Peter M Siba, Christopher L King, Motomi Torii, Chetan E Chitnis, David L Narum, Ivo Mueller, Brendan S Crabb, et al.

Journal article | 2013 | Journal of Immunology

Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs

Daria Van Tyne, Alessandro D Uboldi, Julie Healer, Alan F Cowman, Dyann F Wirth

Journal article | 2013 | Antimicrobial Agents and Chemotherapy

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

Neta Regev-Rudzki, Danny W Wilson, Teresa G Carvalho, Xavier Sisquella, Bradley M Coleman, Melanie Rug, Dejan Bursac, Fiona Angrisano, Michelle Gee, Andrew F Hill, Jake Baum, Alan F Cowman

Journal article | 2013 | Cell

Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome

Justin A Boddey, Teresa G Carvalho, Anthony N Hodder, Tobias J Sargeant, Brad E Sleebs, Danushka Marapana, Sash Lopaticki, Thomas Nebl, Alan F Cowman

Journal article | 2013 | Traffic

Plasmodium Nesting: Remaking the Erythrocyte from the Inside Out

Justin A Boddey, Alan F Cowman

Journal article | 2013 | Annual Review of Microbiology

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

David T Riglar, Kelly L Rogers, Eric Hanssen, Lynne Turnbull, Hayley E Bullen, Sarah C Charnaud, Jude Przyborski, Paul R Gilson, Cynthia B Whitchurch, Brendan S Crabb, Jake Baum, Alan F Cowman

Journal article | 2013 | Nature Communications

Efficient Measurement of Opsonising Antibodies to Plasmodium falciparum Merozoites

Danika L Hill, Emily M Eriksson, Amandine B Carmagnac, Danny W Wilson, Alan F Cowman, Diana S Hansen, Louis Schofield

Journal article | 2012 | PLoS One

Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria

Damien R Drew, Anthony N Hodder, Danny W Wilson, Michael Foley, Ivo Mueller, Peter M Siba, Arlene E Dent, Alan F Cowman, James G Beeson

Journal article | 2012 | PLoS ONE

Avirulence Protein 3a (AVR3a) from the Potato Pathogen Phytophthora infestans Forms Homodimers through Its Predicted Translocation Region and Does Not Specifically Bind Phospholipids

Stephan Wawra, Mark Agacan, Justin A Boddey, Ian Davidson, Claire MM Gachon, Matteo Zanda, Severine Grouffaud, Stephen C Whisson, Paul RJ Birch, Andy J Porter, Pieter van West

Journal article | 2012 | Journal of Biological Chemistry

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Anthony N Hodder, Peter E Czabotar, Alessandro D Uboldi, Oliver B Clarke, Clara S Lin, Julie Healer, Brian J Smith, Alan F Cowman

Journal article | 2012 | Journal of Biological Chemistry

The Plasmodium falciparum Erythrocyte Invasion Ligand Pfrh4 as a Target of Functional and Protective Human Antibodies against Malaria

Linda Reiling, Jack S Richards, Freya JI Fowkes, Danny W Wilson, Watcharee Chokejindachai, Alyssa E Barry, Wai-Hong Tham, Janine Stubbs, Christine Langer, John Donelson, Pascal Michon, Livingstone Tavul, Brendan S Crabb, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article | 2012 | PLoS One

The cellular and molecular basis for malaria parasite invasion of the human red blood cell

Alan F Cowman, Drew Berry, Jake Baum

Journal article | 2012 | Journal of Cell Biology

Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony

Wieteke AM Hoeijmakers, Christian Flueck, Kees-Jan Francoijs, Arne H Smits, Johanna Wetzel, Jennifer C Volz, Alan F Cowman, Till Voss, Hendrik G Stunnenberg, Richard Bartfai

Journal article | 2012 | Cellular Microbiology

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson

Journal article | 2012 | Journal of Clinical Investigation

Unveiling malaria's "cloak of invisibility": The role of PfSET10 in the genetic control of P. falciparum virulence

Jennifer C Volz, Alan F Cowman

Journal article | 2012 | Virulence

Biochemical and Functional Analysis of Two Plasmodium falciparum Blood-Stage 6-Cys Proteins: P12 and P41

Tana Taechalertpaisarn, Cecile Crosnier, S Josefin Bartholdson, Anthony N Hodder, Jenny Thompson, Leyla Y Bustamante, Danny W Wilson, Paul R Sanders, Gavin J Wright, Julian C Rayner, Alan F Cowman, Paul R Gilson, Brendan S Crabb

Journal article | 2012 | PLoS One

Investigation of the Plasmodium falciparum Food Vacuole through Inducible Expression of the Chloroquine Resistance Transporter (PfCRT)

Florian Ehlgen, James S Pham, Tania de Koning-Ward, Alan F Cowman, Stuart A Ralph

Journal article | 2012 | PLoS One

Ag-specific recall of cytokine producing CD4 and CD8 T cells in humans immunized with genetically attenuated Plasmodium falciparum sporozoite

Stasya Zarling, Michele Spring, Lindsey Ehrler, Isaac Chalom, Theresa Funk, Alan Cowman, Christian Ockenhouse, Cate Speake, D Heppner, Patrick Duffy, Stefan Kappe, Urszula Krzych

Conference Proceedings | 2012 | JOURNAL OF IMMUNOLOGY

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn DT Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow

Journal article | 2012 | PLoS One

Biosynthesis, Localization, and Macromolecular Arrangement of the Plasmodium falciparum Translocon of Exported Proteins (PTEX)

Hayley E Bullen, Sarah C Charnaud, Ming Kalanon, David T Riglar, Chaitali Dekiwadia, Niwat Kangwanrangsan, Motomi Torii, Takafumi Tsuboi, Jacob Baum, Stuart A Ralph, Alan F Cowman, Tania F de Koning-Ward, Brendan S Crabb, Paul RD Gilson

Journal article | 2012 | Journal of Biological Chemistry

Antibodies against a Plasmodium falciparum antigen PfMSPDBL1 inhibit merozoite invasion into human erythrocytes

Hirokazu Sakamoto, Satoru Takeo, Alexander G Maier, Jetsumon Sattabongkot, Alan F Cowman, Takafumi Tsuboi

Journal article | 2012 | Vaccine

Spatial Localisation of Actin Filaments across Developmental Stages of the Malaria Parasite

Fiona Angrisano, David T Riglar, Angelika Sturm, Jennifer C Volz, Michael J Delves, Elizabeth S Zuccala, Lynne Turnbull, Chaitali Dekiwadia, Maya A Olshina, Danushka S Marapana, Wilson Wong, Vanessa Mollard, Clare H Bradin, Christopher J Tonkin, Peter W Gunning, Stuart A Ralph, Cynthia B Whitchurch, Robert E Sinden, Alan F Cowman, Geoffrey I McFadden, et al.

Journal article | 2012 | PLoS One

PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division

Jennifer C Volz, Richard Bartfai, Michaela Petter, Christine Langer, Gabrielle A Josling, Takafumi Tsuboi, Frank Schwach, Jake Baum, Julian C Rayner, Henk G Stunnenberg, Michael F Duffy, Alan F Cowman

Journal article | 2012 | Cell Host & Microbe

PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division

JC Volz, R Bartfai, M Petter, C Langer, G JOSLING, T Tsuboi, F Schwach, J Baum, JC Rayner, HG Stunnenberg, MF Duffy, AF Cowman

Journal article | 2012 | Cell Host & Microbe

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Wai-Hong Tham, Julie Healer, Alan F Cowman

Journal article | 2012 | Trends in Parasitology

Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen

Thangavelu U Arumugam, Satoru Takeo, Tsutomu Yamasaki, Amporn Thonkukiatkul, Kazutoyo Miura, Hitoshi Otsuki, Hong Zhou, Carole A Long, Jetsumon Sattabongkot, Jennifer Thompson, Danny W Wilson, James G Beeson, Julie Healer, Brendan S Crabb, Alan F Cowman, Motomi Torii, Takafumi Tsuboi

Journal article | 2011 | Infect. Immun.

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman

Journal article | 2011 | PLoS Pathogens

Quantitative in vivo Analyses Reveal Calcium-dependent Phosphorylation Sites and Identifies a Novel Component of the Toxoplasma Invasion Motor Complex

Thomas Nebl, Judith Helena Prieto, Eugene Kapp, Brian J Smith, Melanie J Williams, John R Yates, Alan F Cowman, Christopher J Tonkin

Journal article | 2011 | PLoS Pathogens

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes

Wai-Hong Tham, Christoph Q Schmidt, Richard E Hauhart, Mara Guariento, Patience B Tetteh-Quarcoo, Sash Lopaticki, John P Atkinson, Paul N Barlow, Alan F Cowman

Journal article | 2011 | Blood

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites

Sebastian A Mikolajczak, John B Sacci, Patricia De La Vega, Nelly Camargo, Kelly VanBuskirk, Urszula Krzych, Jun Cao, Marcelo Jacobs-Lorena, Alan F Cowman, Stefan HI Kappe

Journal article | 2011 | Cellular Microbiology

Revealing a Parasite's Invasive Trick

Jake Baum, Alan F Cowman

Journal article | 2011 | Science

Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman

Journal article | 2011 | PLoS Pathogens

A Genome-wide Chromatin-associated Nuclear Peroxiredoxin from the Malaria Parasite Plasmodium falciparum

Dave Richard, Richard Bartfai, Jennifer Volz, Stuart A Ralph, Sylke Muller, Hendrik G Stunnenberg, Alan F Cowman

Journal article | 2011 | Journal of Biological Chemistry

Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites

Sash Lopaticki, Alexander G Maier, Jennifer Thompson, Danny W Wilson, Wai-Hong Tham, Tony Triglia, Alex Gout, Terence P Speed, James G Beeson, Julie Healer, Alan F Cowman

Journal article | 2011 | Infection and Immunity

Expression of P. falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter

Michaela Petter, Chin Chin Lee, Timothy J Byrne, Katja E Boysen, Jennifer Volz, Stuart A Ralph, Alan F Cowman, Graham V Brown, Michael F Duffy

Journal article | 2011 | PLoS Pathogens

A Tail of Division

Alan F Cowman, Christopher J Tonkin

Journal article | 2011 | Science

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

David T Riglar, Dave Richard, Danny W Wilson, Michelle J Boyle, Chaitali Dekiwadia, Lynne Turnbull, Fiona Angrisano, Danushka S Marapana, Kelly L Rogers, Cynthia B Whitchurch, James G Beeson, Alan F Cowman, Stuart A Ralph, Jake Baum

Journal article | 2011 | Cell Host & Microbe

Has the time come for us to complement our malaria parasites?

Daniel E Goldberg, Chris J Janse, Alan F Cowman, Andrew P Waters

Journal article | 2011 | Trends in Parasitology

Gene deletion from Plasmodium falciparum using FLP and Cre recombinases: Implications for applied site-specific recombination

Matthew T O'Neill, Phuong Thuan, Julie Healer, Dave Richard, Alan F Cowman

Journal article | 2011 | International Journal for Parasitology

Expression of P.falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter

M Petter, C Lee, TJ Byrne, KE Boysen, JC Volz, SAR Ralph, AF Cowman, GV Brown, M Duffy

Journal article | 2011 | PLoS Pathogens

Evidence That the Erythrocyte Invasion Ligand PfRh2 is a Target of Protective Immunity against Plasmodium falciparum Malaria

Linda Reiling, Jack S Richards, Freya JI Fowkes, Alyssa E Barry, Tony Triglia, Watcharee Chokejindachai, Pascal Michon, Livingstone Tavul, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article | 2010 | Journal of Immunology

QUANTIFYING INVASION INHIBITORY ANTIBODIES TO AMA1 IN HUMAN POPULATIONS USING TRANSGENIC PLASMODIUM FALCIPARUM: IMPLICATIONS FOR VACCINE DESIGN

Damien R Drew, Danny W Wilson, Nadia J Cross, Salenna R Elliot, Ivo Muller, Livingstone Tavul, Danielle I Stanisic, Nicolas Senn, Jack Tairaka, Peter M Siba, Julie Healer, Alan F Cowman, Anthony Hodder, James G Beeson

Conference Proceedings | 2010 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

QUANTIFYING THE IMPORTANCE OF PFEMP1 AND OTHER ANTIGENS EXPRESSED ON THE SURFACE OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES AS TARGETS OF PROTECTIVE ANTIBODIES AGAINST MALARIA

Katherine Howell, Jo-Anne Chan, Linda Reiling, Ricardo Ataide, Fiona McCallum, Peter C Bull, Alexander G Maier, Joanne Chesson, George Warimwe, Stephen J Rogerson, Alan F Cowman, Kevin Marsh, James G Beeson

Conference Proceedings | 2010 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A STRUCTURAL AND FUNCTIONAL ANALYSIS OF TWO NOVEL PLASMODIUM FALCIPARUM PROTEINS INVOLVED IN THE ERYTHROCYTE INVASION PROCESS

Anthony Hodder, Peter Czabotar, Alex Uboldi, Ping Canon, Oliver B Clarke, Clara Lin, Julie Healer, Alan F Cowman

Conference Proceedings | 2010 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

PRECLINICAL PRIORITIZATION OF BLOOD STAGE MALARIA VACCINE CANDIDATES

Julie Healer, Alex Uboldi, Ping Cannon, Tony Hodder, Jack Richards, Matt O'Neill, Alex Maier, Satoru Takeo, Thangavelu Arumugam, Motomi Torii, Takafumi Tsuboi, James Beeson, Brendan Crabb, Alan Cowman

Conference Proceedings | 2010 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Association between Naturally Acquired Antibodies to Erythrocyte-Binding Antigens of Plasmodium falciparum and Protection from Malaria and High-Density Parasitemia

Jack S Richards, Danielle I Stanisic, Freya JI Fowkes, Livingstone Tavul, Elijah Dabod, Jennifer K Thompson, Sanjeev Kumar, Chetan E Chitnis, David L Narum, Pascal Michon, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article | 2010 | Clinical Infectious Diseases

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

Wai-Hong Tham, Danny W Wilson, Sash Lopaticki, Christoph Q Schmidt, Patience B Tetteh-Quarcoo, Paul N Barlow, Dave Richard, Jason E Corbin, James G Beeson, Alan F Cowman

Journal article | 2010 | Proceedings of the National Academy of Sciences of the United States of America

Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P-falciparum-infected erythrocyte

Simone Kuelzer, Melanie Rug, Klaus Brinkmann, Ping Cannon, Alan Cowman, Klaus Lingelbach, Gregory L Blatch, Alexander G Maier, Jude M Przyborski

Journal article | 2010 | Cellular Microbiology

Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes

Daniel E Goldberg, Alan F Cowman

Journal article | 2010 | Nature Reviews Microbiology

Editorial - ICOPA down under

Alex Loukas, Terry Spithill, Alan Cowman

Journal article | 2010 | International Journal for Parasitology

Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009

Ngo V Thanh, Tran Q Toan, Alan F Cowman, Gerard J Casey, Bui Q Phuc, Nong T Tien, Nguyen M Hung, Beverley-Ann Biggs

Journal article | 2010 | Malaria Journal

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

Kerstin Leykauf, Moritz Treeck, Paul R Gilson, Thomas Nebl, Thomas Braulke, Alan F Cowman, Tim W Gilberger, Brendan S Crabb

Journal article | 2010 | PLoS Pathogens

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

Stefan HI Kappe, Ashley M Vaughan, Justin A Boddey, Alan F Cowman

Journal article | 2010 | Science

Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites

Dave Richard, Christopher A MacRaild, David T Riglar, Jo-Anne Chan, Michael Foley, Jake Baum, Stuart A Ralph, Raymond S Norton, Alan F Cowman

Journal article | 2010 | Journal of Biological Chemistry

Plasmodium falciparum PF10_0164 (ETRAMP10.3) Is an Essential Parasitophorous Vacuole and Exported Protein in Blood Stages

Drew C MacKellar, Matthew T O'Neill, Ahmed SI Aly, John B Sacci, Alan F Cowman, Stefan HI Kappe

Journal article | 2010 | Eukaryotic Cell

An aspartyl protease directs malaria effector proteins to the host cell

Justin A Boddey, Anthony N Hodder, Svenja Guenther, Paul R Gilson, Heather Patsiouras, Eugene A Kapp, J Andrew Pearce, Tania F de Koning-Ward, Richard J Simpson, Brendan S Crabb, Alan F Cowman

Journal article | 2010 | Nature

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

Jennifer Volz, Teresa G Carvalho, Stuart A Ralph, Paul Gilson, Jenny Thompson, Christopher J Tonkin, Christine Langer, Brendan S Crabb, Alan F Cowman

Journal article | 2010 | International Journal for Parasitology

ACQUISITION OF ANTIBODIES TO THE PFRH2 INVASION LIGANDS OF PLASMODIUM FALCIPARUM AND THEIR ASSOCIATION WITH PROTECTION FROM MALARIA

Linda Reiling, Jack S Richards, Tony Triglia, Watcharee Chokejindachai, John E Donelson, Elijah Dabod, Pascal Michon, Livingstone Tavul, Alan F Cowman, Ivo Mueller, James G Beeson

Conference Proceedings | 2009 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

PFEMP1 IS THE MAJOR TARGET OF ANTIBODIES TO THE SURFACE OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES THAT ARE ASSOCIATED WITH PROTECTION FROM MALARIA

Katherine Howell, Joanne M Chesson, Linda Reiling, Peter C Bull, George Warimwe, Alan F Cowman, Kevin Marsh, James G Beeson

Conference Proceedings | 2009 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Reticulocyte binding protein homologues are key adhesins during erythrocyte invasion by Plasmodium falciparum

Tony Triglia, Wai-Hong Tham, Anthony Hodder, Alan F Cowman

Journal article | 2009 | Cell. Microbiol.

ANTIBODIES AGAINST THE ERYTHROCYTE BINDING ANTIGENS OF PLASMODIUM FALCIPARUM ARE STRONGLY ASSOCIATED WITH PROTECTION AGAINST CLINICAL MALARIA AND HIGH PARASITEMIA

Jack S Richards, Danielle I Stanisic, Pascal Michon, Elijah Dabod, Chetan E Chitnis, David E Narum, Jennifer K Thompson, Alan F Cowman, Ivo Mueller, James G Beeson

Conference Proceedings | 2009 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

EXPORT OF MALARIAL VIRULENCE PROTEINS THAT REMODEL INFECTED HUMAN ERYTHROCYTES

Justin A Boddey, Anthony N Hodder, Svenja Gunther, Paul R Gilson, Heather Patsiouras, Eugene A Kapp, J Andrew Pearce, Richard J Simpson, Brendan S Crabb, Alan F Cowman

Conference Proceedings | 2009 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role

Hayley E Bullen, Christopher J Tonkin, Rebecca A O'Donnell, Wai-Hong Tham, Anthony T Papenfuss, Sven Gould, Alan F Cowman, Brendan S Crabb, Paul R Gilson

Journal article | 2009 | Journal of Biological Chemistry

Differential, Positional-Dependent Transcriptional Response of Antigenic Variation (var) Genes to Biological Stress in Plasmodium falciparum

Elli Rosenberg, Amir Ben-Shmuel, Oshrit Shalev, Rosa Sinay, Alan Cowman, Yaakov Pollack

Journal article | 2009 | PLoS ONE

Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors

Christian Flueck, Richard Bartfai, Jennifer Volz, Igor Niederwieser, Adriana M Salcedo-Amaya, Blaise TF Alako, Florian Ehlgen, Stuart A Ralph, Alan F Cowman, Zbynek Bozdech, Hendrik G Stunnenberg, Till S Voss

Journal article | 2009 | PLoS Pathogens

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

Kelley M VanBuskirk, Matthew T O'Neill, Patricia De la Vega, Alexander G Maier, Urszula Krzych, Jack Williams, Megan G Dowler, John B Sacci, Niwat Kangwanrangsan, Takafumi Tsuboi, Norman M Kneteman, Donald G Heppner, Brant A Murdock, Sebastian A Mikolajczak, Ahmed SI Aly, Alan F Cowman, Stefan HI Kappe

Journal article | 2009 | Proceedings of the National Academy of Sciences

A newly discovered protein export machine in malaria parasites

Tania F de Koning-Ward, Paul R Gilson, Justin A Boddey, Melanie Rug, Brian J Smith, Anthony T Papenfuss, Paul R Sanders, Rachel J Lundie, Alexander G Maier, Alan F Cowman, Brendan S Crabb

Journal article | 2009 | Nature

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

Jake Baum, Anthony T Papenfuss, Gunnar R Mair, Chris J Janse, Dina Vlachou, Andrew P Waters, Alan F Cowman, Brendan S Crabb, Tania F de Koning-Ward

Journal article | 2009 | Nucleic Acids Research

Antibodies to Reticulocyte Binding Protein-Like Homologue 4 Inhibit Invasion of Plasmodium falciparum into Human Erythrocytes

Wai-Hong Tham, Danny W Wilson, Linda Reiling, Lin Chen, James G Beeson, Alan F Cowman

Journal article | 2009 | Infect. Immun.

Malaria parasite proteins that remodel the host erythrocyte

Alexander G Maier, Brian M Cooke, Alan F Cowman, Leann Tilley

Journal article | 2009 | Nature Reviews Microbiology

Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes

Tiffany M DeSimone, Cameron V Jennings, Amy K Bei, Christy Comeaux, Bradley I Coleman, Philippe Refour, Tony Triglia, Janine Stubbs, Alan F Cowman, Manoj T Duraisingh

Journal article | 2009 | Molecular Microbiology

Polymorphisms in Erythrocyte Binding Antigens 140 and 181 Affect Function and Binding but Not Receptor Specificity in Plasmodium falciparum

Alexander G Maier, Jake Baum, Brian Smith, David J Conway, Alan F Cowman

Journal article | 2009 | Infection and Immunity

Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum

Christopher J Tonkin, Celine K Carret, Manoj T Duraisingh, Till S Voss, Stuart A Ralph, Mirja Hommel, Michael F Duffy, Liliana Mancio da Silva, Artur Scherf, Alasdair Ivens, Terence P Speed, James G Beeson, Alan F Cowman

Journal article | 2009 | PLoS Biology

Identification of Rhoptry Trafficking Determinants and Evidence for a Novel Sorting Mechanism in the Malaria Parasite Plasmodium falciparum

Dave Richard, Lev M Kats, Christine Langer, Casilda G Black, Khosse Mitri, Justin A Boddey, Alan F Cowman, Ross L Coppel

Journal article | 2009 | PLoS Pathogens

Role of the Plasmodium Export Element in Trafficking Parasite Proteins to the Infected Erythrocyte

Justin A Boddey, Robert L Moritz, Richard J Simpson, Alan F Cowman

Journal article | 2009 | Traffic

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

Ashley M Vaughan, Matthew T O'Neill, Alice S Tarun, Nelly Camargo, Thuan M Phuong, Ahmed SI Aly, Alan F Cowman, Stefan HI Kappe

Journal article | 2009 | Cellular Microbiology

Reticulocyte-binding protein homologue 5-An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

Jake Baum, Lin Chen, Julie Healer, Sash Lopaticki, Michelle Boyle, Tony Triglia, Florian Ehlgen, Stuart A Ralph, James G Beeson, Alan F Cowman

Journal article | 2009 | International Journal for Parasitology

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Anthony N Hodder, Alexander G Maier, Melanie Rug, Monica Brown, Mirja Hommel, Ivan Pantic, Marina Puig-de-Morales-Marinkovic, Brian Smith, Tony Triglia, James Beeson, Alan F Cowman

Journal article | 2009 | Mol. Microbiol.

Spotlight on malaria: MAM2008

Brian M Cooke, Brendan S Crabb, Alan Cowman

Journal article | 2008 | Trends in Parasitology

Prevalence of polymorphisms in DHFR, DHPS, PFMDR1 and PFCRT genes of Plasmodium falciparum isolates in Quang Tri Province, Vietnam.

Bui Q Phuc, Sonia R Caruana, Alan F Cowman, Beverley-Ann Biggs, Ngo V Thanh, Nong T Tien, Le K Thuan

Journal article | 2008 | Southeast Asian Journal of Tropical Medicine and Public Health

In 2002 an antimalarial drug resistance survey was carried out in a seasonally endemic area of Vietnam. Sulfadoxine/pyrimethamine ..

The genome of the simian and human malaria parasite Plasmodium knowlesi

A Pain, U Bohme, AE Berry, K Mungall, RD Finn, AP Jackson, T Mourier, J Mistry, EM Pasini, MA Aslett, S Balasubrammaniam, K Borgwardt, K Brooks, C Carret, TJ Carver, I Cherevach, T Chillingworth, TG Clark, MR Galinski, N Hall, et al.

Journal article | 2008 | Nature

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

Alexander G Maier, Melanie Rug, Matthew T O'Neill, Monica Brown, Srabasti Chakravorty, Tadge Szestak, Joanne Chesson, Yang Wu, Katie Hughes, Ross L Coppel, Chris Newbold, James G Beeson, Alister Craig, Brendan S Crabb, Alan F Cowman

Journal article | 2008 | Cell

Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism

Nicole S Struck, Susann Herrmann, Christine Langer, Andreas Krueger, Bernardo J Foth, Klemens Engelberg, Ana L Cabrera, Silvia Haase, Moritz Treeck, Matthias Marti, Alan F Cowman, Tobias Spielmann, Tim W Gilberger

Journal article | 2008 | Journal of Cell Science

The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of Plasmodium falciparum-infected erythrocytes

Cornelia Spycher, Melanie Rug, Esther Pachlatko, Eric Hanssen, David Ferguson, Alan F Cowman, Leann Tilley, Hans-Peter Beck

Journal article | 2008 | Molecular Microbiology

Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata

Sven B Gould, Wai-Hong Tham, Alan F Cowman, Geoffrey I McFadden, Ross F Waller

Journal article | 2008 | Molecular Biology and Evolution

The malaria menace

A Cowman

Journal article | 2008 | Australian Life Scientist

Evolution of malaria parasite plastid targeting sequences

Christopher J Tonkin, Bernardo J Foth, Stuart A Ralph, Nicole Struck, Alan F Cowman, Geoffrey I McFadden

Journal article | 2008 | Proceedings of the National Academy of Sciences of the United States of America

Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum

Silvia Haase, Ana Cabrera, Christine Langer, Moritz Treeck, Nicole Struck, Susann Herrmann, Pascal W Jansen, Iris Bruchhaus, Anna Bachmann, Suzana Dias, Alan F Cowman, Hendrik G Stunnenberg, Tobias Spielmann, Tim-Wolf Gilberger

Journal article | 2008 | Infection and Immunity

Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum

Nicole S Struck, Susann Herrmann, Iris Schmuck-Barkmann, Suzana de Souza Dias, Silvia Haase, Ana L Cabrera, Moritz Treeck, Caroline Bruns, Christine Langer, Alan F Cowman, Matthias Marti, Tobias Spielmann, Tim W Gilberger

Journal article | 2008 | Molecular Microbiology

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

Jake Baum, Christopher J Tonkin, Aditya S Paul, Melanie Rug, Brian J Smith, Sven B Gould, Dave Richard, Thomas D Pollard, Alan F Cowman

Journal article | 2008 | Cell Host & Microbe