Natasha Zamudio

Runx3 drives a CD8( ) T cell tissue residency program that is absent in CD4( ) T cells

Raissa Fonseca, Thomas N Burn, Luke C Gandolfo, Sapna Devi, Simone L Park, Andreas Obers, Maximilien Evrard, Susan N Christo, Frank A Buquicchio, Caleb A Lareau, Keely M McDonald, Sarah K Sandford, Natasha M Zamudio, Nagela G Zanluqui, Ali Zaid, Terence P Speed, Ansuman T Satpathy, Scott N Mueller, Francis R Carbone, Laura K Mackay

Journal article  |  2022  |  NATURE IMMUNOLOGY

Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription fac..

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  CELL REPORTS

Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor s..

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  NATURE

Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function1. Among the genes..

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

Joan Barau, Aurélie Teissandier, Natasha Zamudio, Stéphanie Roy, Valérie Nalesso, Yann Hérault, Florian Guillou, Déborah Bourc'his

Journal article  |  2016  |  Science

DNA methylation is prevalent in mammalian genomes and plays a central role in the epigenetic control of development. The mammalian..

DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.

Natasha Zamudio, Joan Barau, Aurélie Teissandier, Marius Walter, Maté Borsos, Nicolas Servant, Déborah Bourc'his

Journal article  |  2015  |  Genes Dev

DNA methylation is essential for protecting the mammalian germline against transposons. When DNA methylation-based transposon cont..

MORC1 represses transposable elements in the mouse male germline

William A Pastor, Hume Stroud, Kevin Nee, Wanlu Liu, Dubravka Pezic, Sergei Manakov, Serena A Lee, Guillaume Moissiard, Natasha Zamudio, Deborah Bourc'his, Alexei A Aravin, Amander T Clark, Steven E Jacobsen

Journal article  |  2014  |  NATURE COMMUNICATIONS

The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of la..

The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals

Rachel Duffie, Sophie Ajjan, Maxim V Greenberg, Natasha Zamudio, Martin Escamilla del Arenal, Julian Iranzo, Ikuhiro Okamoto, Sandrine Barbaux, Patricia Fauque, Deborah Bourc'his

Journal article  |  2014  |  GENES & DEVELOPMENT

Many loci maintain parent-of-origin DNA methylation only briefly after fertilization during mammalian development: Whether this fo..

The mammalian-specific Tex19.1 gene plays an essential role in spermatogenesis and placenta-supported development

Yara Tarabay, Emmanuelle Kieffer, Marius Teletin, Catherine Celebi, Aafke Van Montfoort, Natasha Zamudio, Mayada Achour, Rosy El Ramy, Emese Gazdag, Philippe Tropel, Manuel Mark, Deborah Bourc'his, Stephane Viville

Journal article  |  2013  |  HUMAN REPRODUCTION

STUDY QUESTION: What is the consequence of Tex19.1 gene deletion in mice? SUMMARY ANSWER: The Tex19.1 gene is important in spermat..

DNMT3L Is a Regulator of X Chromosome Compaction and Post-Meiotic Gene Transcription

Natasha M Zamudio, Hamish S Scott, Katja Wolski, Chi-Yi Lo, Charity Law, Dillon Leong, Sarah A Kinkel, Suyinn Chong, Damien Jolley, Gordon K Smyth, David de Kretser, Emma Whitelaw, Moira K O'Bryan

Journal article  |  2011  |  PLOS ONE

Previous studies on the epigenetic regulator DNA methyltransferase 3-Like (DNMT3L), have demonstrated it is an essential regulator..