Kate Graham

Protocol for assessment of the pupillary light reflex in dogs without chemical restraint: preliminary investigation

KL Graham, C McCowan, A White

Journal article  |  2020  |  JOURNAL OF SMALL ANIMAL PRACTICE

OBJECTIVE: To explore the use of a modified pupillometry technique in dogs without chemical restraint. MATERIALS AND METHODS: Foll..

A technique for shotgun proteomic analysis of the precorneal tear film in dogs with naturally occurring primary glaucoma

Kathleen L Graham, Eve Diefenbach, Christina I McCowan, Andrew JR White

Journal article  |  2020  |  VETERINARY OPHTHALMOLOGY

OBJECTIVE: To introduce a protocol for the characterization of protein patterns in tears of dogs with primary angle closure glauco..

IL-21 regulates SOCS1 expression in autoreactive CD8( ) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

Andrew PR Sutherland, Kate L Graham, Michelle Papadimitriou, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  SCIENTIFIC REPORTS

In type 1 diabetes, maturation of activated autoreactive CD8+ T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs..

Optical coherence tomography of the retina, nerve fiber layer, and optic nerve head in dogs with glaucoma

Kathleen L Graham, Christina I McCowan, Kelly Caruso, F Mark Billson, Cameron JG Whittaker, Andrew White

Journal article  |  2019  |  VETERINARY OPHTHALMOLOGY

OBJECTIVE: To evaluate the retina and optic nerve head (ONH) in canine eyes predisposed to glaucoma using optical coherence tomogr..

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  DIABETES

Recent advances in immunotherapeutics have not yet changed the routine management of autoimmune type 1 diabetes. There is an oppor..

Cognate antigen engagement on parenchymal cells stimulates CD8( ) T cell proliferation in situ

Robyn M Sutherland, Sarah L Londrigan, Jamie L Brady, Emma M Carrington, Julia M Marchingo, Susanne Heinzel, Philip D Hodgkin, Kate L Graham, Thomas W Kay, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  NATURE COMMUNICATIONS

T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then..

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

Jessica A Pane, Fiona E Fleming, Kate L Graham, Helen E Thomas, Thomas WH Kay, Barbara S Coulson

Journal article  |  2016  |  SCIENTIFIC REPORTS

Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates dia..

Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

Gaurang Jhala, Jonathan Chee, Prerak M Trivedi, Claudia Selck, Esteban N Gurzov, Kate L Graham, Helen E Thomas, Thomas WH Kay, Balasubramanian Krishnamurthy

Journal article  |  2016  |  JCI INSIGHT

High-affinity self-reactive thymocytes are purged in the thymus, and residual self-reactive T cells, which are detectable in healt..

Perforin facilitates beta cell killing and regulates autoreactive CD8( ) T-cell responses to antigen in mouse models of type 1 diabetes

Prerak Trivedi, Kate L Graham, Balasubramaninan Krishnamurthy, Stacey Fynch, Robyn M Slattery, Thomas Wh Kay, Helen E Thomas

Journal article  |  2016  |  IMMUNOLOGY AND CELL BIOLOGY

In type 1 diabetes, cytotoxic CD8(+) T lymphocytes (CTLs) directly interact with pancreatic beta cells through major histocompatib..

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N Gurzov, Thomas C Brodnicki, Kate L Graham, Jibran A Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E Thomas, Thomas WH Kay

Journal article  |  2015  |  DIABETES

Because regulatory T-cell (Treg) development can be induced by the same agonist self-antigens that induce negative selection, pert..