Fabienne Mackay

CD8 T Cells Promote Pathological Angiogenesis in Ocular Neovascular Disease.

Devy Deliyanti, William A Figgett, Thomas Gebhardt, Joseph A Trapani, Fabienne Mackay, Jennifer L Wilkinson-Berka

Journal article  |  2023  |  Arterioscler Thromb Vasc Biol

BACKGROUND: CD4+ and CD8+ T cells are increased in the ocular fluids of patients with neovascular retinopathy, yet their role in t..

Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization

Marija Dinevska, Samuel S Widodo, Liam Furst, Lucero Cuzcano, Yitong Fang, Stefano Mangiola, Paul J Neeson, Phillip K Darcy, Robert G Ramsay, Ryan Hutchinson, Fabienne MacKay, Michael Christie, Stanley S Stylli, Theo Mantamadiotis

Journal article  |  2022  |  CELLULAR ONCOLOGY

PURPOSE: Tumor cells thrive by adapting to the signals in their microenvironment. To adapt, cancer cells activate signaling and tr..

The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells

Pin Shie Quah, Vivien Sutton, Eden Whitlock, William A Figgett, Daniel M Andrews, Kirsten A Fairfax, Fabienne Mackay

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to inn..

Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor.

Yuan Min Wang, Karli Shaw, Geoff Yu Zhang, Edmund YM Chung, Min Hu, Qi Cao, Yiping Wang, Guoping Zheng, Huiling Wu, Steven J Chadban, Hugh J McCarthy, David CH Harris, Fabienne Mackay, Shane T Grey, Stephen I Alexander

Journal article  |  2022  |  J Am Soc Nephrol

BACKGROUND: The cytokine IL-33 is an activator of innate lymphoid cells 2 (ILC2s) in innate immunity and allergic inflammation. B ..

Understand SLE heterogeneity in the era of omics, big data, and artificial intelligence

Prianka Puri, Simon H Jiang, Yang Yang, Fabienne Mackay, Di Yu

Journal article  |  2021  |  Rheumatology & Autoimmunity

Long-term exposure to monoclonal anti-TNF is associated with an increased risk of lymphoma in BAFF-transgenic mice

Gaetane Nocturne, Bineta Ly, Audrey Paoletti, Juliette Pascaud, Raphaele Seror, Carole Nicco, Fabienne Mackay, FB Vincent, Thierry Lazure, Sophie Ferlicot, Lev Stimmer, Quentin Pascal, Sandrine Roulland, Roman Krzysiek, Salima Hacein-Bey, Frederic Batteux, Xavier Mariette

Journal article  |  2021  |  CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The impact of treatment on the risk of lymphoma in patients with rheumatoid arthritis (RA) is unclear. Here, we aimed to assess if..

B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF

Maha M Bakhuraysah, Paschalis Theotokis, Jae Young Lee, Amani A Alrehaili, Pei-Mun Aui, William A Figgett, Michael F Azari, John-Paul Abou-Afech, Fabienne Mackay, Christopher Siatskas, Frank Alderuccio, Stephen M Strittmatter, Nikolaos Grigoriadis, Steven Petratos

Journal article  |  2021  |  SCIENTIFIC REPORTS

We have previously reported evidence that Nogo-A activation of Nogo-receptor 1 (NgR1) can drive axonal dystrophy during the neurol..

Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation

Yan Zhu, Tatsumi Hirata, Fabienne Mackay, Fujio Murakami

Journal article  |  2020  |  SCIENTIFIC REPORTS

Long distance tangential migration transports neurons from their birth places to distant destinations to be incorporated into neur..

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8( )T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8 T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Journal article  |  2020  |  The Journal of Immunology

Abstract Interactions with the microbiota influence many aspects of immunity, including immune cell development, di..