Lorna Hale

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

Kynan T Lawlor, Jessica M Vanslambrouck, J William Higgins, Alison Chambon, Kristina Bishard, Derek Arndt, Pei Xuan Er, Sean B Wilson, Sara E Howden, Ker Sin Tan, Fanyi Li, Lorna J Hale, Benjamin Shepherd, Stephen Pentoney, Sharon C Presnell, Alice E Chen, Melissa H Little

Journal article  |  2020  |  Nature Materials

Directed differentiation of human pluripotent stem cells to kidney organoids brings the prospect of drug screening, disease modell..

Generating Kidney from Stem Cells

Melissa H Little, Lorna J Hale, Sara E Howden, Santhosh V Kumar

Journal article  |  2019  |  Annual Review of Physiology

Evaluation of variability in human kidney organoids

Belinda Phipson, Pei X Er, Alexander N Combes, Thomas A Forbes, Sara E Howden, Luke Zappia, Hsan-Jan Yen, Kynan T Lawlor, Lorna J Hale, Jane Sun, Ernst Wolvetang, Minoru Takasato, Alicia Oshlack, Melissa H Little

Journal article  |  2019  |  Nature Methods

3D organoid-derived human glomeruli for personalised podocyte disease model ling and drug screening

Lorna J Hale, Sara E Howden, Belinda Phipson, Andrew Lonsdale, Pei X Er, Irene Ghobrial, Salman Hosawi, Sean Wilson, Kynan T Lawlor, Shahnaz Khan, Alicia Oshlack, Catherine Quinlan, Rachel Lennon, Melissa H Little

Journal article  |  2018  |  Nature Communications

RAPID TRANSLATION OF NOVEL NEPHROGENETIC AETIOLOGIES FROM FIRST REPORT TO ACCREDITED DIAGNOSTIC OUTCOME

AJ Mallett, C Patel, J Crawford, L Hale, G Ho, K Holman, B Bennetts, M Little, I Smyth, C Simons

Conference Proceedings  |  2018  |  NEPHROLOGY

Shining a Light on Alport Syndrome

Lorna J Hale, Melissa H Little

Journal article  |  2018  |  Cell Chemical Biology

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

Thomas A Forbes, Sara E Howden, Kynan Lawlor, Belinda Phipson, Jovana Maksimovic, Lorna Hale, Sean Wilson, Catherine Quinlan, Gladys Ho, Katherine Holman, Bruce Bennetts, Joanna Crawford, Peter Trnka, Alicia Oshlack, Chirag Patel, Andrew Mallett, Cas Simons, Melissa H Little

Journal article  |  2018  |  American Journal of Human Genetics

OPTIMISATION OF KIDNEY ORGANOIDS AS A REPRODUCIBLE AND DEVELOPMENTALLY ACCURATE MODEL OF HUMAN KIDNEY DEVELOPMENT AND DISEASE

Melissa H Little, Pei X Er, Belinda Phipson, Jessica Vanslambrouck, Sara Howden, Lorna Hale, Minoru Takasato, A Oshlack

Conference Proceedings  |  2018  |  JOURNAL OF GENE MEDICINE