Kevin Lee

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

Frederick M Lang, Kevin M-C Lee, John R Teijaro, Burkhard Becher, John A Hamilton

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain

Damini Tewari, Andrew D Cook, Ming-Chin Lee, Anne D Christensen, Andrew Croxford, Burkhard Becher, Daniel Poole, Pradeep Rajasekhar, Nigel Bunnett, Julia E Smith, John A Hamilton, Stephen B McMahon

Journal article  |  2020  |  JOURNAL OF NEUROSCIENCE

The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent yea..

GM-CSF: A Promising Target in Inflammation and Autoimmunity

Kevin MC Lee, Adrian A Achuthan, John A Hamilton

Journal article  |  2020  |  IMMUNOTARGETS AND THERAPY

The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro t..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  JOURNAL OF CLINICAL INVESTIGATION

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

Studies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/m..

CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGY

Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, ..

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, w..