Zhenjun Chen

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Zhongfang Wang, Xiaoyun Yang, Jiaying Zhong, Yumin Zhou, Zhiqiang Tang, Haibo Zhou, Jun He, Xinyue Mei, Yonghong Tang, Bijia Lin, Zhenjun Chen, James McCluskey, Ji Yang, Alexandra J Corbett, Pixin Ran

Journal article  |  2021  |  NATURE COMMUNICATIONS

T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is know..

Mouse models illuminate MAIT cell biology

Huimeng Wang, Zhenjun Chen, James McCluskey, Alexandra J Corbett

Journal article  |  2021  |  MOLECULAR IMMUNOLOGY

The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based ..

Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

Alexandra J Corbett, Wael Awad, Huimeng Wang, Zhenjun Chen

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I relate..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Hui Fern Koay, Shian Su, Daniela Amann-Zalcenstein, Stephen R Daley, Iain Comerford, Carly E Whyte, Igor E Konstantinov, Yves d'Udekem, Tracey Baldwin, Peter F Hickey, Stuart P Berzins, Jeffrey YW Mak, Axel Kallies, Zhenjun Chen, Simone Nussing, Katherine Kedzierska, Laura K Mackay, Shaun R McColl, Elissa K Deenick, David P Fairlie, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Journal article  |  2020  |  ALLERGY

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang, Yifan Zhan, Gen Lu

Journal article  |  2020  |  MUCOSAL IMMUNOLOGY

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In e..

Study of MAIT Cell Activation in Viral Infections In Vivo

Timothy SC Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2020  |  MAIT CELLS: METHODS AND PROTOCOLS

MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR)..

MAIT Cells Promote Tumor Initiation, Grow and Metastases via Tumor MR1

Juming Yan, Stacey Allen, Elizabeth McDonald, Indrajit Das, Jeffrey YW Mak, Ligong Liu, David P Fairlie, Bronwyn S Meehan, Zhenjun Chen, Alexandra J Corbett, Antiopi Varelias, Mark J Smyth, Michele WL Teng

Journal article  |  2020  |  CANCER DISCOVERY

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I-related protein 1 (MR1) for their dev..

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Jan Petersen, Laura Ciacchi, Mai T Tran, Khai Lee Loh, Yvonne Kooy-Winkelaar, Nathan P Croft, Melinda Y Hardy, Zhenjun Chen, James McCluskey, Robert P Anderson, Anthony W Purcell, Jason A Tye-Din, Frits Koning, Hugh H Reid, Jamie Rossjohn

Journal article  |  2019  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celia..