Zhenjun Chen

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Journal article  |  2020  |  Allergy

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang, Yifan Zhan, Gen Lu

Journal article  |  2020  |  Mucosal Immunology

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In e..

Study of MAIT Cell Activation in Viral Infections In Vivo.

Timothy SC Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR)..

MAIT Cells Promote Tumor Initiation, Grow and Metastases via Tumor MR1

Juming Yan, Stacey Allen, Elizabeth McDonald, Indrajit Das, Jeffrey YW Mak, Ligong Liu, David P Fairlie, Bronwyn S Meehan, Zhenjun Chen, Alexandra J Corbett, Antiopi Varelias, Mark J Smyth, Michele WL Teng

Journal article  |  2020  |  Cancer Discovery

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I-related protein 1 (MR1) for their dev..

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Jan Petersen, Laura Ciacchi, Mai T Tran, Khai Lee Loh, Yvonne Kooy-Winkelaar, Nathan P Croft, Melinda Y Hardy, Zhenjun Chen, James McCluskey, Robert P Anderson, Anthony W Purcell, Jason A Tye-Din, Frits Koning, Hugh H Reid, Jamie Rossjohn

Journal article  |  2019  |  Nature Structural & Molecular Biology

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celia..

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.

Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett

Journal article  |  2019  |  Current Protocols in Immunology

This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Michael NT Souter, Liyen Loh, Shihan Li, Bronwyn S Meehan, Nicholas A Gherardin, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, Katherine Kedzierska, Daniel G Pellicci, Zhenjun Chen, Lars Kjer-Nielsen, Alexandra J Corbett, James McCluskey, Sidonia BG Eckle

Journal article  |  2019  |  Current Protocols in Immunology

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility comp..

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Huimeng Wang, Lars Kjer-Nielsen, Mai Shi, Criselle D'Souza, Troi J Pediongco, Hanwei Cao, Lyudmila Kostenko, Xin Yi Lim, Sidonia BG Eckle, Bronwyn S Meehan, Tianyuan Zhu, Bingjie Wang, Zhe Zhao, Jeffrey YW Mak, David P Fairlie, Michele WL Teng, Jamie Rossjohn, Di Yu, Barbara Fazekas de St Groth, George Lovrecz, et al.

Journal article  |  2019  |  Science Immunology

Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthe..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nussing, K Kedzierska, et al.

Journal article  |  2019  |  Science Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

IL-23 co-stimulation drives antigen-specific MAIT cell activation and enables vaccination against bacterial infection

H Wang, L Kjer-Nielsen, M Shi, DC Souza, T Pediongco, H Cao, L Kostenko, X Lim, S Eckle, B Meeha, B Wang, T Zhu, J Mak, D Fairlie, M Teng, J Rossjohn, D Yu, B Groth, J McCluskey, R Strugnell, et al.

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Timothy SC Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J Pediongco, Bronwyn S Meehan, Lyudmila Kostenko, Stephen J Turner, Alexandra J Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey

Journal article  |  2019  |  Cell Reports

Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice

Manisha Pandey, Ainslie Calcutt, Victoria Ozberk, Zhenjun Chen, Matthew Croxen, Jessica Powell, Emma Langshaw, Jamie-Lee Mills, Freda E-C Jen, James McCluskey, Jenny Robson, Gregory J Tyrrell, Michael F Good

Journal article  |  2019  |  SCIENCE ADVANCES

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2019  |  Nature Communications

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

The early proximal alpha beta TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Steven C Neier, Alejandro Ferrer, Katelynn M Wilton, Stephen EP Smith, April MH Kelcher, Kevin D Pavelko, Jenna M Canfield, Tessa R Davis, Robert J Stiles, Zhenjun Chen, James McCluskey, Scott R Burrows, Jamie Rossjohn, Deanne M Hebrink, Eva M Carmona, Andrew H Limper, Dietmar J Kappes, Peter J Wettstein, Aaron J Johnson, Larry R Pease, et al.

Journal article  |  2019  |  Science Immunology

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn S Meehan, Axel Kallies, Dale I Godfrey, Patrick C Reading, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Revealing the protective and pathogenic potential of MAIT cells

Criselle D'Souza, Zhenjun Chen, Alexandra J Corbett

Journal article  |  2018  |  Molecular Immunology

MAIT cells contribute to a protective antiviral innate response to influenza infection

Timothy Hinks, Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Patrick Reading, Alexandra Corbett, James Mccluskey, Paul Klenerman, Katherine Kedzierska

Conference Proceedings  |  2018  |  Respiratory infections

MAIT cells protect against pulmonary Legionella longbeachae infection

Huimeng Wang, Criselle D'Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J Pediongco, Sidonia BG Eckle, Bronwyn S Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Yoichiro Iwakura, Jennifer M Gunnersen, Andrew W Stent, Dale I Godfrey, Jamie Rossjohn, Glen P Westall, Lars Kjer-Nielsen, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

An overview on the identification of MAIT cell antigens

Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey YW Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia BG Eckle

Journal article  |  2018  |  Immunology and Cell Biology

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

Criselle D'Souza, Troi Pediongco, Huimeng Wang, Jean-Pierre Y Scheerlinck, Lyudmila Kostenko, Robyn Esterbauer, Andrew W Stent, Sidonia BG Eckle, Bronwyn S Meehan, Richard A Strugnell, Hanwei Cao, Ligong Liu, Jeffrey YW Mak, George Lovrecz, Louis Lu, David P Fairlie, Jamie Rossjohn, James McCluskey, Alison L Every, Zhenjun Chen, et al.

Journal article  |  2018  |  The Journal of Immunology

MAIT cells protect against fatal intracellular pulmonary legionella infection via IFN-gamma

Timothy Hinks, Huimeng Wang, Criselle D'Souza, Lyudmila Kostenko, Xin Yi Lim, Troi Pediongco, Shihan Li, Sidonia Eckle, Bronwyn Meehan, Nancy Wang, Alexandra Corbett, Lars Kjer-Nielsen, Richard Strugnell, James McCluskey, Zhenjun Chen

Conference Proceedings  |  2017  |  Respiratory Infections

Vitamin B2 related molecules that activate T cells

Jeffrey Mak, Weijun Xu, Robert Reid, Alexandra Corbett, Bronwyn Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David Fairlie

Conference Proceedings  |  2017  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Andrew N Keller, Sidonia BG Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes, Jeffrey YW Mak, Bronwyn S Meehan, Troi Pediongco, Richard W Birkinshaw, Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Lars Kjer-Nielsen, Nicholas A Gherardin, Dale I Godfrey, Lyudmila Kostenko, Alexandra J Corbett, Anthony W Purcell, David P Fairlie, James McCluskey, et al.

Journal article  |  2017  |  Nature Immunology

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Jeffrey YW Mak, Weijun Xu, Robert C Reid, Alexandra J Corbett, Bronwyn S Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P Fairlie

Journal article  |  2017  |  NATURE COMMUNICATIONS

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

Z Chen, H Wang, C D'Souza, S Sun, L Kostenko, SBG Eckle, BS Meehan, DC Jackson, RA Strugnell, H Cao, N Wang, DP Fairlie, L Liu, DI Godfrey, J Rossjohn, J McCluskey, AJ Corbett

Journal article  |  2017  |  Mucosal Immunology

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Hui-Fern Koay, Nicholas A Gherardin, Anselm Enders, Liyen Loh, Laura K Mackay, Catarina F Almeida, Brendan E Russ, Claudia A Nold-Petry, Marcel F Nold, Sammy Bedoui, Zhenjun Chen, Alexandra J Corbett, Sidonia BG Eckle, Bronwyn Meehan, Yves d'Udekem, Igor E Konstantinov, Martha Lappas, Ligong Liu, Chris C Goodnow, David P Fairlie, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1

Hamish EG McWilliam, Sidonia BG Eckle, Alex Theodossis, Ligong Liu, Zhenjun Chen, Jacinta M Wubben, David P Fairlie, Richard A Strugnell, Justine D Mintern, James McCluskey, Jamie Rossjohn, Jose A Villadangos

Journal article  |  2016  |  Nature Immunology

Structural and functional characterisation of ferret interleukin-2

Bin Ren, William J McKinstry, Pham Tam, Janet Newman, Daniel S Layton, Andrew G Bean, Zhenjun Chen, Karen L Laurie, Kathryn Borg, Ian G Barr, Timothy E Adams

Journal article  |  2016  |  Developmental & Comparative Immunology

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

Sidonia BG Eckle, Alexandra J Corbett, Andrew N Keller, Zhenjun Chen, Dale I Godfrey, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Jamie Rossjohn, James McCluskey

Journal article  |  2015  |  Journal of Biological Chemistry

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Dennis X Beringer, Fleur S Kleijwegt, Florian Wiede, Arno R van der Slik, Khai Lee Loh, Jan Petersen, Nadine L Dudek, Gaby Duinkerken, Sandra Laban, Antoinette Joosten, Julian P Vivian, Zhenjun Chen, Adam P Uldrich, Dale I Godfrey, James McCluskey, David A Price, Kristen J Radford, Anthony W Purcell, Tatjana Nikolic, Hugh H Reid, et al.

Journal article  |  2015  |  Nature Immunology

T-cell antigen formed from distinct metabolic pathways

Jeffrey Mak, Alexandra Corbett, Sidonia Eckle, Richard Birkinshaw, Ligong Liu, Onisha Patel, Jennifer Mahony, Zhenjun Chen, Rangsima Reantragoon, Bronwyn Meehan, Hanwei Cao, Nicholas Williamson, Richard Strugnell, Douwe Van Sinderen, David Fairlie, Lars Kjer-Nielsen, Jamie Rossjohn, James McCluskey

Conference Proceedings  |  2015  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

Azad Rahimpour, Hui Fern Koay, Anselm Enders, Rhiannon Clanchy, Sidonia BG Eckle, Bronwyn Meehan, Zhenjun Chen, Belinda Whittle, Ligong Liu, David P Fairlie, Chris C Goodnow, James McCluskey, Jamie Rossjohn, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

Molecular architecture of the alpha beta T cell receptor-CD3 complex

Michael E Birnbaum, Richard Berry, Yu-Shan Hsiao, Zhenjun Chen, Miguel A Shingu-Vazquez, Xiaoling Yu, Deepa Waghray, Suzanne Fischer, James McCluskey, Jamie Rossjohn, Thomas Walz, K Christopher Garcia

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

Sidonia BG Eckle, Richard W Birkinshaw, Lyudmila Kostenko, Alexandra J Corbett, Hamish EG McWilliam, Rangsima Reantragoon, Zhenjun Chen, Nicholas A Gherardin, Travis Beddoe, Ligong Liu, Onisha Patel, Bronwyn Meehan, David P Fairlie, Jose A Villadangos, Dale I Godfrey, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn

Journal article  |  2014  |  JOURNAL OF EXPERIMENTAL MEDICINE

A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

Yu Chih Liu, Zhenjun Chen, Michelle A Neller, John J Miles, Anthony W Purcell, James McCluskey, Scott R Burrows, Jamie Rossjohn, Stephanie Gras

Journal article  |  2014  |  Journal of Biological Chemistry

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Alexandra J Corbett, Sidonia BG Eckle, Richard W Birkinshaw, Ligong Liu, Onisha Patel, Jennifer Mahony, Zhenjun Chen, Rangsima Reantragoon, Bronwyn Meehan, Hanwei Cao, Nicholas A Williamson, Richard A Strugnell, Douwe Van Sinderen, Jeffrey YW Mak, David P Fairlie, Lars Kjer-Nielsen, Jamie Rossjohn, James McCluskey

Journal article  |  2014  |  Nature

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Rangsima Reantragoon, Alexandra J Corbett, Isaac G Sakala, Nicholas A Gherardin, John B Furness, Zhenjun Chen, Sidonia BG Eckle, Adam P Uldrich, Richard W Birkinshaw, Onisha Patel, Lyudmila Kostenko, Bronwyn Meehan, Katherine Kedzierska, Ligong Liu, David P Fairlie, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey, Lars Kjer-Nielsen

Journal article  |  2013  |  Journal of Experimental Medicine

HLA Peptide Length Preferences Control CD8( ) T Cell Responses

Melissa J Rist, Alex Theodossis, Nathan P Croft, Michelle A Neller, Andrew Welland, Zhenjun Chen, Lucy C Sullivan, Jacqueline M Burrows, John J Miles, Rebekah M Brennan, Stephanie Gras, Rajiv Khanna, Andrew G Brooks, James McCluskey, Anthony W Purcell, Jamie Rossjohn, Scott R Burrows

Journal article  |  2013  |  Journal of Immunology

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Onisha Patel, Lars Kjer-Nielsen, Jerome Le Nours, Sidonia BG Eckle, Richard Birkinshaw, Travis Beddoe, Alexandra J Corbett, Ligong Liu, John J Miles, Bronwyn Meehan, Rangsima Reantragoon, Maria L Sandoval-Romero, Lucy C Sullivan, Andrew G Brooks, Zhenjun Chen, David P Fairlie, James McCluskey, Jamie Rossjohn

Journal article  |  2013  |  Nature Communications

MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Patricia T Illing, Julian P Vivian, Nadine L Dudek, Lyudmila Kostenko, Zhenjun Chen, Mandvi Bharadwaj, John J Miles, Lars Kjer-Nielsen, Stephanie Gras, Nicholas A Williamson, Scott R Burrows, Anthony W Purcell, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Journal of Experimental Medicine

The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule

Yu Chih Liu, Zhenjun Chen, Scott R Burrows, Anthony W Purcell, James McCluskey, Jamie Rossjohn, Stephanie Gras

Journal article  |  2012  |  Journal of Biological Chemistry

A Structural Basis for Varied alpha beta TCR Usage against an Immunodominant EBV Antigen Restricted to a HLA-B8 Molecule

Stephanie Gras, Pascal G Wilmann, Zhenjun Chen, Hanim Halim, Yu Chih Liu, Lars Kjer-Nielsen, Anthony W Purcell, Scott R Burrows, James McCluskey, Jamie Rossjohn

Journal article  |  2012  |  Journal of Immunology

An Insertion Mutant in DQA1*0501 Restores Susceptibility to HLA-DM: Implications for Disease Associations

Tieying Hou, Henriette Macmillan, Zhenjun Chen, Catherine L Keech, Xi Jin, John Sidney, Michael Strohman, Taejin Yoon, Elizabeth D Mellins

Journal article  |  2011  |  Journal of Immunology

Insight into the basis of autonomous immunoreceptor activation

Richard Berry, Zhenjun Chen, James McCluskey, Jamie Rossjohn

Journal article  |  2011  |  Trends in Immunology

The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection

Stephanie Gras, Lars Kjer-Nielsen, Zhenjun Chen, Jamie Rossjohn, James McCluskey

Journal article  |  2011  |  Immunology & Cell Biology

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Siew Siew Pang, Richard Berry, Zhenjun Chen, Lars Kjer-Nielsen, Matthew A Perugini, Glenn F King, Christina Wang, Sock Hui Chew, Nicole L La Gruta, Neal K Williams, Travis Beddoe, Tony Tiganis, Nathan P Cowieson, Dale I Godfrey, Anthony W Purcell, Matthew CJ Wilce, James McCluskey, Jamie Rossjohn

Journal article  |  2010  |  Nature

Allelic polymorphism in the T cell receptor and its impact on immune responses

Stephanie Gras, Zhenjun Chen, John J Miles, Yu Chih Liu, Melissa J Bell, Lucy C Sullivan, Lars Kjer-Nielsen, Rebekah M Brennan, Jacqueline M Burrows, Michelle A Neller, Rajiv Khanna, Anthony W Purcell, Andrew G Brooks, James McCluskey, Jamie Rossjohn, Scott R Burrows

Journal article  |  2010  |  Journal of Experimental Medicine

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Scott R Burrows, Zhenjun Chen, Julia K Archbold, Fleur E Tynan, Travis Beddoe, Lars Kjer-Nielsen, John J Miles, Rajiv Khanna, Denis J Moss, Yu Chih Liu, Stephanie Gras, Lyudmila Kostenko, Rebekah M Brennan, Craig S Clements, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

T Cell Allorecognition via Molecular Mimicry

Whitney A Macdonald, Zhenjun Chen, Stephanie Gras, Julia K Archbold, Fleur E Tynan, Craig S Clements, Mandvi Bharadwaj, Lars Kjer-Nielsen, Philippa M Saunders, Matthew CJ Wilce, Fran Crawford, Brian Stadinsky, David Jackson, Andrew G Brooks, Anthony W Purcell, John W Kappler, Scott R Burrows, Jamie Rossjohn, James McCluskey

Journal article  |  2009  |  Immunity

Antigen Ligation Triggers a Conformational Change within the Constant Domain of the alpha beta T Cell Receptor

Travis Beddoe, Zhenjun Chen, Craig S Clements, Lauren K Ely, Simon R Bushell, Julian P Vivian, Lars Kjer-Nielsen, Siew Siew Pang, Michelle A Dunstone, Yu Chih Liu, Whitney A Macdonald, Matthew A Perugini, Matthew CJ Wilce, Scott R Burrows, Anthony W Purcell, Tony Tiganis, Stephen P Bottomley, James McCluskey, Jamie Rossjohn

Journal article  |  2009  |  Immunity

Resistance to Celiac Disease in Humanized HLA-DR3-DQ2-Transgenic Mice Expressing Specific Anti-Gliadin CD4( ) T Cells

Andrea L de Kauwe, Zhenjun Chen, Robert P Anderson, Catherine L Keech, Jason D Price, Odilia Wijburg, David C Jackson, Jodi Ladhams, Janette Allison, James McCluskey

Journal article  |  2009  |  Journal of Immunology

Immune Tolerance Induced By Peptide Immunotherapy in An HLA Dq2-Dependent Mouse Model of Gluten Immunity

Catherine L Keech, James Dromey, Zhenjun Chen, Robert P Anderson, James McCluskey

Conference Proceedings  |  2009  |  GASTROENTEROLOGY

Human leukocyte antigen class I-restricted activation of CD8( ) T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Diana Chessman, Lyudmila Kostenko, Tessa Lethborg, Anthony W Purcell, Nicholas A Williamson, Zhenjun Chen, Lars Kjer-Nielsen, Nicole A Mifsud, Brian D Tait, Rhonda Holdsworth, Coral Ann Almeida, David Nolan, Whitney A Macdonalds, Julia K Archbold, Anthony D Kellerher, Debbie Marriott, Simon Mallal, Mandvi Bharadwaj, Jamie Rossjohn, James McCluskey

Journal article  |  2008  |  Immunity

T cell Epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQBI*0201

Nadine L Dudek, Shannon Maier, Zhen-Jun Chen, Philip A Mudd, Stuart I Mannering, David C Jackson, Weiguang Zeng, Catherine L Keech, Kassie Hamlin, Zi-Jian Pan, Karen Davis-Schwarz, Jennifer Workman-Azbill, Michael Bachmann, James McCluskey, A Darise Farris

Journal article  |  2007  |  Arthritis and Rheumatism

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease

Kate N Henderson, Jason A Tye-Din, Hugh H Reid, Zhenjun Chen, Natalie A Borg, Tim Beissbarth, Arthur Tatham, Stuart I Mannering, Anthony W Purcell, Nadine L Dudek, David A van Heel, James McCluskey, Jamie Rossjohn, Robert P Anderson

Journal article  |  2007  |  Immunity

Establishment of the mouse cell line expressing human leukocyte antigen-DR4 (*0405) molecules (in Chinese with English abstract)

Y Zhao, Z Xiang, Z Chen, L Zhang, Z Li

Journal article  |  2007  |  Chinese journal of allergy & clinical immunology

Novel T cell epitopes of the La/SS-B autoantigen in mice expressing human transgenic HLA class II haplotype DRB1*0301/DQB1*0201.

Shannon Maier, Philip Mudd, Kassie Hamlin, Zi-jian Pan, Karen Davis-Schwarz, Jennifer Workman, Joanne Gross, Michael Bachmann, Zhenjun Chen, Darise Farris

Conference Proceedings  |  2006  |  ARTHRITIS AND RHEUMATISM

Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses

Z Chen, AL de Kauwe, C Keech, O Wijburg, K Simpfendorfer, WS Alexander, J McCluskey

Journal article  |  2006  |  Tissue Antigens

Gluten-immunity resembling coeliac disease in HLA transgenic mice

AL De Kauwe, Z Chen, RP Anderson, J Allison, CL Keech, J McCluskey

Journal article  |  2005  |  Tissue Antigens

Human-like recognition of a dominant coeliac disease epitope by murine CD4( ) T cells from HLA DR3-DQ2 transgenic animals

Z Chen, AL De Kauwe, RP Anderson, J McCluskey

Conference Proceedings  |  2005  |  Tissue Antigens

A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice

ZJ Chen, N Dudek, O Wijburg, R Strugnell, L Brown, G Deliyannis, D Jackson, F Koentgen, T Gordon, J McCluskey

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

HLA class II phenotype controls diversification of the autoantibody response in primary Sjogren's syndrome (pSS)

M Rischmueller, S Lester, Z Chen, G Champion, R Van den Berg, R Beer, T Coates, J McCluskey, T Gordon

Journal article  |  1998  |  Clinical and Experimental Immunology

Platelet antigen allele frequencies in Australian Aboriginal and Caucasian populations

ZJ Chen, S Lester, B Boettcher, J McCluskey

Journal article  |  1997  |  Pathology

Somatic Mutation Assays: Other gene assays

Z Chen

Book Chapter  |  1997

Somatic Mutation Assays: T cell receptor (TCR) genes

Z Chen

Book Chapter  |  1997

Somatic Mutation Assays: Human leucocyte antigen A (HLA-A) assay

Z Chen

Book Chapter  |  1997

Somatic Mutation Assays: Glycophorin A (GPA) locus

Z Chen

Book Chapter  |  1997

HLA matching of unrelated bone marrow donor transplants provided by the australian bone marrow donor registry

S Lester, X Gao, Zhenjun Chen, I Humphreys, G Bennett, J Paris, B Tait, M Varney, A Geczy, J McCluskey

Journal article  |  1996  |  Human Immunology

HLA diversity in the yuendumu australian aboriginal population

S Lester, X Gao, G Bennett, Zhenjun Chen, K Lienert, B Tait, M Varney, J McCluskey

Journal article  |  1996  |  Human Immunology

Glycophorin A and its potential as a new biodosimeter

Z Chen, J Wang

Journal article  |  1995  |  International Journal of Radiation Medicine and Nuclear Medicine

TCR, a new biodosimeter and its potential implications in radiobiology research

Z Chen, J Wang, Z Wang

Journal article  |  1995  |  International Journal of Radiation Medicine and Nuclear Medicine

Stable chromosome aberrations and dose estimation in Chinese medical X-ray workers

Z Wang, X Liu, J Li, Z Chen, D Li, W Yu, W Tang

Journal article  |  1995  |  Carcinogenesis, Teratogenesis & Mutations

Study on micronucleus frequencies in human lymphocytes induced by irradiation–Methodology and dose effect relationship

Z Wang, Z Ge, W Tang, Z Chen, Y Wang

Journal article  |  1994  |  Chinese Journal of Radiological Health

An assay of obtaining intact cytoplasm in cytokinsis-blocked spontaneous micronucleus research

W Tang, Z Wang, Z Chen, Y Wang

Journal article  |  1993  |  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

Research on dose response of micronuclei in human lymphocyte induced by low level irradiation

Z Wang, W Tang, Z Chen, Y Wang

Journal article  |  1993  |  Fushe Yanjiu yu Fushe Gongyi Xuebao/Journal of Radiation Research and Radiation Processing

Comparative study on different methods of measuring micronuclei in human lymphocytes induced by radiation

Z Wang, W Tang, Z Chen, Y Wang

Journal article  |  1993  |  Chinese Journal of Radiological Medicine and Protection

Study on factors influencing cytokinesis blocked micronucleus frequencies

Y Wang, Z Wang, W Tang, Z Chen

Journal article  |  1992  |  Chinese Journal of Radiological Health

Chromosome fragile sites in peripheral blood cells in patients with primary hepatocellular carcinoma or liver cirrhosis

Z Chen, B Zhang

Journal article  |  1992  |  Chinese Journal of Medical Genetics

Advances in the research of biological dosimeters for previous exposure

Z Wang, Z Chen

Journal article  |  1991  |  International Journal of Radiation Medicine and Nuclear Medicine

Biological significance of stable chromosome aberrations in previously exposed cases

Z Chen, Z Wang

Journal article  |  1991  |  International Journal of Radiation Medicine and Nuclear Medicine

An improved, rapid and sensitive method for measuring human HPRT mutation

Z Wang, Y Wang, Y Li, W Tang, Z Chen

Journal article  |  1991  |  Carcinogenesis Teratogenesis & Mutation

Priming programed Mucosal-Associated Invariant T cells protect against systemic or local bacterial infection

Zhe Zhao, Mai Shi, Tianyuan Zhu, Huimeng Wang, Troi Pediongco, Xin Yi Lim, Bronwyn Meehan, Adam Nelson, David Fairlie, Jeffrey Mak, Sidonia Eckle, Jamie Rossjohn, James McCluskey, Alexandra Corbett, Zhenjun Chen

Journal article

Abstract Mucosal-Associated Invariant T (MAIT) cells have potent antibacterial functions. Their protective capacity, in vi..