Rob De Rose

Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan‐Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez‐Jugo, Francesca Cavalieri, Frank Caruso

Journal article  |  2023  |  Angewandte Chemie

Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso

Journal article  |  2023  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..

Subcutaneous delivery of a dendrimer-BH3 mimetic improves lymphatic uptake and survival in lymphoma.

Orlagh M Feeney, Katie Ardipradja, Ka Fung Noi, Dharmini Mehta, Robert De Rose, Daniel Yuen, Angus PR Johnston, Lee Kingston, Cecilia Ericsson, Charles S Elmore, Richard Hufton, David J Owen, Marianne B Ashford, Christopher JH Porter

Journal article  |  2022  |  J Control Release

As a malignant tumour of lymphatic origin, B-cell lymphoma represents a significant challenge for drug delivery, where effective t..

Template-Assisted Antibody Assembly: A Versatile Approach for Engineering Functional Antibody Nanoparticles

Y Hu, J Li, Y Ju, ZH Houston, NL Fletcher, R De Rose, S Fernandes, CE Hagemeyer, K Alt, KJ Thurecht, C Cortez-Jugo, F Caruso

Journal article  |  2022  |  Chemistry of Materials

The clinical success of monoclonal antibody therapy has inspired research in understanding the fundamental molecular basis of anti..

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

Agata Radziwon, Sukhvir K Bhangu, Soraia Fernandes, Christina Cortez-Jugo, Robert De Rose, Brendan Dyett, Marcin Wojnilowicz, Petra Laznickova, Jan Fric, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

Journal article  |  2022  |  NANOSCALE

Engineered nanoparticles for the encapsulation of bioactive agents hold promise to improve disease diagnosis, prevention and thera..

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.

Nicholas A Gherardin, Samuel J Redmond, Hamish EG McWilliam, Catarina F Almeida, Katherine HA Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J Ross, Catriona V Nguyen-Robertson, Shian Su, Matthew E Ritchie, Jose A Villadangos, D Branch Moody, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2021  |  Science Immunology

CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool...

In Vivo Quantification of Nanoparticle Association with Immune Cell Subsets in Blood

Yih Rue Ong, Robert De Rose, Angus PR Johnston

Journal article  |  2021  |  ADVANCED HEALTHCARE MATERIALS

Nanoparticles offer great promise for more effective drug delivery. However, their particulate nature typically results in rapid s..

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies

Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent

Journal article  |  2019  |  ADVANCED HEALTHCARE MATERIALS

Low-fouling or "stealth" particles composed of poly(ethylene glycol) (PEG) display a striking ability to evade phagocytic cell upt..

Mycobacteria-Specific Mono- and Polyfunctional CD4 T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study

Marc Tebruegge, Nicole Ritz, Susan Donath, Binita Dutta, Benjamin Forbes, Vanessa Clifford, Christel Zufferey, Robert De Rose, Roy M Robins-Browne, Willem Hanekom, Stephen M Graham, Tom Connell, Nigel Curtis

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Background: Current immune-based TB tests, including the tuberculin skin test (TST) and interferon-gamma release assays (IGRA), ha..

Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles

Liyu Chen, Joshua J Glass, Robert De Rose, Claudia Sperling, Stephen J Kent, Zachary H Houston, Nicholas L Fletcher, Barbara E Rolfe, Kristofer J Thurecht

Journal article  |  2018  |  ACS APPLIED BIO MATERIALS

The benefits of nanomedicine may be restricted by hemocompatibility and immunoreactivity problems arising from administration of e..