Laura Baglietto

Novel mammogram-based measures improve breast cancer risk prediction beyond an established mammographic density measure

Tuong L Nguyen, Daniel F Schmidt, Enes Makalic, Gertraud Maskarinec, Shuai Li, Gillian S Dite, Ye K Aung, Christopher F Evans, Ho N Trinh, Laura Baglietto, Jennifer Stone, Yun-Mi Song, Joohon Sung, Robert J MacInnis, Pierre-Antoine Dugue, James G Dowty, Mark A Jenkins, Roger L Milne, Melissa C Southey, Graham G Giles, et al.

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CANCER

Mammograms contain information that predicts breast cancer risk. We developed two novel mammogram-based breast cancer risk measure..

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Amedeo Gagliardi, Pierre-Antoine Dugue, Therese H Nost, Melissa C Southey, Daniel D Buchanan, Daniel F Schmidt, Enes Makalic, Allison M Hodge, Dallas R English, Nicole W Doo, John L Hopper, Gianluca Severi, Laura Baglietto, Alessio Naccarati, Sonia Tarallo, Luigia Pace, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, et al.

Journal article  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..

Interval breast cancer risk associations with breast density, family history and breast tissue aging

Tuong L Nguyen, Shuai Li, Gillian S Dite, Ye K Aung, Christopher F Evans, Ho N Trinh, Laura Baglietto, Jennifer Stone, Yun-Mi Song, Joohon Sung, Dallas R English, Mark A Jenkins, Pierre-Antoine Dugue, Roger L Milne, Melissa C Southey, Graham G Giles, Malcolm C Pike, John L Hopper

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF CANCER

Interval breast cancers (those diagnosed between recommended mammography screens) generally have poorer outcomes and are more comm..

Appraising the causal relevance of DNA methylation for risk of lung cancer

Thomas Battram, Rebecca C Richmond, Laura Baglietto, Philip C Haycock, Vittorio Perduca, Stig E Bojesen, Tom R Gaunt, Gibran Hemani, Florence Guida, Robert Carreras-Torres, Rayjean Hung, Christopher Amos, Joshua R Freeman, Torkjel M Sandanger, Therese H Nost, Borge G Nordestgaard, Andrew E Teschendorff, Silvia Polidoro, Paolo Vineis, Gianluca Severi, et al.

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

BACKGROUND: DNA methylation changes in peripheral blood have recently been identified in relation to lung cancer risk. Some of the..

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

Shuai Li, Pierre-Antoine Dugue, Laura Baglietto, Gianluca Severi, Ee Ming Wong, Tuong L Nguyen, Jennifer Stone, Dallas R English, Melissa C Southey, Graham G Giles, John L Hopper, Roger L Milne

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF CANCER

Age- and body mass index (BMI)-adjusted mammographic density is one of the strongest breast cancer risk factors. DNA methylation i..

Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

Pierre-Antoine Dugue, Chol-Hee Jung, Jihoon E Joo, Xiaochuan Wang, Ee Ming Wong, Enes Makalic, Daniel F Schmidt, Laura Baglietto, Gianluca Severi, Melissa C Southey, Dallas R English, Graham G Giles, Roger L Milne

Journal article  |  2019  |  EPIGENETICS

We conducted a genome-wide association study of blood DNA methylation and smoking, attempted replication of previously discovered ..

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Celine M Vachon, Christopher G Scott, Rulla M Tamimi, Deborah J Thompson, Peter A Fasching, Jennifer Stone, Melissa C Southey, Stacey Winham, Sara Lindstrom, Jenna Lilyquist, Graham G Giles, Roger L Milne, Robert J MacInnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, et al.

Journal article  |  2019  |  BREAST CANCER RESEARCH

BACKGROUND: Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of comm..

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants

Sehee Kim, Miao Wang, Jonathan P Tyrer, Allan Jensen, Ashley Wiensch, Gang Liu, Alice W Lee, Roberta B Ness, Maxwell Salvatore, Shelley S Tworoger, Alice S Whittemore, Hoda Anton-Culver, Weiva Sieh, Sara H Olson, Andrew Berchuck, Ellen L Goode, Marc T Goodman, Jennifer Anne Doherty, Georgia Chenevix-Trench, Mary Anne Rossing, et al.

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF CANCER

As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study consid..

Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk

Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E Jones, Minouk J Schoemaker, Nick Orr, Katarzyna Tomczyk, Nichola Johnson, Olivia Fletcher, Vittorio Perduca, Laura Baglietto, et al.

Journal article  |  2019  |  CLINICAL EPIGENETICS

BACKGROUND: It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesiz..

Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

F Perrier, V Viallon, S Ambatipudi, A Ghantous, C Cuenin, H Hernandez-Vargas, V Chajes, L Baglietto, M Matejcic, H Moreno-Macias, T Kuehn, H Boeing, A Karakatsani, A Kotanidou, A Trichopoulou, S Sieri, S Panico, F Fasanelli, M Dolle, C Onland-Moret, et al.

Journal article  |  2019  |  CLINICAL EPIGENETICS

BACKGROUND: There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Al..