Jian Kang

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  The EMBO Journal

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.

Elaine Sanij, Katherine Hannan, Jiachen Xuan, Shunfei Yan, Jessica A Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Sarah Ellis, Carleen Cullinane, Gretchen Poortinga, Kum Kum Khanna, Linda Mileshkin, Grant A McArthur, John Soong, Els M Berns, et al.

Journal article  |  2020  |  CLINICAL CANCER RESEARCH

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..

Oncogene-induced senescence: From biology to therapy

Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan

Journal article  |  2020  |  Mechanisms of Ageing and Development

Oncogene-induced senescence (OIS) is a powerful intrinsic tumor-suppressive mechanism, arresting cell cycle progression upon oncog..

A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2020  |  Cell Death and Differentiation

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan

Journal article  |  2019

Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson

Journal article  |  2019  |  bioRxiv

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-in-human t..

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

Chentao Ge, Hemiao Huang, Feiyan Huang, Tianxin Yang, Tengfei Zhang, Hongzhang Wu, Hanwei Zhou, Qi Chen, Yue Shi, Yanfang Sun, Liangjue Liu, Xi Wang, Richard B Pearson, Yihai Cao, Jian Kang, Caiyun Fu

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of USA