Maryam Rashidi

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases

Maryam Rashidi, Ian P Wicks, James E Vince

Journal article  |  2020  |  TRENDS IN MOLECULAR MEDICINE

The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation..

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1 beta Release

Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James M Murphy, Ian P Wicks, James E Vince

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-depe..

CD52 inhibits Toll-like receptor activation of NF-kappa B and triggers apoptosis to suppress inflammation

Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O'Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison

Journal article  |  2018  |  CELL DEATH AND DIFFERENTIATION

Soluble CD52 is a small glycoprotein that suppresses T-cell activation, but its effect on innate immune cell function is unknown. ..

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters, Maryam Rashidi, Ian P Wicks, Warren S Alexander, Yasuhiro Mitsuuchi, Christopher A Benetatos, Stephen M Condon, W Wei-Lynn Wong, John Silke, David L Vaux, James E Vince

Journal article  |  2015  |  NATURE COMMUNICATIONS

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of i..