Abdou Hachani

Bioinformatic Analysis of the Campylobacter jejuni Type VI Secretion System and Effector Prediction

Luca Robinson, Janie Liaw, Zahra Omole, Dong Xia, Arnoud HM van Vliet, Nicolae Corcionivoschi, Abderrahman Hachani, Ozan Gundogdu

Journal article  |  2021  |  FRONTIERS IN MICROBIOLOGY

The Type VI Secretion System (T6SS) has important roles relating to bacterial antagonism, subversion of host cells, and niche colo..

Intracellular Staphylococcus aureus and host cell death pathways

Ye Mon Soe, Sammy Bedoui, Timothy P Stinear, Abderrahman Hachani

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have c..

From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System

Thomas E Wood, Ezra Aksoy, Abderrahman Hachani

Journal article  |  2020  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

The health of mammals depends on a complex interplay with their microbial ecosystems. Compartments exposed to external environment..

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  INFECTION AND IMMUNITY

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton

Journal article  |  2020  |  INFECTION AND IMMUNITY

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..

The Campylobacter jejuni Type VI Secretion System Enhances the Oxidative Stress Response and Host Colonization

Janie Liaw, Geunhye Hong, Cadi Davies, Abdi Elmi, Filip Sima, Alexandros Stratakos, Lavinia Stef, Ioan Pet, Abderrahman Hachani, Nicolae Corcionivoschi, Brendan W Wren, Ozan Gundogdu, Nick Dorrell

Journal article  |  2019  |  FRONTIERS IN MICROBIOLOGY

The role of the Type VI secretion system (T6SS) in Campylobacter jejuni is poorly understood despite an increasing prevalence of t..

The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology

Thomas E Wood, Sophie A Howard, Andreas Forster, Laura M Nolan, Eleni Manoli, Nathan P Bullen, Hamish CL Yau, Abderrahman Hachani, Richard D Hayward, John C Whitney, Waldemar Vollmer, Paul S Freemont, Alain Filloux

Journal article  |  2019  |  CELL REPORTS

The type VI secretion system (T6SS) is crucial in interbacterial competition and is a virulence determinant of many Gram-negative ..

Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

Romain Guerillot, Xenia Kostoulias, Liam Donovan, Lucy Li, Glen P Carter, Abderrahman Hachani, Koen Vandelannoote, Stefano Giulieri, Ian R Monk, Mayu Kunimoto, Lora Starrs, Gaetan Burgio, Torsten Seemann, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic and persistent infections despite active ..

Type VI secretion and anti-host effectors

Abderrahman Hachani, Thomas E Wood, Alain Filloux

Journal article  |  2016  |  CURRENT OPINION IN MICROBIOLOGY

Secretion systems play a central role in infectious diseases by enabling pathogenic bacteria to deliver virulence factors into tar..

Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network

Thibault G Sana, Christoph Baumann, Andreas Merdes, Chantal Soscia, Thomas Rattei, Abderrahman Hachani, Cerith Jones, Keiryn L Bennett, Alain Filloux, Giulio Superti-Furga, Rome Voulhoux, Sophie Bleves

Journal article  |  2015  |  MBIO

UNLABELLED: Invasion of nonphagocytic cells through rearrangement of the actin cytoskeleton is a common immune evasion mechanism u..