Kamlesh Khunti

Relevance of physical function in the association of red and processed meat intake with all-cause, cardiovascular, and cancer mortality.

Stavroula Argyridou, Francesco Zaccardi, Melanie J Davies, Kamlesh Khunti, Thomas Yates

Journal article  |  2019  |  Nutrition, Metabolism and Cardiovascular Diseases

BACKGROUND AND AIMS: Intake of red and processed meat has been associated with a higher risk of morbidity and mortality; it is unk..

Association of circulating osteocalcin with cardiovascular disease and intermediate cardiovascular phenotypes: systematic review and meta-analysis.

Samuel Seidu, Setor K Kunutsor, Kamlesh Khunti

Journal article  |  2019  |  Scandinavian Cardiovascular Journal

Objectives. Circulating osteocalcin (OC), a marker which is central in bone mineralization, may be involved in the atherosclerotic..

Effectiveness of psychoeducational interventions for the treatment of diabetes-specific emotional distress and glycaemic control in people with type 2 diabetes: A systematic review and meta-analysis.

N Perrin, DH Bodicoat, MJ Davies, N Robertson, FJ Snoek, K Khunti

Journal article  |  2019  |  Primary Care Diabetes

AIMS: Psychological comorbidity, such as depression and/or diabetes-specific emotional distress (DSD), is highly prevalent in peop..

Treatment patterns and associated factors in 14 668 people with type 2 diabetes initiating a second-line therapy: Results from the global DISCOVER study programme.

Antonio Nicolucci, Bernard Charbonnel, Marília B Gomes, Kamlesh Khunti, Mikhail Kosiborod, Marina V Shestakova, Iichiro Shimomura, Hirotaka Watada, Hungta Chen, Javier Cid-Ruzafa, Peter Fenici, Niklas Hammar, Filip Surmont, Fengming Tang, Stuart Pocock

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIM: To evaluate treatment data from DISCOVER (NCT02322762 and NCT02226822), a global, prospective, observational study programme ..

Type 2 diabetes treatment and outcomes worldwide: A short review of the DISCOVER study programme.

Kamlesh Khunti, Linong Ji, Jesús Medina, Filip Surmont, Mikhail Kosiborod

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

The global burden of type 2 diabetes (T2D) is increasing, indicating an urgent need for improved disease prevention and management..

A data-driven, meaningful, easy to interpret, standardised accelerometer outcome variable for global surveillance.

Alex V Rowlands, Lauren B Sherar, Stuart J Fairclough, Tom Yates, Charlotte L Edwardson, Deirdre M Harrington, Melanie J Davies, Fehmidah Munir, Kamlesh Khunti, Victoria H Stiles

Journal article  |  2019  |  Journal of Science and Medicine in Sport

OBJECTIVES: Our aim is to demonstrate how a data-driven accelerometer metric, the acceleration above which a person's most active ..

Statins and risk of thromboembolism: A meta-regression to disentangle the efficacy-to-effectiveness gap using observational and trial evidence.

Joanne K Miksza, Francesco Zaccardi, Setor K Kunutsor, Samuel Seidu, Melanie J Davies, Kamlesh Khunti

Journal article  |  2019  |  Nutrition, Metabolism and Cardiovascular Diseases

BACKGROUND AND AIMS: Meta-analyses of randomised controlled trials (RCTs) and observational studies indicate a lower risk of venou..

Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis.

A Farooqi, K Khunti, S Abner, C Gillies, R Morriss, S Seidu

Journal article  |  2019  |  Diabetes Research and Clinical Practice

OBJECTIVE: To examine the association of comorbid occurrence of diabetes and depression with risk of cardiovascular endpoints incl..

Impact of Depression and Anxiety on Change to Physical Activity Following a Pragmatic Diabetes Prevention Program Within Primary Care: Pooled Analysis From Two Randomized Controlled Trials.

Thomas Yates, Laura J Gray, Joseph Henson, Charlotte L Edwardson, Kamlesh Khunti, Melanie J Davies

Journal article  |  2019  |  Diabetes Care

OBJECTIVE: The impact of major affective disorders on the effectiveness of diabetes prevention programs at promoting health behavi..

Addressing cardiovascular risk in type 2 diabetes mellitus: a report from the European Society of Cardiology Cardiovascular Roundtable.

Francesco Cosentino, Antonio Ceriello, Florian MM Baeres, Paola Fioretto, Alan Garber, Wendy Gattis Stough, Jyothis T George, Peter J Grant, Kamlesh Khunti, Anna Maria Langkilde, Jorge Plutzky, Lars Rydén, André Scheen, Eberhard Standl, Jaakko Tuomilehto, Faiez Zannad

Journal article  |  2019  |  European Heart Journal

Association of depression and anxiety with clinical, sociodemographic, lifestyle and environmental factors in South Asian and white European individuals at high risk of diabetes.

C Razieh, K Khunti, MJ Davies, CL Edwardson, J Henson, N Darko, A Comber, A Jones, T Yates

Journal article  |  2019  |  Diabetic Medicine

AIM: To investigate the prevalence and correlates of depressive and anxiety symptoms within South Asian and white European populat..

Process evaluation of the school-based Girls Active programme.

Trish Gorely, Deirdre M Harrington, Danielle H Bodicoat, Melanie J Davies, Kamlesh Khunti, Lauren B Sherar, Rhiannon Tudor-Edwards, Thomas Yates, Charlotte L Edwardson

Journal article  |  2019  |  BMC Public Health

BACKGROUND: Girls Active is a physical activity programme, delivered in UK secondary schools, with the aim of increasing moderate-..

Individualised targets for insulin initiation in type 2 diabetes mellitus-the influence of physician and practice: a cross-sectional study in eight European countries.

Anne Meike Boels, Elwin Koning, Rimke C Vos, Kamlesh Khunti, Guy Ehm Rutten

Journal article  |  2019  |  BMJ Open

OBJECTIVES: To determine at what glycated haemoglobin (HbA1c) level physicians from eight European countries would initiate insuli..

A fitting problem: Standardising shoe fit standards to reduce related diabetic foot ulcers.

Petra J Jones, Richard J Bibb, Melanie J Davies, Kamlesh Khunti, Matthew McCarthy, Daniel TP Fong, David Webb

Journal article  |  2019  |  Diabetes Research and Clinical Practice

AIMS: Incorrectly fitting shoes are implicated in callus formation and a significant proportion of diabetic foot ulcers, yet remai..

Temporal variation of renal function in people with type 2 diabetes mellitus: A retrospective UK clinical practice research datalink cohort study.

Dionysis Spanopoulos, Hajra Okhai, Francesco Zaccardi, Abigail Tebboth, Brendan Barrett, Michael Busse, Joanne Webb, Kamlesh Khunti

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIM: To characterize the longitudinal variability of estimated glomerular filtration rate (eGFR) in people with type 2 diabetes me..

Factors influencing safe glucose-lowering in older adults with type 2 diabetes: A PeRsOn-centred ApproaCh To IndiVidualisEd (PROACTIVE) Glycemic Goals for older people: A position statement of Primary Care Diabetes Europe.

CE Hambling, K Khunti, X Cos, J Wens, L Martinez, P Topsever, S Del Prato, A Sinclair, G Schernthaner, G Rutten, S Seidu

Journal article  |  2019  |  Primary Care Diabetes

Diabetes in later life is associated with a range of factors increasing the complexity of glycaemic management. This position stat..

Postpartum monitoring of women with a history of gestational diabetes - A cross-sectional study of an inner-city population.

Radia Fahami, Nafeesa Dhalwani, Kamlesh Khunti, Melanie Davies, Sam Seidu

Journal article  |  2019  |  Primary Care Diabetes

This was a cross-sectional analysis (1980-2017) in Leicester to examine the proportion of women with a history of gestational diab..

20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study.

Claire A Lawson, Francesco Zaccardi, Iain Squire, Suping Ling, Melanie J Davies, Carolyn SP Lam, Mamas A Mamas, Kamlesh Khunti, Umesh T Kadam

Journal article  |  2019  |  The Lancet Public Health

BACKGROUND: Heart failure is an important public health issue affecting about 1 million people in the UK, but contemporary trends ..

Glycated Hemoglobin Level Goal Achievement in Adults With Type 2 Diabetes in Canada: Still Room for Improvement.

Lawrence A Leiter, Alice YY Cheng, Jean-Marie Ekoé, Ronald M Goldenberg, Stewart B Harris, Irene M Hramiak, Kamlesh Khunti, Peter J Lin, Jean-François Richard, Peter A Senior, Jean-François Yale, Lianne Goldin, Mary K Tan, Anatoly Langer

Journal article  |  2019  |  Canadian Journal of Diabetes

OBJECTIVES: To describe the clinical histories and management of adults with type 2 diabetes who were not reaching their target gl..

Association of smoking and cardiometabolic parameters with albuminuria in people with type 2 diabetes mellitus: a systematic review and meta-analysis.

Debasish Kar, Clare Gillies, Mintu Nath, Kamlesh Khunti, Melanie J Davies, Samuel Seidu

Journal article  |  2019  |  Acta Diabetologica

AIMS: Smoking is a strong risk factor for albuminuria in people with type 2 diabetes mellitus (T2DM). However, it is unclear wheth..

Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease.

Ceri Rowe, Alice J Sitch, Jonathan Barratt, Elizabeth A Brettell, Paul Cockwell, R Neil Dalton, Jon J Deeks, Gillian Eaglestone, Tracy Pellatt-Higgins, Philip A Kalra, Kamlesh Khunti, Fiona C Loud, Frances S Morris, Ryan S Ottridge, Paul E Stevens, Claire C Sharpe, Andrew J Sutton, Maarten W Taal, Edmund J Lamb, undefined eGFR-C Study Group

Journal article  |  2019  |  Kidney International

When assessing changes in glomerular filtration rate (GFR) it is important to differentiate pathological change from intrinsic bio..

Evaluation and refinement of the PRESTARt tool for identifying 12-14 year olds at high lifetime risk of developing type 2 diabetes compared to a clinicians assessment of risk: a cross-sectional study.

Laura J Gray, Emer M Brady, Olatz Albaina, Charlotte L Edwardson, Deirdre Harrington, Kamlesh Khunti, Joanne Miksza, João Filipe Raposo, Ellesha Smith, Andriani Vazeou, Itziar Vergara, Susann Weihrauch-Blüher, Melanie J Davies, undefined PRE-STARt Collaborative

Journal article  |  2019  |  BMC Endocrine Disorders

BACKGROUND: Traditionally Type 2 Diabetes Mellitus (T2DM) was associated with older age, but is now being increasingly diagnosed i..

Incidence and severity of hypoglycaemia in type 2 diabetes by treatment regimen: A UK multisite 12-month prospective observational study.

Alison J Dunkley, Claire Fitzpatrick, Laura J Gray, Ghazala Waheed, Simon R Heller, Brian M Frier, Melanie J Davies, Kamlesh Khunti, undefined Primary Care Diabetes Society

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIMS: To determine the incidence and severity of self-reported hypoglycaemia in a primary care population with type 2 diabetes. Th..

Deintensification in older patients with type 2 diabetes: A systematic review of approaches, rates and outcomes.

Samuel Seidu, Setor K Kunutsor, Pinar Topsever, Clare E Hambling, Francesc X Cos, Kamlesh Khunti

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIM: To assess deintensification approaches and rates and evaluate the harm and benefits of deintensification with antidiabetic me..

Efficacy of low- and very-low-energy diets in people with type 2 diabetes mellitus: A systematic review and meta-analysis of interventional studies.

David E Kloecker, Francesco Zaccardi, Emma Baldry, Melanie J Davies, Kamlesh Khunti, David R Webb

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIMS: To review systematically and quantify the weight loss achieved through low- (LEDs) and very-low-energy diets (VLEDs) in peop..

Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study.

Yogini V Chudasama, Kamlesh K Khunti, Francesco Zaccardi, Alex V Rowlands, Thomas Yates, Clare L Gillies, Melanie J Davies, Nafeesa N Dhalwani

Journal article  |  2019  |  BMC Medicine

BACKGROUND: Multimorbidity is an emerging public health priority. Physical activity (PA) is recommended as one of the main lifesty..

Aspirin has potential benefits for primary prevention of cardiovascular outcomes in diabetes: updated literature-based and individual participant data meta-analyses of randomized controlled trials.

Samuel Seidu, Setor K Kunutsor, Howard D Sesso, JM Gaziano, JE Buring, Maria Carla Roncaglioni, Kamlesh Khunti

Journal article  |  2019  |  Cardiovascular Diabetology

BACKGROUND: The clinical benefit of aspirin for the primary prevention of cardiovascular disease (CVD) in diabetes remains uncerta..

The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal insulin in a real-world setting.

Luigi F Meneghini, Didac Mauricio, Emanuela Orsi, Nebojsa M Lalic, Anna MG Cali, Jukka Westerbacka, Peter Stella, Christophe Candelas Dea, Valerie Pilorget, Riccardo Perfetti, Kamlesh Khunti, undefined DUNE investigators

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIMS: To describe in a real-world setting the achievement of physician-selected individualized HbA1c targets in individuals with t..

Glycaemic control after treatment intensification in patients with type 2 diabetes uncontrolled on two or more non-insulin antidiabetic drugs in a real-world setting.

Silvia Canivell, Manel Mata-Cases, Jordi Real, Josep Franch-Nadal, Bogdan Vlacho, Kamlesh Khunti, Mònica Gratacòs, Dídac Mauricio

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIM: To assess glycaemic control after treatment intensification in patients with type 2 diabetes uncontrolled on ≥2 non-insulin a..

Comparative Relevance of Physical Fitness and Adiposity on Life Expectancy: A UK Biobank Observational Study.

Francesco Zaccardi, Melanie J Davies, Kamlesh Khunti, Tom Yates

Journal article  |  2019  |  Mayo Clinic Proceedings

OBJECTIVE: To investigate the extent to which 2 measures of physical fitness-walking pace and handgrip strength-are associated wit..

Biochemical Urine Testing of Adherence to Cardiovascular Medications Reveals High Rates of Nonadherence in People Attending Their Annual Review for Type 2 Diabetes.

Prashanth Patel, Pankaj Gupta, Angela Burns, Ali A Mohamed, Richard Cole, Dan Lane, Samuel Seidu, Kamlesh Khunti

Journal article  |  2019  |  Diabetes Care

OBJECTIVE: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a new method to objectively and robustly detect nonadheren..

Wrist-Worn Accelerometer-Brand Independent Posture Classification-Corrigendum.

Journal article  |  2019  |  Medicine & Science in Sports & Exercise

Treatment of type 2 diabetes mellitus worldwide: Baseline patient characteristics in the global DISCOVER study.

Marilia B Gomes, Wolfgang Rathmann, Bernard Charbonnel, Kamlesh Khunti, Mikhail Kosiborod, Antonio Nicolucci, Stuart J Pocock, Marina V Shestakova, Iichiro Shimomura, Fengming Tang, Hirotaka Watada, Hungta Chen, Javier Cid-Ruzafa, Peter Fenici, Niklas Hammar, Filip Surmont, Linong Ji, undefined DISCOVER investigators

Journal article  |  2019  |  Diabetes Research and Clinical Practice

AIMS: To describe the characteristics and treatment of patients with type 2 diabetes mellitus initiating a second-line glucose-low..

Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management.

undefined International Hypoglycaemia Study Group

Journal article  |  2019  |  The Lancet Diabetes & Endocrinology

Hypoglycaemia has long been recognised as a dangerous side-effect of treatment of diabetes with insulin or insulin secretagogues. ..

Statin Use in Primary Prevention: A Simple Trial-Based Approach Compared With Guideline-Recommended Risk Algorithms for Selection of Eligible Patients.

Kamlesh Khunti, Hyejung Jung, Antonio L Dans, Claes Held, Gilles R Dagenais, Salim Yusuf, Eva Lonn

Journal article  |  2019  |  Canadian Journal of Cardiology

BACKGROUND: Cardiovascular disease risk assessment tools help identify individuals likely to benefit from preventative therapies. ..

Authors' Reply to Gough: "Achieving Glycaemic Control with Concentrated Insulin in Patients with Type 2 Diabetes".

Sudesna Chatterjee, Kamlesh Khunti, Melanie Davies

Journal article  |  2019  |  Drugs

Reply to Mantovani: "Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes".

Francesco Zaccardi, Amy E Morrison, Kamlesh Khunti, Melanie J Davies

Journal article  |  2019  |  Liver International

Cardiovascular, cancer and mortality events after bariatric surgery in people with and without pre-existing diabetes: A nationwide study.

Nafeesa N Dhalwani, Francesco Zaccardi, Hina Waheed, Jemma Mytton, Dimitris Papamargaritis, David R Webb, Felicity Evison, Richard Lilford, Melanie J Davies, Kamlesh Khunti

Journal article  |  2019  |  Journal of Diabetes

BACKGROUND: Bariatric surgery reduces cardiovascular events and mortality risk in obese individuals. However, it is unclear whethe..

Improving quality in cardiometabolic medicine real-world evidence.

Briana Coles, Freya Tyrer, Kamlesh Khunti

Journal article  |  2019  |  Primary Care Diabetes

Cardiovascular efficacy and safety of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists: a systematic review and network meta-analysis.

H Hussein, F Zaccardi, K Khunti, S Seidu, MJ Davies, LJ Gray

Journal article  |  2019  |  Diabetic Medicine

AIMS: To compare the cardiovascular efficacy and safety of sodium-glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like pe..

Corrections to: Achieving Glycaemic Control with Concentrated Insulin in Patients with Type 2 Diabetes.

Sudesna Chatterjee, Kamlesh Khunti, Melanie J Davies

Journal article  |  2019  |  Drugs

In several sections of this review article, insulin degludec U100 has been incorrectly referred to as a highly concentrated basal ..

Rationale, design and study protocol of the randomised controlled trial: Diabetes Interventional Assessment of Slimming or Training tO Lessen Inconspicuous Cardiovascular Dysfunction (the DIASTOLIC study).

Gaurav Singh Gulsin, Emer M Brady, Daniel J Swarbrick, Lavanya Athithan, Joseph Henson, Emma Baldry, John McAdam, Anna-Marie Marsh, Kelly S Parke, Joanne V Wormleighton, Eylem Levelt, Thomas Yates, Danielle Bodicoat, Kamlesh Khunti, Melanie J Davies, Gerry P McCann

Journal article  |  2019  |  BMJ Open

INTRODUCTION: Despite their young age and relatively short duration of disease, younger adults with type 2 diabetes (T2D) already ..

Effects of blood pressure and lipid lowering on cognition Results from the HOPE-3 study

Jackie Bosch, Martin O'Donnell, Balakumar Swaminathan, Eva Marie Lonn, Mikul Sharma, Gilles Dagenais, Rafael Diaz, Kamlesh Khunti, Basil S Lewis, Alvaro Avezum, Claes Held, Matyas Keltai, Christopher Reid, William D Toff, Antonio Dans, Lawrence A Leiter, Karen Sliwa, Shun Fu Lee, Janice M Pogue, Robert Hart, et al.

Journal article  |  2019  |  Neurology

The Standard of Care in Type 2 Diabetes: Re-evaluating the Treatment Paradigm

V Mohan, ME Cooper, DR Matthews, K Khunti

Journal article  |  2019  |  Diabetes Therapy

Eligibility of patients with type 2 diabetes for sodium-glucose cotransporter 2 inhibitor cardiovascular outcomes trials: A global perspective from the DISCOVER study

S Pintat, P Fenici, N Hammar, L Ji, K Khunti, J Medina, F Tang, E Wittbrodt, F Surmont

Journal article  |  2019  |  BMJ Open Diabetes Research & Care

ObjectiveTo assess the eligibility of patients participating in DISCOVER (a 3-year, prospective, observational study program of 15..

Multimorbidity and lifestyle factors among adults with intellectual disabilities: a cross-sectional analysis of a UK cohort.

F Tyrer, AJ Dunkley, J Singh, C Kristunas, K Khunti, S Bhaumik, MJ Davies, TE Yates, LJ Gray

Journal article  |  2019  |  Journal of Intellectual Disability Research

BACKGROUND: Multimorbidity [two or more conditions in addition to intellectual disability (ID)] is known to be more common among p..

Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes: A meta-analysis with bias analysis.

Amy E Morrison, Francesco Zaccardi, Kamlesh Khunti, Melanie J Davies

Journal article  |  2019  |  Liver International

BACKGROUND & AIMS: A causal association of non-alcoholic fatty liver disease (NAFLD) with cardiovascular disease (CVD) and type 2 ..

Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5-year and longer-term modelled outcomes of the ADDITION-Leicester study.

David Webb, Jolyon Dales, Francesco Zaccardi, Sian Hill, Corran Moore, Azhar Farooqi, Simon Griffin, Melanie Davies, Kamlesh Khunti

Journal article  |  2019  |  Diabetes/Metabolism Research and Reviews

AIMS: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provid..

Prevalence and progression of diabetic nephropathy in South Asian, white European and African Caribbean people with type 2 diabetes: A systematic review and meta-analysis.

Chandni Jadawji, Winston Crasto, Clare Gillies, Debasish Kar, Melanie J Davies, Kamlesh Khunti, Samuel Seidu

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

AIMS: To conduct a systematic review and meta-analysis of published observational evidence to assess the difference in the prevale..

Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis.

Lorenzo M Vetrone, Francesco Zaccardi, David R Webb, Sam Seidu, Nitin N Gholap, Dario Pitocco, Melanie J Davies, Kamlesh Khunti

Journal article  |  2019  |  Acta Diabetologica

AIMS: To investigate cardiovascular disease and mortality trends in control arm participants of diabetes cardiovascular outcome tr..

Therapeutic Inertia and the Legacy of Dysglycemia on the Microvascular and Macrovascular Complications of Diabetes.

Kamlesh Khunti, Samuel Seidu

Journal article  |  2019  |  Diabetes Care

Response to commentary by Rhew and colleagues on: Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.

Setor K Kunutsor, Samuel Seidu, Kamlesh Khunti

Journal article  |  2019  |  Annals of Medicine

Conceptualizing multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy.

Umesh T Kadam, Isobel Roberts, Simon White, Ruth Bednall, Kamlesh Khunti, Peter M Nilsson, Claire A Lawson

Journal article  |  2019  |  Journal of Clinical Epidemiology

With older and aging populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guide..

Should sodium-glucose co-transporter-2 inhibitors be considered as first-line oral therapy for people with type 2 diabetes?

Kamlesh Khunti, Samuel Seidu, Melanie J Davies

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

Meta-analysis of the influence of lifestyle changes for preoperative weight loss on surgical outcomes.

M Roman, A Monaghan, GF Serraino, D Miller, S Pathak, F Lai, F Zaccardi, A Ghanchi, K Khunti, MJ Davies, GJ Murphy

Journal article  |  2019  |  BJS

BACKGROUND: The aim was to investigate whether preoperative weight loss results in improved clinical outcomes in surgical patients..

Achieving Glycaemic Control with Concentrated Insulin in Patients with Type 2 Diabetes.

Sudesna Chatterjee, Kamlesh Khunti, Melanie J Davies

Journal article  |  2019  |  Drugs

The recent introduction of the second-generation long-acting analogue insulins degludec and insulin glargine U300 have increased t..

Correction to: Achieving Glycaemic Control with Concentrated Insulin in Patients with Type 2 Diabetes.

Sudesna Chatterjee, Kamlesh Khunti, Melanie J Davies

Journal article  |  2019  |  Drugs

Page 7, Section 4.1, third paragraph, which previously read.

Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial.

Richard IG Holt, Rebecca Gossage-Worrall, Daniel Hind, Michael J Bradburn, Paul McCrone, Tiyi Morris, Charlotte Edwardson, Katharine Barnard, Marian E Carey, Melanie J Davies, Chris M Dickens, Yvonne Doherty, Angela Etherington, Paul French, Fiona Gaughran, Kathryn E Greenwood, Sridevi Kalidindi, Kamlesh Khunti, Richard Laugharne, John Pendlebury, et al.

Journal article  |  2019  |  The British Journal of Psychiatry

BACKGROUND: Obesity is a major challenge for people with schizophrenia.AimsWe assessed whether STEPWISE, a theory-based, group str..

Update on the General Practice Optimising Structured Monitoring to Improve Clinical Outcomes in Type 2 Diabetes (GP-OSMOTIC) trial: statistical analysis plan for a multi-centre randomised controlled trial

Sharmala Thuraisingam, Patty Chondros, Max Catchpool, Kim Dalziel, Jo-Anne Manski-Nankervis, Jane Speight, Elizabeth Holmes-Truscott, Ralph Audehm, Jason Chiang, Irene Blackberry, David O'Neal, Kamlesh Khunti, James Best, John Furler

Journal article  |  2019  |  Trials

Differences in objectively measured physical activity and sedentary behaviour between white Europeans and south Asians recruited from primary care: cross-sectional analysis of the PROPELS trial.

Gregory JH Biddle, Charlotte L Edwardson, Alex V Rowlands, Melanie J Davies, Danielle H Bodicoat, Wendy Hardeman, Helen Eborall, Stephen Sutton, Simon Griffin, Kamlesh Khunti, Thomas Yates

Journal article  |  2019  |  BMC Public Health

BACKGROUND: Self-reported data have consistently shown South Asians (SAs) to be less physically active than White Europeans (WEs) ..

Personalising treatment for type 2 diabetes: Why is NICE so behind?

S Seidu, K Khunti

Journal article  |  2019  |  Clinical Pharmacist

Objective measures of non-adherence in cardiometabolic diseases: A review focused on urine biochemical screening

D Lane, P Patel, K Khunti, P Gupta

Journal article  |  2019  |  Patient Preference and Adherence

Hypoglycaemia is associated with increased risk of fractures in patients with type 2 diabetes mellitus: a cohort study.

Antiopi Ntouva, Konstantinos A Toulis, Deepikshana Keerthy, Nicola J Adderley, Wasim Hanif, Rasiah Thayakaran, Krishna Gokhale, G Neil Thomas, Kamlesh Khunti, Abd A Tahrani, Krishnarajah Nirantharakumar

Journal article  |  2019  |  European Journal of Endocrinology

Objective Type 2 diabetes is associated with an increased risk of fracture. Any factor that incrementally increases this risk shou..

Micro-costing and a cost-consequence analysis of the 'Girls Active' programme: A cluster randomised controlled trial.

Joanna M Charles, Deirdre M Harrington, Melanie J Davies, Charlotte L Edwardson, Trish Gorely, Danielle H Bodicoat, Kamlesh Khunti, Lauren B Sherar, Thomas Yates, Rhiannon Tudor Edwards

Journal article  |  2019  |  PLOS ONE

Physical inactivity has been identified as a leading risk factor for premature mortality globally, and adolescents, in particular,..

Baby Steps - a structured group education programme with accompanying mobile web application designed to promote physical activity in women with a history of gestational diabetes: study protocol for a randomised controlled trial.

Nithya Sukumar, Helen Dallosso, Ponnusamy Saravanan, Tom Yates, Carol Telling, Karen Shorthose, Alison Northern, Sally Schreder, Christopher Brough, Laura J Gray, Melanie J Davies, Kamlesh Khunti

Journal article  |  2018  |  Trials

BACKGROUND: A diagnosis of gestational diabetes (GDM) is associated with an over sevenfold increase in the risk of developing type..

Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease.

Claire A Lawson, Mamas A Mamas, Peter W Jones, Lucy Teece, Gerry McCann, Kamlesh Khunti, Umesh T Kadam

Journal article  |  2018  |  JAMA Network Open

Importance: In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effec..

Body mass index and mortality in people with and without diabetes: A UK Biobank study.

NN Dhalwani, F Zaccardi, MJ Davies, K Khunti

Journal article  |  2018  |  Nutrition, Metabolism and Cardiovascular Diseases

BACKGROUND AND AIMS: To investigate the association of body mass index with all-cause, cardiovascular and cancer mortality in indi..

Clinical management of type 2 diabetes in south Asia.

Anoop Misra, Naveed Sattar, Nikhil Tandon, Usha Shrivastava, Naval K Vikram, Kamlesh Khunti, Andrew P Hills

Journal article  |  2018  |  The Lancet Diabetes & Endocrinology

Compared with other ethnic groups, south Asian people with type 2 diabetes tend to develop the disease at a younger age and manife..

Public health and health systems: implications for the prevention and management of type 2 diabetes in south Asia.

Andrew P Hills, Anoop Misra, Jason MR Gill, Nuala M Byrne, Mario J Soares, Ambady Ramachandran, Latha Palaniappan, Steven J Street, Ranil Jayawardena, Kamlesh Khunti, Ross Arena

Journal article  |  2018  |  The Lancet Diabetes & Endocrinology

Many non-communicable chronic diseases, including type 2 diabetes, are highly prevalent, costly, and largely preventable. The prev..

Epidemiology and determinants of type 2 diabetes in south Asia.

Andrew P Hills, Ross Arena, Kamlesh Khunti, Chittaranjan Sakerlal Yajnik, Ranil Jayawardena, Christiani Jeyakumar Henry, Steven J Street, Mario J Soares, Anoop Misra

Journal article  |  2018  |  The Lancet Diabetes & Endocrinology

Type 2 diabetes has rapidly developed into a major public health problem in south Asia (defined here as Bangladesh, Bhutan, India,..

Effects of intensive interventions compared to standard care in people with type 2 diabetes and microalbuminuria on risk factors control and cardiovascular outcomes: A systematic review and meta-analysis of randomised controlled trials.

Muhammad Usman, Clare L Gillies, Kamlesh Khunti, Melanie J Davies

Journal article  |  2018  |  Diabetes Research and Clinical Practice

AIMS: The effect of intensive glycaemic control, blood pressure control and lipid levels control alone or as part of a multifactor..

Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program).

Mikhail Kosiborod, Marilia B Gomes, Antonio Nicolucci, Stuart Pocock, Wolfgang Rathmann, Marina V Shestakova, Hirotaka Watada, Iichiro Shimomura, Hungta Chen, Javier Cid-Ruzafa, Peter Fenici, Niklas Hammar, Filip Surmont, Fengming Tang, Kamlesh Khunti, undefined DISCOVER investigators

Journal article  |  2018  |  Cardiovascular Diabetology

BACKGROUND: The global prevalence of type 2 diabetes-related complications is not well described. We assessed prevalence of vascul..

Comparison of the HAT study, the largest global hypoglycaemia study to date, with similar large real-world studies.

Ulrik Pedersen-Bjergaard, Saud Alsifri, Ronnie Aronson, Maja Cigrovski Berković, Gagik Galstyan, Helge Gydesen, Jesper Barner Lekdorf, Bernhard Ludvik, Erik Moberg, Ambady Ramachandran, Kamlesh Khunti

Journal article  |  2018  |  Diabetes, Obesity and Metabolism

AIMS: Optimal diabetes care requires clear understanding of the incidence of hypoglycaemia in real-world clinical practice. Curren..

Efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes: a systematic review and network meta-analysis study protocol.

Humaira Hussein, Francesco Zaccardi, Nafeesa N Dhalwani, Melanie J Davies, Kamlesh Khunti, Laura J Gray

Journal article  |  2018  |  BMJ Open

INTRODUCTION: Sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are tw..

Structured lifestyle education to support weight loss for people with schizophrenia, schizoaffective disorder and first episode psychosis: the STEPWISE RCT.

Richard Ig Holt, Daniel Hind, Rebecca Gossage-Worrall, Michael J Bradburn, David Saxon, Paul McCrone, Tiyi A Morris, Angela Etherington, David Shiers, Katharine Barnard, Lizzie Swaby, Charlotte Edwardson, Marian E Carey, Melanie J Davies, Christopher M Dickens, Yvonne Doherty, Paul French, Kathryn E Greenwood, Sridevi Kalidindi, Kamlesh Khunti, et al.

Journal article  |  2018  |  Health Technology Assessment

BACKGROUND: Obesity is twice as common in people with schizophrenia as in the general population. The National Institute for Healt..

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.

Diana L Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K Andersen, Alessandra Chesi, Mohammad I Hawa, Asa Davis, Kenyaita M Hodge, Jonathan P Bradfield, Kaixin Zhou, Vanessa C Guy, Mikael Åkerlund, Mette Wod, Lars G Fritsche, Henrik Vestergaard, James Snyder, Kurt Højlund, Allan Linneberg, Annemari Käräjämäki, Ivan Brandslund, et al.

Journal article  |  2018  |  Diabetes Care

OBJECTIVE: Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, the..

Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician.

Lawrence Blonde, Kamlesh Khunti, Stewart B Harris, Casey Meizinger, Neil S Skolnik

Journal article  |  2018  |  Advances in Therapy

Real-world studies have become increasingly important in providing evidence of treatment effectiveness in clinical practice. While..

The ready to reduce risk (3R) study for a group educational intervention with telephone and text messaging support to improve medication adherence for the primary prevention of cardiovascular disease: Protocol for a randomized controlled trial

JL Byrne, HM Dallosso, S Rogers, LJ Gray, G Waheed, P Patel, P Gupta, Y Doherty, M Davies, K Khunti

Journal article  |  2018  |  JMIR Research Protocols

Cost-Utility of an Objective Biochemical Measure to Improve Adherence to Antihypertensive Treatment.

Alexander V van Schoonhoven, Antoinette DI van Asselt, Maciej Tomaszewski, Prashanth Patel, Kamlesh Khunti, Pankaj Gupta, Maarten J Postma

Journal article  |  2018  |  Hypertension

Nonadherence to antihypertensive medications is known to be a major health problem. Novel biochemical analyses using liquid chroma..

Movement through Active Personalised engagement (MAP) - a self-management programme designed to promote physical activity in people with multimorbidity: study protocol for a randomised controlled trial.

Helen Dallosso, Tom Yates, Hamidreza Mani, Laura J Gray, Nafeesa Dhalwani, Emma Baldry, Clare Gillies, Sue Cradock, Mark Batt, Melanie J Davies, Kamlesh Khunti

Journal article  |  2018  |  Trials

BACKGROUND: Multimorbidity, defined as two or more concurrent chronic diseases within the same individual, is becoming the clinica..

Associations of Physical Behaviours and Behavioural Reallocations with Markers of Metabolic Health: A Compositional Data Analysis.

Gregory JH Biddle, Charlotte L Edwardson, Joseph Henson, Melanie J Davies, Kamlesh Khunti, Alex V Rowlands, Thomas Yates

Journal article  |  2018  |  International Journal of Environmental Research and Public Health

Standard statistical modelling has shown that the reallocation of sitting time to either standing or stepping may be beneficial fo..

Physical Activity after Cardiac EventS (PACES) - a group education programme with subsequent text-message support designed to increase physical activity in individuals with diagnosed coronary heart disease: study protocol for a randomised controlled trial.

Louisa Y Herring, Helen Dallosso, Sudesna Chatterjee, Danielle Bodicoat, Sally Schreder, Kamlesh Khunti, Tom Yates, Sam Seidu, Ian Hudson, Melanie J Davies

Journal article  |  2018  |  Trials

BACKGROUND: Coronary heart disease (CHD) represents approximately 13% of deaths worldwide and is the leading cause of death in the..

The Berlin Declaration: A call to improve early actions related to type 2 diabetes. Why is primary care important?

Kamlesh Khunti, James R Gavin, Andrew JM Boulton, Rick Blickstead, Margaret McGill, Antonio Ceriello, Itamar Raz, Shaukat Sadikot, David A Wood, Xavier Cos, Sanjay Kalra, Ashok Kumar Das, Cutberto Espinosa López, undefined Berlin Declaration Steering Group

Journal article  |  2018  |  Primary Care Diabetes

Diabetes is epidemic worldwide and places a huge burden on healthcare systems. The majority of the cost of type 2 diabetes (T2D) i..

Time to Treatment Intensification After Monotherapy Failure and Its Association With Subsequent Glycemic Control Among 93,515 Patients With Type 2 Diabetes.

Urvi Desai, Noam Y Kirson, Jennifer Kim, Kamlesh Khunti, Sarah King, Erich Trieschman, Michael Hellstern, Phillip R Hunt, Jayanti Mukherjee

Conference Proceedings  |  2018  |  Diabetes Care

OBJECTIVE: The goal of this study was to evaluate the association between the timing of treatment intensification and subsequent g..

Interventions for Improving Modifiable Risk Factor Control in the Secondary Prevention of Stroke.

Bernadeta Bridgwood, Kate E Lager, Amit K Mistri, Kamlesh Khunti, Andrew D Wilson, Priya Modi

Journal article  |  2018  |  Stroke

Association of hypoglycaemia and risk of cardiac arrhythmia in patients with diabetes mellitus: A systematic review and meta-analysis.

Claire Fitzpatrick, Sudesna Chatterjee, Samuel Seidu, Danielle H Bodicoat, G Andre Ng, Melanie J Davies, Kamlesh Khunti

Journal article  |  2018  |  Diabetes, Obesity and Metabolism

AIMS: Hypoglycaemia is associated with increased cardiovascular risk among individuals with diabetes mellitus. It has been hypothe..

GP-OSMOTIC trial protocol: an individually randomised controlled trial to determine the effect of retrospective continuous glucose monitoring (r-CGM) on HbA1c in adults with type 2 diabetes in general practice

John Furler, David Norman O'Neal, Jane Speight, Irene Blackberry, Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Katie de La Rue, Louise Ginnivan, Jessica Lea Browne, Elizabeth Holmes-Truscott, Kamlesh Khunti, Kim Dalziel, Jason Chiang, Ralph Audehm, Mark Kennedy, Malcolm Clark, Alicia Josephine Jenkins, Danny Liew, Philip Clarke, James Best

Journal article  |  2018  |  BMJ Open

Rates of myocardial infarction and stroke in patients initiating treatment with SGLT2-inhibitors versus other glucose-lowering agents in real-world clinical practice: Results from the CVD-REAL study.

Mikhail Kosiborod, Kåre I Birkeland, Matthew A Cavender, Alex Z Fu, John P Wilding, Kamlesh Khunti, Reinhard W Holl, Anna Norhammar, Marit E Jørgensen, Eric T Wittbrodt, Marcus Thuresson, Johan Bodegård, Niklas Hammar, Peter Fenici, undefined CVD-REAL Investigators and Study Group

Journal article  |  2018  |  Diabetes, Obesity and Metabolism

The multinational, observational CVD-REAL study recently showed that initiation of sodium-glucose co-transporter-2 inhibitors (SGL..

Changes in HbA1c and weight, and treatment persistence, over the 18 months following initiation of second-line therapy in patients with type 2 diabetes: results from the United Kingdom Clinical Practice Research Datalink.

John Wilding, Thomas Godec, Kamlesh Khunti, Stuart Pocock, Robin Fox, Liam Smeeth, Per Clauson, Peter Fenici, Niklas Hammar, Jesús Medina

Journal article  |  2018  |  BMC Medicine

BACKGROUND: Intensification of metformin monotherapy with additional glucose-lowering drugs is often required in patients with typ..

Alogliptin in Patients with Type 2 Diabetes Receiving Metformin and Sulfonylurea Therapies in the EXAMINE Trial.

William B White, Simon R Heller, Christopher P Cannon, Heena Howitt, Kamlesh Khunti, Richard M Bergenstal, undefined EXAMINE Investigators

Journal article  |  2018  |  The American Journal of Medicine

BACKGROUND: We evaluated the antihyperglycemic efficacy and safety of adding the dipeptidyl dipeptidase-4 inhibitor alogliptin to ..

Cardiovascular Events Associated With SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL 2 Study.

Mikhail Kosiborod, Carolyn SP Lam, Shun Kohsaka, Dae Jung Kim, Avraham Karasik, Jonathan Shaw, Navdeep Tangri, Su-Yen Goh, Marcus Thuresson, Hungta Chen, Filip Surmont, Niklas Hammar, Peter Fenici, undefined CVD-REAL Investigators and Study Group

Journal article  |  2018  |  Journal of the American College of Cardiology

BACKGROUND: Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium-glucose cotransporter-2 inhibito..

SGLT-2 Inhibitors and Cardiovascular Risk: An Analysis of CVD-REAL.

Matthew A Cavender, Anna Norhammar, Kåre I Birkeland, Marit Eika Jørgensen, John P Wilding, Kamlesh Khunti, Alex Z Fu, Johan Bodegård, Betina T Blak, Eric Wittbrodt, Marcus Thuresson, Peter Fenici, Niklas Hammar, Mikhail Kosiborod, undefined CVD-REAL Investigators and Study Group

Journal article  |  2018  |  Journal of the American College of Cardiology

BACKGROUND: Prior studies found patients treated with sodium-glucose co-transporter-2 inhibitors (SGLT-2i) had lower rates of deat..

Weight loss and mortality risk in patients with different adiposity at diagnosis of type 2 diabetes: a longitudinal cohort study

Ebenezer S Adjah Owusu, Mayukh Samanta, Jonathan E Shaw, Azeem Majeed, Kamlesh Khunti, Sanjoy K Paul

Journal article  |  2018  |  Nutrition & Diabetes

SGLT2 inhibitors and renal outcomes in type 2 diabetes with or without renal impairment: A systematic review and meta-analysis.

Samuel Seidu, Setor K Kunutsor, Xavier Cos, Syed Gillani, Kamlesh Khunti, undefined For and on behalf of Primary Care Diabetes Europe

Journal article  |  2018  |  Primary Care Diabetes

BACKGROUND: Sodium-glucose co-transporter 2 (SGLT2) inhibitors may have renal protective effects in people with impaired kidney fu..

The general practitioner prompt study to reduce cardiovascular and renal complications in patients with type 2 diabetes and renal complications: Protocol and baseline characteristics for a cluster randomized controlled trial

A Willis, W Crasto, L Gray, H Dallosso, G Waheed, G Gray, MJ Davies, K Khunti

Journal article  |  2018  |  JMIR Research Protocols

Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity: a matched case-control analysis

Ebenezer S Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti, Sanjoy K Paul

Journal article  |  2018  |  Cardiovascular Diabetology

The Berlin Declaration: A call to action to improve early actions related to type 2 diabetes. How can specialist care help?

Antonio Ceriello, James R Gavin, Andrew JM Boulton, Rick Blickstead, Margaret McGill, Itamar Raz, Shaukat Sadikot, David A Wood, Xavier Cos, Kamlesh Khunti, Sanjay Kalra, Ashok Kumar Das, Cutberto Espinosa López, undefined Berlin Declaration Steering Group

Journal article  |  2018  |  Diabetes Research and Clinical Practice

Diabetes is a major global epidemic and places a huge burden on healthcare systems worldwide. The complications of type 2 diabetes..

Sleep duration, obesity and insulin resistance in a multi-ethnic UK population at high risk of diabetes.

EM Brady, DH Bodicoat, AP Hall, K Khunti, T Yates, C Edwardson, MJ Davies

Journal article  |  2018  |  Diabetes Research and Clinical Practice

AIMS: Investigating the association between sleep duration, obesity, adipokines and insulin resistance (via Leptin:Adiponectin rat..

Effectiveness of the 'Girls Active' school-based physical activity programme: A cluster randomised controlled trial.

Deirdre M Harrington, Melanie J Davies, Danielle H Bodicoat, Joanna M Charles, Yogini V Chudasama, Trish Gorely, Kamlesh Khunti, Tatiana Plekhanova, Alex V Rowlands, Lauren B Sherar, Rhiannon Tudor Edwards, Thomas Yates, Charlotte L Edwardson

Journal article  |  2018  |  International Journal of Behavioral Nutrition and Physical Activity

BACKGROUND: Globally, adolescent girls' physical activity (PA) levels are low. The 'Girls Active' secondary school-based programme..

Polycystic ovary syndrome: An underestimated problem in primary care.

Hamidreza Mani, Miles J Levy, Kamlesh Khunti

Journal article  |  2018  |  International Journal of Clinical Practice

Type 2 diabetes - Authors' reply.

Sudesna Chatterjee, Kamlesh Khunti, Melanie J Davies

Journal article  |  2018  |  The Lancet

The impact of neighbourhood walkability on the effectiveness of a structured education programme to increase objectively measured walking.

P Carter, DH Bodicoat, A Jones, K Khunti, MJ Davies, CL Edwardson, J Henson, T Yates, E Coombes

Journal article  |  2018  |  Journal of Public Health

Background: Incorporating physical activity into daily activities is key for the effectiveness of lifestyle education intervention..

Achievement of guideline targets for blood pressure, lipid, and glycaemic control in type 2 diabetes: A meta-analysis.

Kamlesh Khunti, Antonio Ceriello, Xavier Cos, Christophe De Block

Journal article  |  2018  |  Diabetes Research and Clinical Practice

We assessed global achievement of targets recommended by the American Diabetes Association (ADA), European Association for the Stu..

Associations Between Sedentary Behaviors and Cognitive Function: Cross-Sectional and Prospective Findings From the UK Biobank.

Kishan Bakrania, Charlotte L Edwardson, Kamlesh Khunti, Stephan Bandelow, Melanie J Davies, Thomas Yates

Journal article  |  2018  |  American Journal of Epidemiology

We investigated the cross-sectional and prospective associations between different sedentary behaviors and cognitive function in a..

Response by Kosiborod et al to Letters Regarding Article, "Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors)".

Mikhail Kosiborod, Matthew A Cavender, Alex Z Fu, John P Wilding, Kamlesh Khunti, Reinhard W Holl, Anna Norhammar, Kåre I Birkeland, Marit Eika Jørgensen, Marcus Thuresson, Niki Arya, Johan Bodegård, Niklas Hammar, Peter Fenici, undefined CVD-REAL Investigators and Study Group

Journal article  |  2018  |  Circulation

Technology and chronic disease management - Authors' reply.

Sudesna Chatterjee, Melanie J Davies, Simon Heller, Jane Speight, Frank J Snoek, Kamlesh Khunti

Journal article  |  2018  |  The Lancet Diabetes & Endocrinology

Accelerometer-assessed Physical Activity in Epidemiology: Are Monitors Equivalent?

Alex V Rowlands, Evgeny M Mirkes, Tom Yates, Stacey Clemes, Melanie Davies, Kamlesh Khunti, Charlotte L Edwardson

Journal article  |  2018  |  Medicine & Science in Sports & Exercise

PURPOSE: Accelerometers are increasingly being used to assess physical activity in large-scale surveys. Establishing whether key p..

What have we learnt from "real world" data, observational studies and meta-analyses.

Sudesna Chatterjee, Melanie J Davies, Kamlesh Khunti

Journal article  |  2018  |  Diabetes, Obesity and Metabolism

The incretin therapies glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-IV (DPP-IV) inhibitors are no..

Moderate increases in daily step count are associated with reduced IL6 and CRP in women with PCOS

MA Webb, H Mani, SJ Robertson, HL Waller, DR Webb, CL Edwardson, DH Bodicoat, T Yates, K Khunti, MJ Davies

Journal article  |  2018  |  Endocrine Connections

Aims Physical activity has been proposed to be an effective non-pharmacological method of reducing systemic inflammation and there..

Sedentary Time and MRI-Derived Measures of Adiposity in Active Versus Inactive Individuals.

Joseph Henson, Charlotte L Edwardson, Bruno Morgan, Mark A Horsfield, Kamlesh Khunti, Melanie J Davies, Thomas Yates

Journal article  |  2018  |  Obesity

OBJECTIVE: The aim of this study was to examine cross-sectional associations between objectively measured sedentary time and magne..

Structured education programme for women with polycystic ovary syndrome: A randomised controlled trial

H Mani, Y Chudasama, M Hadjiconstantinou, DH Bodicoat, C Edwardson, MJ Levy, LJ Gray, J Barnett, H Daly, TA Howlett, K Khunti, MJ Davies

Journal article  |  2018  |  Endocrine Connections

Objective To evaluate the effectiveness of a structured education programmes in women with polycystic ovary syndrome (PCOS). Met..

Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease: A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial

Philip Joseph, Eva Lonn, Jackie Bosch, Patricio Lopez, Jun Zhu, Matyas Keltai, Anthony Dans, Christopher Reid, Kamlesh Khunti, William Toff, Leopoldo Piegas, Jae-Hyung Kim, Balakumar Swaminathan, Michael Bohm, Salim Yusuf

Journal article  |  2018  |  Canadian Journal of Cardiology

Real-world evaluation of the DESMOND type 2 diabetes education and self-management programme

S Chatterjee, MJ Davies, B Stribling, A Farooqi, K Khunti

Journal article  |  2018  |  Practical Diabetes

Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population: Stratification by Diabetic Glycemic Control and Medication Intensification.

Claire A Lawson, Peter W Jones, Lucy Teece, Sandra B Dunbar, Petar M Seferovic, Kamlesh Khunti, Mamas Mamas, Umesh T Kadam

Journal article  |  2018  |  JACC: Heart Failure

OBJECTIVES: This study sought to investigate in the general heart failure (HF) population, whether the associations between type 2..

Associations of Physical Activity Intensities with Markers of Insulin Sensitivity.

Charlotte Jelleyman, Charlotte L Edwardson, Joseph Henson, Laura J Gray, Alex V Rowlands, Kamlesh Khunti, Melanie J Davies, Thomas Yates

Journal article  |  2017  |  Medicine & Science in Sports & Exercise

BACKGROUND: Objectively measured physical activity (PA) intensity has traditionally been categorized as light, moderate, and vigor..

Barriers and Facilitators to Healthy Lifestyle Changes in Minority Ethnic Populations in the UK: a Narrative Review.

Naina Patel, Harriet Batista Ferrer, Freya Tyrer, Paula Wray, Azhar Farooqi, Melanie J Davies, Kamlesh Khunti

Journal article  |  2017  |  Journal of Racial and Ethnic Health Disparities

Minority ethnic populations experience a disproportionate burden of health inequalities compared with the rest of the population, ..

Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study.

Thomas Yates, Francesco Zaccardi, Nafeesa N Dhalwani, Melanie J Davies, Kishan Bakrania, Carlos A Celis-Morales, Jason MR Gill, Paul W Franks, Kamlesh Khunti

Journal article  |  2017  |  European Heart Journal

Aims: To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer m..

Fitness Moderates Glycemic Responses to Sitting and Light Activity Breaks

Matthew McCarthy, Charlotte L Edwardson, Melanie J Davies, Joesph Henson, Danielle H Bodicoat, Kamlesh Khunti, David W Dunstan, James A King, Thomas Yates

Journal article  |  2017  |  Medicine & Science in Sports & Exercise

Association between polypharmacy and falls in older adults: a longitudinal study from England.

Nafeesa N Dhalwani, Radia Fahami, Harini Sathanapally, Sam Seidu, Melanie J Davies, Kamlesh Khunti

Journal article  |  2017  |  BMJ Open

OBJECTIVES: Assess the longitudinal association between polypharmacy and falls and examine the differences in this association by ..

Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes.

Kamlesh Khunti, Saud Alsifri, Ronnie Aronson, Maja Cigrovski Berković, Catherine Enters-Weijnen, Tom Forsén, Gagik Galstyan, Petronella Geelhoed-Duijvestijn, Margalit Goldfracht, Helge Gydesen, Rahul Kapur, Nebojsa Lalic, Bernhard Ludvik, Erik Moberg, Ulrik Pedersen-Bjergaard, Ambady Ramachandran, undefined HAT Investigator Group

Journal article  |  2017  |  Diabetes Research and Clinical Practice

AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countr..

Comparison of body mass index at diagnosis of diabetes in a multi-ethnic population: A case-control study with matched non-diabetic controls

Sanjoy K Paul, Ebenezer S Owusu Adjah, Mayukh Samanta, Kiran Patel, Srikanth Bellary, Wasim Hanif, Kamlesh Khunti

Journal article  |  2017  |  Diabetes, Obesity and Metabolism

Efficacy and Safety of IDegLira in Participants with Type 2 Diabetes in India Uncontrolled on Oral Antidiabetic Drugs and Basal Insulin: Data from the DUAL Clinical Trial Program

K Khunti, V Mohan, SM Jain, TW Boesgaard, K Begtrup, B Sethi

Journal article  |  2017  |  Diabetes Therapy

Associations Between Anthropometric Measurements and Cardiometabolic Risk Factors in White European and South Asian Adults in the United Kingdom.

Farah F Kidy, Nafeesa Dhalwani, Deirdre M Harrington, Laura J Gray, Danielle H Bodicoat, David Webb, Melanie J Davies, Kamlesh Khunti

Journal article  |  2017  |  Mayo Clinic Proceedings

OBJECTIVE: To investigate the association of 4 anthropometric measurements with cardiometabolic risk factors in a UK biethnic samp..

Integrated primary care: is this the solution to the diabetes epidemic?

S Seidu, MJ Davies, A Farooqi, K Khunti

Journal article  |  2017  |  Diabetic Medicine

Cardiovascular risk factors and incident albuminuria in screen-detected type 2 diabetes.

DR Webb, F Zaccardi, MJ Davies, SJ Griffin, NJ Wareham, RK Simmons, GE Rutten, A Sandbaek, T Lauritzen, K Borch-Johnsen, K Khunti

Journal article  |  2017  |  Diabetes/Metabolism Research and Reviews

BACKGROUND: It is unclear whether cardiovascular risk factor modification influences the development of renal disease in people wi..

Associations of moderate-to-vigorous-intensity physical activity and body mass index with glycated haemoglobin within the general population: a cross-sectional analysis of the 2008 Health Survey for England.

Kishan Bakrania, Thomas Yates, Charlotte L Edwardson, Danielle H Bodicoat, Dale W Esliger, Jason MR Gill, Aadil Kazi, Latha Velayudhan, Alan J Sinclair, Naveed Sattar, Stuart JH Biddle, Mark Hamer, Melanie J Davies, Kamlesh Khunti

Journal article  |  2017  |  BMJ Open

OBJECTIVES: To investigate the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and bo..

Evaluating the impact of an enhanced primary care diabetes service on diabetes outcomes: A before-after study.

S Seidu, DH Bodicoat, MJ Davies, H Daly, B Stribling, A Farooqi, EM Brady, K Khunti

Journal article  |  2017  |  Primary Care Diabetes

Diabetes is an ambulatory care-sensitive condition and a high quality primary care or risk factor control can lead to a decrease i..

Association Between Lifestyle Factors and the Incidence of Multimorbidity in an Older English Population.

Nafeesa N Dhalwani, Francesco Zaccardi, Gary O'Donovan, Patrice Carter, Mark Hamer, Thomas Yates, Melanie Davies, Kamlesh Khunti

Journal article  |  2017  |  The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Background: Evidence on the role of lifestyle factors in relation to multimorbidity, especially in elderly populations, is scarce...

Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis

Zin Z Htike, Francesco Zaccardi, Dimitris Papamargaritis, David R Webb, Kamlesh Khunti, Melanie J Davies

Journal article  |  2017  |  Diabetes, Obesity and Metabolism

Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials.

SK Kunutsor, S Seidu, K Khunti

Journal article  |  2017  |  Diabetic Medicine

AIMS: To evaluate the benefits and harms of aspirin for the primary prevention of cardiovascular disease and all-cause mortality e..

Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus.

Kishan Bakrania, Charlotte L Edwardson, Kamlesh Khunti, Joseph Henson, Emmanuel Stamatakis, Mark Hamer, Melanie J Davies, Thomas Yates

Journal article  |  2017  |  Preventive Medicine Reports

The relationships of physical activity and sedentary time with all-cause mortality in those at high risk of type 2 diabetes mellit..

Clinical inertia to insulin initiation and intensification in the UK: A focused literature review

Kamlesh Khunti, David Millar-Jones

Journal article  |  2017  |  Primary Care Diabetes

Associations of reallocating sitting time into standing or stepping with glucose, insulin and insulin sensitivity: a cross-sectional analysis of adults at risk of type 2 diabetes

Charlotte L Edwardson, Joe Henson, Danielle H Bodicoat, Kishan Bakrania, Kamlesh Khunti, Melanie J Davies, Thomas Yates

Journal article  |  2017  |  BMJ Open

Exploring the characteristics of suboptimally controlled patients after 24 weeks of basal insulin treatment: An individualized approach to intensification

Kamlesh Khunti, Taner Damci, Lise Lotte Husemoen, Vinay Babu, Andreas Liebl

Journal article  |  2017  |  Diabetes Research and Clinical Practice

Variations in coronary mortality rates between English primary care trusts: observational study 1993-2010.

LS Levene, R Baker, K Khunti, MJG Bankart

Journal article  |  2016  |  Journal of Public Health

Management of type 2 diabetes: the current situation and key opportunities to improve care in the UK.

SC Bain, M Feher, D Russell-Jones, K Khunti

Journal article  |  2016  |  Diabetes, Obesity and Metabolism

In common with global trends, the number of individuals with type 2 diabetes in the UK is rising, driven largely by obesity. The i..

Impact of Information Technology-Based Interventions for Type 2 Diabetes Mellitus on Glycemic Control: A Systematic Review and Meta-Analysis.

Nouf Sahal Alharbi, Nada Alsubki, Simon Jones, Kamlesh Khunti, Neil Munro, Simon de Lusignan

Journal article  |  2016  |  Journal of Medical Internet Research

BACKGROUND: Information technology-based interventions are increasingly being used to manage health care. However, there is confli..

Relationship of cardiometabolic parameters in non-smokers, current smokers, and quitters in diabetes: a systematic review and meta-analysis

Debasish Kar, Clare Gillies, Francesco Zaccardi, David Webb, Samuel Seidu, Solomon Tesfaye, Melanie Davies, Kamlesh Khunti

Journal article  |  2016  |  Cardiovascular Diabetology

Intensity Thresholds on Raw Acceleration Data: Euclidean Norm Minus One (ENMO) and Mean Amplitude Deviation (MAD) Approaches

Kishan Bakrania, Thomas Yates, Alex V Rowlands, Dale W Esliger, Sarah Bunnewell, James Sanders, Melanie Davies, Kamlesh Khunti, Charlotte L Edwardson

Journal article  |  2016  |  PLOS ONE

Guidelines for managing diabetes in Ramadan.

S Ali, MJ Davies, EM Brady, LJ Gray, K Khunti, SA Beshyah, W Hanif

Journal article  |  2016  |  Diabetic Medicine

BACKGROUND: Globally there are approximately 90 million Muslims with diabetes of which approximately 400 000 reside within the UK...

Raw Accelerometer Data Analysis with GGIR R-package: Does Accelerometer Brand Matter?

Alex V Rowlands, Tom Yates, Melanie Davies, Kamlesh Khunti, Charlotte L Edwardson

Journal article  |  2016  |  Medicine & Science in Sports & Exercise

Do Web-Based Interventions Improve Well-Being in Type 2 Diabetes? A Systematic Review and Meta-Analysis

Michelle Hadjiconstantinou, Jo Byrne, Danielle H Bodicoat, Noelle Robertson, Helen Eborall, Kamlesh Khunti, Melanie J Davies

Journal article  |  2016  |  Journal of Medical Internet Research

A community faith centre based screening and educational intervention to reduce the risk of type 2 diabetes: A feasibility study.

A Willis, M Roshan, N Patel, LJ Gray, T Yates, M Davies, K Khunti

Journal article  |  2016  |  Diabetes Research and Clinical Practice

AIMS: People of South Asian origin experience higher rates of diabetes and complications of diabetes compared to white Europeans. ..

Moderate to vigorous physical activity, not sedentary time, is associated with total and regional adiposity in a sample of UK adults at risk of type 2 diabetes.

DM Harrington, CL Edwardson, J Henson, K Khunti, T Yates, MJ Davies

Journal article  |  2016  |  Physiological Measurement

How sedentary time (ST) relates to total and regional adiposity and whether these associations are independent of moderate- to vig..

STEPWISE - STructured lifestyle Education for People WIth SchizophrEnia: a study protocol for a randomised controlled trial

Rebecca Gossage-Worrall, Richard IG Holt, Katharine Barnard, Marian E Carey, Melanie J Davies, Chris Dickens, Yvonne Doherty, Charlotte Edwardson, Paul French, Fiona Gaughran, Kathryn Greenwood, Sridevi Kalidindi, Daniel Hind, Kamlesh Khunti, Paul McCrone, Jonathan Mitchell, John Pendlebury, Shanaya Rathod, David Shiers, Najma Siddiqi, et al.

Journal article  |  2016  |  Trials

A retrospective evaluation of the NHS Health Check Programme in a multi-ethnic population.

P Carter, DH Bodicoat, MJ Davies, NB Ashra, D Riley, N Joshi, A Farooqi, I Browne, K Khunti

Journal article  |  2016  |  Journal of Public Health

BACKGROUND: The NHS Health Check Programme was introduced in 2009 to improve primary prevention of coronary heart disease, stroke,..

Development of a lifestyle intervention using the MRC framework for diabetes prevention in people with impaired glucose regulation.

Jacqui Troughton, Sudesna Chatterjee, Siân E Hill, Heather Daly, Lorraine Martin Stacey, Margaret A Stone, Naina Patel, Kamlesh Khunti, Thomas Yates, Laura J Gray, Melanie J Davies

Journal article  |  2016  |  Journal of Public Health

BACKGROUND: We report development of a group-based lifestyle intervention, Let's Prevent, using the UK Medical Research Council (M..

Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin-treated type 1 and type 2 diabetes: the global HAT study.

K Khunti, S Alsifri, R Aronson, M Cigrovski Berković, C Enters-Weijnen, T Forsén, G Galstyan, P Geelhoed-Duijvestijn, M Goldfracht, H Gydesen, R Kapur, N Lalic, B Ludvik, E Moberg, U Pedersen-Bjergaard, A Ramachandran, undefined HAT Investigator Group

Journal article  |  2016  |  Diabetes, Obesity and Metabolism

AIMS: To determine the global extent of hypoglycaemia experienced by patients with diabetes using insulin, as there is a lack of d..

A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study

Rebecca K Simmons, Knut Borch-Johnsen, Torsten Lauritzen, Guy EHM Rutten, Annelli Sandaek, Maureen van den Donk, James A Black, Libo Tao, Edward CF Wilson, Melanie J Davies, Kamlesh Khunti, Stephen J Sharp, Nicholas J Wareham, Simon J Griffin

Journal article  |  2016  |  Health Technology Assessment

Assessment of response rates and yields for Two opportunistic Tools for Early detection of Non-diabetic hyperglycaemia and Diabetes (ATTEND). A randomised controlled trial and cost-effectiveness analysis.

K Khunti, CL Gillies, H Dallosso, EM Brady, LJ Gray, G Kilgallen, A Willis, A Zafar, MJ Davies

Journal article  |  2016  |  Diabetes Research and Clinical Practice

AIMS: To assess the opportunistic use in primary care of a computer risk score versus a self-assessment risk score for undiagnosed..

Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis.

F Zaccardi, DR Webb, ZZ Htike, D Youssef, K Khunti, MJ Davies

Journal article  |  2016  |  Diabetes, Obesity and Metabolism

AIM: To assess the comparative efficacy and safety of sodium-glucose co-transporter-2 (SGLT2) inhibitors in adults with type 2 dia..

Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study

Francesco Zaccardi, Melanie J Davies, Nafeesa N Dhalwani, David R Webb, Gemma Housley, Dominic Shaw, James W Hatton, Kamlesh Khunti

Journal article  |  2016  |  The Lancet Diabetes & Endocrinology

Rationale and design of the randomised controlled trial to assess the impact of liraglutide on cardiac function and structure in young adults with type 2 diabetes (the LYDIA study).

ZZ Htike, T Yates, EM Brady, D Webb, LJ Gray, D Swarbrick, GP McCann, K Khunti, MJ Davies

Journal article  |  2016  |  Cardiovascular Diabetology

BACKGROUND: The prevalence of type 2 diabetes (T2DM) in younger adults is growing. Compared to the late onset T2DM, it is well rec..

Impact of the National Health Service Health Check on cardiovascular disease risk: a difference-in-differences matching analysis

Kiara Chu-Mei Chang, John Tayu Lee, Eszter P Vamos, Michael Soljak, Desmond Johnston, Kamlesh Khunti, Azeem Majeed, Christopher Millett

Journal article  |  2016  |  Canadian Medical Association Journal

The diabetes mellitus tsunami: worse than the 'Spanish flu' pandemic?

Thomas Yates, Kamlesh Khunti

Journal article  |  2016  |  Nature Reviews Endocrinology

Glucagon like peptide-1 receptor agonist (GLP-1RA) therapy in management of type 2 diabetes: Choosing the right agent for individualised care

ZZ Htike, F Zaccardi, S Chatterjee, K Khunti, MJ Davies

Journal article  |  2016  |  British Journal of Diabetes

Engagement, Retention, and Progression to Type 2 Diabetes: A Retrospective Analysis of the Cluster-Randomised "Let's Prevent Diabetes" Trial

Laura J Gray, Thomas Yates, Jacqui Troughton, Kamlesh Khunti, Melanie J Davies

Journal article  |  2016  |  PLOS Medicine

New drug treatments versus structured education programmes for type 2 diabetes: comparing cost-effectiveness

Kamlesh Khunti, Sudesna Chatterjee, Marian Carey, Heather Daly, Harriet Batista-Ferrer, Melanie J Davies

Journal article  |  2016  |  The Lancet Diabetes & Endocrinology

Optimizing management of glycaemia

Sudesna Chatterjee, Kamlesh Khunti, Melanie J Davies

Journal article  |  2016  |  Best Practice & Research Clinical Endocrinology & Metabolism

Accuracy of Posture Allocation Algorithms for Thigh- and Waist-Worn Accelerometers

Charlotte L Edwardson, Alex V Rowlands, Sarah Bunnewell, James Sanders, Dale W Esliger, Trish Gorely, Sophie O'Connell, Melanie J Davies, Kamlesh Khunti, Thomas Yates

Journal article  |  2016  |  Medicine & Science in Sports & Exercise

Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease

Salim Yusuf, Eva Lonn, Prem Pais, Jackie Bosch, Patricio Lopez-Jaramillo, Jun Zhu, Denis Xavier, Alvaro Avezum, Lawrence A Leiter, Leopoldo S Piegas, Alexander Parkhomenko, Matyas Keltai, Katalin Keltai, Karen Sliwa, Irina Chazova, Ron JG Peters, Claes Held, Khalid Yusoff, Basil S Lewis, Petr Jansky, et al.

Journal article  |  2016  |  New England Journal of Medicine

Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease

Eva M Lonn, Jackie Bosch, Patricio Lopez-Jaramillo, Jun Zhu, Lisheng Liu, Prem Pais, Rafael Diaz, Denis Xavier, Karen Sliwa, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Katalin Keltai, Matyas Keltai, Irina Chazova, Ron JG Peters, Claes Held, Khalid Yusoff, Basil S Lewis, Petr Jansky, et al.

Journal article  |  2016  |  New England Journal of Medicine

Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease.

Salim Yusuf, Jackie Bosch, Gilles Dagenais, Jun Zhu, Denis Xavier, Lisheng Liu, Prem Pais, Patricio López-Jaramillo, Lawrence A Leiter, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Alexander Parkhomenko, Katalin Keltai, Matyas Keltai, Karen Sliwa, Ron JG Peters, Claes Held, Irina Chazova, Khalid Yusoff, et al.

Journal article  |  2016  |  New England Journal of Medicine

BACKGROUND: Previous trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events amon..

Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis

Suzy V Hope, Sophie Wienand-Barnett, Maggie Shepherd, Sophie M King, Charles Fox, Kamlesh Khunti, Richard A Oram, Bea A Knight, Andrew T Hattersley, Angus G Jones, Beverley M Shields

Journal article  |  2016  |  British Journal of General Practice

Nonexercise Equations to Estimate Fitness in White European and South Asian Men

Gary O'Donovan, Kishan Bakrania, Nazim Ghouri, Thomas Yates, Laura J Gray, Mark Hamer, Emmanuel Stamatakis, Kamlesh Khunti, Melanie Davies, Naveed Sattar, Jason MR Gill

Journal article  |  2016  |  Medicine & Science in Sports & Exercise

Sedentary Sphere: Wrist-Worn Accelerometer-Brand Independent Posture Classification

Alex V Rowlands, Thomas Yates, Tim S Olds, Melanie Davies, Kamlesh Khunti, Charlotte L Edwardson

Journal article  |  2016  |  Medicine & Science in Sports & Exercise

New insulins and newer insulin regimens: a review of their role in improving glycaemic control in patients with diabetes.

S Gururaj Setty, W Crasto, J Jarvis, K Khunti, MJ Davies

Journal article  |  2016  |  Postgraduate Medical Journal

The legacy effect of early good glycaemic control in people with diabetes shows it is associated with reduction of microvascular a..

Effects of glucose-lowering and multifactorial interventions on cardiovascular and mortality outcomes: a meta-analysis of randomized control trials.

S Seidu, FA Achana, LJ Gray, MJ Davies, K Khunti

Journal article  |  2016  |  Diabetic Medicine

INTRODUCTION: The effect of intensive glycaemic control alone or as part of a multifactorial intervention on cardiovascular and mo..

A systematic review of interventions targeting primary care or community based professionals on cardio-metabolic risk factor control in people with diabetes.

S Seidu, NS Walker, DH Bodicoat, MJ Davies, K Khunti

Journal article  |  2016  |  Diabetes Research and Clinical Practice

OBJECTIVE: To review the interventions targeting primary care or community based professionals on glycaemic and cardiovascular ris..

A community based primary prevention programme for type 2 diabetes integrating identification and lifestyle intervention for prevention: the Let's Prevent Diabetes cluster randomised controlled trial

Melanie J Davies, Laura J Gray, Jacqui Troughton, Alastair Gray, Jaakko Tuomilehto, Azhar Farooqi, Kamlesh Khunti, Thomas Yates

Journal article  |  2016  |  Preventive Medicine

Long terms trends of multimorbidity and association with physical activity in older English population

Nafeesa N Dhalwani, Gary O'Donovan, Francesco Zaccardi, Mark Hamer, Thomas Yates, Melanie Davies, Kamlesh Khunti

Journal article  |  2016  |  International Journal of Behavioral Nutrition and Physical Activity

Benefits and Harms of Once-Weekly Glucagon-like Peptide-1 Receptor Agonist Treatments A Systematic Review and Network Meta-analysis

Francesco Zaccardi, Zin Zin Htike, David R Webb, Kamlesh Khunti, Melanie J Davies

Journal article  |  2016  |  Annals of Internal Medicine

Associations of mutually exclusive categories of physical activity and sedentary time with markers of cardiometabolic health in English adults: a cross-sectional analysis of the Health Survey for England

Kishan Bakrania, Charlotte L Edwardson, Danielle H Bodicoat, Dale W Esliger, Jason MR Gill, Aadil Kazi, Latha Velayudhan, Alan J Sinclair, Naveed Sattar, Stuart JH Biddle, Kamlesh Khunti, Melanie Davies, Thomas Yates

Journal article  |  2016  |  BMC Public Health

Developing a Conceptually Equivalent Type 2 Diabetes Risk Score for Indian Gujaratis in the UK

Naina Patel, Andrew Willis, Margaret Stone, Shaun Barber, Laura Gray, Melanie Davies, Kamlesh Khunti

Journal article  |  2016  |  Journal of Diabetes Research

Estimating the economic burden of cardiovascular events in patients receiving lipid-modifying therapy in the UK

Mark D Danese, Michelle Gleeson, Lucie Kutikova, Robert I Griffiths, Ali Azough, Kamlesh Khunti, Sreenivasa Rao Kondapally Seshasai, Kausik K Ray

Journal article  |  2016  |  BMJ Open

Type 2 diabetes: lifetime risk of advancing from prediabetes

Kamlesh Khunti, Danielle H Bodicoat, Melanie J Davies

Journal article  |  2016  |  The Lancet Diabetes & Endocrinology

The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies.

Melanie Davies, Sudesna Chatterjee, Kamlesh Khunti

Journal article  |  2016  |  Clinical Pharmacology: Advances and Applications

Worldwide, an estimated 200 million people have chronic kidney disease (CKD), the most common causes of which include hypertension..

Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study

Joseph Henson, Melanie J Davies, Danielle H Bodicoat, Charlotte L Edwardson, Jason MR Gill, David J Stensel, Keith Tolfrey, David W Dunstan, Kamlesh Khunti, Thomas Yates

Journal article  |  2016  |  Diabetes Care

Cardiorespiratory fitness and risk of type 2 diabetes mellitus: A 23-year cohort study and a meta-analysis of prospective studies

Francesco Zaccardi, Gary O'Donovan, David R Webb, Thomas Yates, Sudhir Kurl, Kamlesh Khunti, Melanie J Davies, Jari A Laukkanen

Journal article  |  2015  |  Atherosclerosis

The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis.

C Jelleyman, T Yates, G O'Donovan, LJ Gray, JA King, K Khunti, MJ Davies

Journal article  |  2015  |  Obesity Reviews

The aim of this meta-analysis was to quantify the effects of high-intensity interval training (HIIT) on markers of glucose regulat..

Methods Used in Economic Evaluations of Chronic Kidney Disease Testing - A Systematic Review

Andrew J Sutton, Katie Breheny, Jon Deeks, Kamlesh Khunti, Claire Sharpe, Ryan S Ottridge, Paul E Stevens, Paul Cockwell, Philp A Kalra, Edmund J Lamb

Journal article  |  2015  |  PLOS ONE

Explaining engagement in self-monitoring among participants of the DESMOND Self-monitoring Trial: a qualitative interview study

Helen C Eborall, Helen M Dallosso, Sarah McNicol, Jane Speight, Kamlesh Khunti, Melanie J Davi, Simon R Heller

Journal article  |  2015  |  Family Practice

Clinical characteristics of polycystic ovary syndrome: investigating differences in White and South Asian women

Hamidreza Mani, Melanie J Davies, Danielle H Bodicoat, Miles J Levy, Laura J Gray, Trevor A Howlett, Kamlesh Khunti

Journal article  |  2015  |  Clinical Endocrinology

Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686.

Francesco Zaccardi, David R Webb, Kamlesh Khunti, Melanie J Davies

Journal article  |  2015  |  Diabetes

Systematic Review and Meta-Analysis of Response Rates and Diagnostic Yield of Screening for Type 2 Diabetes and Those at High Risk of Diabetes

Kamlesh Khunti, Hamidreza Mani, Felix Achana, Nicola Cooper, Laura J Gray, Melanie J Davies

Journal article  |  2015  |  PLOS ONE

Coverage of a national cardiovascular risk assessment and management programme (NHS Health Check): Retrospective database study

Kiara Chu-Mei Chang, Michael Soljak, John Tayu Lee, Maria Woringer, Desmond Johnston, Kamlesh Khunti, Azeem Majeed, Christopher Millett

Journal article  |  2015  |  Preventive Medicine

Using an interactive DVD about type 2 diabetes and insulin therapy in a UK South Asian community and in patient education and healthcare provider training

Naina Patel, Margaret A Stone, Michelle Hadjiconstantinou, Steve Hiles, Jacqui Troughton, Lorraine Martin-Stacey, Heather Daly, Marian Carey, Anita Khulpateea, Melanie J Davies, Kamlesh Khunti

Journal article  |  2015  |  Patient Education and Counseling

Delay in treatment intensification increases the risks of cardiovascular events in patients with type 2 diabetes

Sanjoy K Paul, Kerenaftali Klein, Brian L Thorsted, Michael L Wolden, Kamlesh Khunti

Journal article  |  2015  |  Cardiovascular Diabetology

Inverse association between fasting plasma glucose and risk of ventricular arrhythmias

Francesco Zaccardi, David R Webb, Sudhir Kurl, Kamlesh Khunti, Melanie J Davies, Jari A Laukkanen

Journal article  |  2015  |  Diabetologia

Associations of Sedentary Time with Fat Distribution in a High-Risk Population

Joseph Henson, Charlotte L Edwardson, Bruno Morgan, Mark A Horsfield, Danielle H Bodicoat, Stuart JH Biddle, Trish Gorely, Myra A Nimmo, Gerry P Mccann, Kamlesh Khunti, Melanie J Davies, Thomas Yates

Journal article  |  2015  |  Medicine & Science in Sports & Exercise

PRomotion Of Physical activity through structured Education with differing Levels of ongoing Support for people at high risk of type 2 diabetes (PROPELS): study protocol for a randomized controlled trial

Tom Yates, Simon Griffin, Danielle H Bodicoat, Gwen Brierly, Helen Dallosso, Melanie J Davies, Helen Eborall, Charlotte Edwardson, Mike Gillett, Laura Gray, Wendy Hardeman, Sian Hill, Katie Morton, Stephen Sutton, Jacqui Troughton, Kamlesh Khunti

Journal article  |  2015  |  Trials

Safety and effectiveness of non-insulin glucose-lowering agents in the treatment of people with type 2 diabetes who observe Ramadan: a systematic review and meta-analysis.

LJ Gray, J Dales, EM Brady, K Khunti, W Hanif, MJ Davies

Journal article  |  2015  |  Diabetes, Obesity and Metabolism

AIM: To determine which non-insulin glucose-lowering treatment regimens are most appropriate in people with type 2 diabetes who ch..

Objectively measured sedentary time and associations with insulin sensitivity: Importance of reallocating sedentary time to physical activity

Thomas Yates, Joseph Henson, Charlotte Edwardson, David Dunstan, Danielle H Bodicoat, Kamlesh Khunti, Melanie J Davies

Journal article  |  2015  |  Preventive Medicine

Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial.

L Tao, ECF Wilson, NJ Wareham, A Sandbaek, GEHM Rutten, T Lauritzen, K Khunti, MJ Davies, K Borch-Johnsen, SJ Griffin, RK Simmons

Journal article  |  2015  |  Diabetic Medicine

AIMS: To examine the short- and long-term cost-effectiveness of intensive multifactorial treatment compared with routine care amon..

The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis

Jessica E Potts, Laura J Gray, Emer M Brady, Kamlesh Khunti, Melanie J Davies, Danielle H Bodicoat

Journal article  |  2015  |  PLOS ONE

Prevalence and Incidence of Hypoglycaemia in 532,542 People with Type 2 Diabetes on Oral Therapies and Insulin: A Systematic Review and Meta-Analysis of Population Based Studies

Chloe L Edridge, Alison J Dunkley, Danielle H Bodicoat, Tanith C Rose, Laura J Gray, Melanie J Davies, Kamlesh Khunti

Journal article  |  2015  |  PLOS ONE

A cluster randomised controlled trial to investigate the effectiveness and cost effectiveness of the 'Girls Active' intervention: a study protocol

CL Edwardson, DM Harrington, T Yates, DH Bodicoat, K Khunti, T Gorely, LB Sherar, RT Edwards, C Wright, K Harrington, MJ Davies

Journal article  |  2015  |  BMC Public Health

Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: A prospective study.

F Zaccardi, DR Webb, P Carter, D Pitocco, K Khunti, MJ Davies, S Kurl, JA Laukkanen

Journal article  |  2015  |  Nutrition, Metabolism and Cardiovascular Diseases

BACKGROUND AND AIMS: Previous prospective studies showing a positive association between serum calcium and incidence of type 2 dia..

Is the number of fast-food outlets in the neighbourhood related to screen-detected type 2 diabetes mellitus and associated risk factors?

Danielle H Bodicoat, Patrice Carter, Alexis Comber, Charlotte Edwardson, Laura J Gray, Sian Hill, David Webb, Thomas Yates, Melanie J Davies, Kamlesh Khunti

Journal article  |  2015  |  Public Health Nutrition

The impact of a programme to improve quality of care for people with type 2 diabetes on hard to reach groups: The GEDAPS study

Danielle H Bodicoat, Xavier Mundet, Melanie J Davies, Kamlesh Khunti, Pilar Roura, Josep Franch, Manel Mata-Cases, Xavier Cos, J Franciso Cano

Journal article  |  2015  |  Primary Care Diabetes

Effect of the PPARG2 Pro12Al alpha Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Thomas Yates, Melanie J Davies, Joseph Henson, Charlotte Edwardson, David Webb, Danielle H Bodicoat, M'Balu Webb, Philip Howard, Jackie A Cooper, Steve E Humphries, Kamlesh Khunti, Philippa Talmud

Journal article  |  2015  |  PLOS ONE

Concerns and perceptions about necessity in relation to insulin therapy in an ethnically diverse UK population with Type 2 diabetes: a qualitative study focusing mainly on people of South Asian origin.

N Patel, MA Stone, C McDonough, MJ Davies, K Khunti, H Eborall

Journal article  |  2015  |  Diabetic Medicine

AIM: To explore attitudes towards insulin acceptance an ethnically diverse population of people with Type 2 diabetes. METHODS: We ..

The cost-effectiveness of testing strategies for type 2 diabetes: a modelling study

Mike Gillett, Alan Brennan, Penny Watson, Kamlesh Khunti, Melanie Davies, Samiul Mostafa, Laura J Gray

Journal article  |  2015  |  Health Technology Assessment

Survival in South Asian and White European patients after acute myocardial infarction

Nitin N Gholap, Kamlesh Khunti, Melanie J Davies, Danielle H Bodicoat, Iain B Squire

Journal article  |  2015  |  Heart

Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes.

RW Major, MJ Davies, W Crasto, LJ Gray, DR Webb, K Khunti

Journal article  |  2015  |  Journal of Human Hypertension

Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to dete..

Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes receiving structured education: a cluster randomized controlled trial.

HM Dallosso, DH Bodicoat, M Campbell, ME Carey, MJ Davies, HC Eborall, M Hadjiconstantinou, K Khunti, J Speight, S Heller

Journal article  |  2015  |  Diabetic Medicine

AIMS: To compare the effectiveness and acceptability of self-monitoring of blood glucose with self-monitoring of urine glucose in ..

A Decision Support Tool for Appropriate Glucose-Lowering Therapy in Patients with Type 2 Diabetes

F Javier Ampudia-Blasco, Pierre Yves Benhamou, Guillaume Charpentier, Agostino Consoli, Michaela Diamant, Baptist Gallwitz, Kamlesh Khunti, Chantal Mathieu, Martin Ridderstrale, Jochen Seufert, Cees Tack, Tina Vilsboll, Phan Tra-Mi, Herman Stoevelaar

Journal article  |  2015  |  Diabetes Technology & Therapeutics

Preventing the progression to Type 2 diabetes mellitus in adults at high risk: A systematic review and network meta-analysis of lifestyle, pharmacological and surgical interventions

John W Stevens, Kamlesh Khunti, Rebecca Harvey, Maxine Johnson, Louise Preston, Helen Buckley Woods, Melanie Davies, Elizabeth Goyder

Journal article  |  2015  |  Diabetes Research and Clinical Practice

Acknowledging and allocating responsibility for clinical inertia in the management of Type 2 diabetes in primary care: a qualitative study.

A Zafar, MA Stone, MJ Davies, K Khunti

Journal article  |  2015  |  Diabetic Medicine

AIMS: Failure to intensify treatment in patients with Type 2 diabetes with suboptimal blood glucose control has been termed clinic..

Hypoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in Insulin-Treated People With Type 1 and Type 2 Diabetes: A Cohort Study

Kamlesh Khunti, Melanie Davies, Azeem Majeed, Brian Larsen Thorsted, Michael Lyng Wolden, Sanjoy K Paul

Journal article  |  2015  |  Diabetes Care

Serum potassium and glucose regulation in the ADDITION-Leicester screening study.

Patrice Carter, Danielle H Bodicoat, Lauren M Quinn, Francesco Zaccardi, David R Webb, Kamlesh Khunti, Melanie J Davies

Journal article  |  2015  |  Journal of Diabetes Research

INTRODUCTION: Previous observational studies have shown conflicting results between plasma K+ concentrations and risk of type 2 di..

Health economic evaluation of type 2 diabetes mellitus: a clinical practice focused review.

Andreas Liebl, Kamlesh Khunti, Domingo Orozco-Beltran, Jean-Francois Yale

Journal article  |  2015  |  Clinical Medicine Insights: Endocrinology and Diabetes

Type 2 diabetes mellitus (T2D) is a growing healthcare burden primarily due to long-term complications. Strict glycemic control he..

Differences in levels of physical activity between White and South Asian populations within a healthcare setting: impact of measurement type in a cross-sectional study

Thomas Yates, Joe Henson, Charlotte Edwardson, Danielle H Bodicoat, Melanie J Davies, Kamlesh Khunti

Journal article  |  2015  |  BMJ Open

Obesity paradox in people newly diagnosed with type 2 diabetes with and without prior cardiovascular disease

G Thomas, K Khunti, V Curcin, M Molokhia, C Millett, A Majeed, S Paul

Journal article  |  2014  |  Diabetes, Obesity and Metabolism

Prescribing in pregnancy for women with diabetes: use of potential teratogenic drugs and contraception.

SI Makda, MJ Davies, E Wilmot, J Bankart, T Yates, EM Varghese, H Fisher, A Anwar, K Khunti

Journal article  |  2013  |  Diabetic Medicine

AIMS: To describe contraception use and the prescription of drugs that are either not recommended in pregnancy or are potentially ..