Brooke Harcourt

Time spent watching television impacts on body mass index in youth with obesity, but only in those with shortest sleep duration

Daniel M Golshevsky, Costan Magnussen, Markus Juonala, Kung-Ting Kao, Brooke E Harcourt, Matthew A Sabin

Journal article  |  2019  |  Journal of Paediatrics and Child Health

Neighbourhood socioeconomic circumstances, adiposity and cardiometabolic risk measures in children with severe obesity

Markus Juonala, Brooke E Harcourt, Christoph Saner, Manpreet Sethi, Richard Saffery, Costan G Magnussen, David P Burgner, Matthew A Sabin

Journal article  |  2019  |  Obesity Research & Clinical Practice

BACKGROUND: It has recently been shown that neighbourhood socioeconomic disadvantage in childhood is associated with obesity, hype..

Psychosocial measures and weight change in a clinical paediatric population with obesity

Brooke E Harcourt, Anke Pons, Kung-Ting Kao, Celia Twindyakirana, Erin Alexander, Sarah Haberle, Zoe McCallum, Matthew A Sabin

Journal article  |  2019  |  Quality of Life Research

Sex and puberty-related differences in metabolomic profiles associated with adiposity measures in youth with obesity

Christoph Saner, Brooke E Harcourt, Ahwan Pandey, Susan Ellul, Zoe McCallum, Kung-Ting Kao, Celia Twindyakirana, Anke Pons, Erin J Alexander, Richard Saffery, David P Burgner, Markus Juonala, Matthew A Sabin

Journal article  |  2019  |  Metabolomics

Serum IGFBP-2 levels are associated with reduced insulin sensitivity in obese children

SW Yau, BE Harcourt, K-T Kao, EJ Alexander, VC Russo, GA Werther, MA Sabin

Journal article  |  2018  |  Clinical Obesity

RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-beta and Increasing Resistance to Apoptosis

Shinji Hagiwara, Karly Sourris, Mark Ziemann, Tieqiao Wu, Muthukumar Mohan, Aaron D McClelland, Eoin Brennan, Josephine Forbes, Melinda Coughlan, Brooke Harcourt, Sally Penfold, Bo Wang, Gavin Higgins, Raelene Pickering, Assam El-Osta, Merlin C Thomas, Mark E Cooper, Phillip Kantharidis

Journal article  |  2018  |  Diabetes

Allelic Variation in Key Fitness Genes is Linked with Increased Severity of Obesity in Overweight/obese Youth

Christoph Saner, Brooke E Harcourt, Markus Juonala, Kung-Ting Kao, Peter Houweling, Fleur Garton, Kathryn N North, Matthew A Sabin

Conference Proceedings  |  2018  |  HORMONE RESEARCH IN PAEDIATRICS

Maternal inheritance of BDNF deletion, with phenotype of obesity and developmental delay in mother and child

Brooke E Harcourt, Denise VR Bullen, Kung-Ting Kao, Daniella Tassoni, Erin J Alexander, Trent Burgess, Susan M White, Matthew A Sabin

Journal article  |  2018  |  American Journal of Medical Genetics Part A

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Melinda T Coughlan, Nguyen Tuong-Vi, Sally A Penfold, Gavin C Higgins, Vicki Thallas-Bonke, Sih Min Tan, Nicole J Van Bergen, Karly C Sourris, Brooke E Harcourt, David R Thorburn, Ian A Trounce, Mark E Cooper, Josephine M Forbes

Journal article  |  2016  |  Clinical Science

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

Melinda T Coughlan, Gavin C Higgins, Nguyen Tuong-Vi, Sally A Penfold, Vicki Thallas-Bonke, Sih Mm Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Karly C Sourris, Brooke E Harcourt, Ian A Trounce, Portia M Robb, Adrienne Laskowski, Sean L McGee, Amanda J Genders, Ken Walder, Brian G Drew, Paul Gregorevic, Hongwei Qian, et al.

Journal article  |  2016  |  Diabetes

Deficiency in Apoptosis Inducing Factor Recapitulates Diabetic Nephropathy via Aberrant Mitochondrial Homeostasis

Melinda T Coughlan, Gavin C Higgins, Tuong-Vi Nguyen, Sally A Penfold, Vicki Thallas-Bonke, Sih Min Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Ian A Trounce, Karly C Sourris, Brooke E Harcourt, Portia M Robb, Adrienne Laskowski, Sean L Mcgee, Ken Walder, Paul Gregorevic, Hongwei Qian, Merlin C Thomas, Brian G Drew, et al.

Conference Proceedings  |  2015  |  DIABETES

A rapid extraction method for glycogen from formalin-fixed liver

Mitchell A Sullivan, Shihan Li, Samuel TN Aroney, Bin Deng, Cheng Li, Eugeni Roura, Benjamin L Schulz, Brooke E Harcourt, Josephine M Forbes, Robert G Gilbert

Journal article  |  2015  |  Carbohydrate Polymers

Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?

Mitchell A Sullivan, Brooke E Harcourt, Ping Xu, Josephine M Forbes, Robert G Gilbert

Journal article  |  2015  |  Current Drug Targets

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Sumaira Z Hasnain, Danielle J Borg, Brooke E Harcourt, Hui Tong, Yonghua H Sheng, Choa Ping Ng, Indrajit Das, Ran Wang, Alice C-H Chen, Thomas Loudovaris, Thomas W Kay, Helen E Thomas, Jonathan P Whitehead, Josephine M Forbes, Johannes B Prins, Michael A McGuckin

Journal article  |  2014  |  Nature Medicine

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Greg Tesch, Karly C Sourris, Shaun A Summers, Domenica McCarthy, Micheal S Ward, Danielle J Borg, Linda A Gallo, Amelia K Fotheringham, Allison R Pettit, Felicia YT Yap, Brooke E Harcourt, Adeline LY Tan, Joshua Y Kausman, David Nikolic-Paterson, Arthur R Kitching, Josephine M Forbes

Journal article  |  2014  |  Diabetologia

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

Kei Fukami, Sho-ichi Yamagishi, Melinda T Coughlan, Brooke E Harcourt, Phillip Kantharidis, Vicki Thallas-Bonke, Seiya Okuda, Mark E Cooper, Josephine M Forbes

Journal article  |  2014  |  Diabetology & Metabolic Syndrome

FLUX OF ADVANCED GLYCATION END PRODUCTS ACROSS THE KIDNEY AS A CONTRIBUTOR TO RENAL DISEASE IN DIABETES

C Leung, AK Fotheringham, A Zhuang, DJ Borg, MS Ward, MT Coughlan, DA Mccarthy, LA Gallo, BE Harcourt, JM Forbes

Conference Proceedings  |  2014  |  NEPHROLOGY

DEFECTIVE MITOPHAGY ACTIVITY IN EXPERIMENTAL DIABETIC NEPHROPATHY

GC Higgins, TV Nguyen, SA Penfold, V Thallas-Bonke, BE Harcourt, PM Robb, G Ramm, G Jerums, A Skene, R Macisaac, EI Ekinci, DA Power, KE White, RW Bilous, ME Cooper, JM Forbes, MT Coughlan

Conference Proceedings  |  2014  |  NEPHROLOGY

Coming full circle in diabetes mellitus: from complications to initiation

Brooke E Harcourt, Sally A Penfold, Josephine M Forbes

Journal article  |  2013  |  Nature Reviews Endocrinology

Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

Vicki Thallas-Bonke, Melinda T Coughlan, Adeline LY Tan, Brooke E Harcourt, Philip E Morgan, Michael J Davies, Leon A Bach, Mark E Cooper, Josephine M Forbes

Journal article  |  2013  |  Nephrology

Pathogenesis of Diabetic Microvascular Complications

Brooke Harcourt, Josephine FORBES

Book Chapter  |  2013

Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice

Brooke E Harcourt, Josephine M Forbes, Vance B Matthews

Journal article  |  2012  |  Nephrology

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

Karly C Sourris, Brooke E Harcourt, Peter H Tang, Amy L Morley, Huynh Karina, Sally A Penfold, Melinda T Coughlan, Mark E Cooper, Nguyen Tuong-Vi, Rebecca H Ritchie, Josephine M Forbes

Journal article  |  2012  |  Free Radical Biology and Medicine

Targeted reduction of advanced glycation improves renal function in obesity

Brooke E Harcourt, Karly C Sourris, Melinda T Coughlan, Karen Z Walker, Sonia L Dougherty, Sofianos Andrikopoulos, Amy L Morley, Vicki Thallas-Bonke, Vibhasha Chand, Sally A Penfold, Maximilian PJ de Courten, Merlin C Thomas, Bronwyn A Kingwell, Angelika Bierhaus, Mark E Cooper, Barbora de Courten, Josephine M Forbes

Journal article  |  2011  |  Kidney International

‘RAGE, Adipose Derived Estrogens and Dietary AGEs; Interactions in Obesity Induced Kidney Disease’

Brooke E Harcourt

Thesis / Dissertation  |  2011

Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy

Adeline LY Tan, Karly C Sourris, Brooke E Harcourt, Vicki Thallas-Bonke, Sally Penfold, Sofianos Andrikopoulos, Merlin C Thomas, Richard C O'Brien, Angelika Bierhaus, Mark E Cooper, Josephine M Forbes, Melinda T Coughlan

Journal article  |  2010  |  American Journal of Physiology: Renal Physiology

Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy

Karly C Sourris, Brooke E Harcourt, Sally A Penfold, Felicia YT Yap, Amy L Morley, Philip E Morgan, Michael J Davies, Scott T Baker, George Jerums, Josephine M Forbes

Journal article  |  2010  |  Experimental Diabetes Research

RAGE-induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

Melinda T Coughlan, David R Thorburn, Sally A Penfold, Adrienne Laskowski, Brooke E Harcourt, Karly C Sourris, Adeline LY Tan, Kei Fukami, Vicki Thallas-Bonke, Peter P Nawroth, Michael Brownlee, Angelika Bierhaus, Mark E Cooper, Josephine M Forbes

Journal article  |  2009  |  Journal of the American Society of Nephrology

A New Perspective on Therapeutic Inhibition of Advanced Glycation in Diabetic Microvascular Complications: Common Downstream Endpoints Achieved Through Disparate Therapeutic Approaches?

Karly C Sourris, Brooke E Harcourt, Josephine M Forbes

Journal article  |  2009  |  American Journal of Nephrology

Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs

Christos Tikellis, Merlin C Thomas, Brooke E Harcourt, Melinda T Coughlan, Josepha Pete, Katarzyna Bialkowski, Adeline Tan, Angelika Bierhaus, Mark E Cooper, Josephine M Forbes

Journal article  |  2008  |  American Journal of Physiology-Endocrinology and Metabolism