Brooke Harcourt

Decreasing severity of obesity from early to late adolescence and young adulthood associates with longitudinal metabolomic changes implicated in lower cardiometabolic disease risk

Toby Mansell, Costan G Magnussen, Joel Nuotio, Tomi T Laitinen, Brooke E Harcourt, Siroon Bekkering, Zoe McCallum, Kung-Ting Kao, Matthew A Sabin, Markus Juonala, Richard Saffery, David Burgner, Christoph Saner

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF OBESITY

BACKGROUND: Obesity in childhood is associated with metabolic dysfunction, adverse subclinical cardiovascular phenotypes and adult..

Modest decrease in severity of obesity in adolescence associates with low arterial stiffness

Christoph Saner, Tomi T Laitinen, Joel Nuotio, Sarah J Arnup, Brooke E Harcourt, Siroon Bekkering, Zoe McCallum, Kung-Ting Kao, Marco Janner, Costan G Magnussen, Matthew A Sabin, Markus Juonala, David P Burgner

Journal article  |  2021  |  ATHEROSCLEROSIS

BACKGROUND AND AIMS: Childhood obesity is associated with cardiovascular risk factors (CVRF), subclinical cardiovascular phenotype..

Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model.

Danielle J Borg, Pouya Faridi, Kai Lin Giam, Peta Reeves, Amelia K Fotheringham, Domenica A McCarthy, Sherman Leung, Micheal S Ward, Brooke E Harcourt, Rochelle Ayala, Jean L Scheijen, David Briskey, Nadine L Dudek, Casper G Schalkwijk, Raymond Steptoe, Anthony W Purcell, Josephine M Forbes

Journal article  |  2021  |  Metabolites

Mechanisms by which advanced glycation end products (AGEs) contribute to type 1 diabetes (T1D) pathogenesis are poorly understood...

Processed foods drive intestinal barrier permeability and microvascular diseases.

Matthew Snelson, Sih Min Tan, Rachel E Clarke, Cassandra de Pasquale, Vicki Thallas-Bonke, Tuong-Vi Nguyen, Sally A Penfold, Brooke E Harcourt, Karly C Sourris, Runa S Lindblom, Mark Ziemann, David Steer, Assam El-Osta, Michael J Davies, Leigh Donnellan, Permal Deo, Nicole J Kellow, Mark E Cooper, Trent M Woodruff, Charles R Mackay, et al.

Journal article  |  2021  |  Sci Adv

Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as c..

Lower grip strength in youth with obesity identifies those with increased cardiometabolic risk

Tomi T Laitinen, Christoph Saner, Joel Nuotio, Matthew A Sabin, Brooklyn J Fraser, Brooke Harcourt, Markus Juonala, David P Burgner, Costan G Magnussen

Journal article  |  2020  |  OBESITY RESEARCH & CLINICAL PRACTICE

BACKGROUND: We examined whether grip strength differentiates youth with obesity with increased cardiometabolic risk. METHODS: The ..

Evidence for Protein Leverage in Children and Adolescents with Obesity

Christoph Saner, Daniella Tassoni, Brooke E Harcourt, Kung-Ting Kao, Erin J Alexander, Zoe McCallum, Timothy Olds, Alex Rowlands, David P Burgner, Stephen J Simpson, David Raubenheimer, Alistair M Senior, Markus Juonala, Matthew A Sabin

Journal article  |  2020  |  OBESITY

OBJECTIVE: The aim of this study was to test the protein leverage hypothesis in a cohort of youth with obesity. METHODS: A retrosp..

Time spent watching television impacts on body mass index in youth with obesity, but only in those with shortest sleep duration

Daniel M Golshevsky, Costan Magnussen, Markus Juonala, Kung-Ting Kao, Brooke E Harcourt, Matthew A Sabin

Journal article  |  2019  |  JOURNAL OF PAEDIATRICS AND CHILD HEALTH

AIM: To determine the interplay between sleep and sedentary behaviours on body mass index (BMI) in children with obesity. METHODS:..

Neighbourhood socioeconomic circumstances, adiposity and cardiometabolic risk measures in children with severe obesity

Markus Juonala, Brooke E Harcourt, Christoph Saner, Manpreet Sethi, Richard Saffery, Costan G Magnussen, David P Burgner, Matthew A Sabin

Journal article  |  2019  |  OBESITY RESEARCH & CLINICAL PRACTICE

BACKGROUND: It has recently been shown that neighbourhood socioeconomic disadvantage in childhood is associated with obesity, hype..

Psychosocial measures and weight change in a clinical paediatric population with obesity

Brooke E Harcourt, Anke Pons, Kung-Ting Kao, Celia Twindyakirana, Erin Alexander, Sarah Haberle, Zoe McCallum, Matthew A Sabin

Journal article  |  2019  |  QUALITY OF LIFE RESEARCH

PURPOSE: Poor quality of life has been shown to occur in youth with obesity. This study aimed to assess associations between healt..

Sex and puberty-related differences in metabolomic profiles associated with adiposity measures in youth with obesity

Christoph Saner, Brooke E Harcourt, Ahwan Pandey, Susan Ellul, Zoe McCallum, Kung-Ting Kao, Celia Twindyakirana, Anke Pons, Erin J Alexander, Richard Saffery, David P Burgner, Markus Juonala, Matthew A Sabin

Journal article  |  2019  |  METABOLOMICS

BACKGROUND: Specific patterns of metabolomic profiles relating to cardiometabolic disease are associated with increased weight in ..