Marios Koutsakos

SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki, et al.

Journal article  |  2021  |  VACCINE

Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..

Natural killer cell receptors regulate responses of HLA-E-restricted T cells.

Lucy C Sullivan, Thi HO Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline ML Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks

Journal article  |  2021  |  Sci Immunol

Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses. These..

High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshanski, William Heath, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

Journal article  |  2021

Although co-expression of CD38 and HLA-DR on CD8 + T cells reflects activation during influenza, SARS-CoV-2, Dengue, Ebola and HIV..

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Henry J Sutton, Racheal Aye, Azza H Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T Daniel Andrews, Marios Koutsakos, Thi HO Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A Berry, KC Natasha, Sumana Chakravarty, B Kim Lee Sim, Adam K Wheatley, et al.

Journal article  |  2021  |  CELL REPORTS

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of bot..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao, et al.

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..

The rise and fall of bone marrow plasma cells after influenza vaccination

Marios Koutsakos, Ali H Ellebedy

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

A recent report by Davis et al. shows that following vaccination, B-cell activation results in the emergence of a population of an..

Viral burden, inflammatory milieu and CD8( )T-cell responses to influenza virus in a second-generation thiazolide (RM-5061) and oseltamivir combination therapy study

Simone Nuessing, Edin Mifsud, Luca Hensen, Marios Koutsakos, Zhongfang Wang, Lukasz Kedzierski, Francesca Mercuri, Jean-Francois Rossignol, Aeron C Hurt, Katherine Kedzierska

Journal article  |  2020  |  INFLUENZA AND OTHER RESPIRATORY VIRUSES

BACKGROUND: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and..