Marios Koutsakos

Viral burden, inflammatory milieu and CD8 T-cell responses to influenza virus in a second-generation thiazolide (RM-5061) and oseltamivir combination therapy study.

Simone Nüssing, Edin Mifsud, Luca Hensen, Marios Koutsakos, Zhongfang Wang, Lukasz Kedzierski, Francesca Mercuri, Jean-Francois Rossignol, Aeron C Hurt, Katherine Kedzierska

Journal article  |  2020  |  Influenza and Other Respiratory Viruses

BACKGROUND: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and..

Monocyte apoptotic bodies are vehicles for influenza A virus propagation

Georgia K Atkin-Smith, Mubing Duan, Damien J Zanker, Liyen Loh, Thi HO Nguyen, Marios Koutsakos, Tien Nguyen, Xiangrui Jiang, Julio Carrera, Thanh Kha Phan, Chuanxin Liu, Stephanie Paone, Sara Oveissi, Amy L Hodge, Amy A Baxter, Katherine Kedzierska, Jason M Mackenzie, Mark D Hulett, Pamuk Bilsel, Weisan Chen, et al.

Journal article  |  2020  |  Communications Biology

The disassembly of apoptotic cells into small membrane-bound vesicles termed apoptotic bodies (ApoBDs) is a hallmark of apoptosis;..

The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease

Katherine Kedzierska, Marios Koutsakos

Journal article  |  2020  |  Viral Immunology

A seminal discovery of major histocompatibility complex (MHC) restriction in T cell recognition by Peter Doherty and Rolf Zinkerna..

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

Irani Thevarajan, Thi HO Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven YC Tong, Sharon R Lewin, Katherine Kedzierska

Journal article  |  2020  |  Nature Medicine

Influenza A Virus-Infected Lung Epithelial Cell Co-Culture with Human Peripheral Blood Mononuclear Cells.

Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Timothy SC Hinks

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

Sensing of influenza A virus (IAV) infection by pattern recognition receptors can occur by either direct infection of lung epithel..

Study of MAIT Cell Activation in Viral Infections In Vivo.

Timothy SC Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR)..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  Nature Immunology

Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Yi Liu, Hyon-Xhi Tan, Marios Koutsakos, Sinthujan Jegaskanda, Robyn Esterbauer, Danielle Tilmanis, Malet Aban, Katherine Kedzierska, Aeron C Hurt, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Nature Communications

With a Little Help from T Follicular Helper Friends: Humoral Immunity to Influenza Vaccination

Marios Koutsakos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  The Journal of Immunology

Immune Responses to Avian Influenza Viruses

Marios Koutsakos, Katherine Kedzierska, Kanta Subbarao

Journal article  |  2019  |  The Journal of Immunology

Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Journal article  |  2019  |  Clinical & Translational Immunology

MAIT CELLS CONTRIBUTE TO A PROTECTIVE ANTIVIRAL INNATE RESPONSE TO INFLUENZA INFECTION

TSC Hinks, B van Wilgenburg, L Loh, TJ Pediongco, H Wang, M Shi, Z Zhao, M Koutsakos, S Nussing, S Sant, Z Wang, C D'Souza, CF Almeida, P Reading, AJ Corbett, J McCluskey, P Klenerman, K Kedzierska

Conference Proceedings  |  2018  |  The influence of influenza: from cells to humans

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn S Meehan, Axel Kallies, Dale I Godfrey, Patrick C Reading, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

MAIT cells contribute to a protective antiviral innate response to influenza infection

Timothy Hinks, Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Patrick Reading, Alexandra Corbett, James Mccluskey, Paul Klenerman, Katherine Kedzierska

Conference Proceedings  |  2018  |  Respiratory infections

Single-Cell Approach to Influenza Specific CD8( ) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

Sneha Sant, Ludiyine Grzelak, Zhongfang Wang, Angela Pizzollal, Manbs Koutsakos, Jane Crowe, Thomas Loudoyaris, Stuart I Mannering, Glen P Westall, Linda M Wakiml, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G Thomas, Liyen Loh, Thi H Nguyen, Katherine Kedzierska

Journal article  |  2018  |  Frontiers in Immunology

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn Meehan, Dale Godfrey, Patrick Reading, Alexandra Corbett, James McCluskey, et al.

Journal article  |  2018  |  Nature Communications

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lung..

Clonally diverse CD38( )HLA-DR( )CD8( ) T cells persist during fatal H7N9 disease

Zhongfang Wang, Lingyan Zhu, Thi HO Nguyen, Yanmin Wan, Sneha Sant, Sergio M Quinones-Parra, Jeremy Chase Crawford, Auda A Eltahla, Simone Rizzetto, Rowena A Bull, Chenli Qiu, Marios Koutsakos, E Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen, et al.

Journal article  |  2018  |  Science Translational Medicine

Perturbed CD8( ) T cell immunity across universal influenza epitopes in the elderly

Thi HO Nguyen, Sneha Sant, Nicola L Bird, Emma J Grant, E Bridie Clemens, Marios Koutsakos, Sophie A Valkenburg, Stephanie Gras, Martha Lappas, Anthony Jaworowski, Jane Crowe, Liyen Loh, Katherine Kedzierska

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

Innate and adaptive T cells in influenza disease

Simone Nuessing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2018  |  FRONTIERS OF MEDICINE

Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine

Regan J Anderson, Jasmine Li, Lukasz Kedzierski, Benjamin J Compton, Colin M Hayman, Taryn L Osmond, Ching-wen Tang, Kathryn J Farrand, Hui-Fern Koay, Catarina Filipa Dos Santos Sa E Almeida, Lauren R Holz, Geoffrey M Williams, Margaret A Brimble, Zhongfang Wang, Marios Koutsakos, Katherine Kedzierska, Dale I Godfrey, Ian F Hermans, Stephen J Turner, Gavin F Painter

Journal article  |  2017  |  ACS Chemical Biology

Uncomplicated Cystitis in an Adult Male Following Influenza B Virus Infection

Robert J Allen, Marios Koutsakos, Aeron C Hurt, Katherine Kedzierska

Journal article  |  2017  |  American Journal of Case Reports

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Liyen Loh, Zhongfang Wang, Sneha Sant, Marios Koutsakos, Sinthujan Jegaskanda, Alexandra J Corbett, Ligong Liu, David P Fairlie, Jane Crowe, Jamie Rossjohn, Jianqing Xu, Peter C Doherty, James McCluskey, Katherine Kedzierska

Journal article  |  2016  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knowns and unknowns of influenza B viruses

Marios Koutsakos, Ho Nguyen Thi, Wendy S Barclay, Katherine Kedzierska

Journal article  |  2016  |  FUTURE MICROBIOLOGY