Jennifer Flegg

An Activation-Clearance Model for Plasmodium vivax Malaria.

Somya Mehra, James M McCaw, Mark B Flegg, Peter G Taylor, Jennifer A Flegg

Journal article  |  2020  |  Bulletin of Mathematical Biology

Malaria is an infectious disease with an immense global health burden. Plasmodium vivax is the most geographically widespread spec..

A Current Perspective on Wound Healing and Tumour-Induced Angiogenesis.

Jennifer A Flegg, Shakti N Menon, Helen M Byrne, DL Sean McElwain

Journal article  |  2020  |  Bulletin of Mathematical Biology

Angiogenesis, or capillary growth from pre-existing vasculature, is an essential component of several physiological processes, bot..

A mathematical model of the use of supplemental oxygen to combat surgical site infection

Chathranee Jayathilake, Philip K Maini, Harriet W Hopf, DL Sean McElwain, Helen M Byrne, Mark B Flegg, Jennifer A Flegg

Journal article  |  2019  |  Journal of Theoretical Biology

Mathematical Modelling and Avascular Tumour Growth: Interdisciplinary Research

JA Flegg, N Nataraj

Journal article  |  2019  |  Resonance

Malaria parasite clearance rate regression: an R software package for a Bayesian hierarchical regression model.

Saeed Sharifi-Malvajerdi, Feiyu Zhu, Colin B Fogarty, Michael P Fay, Rick M Fairhurst, Jennifer A Flegg, Kasia Stepniewska, Dylan S Small

Journal article  |  2019  |  Malaria Journal

BACKGROUND: Emerging resistance to anti-malarial drugs has led malaria researchers to investigate what covariates (parasite and ho..

Physiological factors leading to a successful vaccination: A computational approach

Dominic L Maderazo, Jennifer A Flegg, Melanie R Neeland, Michael J de Veer, Mark B Flegg

Journal article  |  2018  |  Journal of Theoretical Biology

Agent-based models of malaria transmission: a systematic review

Neal R Smith, James M Trauer, Manoj Gambhir, Jack S Richards, Richard J Maude, Jonathan M Keith, Jennifer A Flegg

Journal article  |  2018  |  Malaria Journal

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II

Qing-Hua Zhang, Wai Shan Yuen, Deepak Adhikari, Jennifer A Flegg, Greg FitzHarris, Marco Conti, Piotr Sicinski, Ibtissem Nabti, Petros Marangos, John Carroll

Journal article  |  2017  |  The Journal of Cell Biology

Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda

Aimee R Taylor, Jennifer A Flegg, Chris C Holmes, Philippe J Guerin, Carol H Sibley, Melissa D Conrad, Grant Dorsey, Philip J Rosenthal

Journal article  |  2017  |  Open Forum Infectious Diseases

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia

Eric PM Grist, Jennifer A Flegg, Georgina Humphreys, Ignacio Suay Mas, Tim JC Anderson, Elizabeth A Ashley, Nicholas PJ Day, Mehul Dhorda, Arjen M Dondorp, M Abul Faiz, Peter W Gething, Tran T Hien, Tin M Hlaing, Mallika Imwong, Jean-Marie Kindermans, Richard J Maude, Mayfong Mayxay, Marina McDew-White, Didier Menard, Shalini Nair, et al.

Journal article  |  2016  |  International Journal of Health Geographics

On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process

Jennifer A Flegg, Shakti N Menon, Philip K Maini, DL Sean McElwain

Journal article  |  2015  |  Frontiers in Physiology

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis

Salim Abdulla, Elizabeth A Ashley, Quique Bassat, Delia Bethell, Anders Bjorkman, Steffen Borrmann, Umberto D'Alessandro, Prabin Dahal, Nicholas P Day, Mahamadou Diakite, Abdoulaye A Djimde, Arjen M Dondorp, Socheat Duong, Michael D Edstein, Rick M Fairhurst, M Abul Faiz, Catherine Falade, Jennifer A Flegg, Carole Fogg, Raquel Gonzalez, et al.

Journal article  |  2015  |  Malaria Journal

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

Salim Abdulla, Ishag Adam, George O Adjei, Martin A Adjuik, Bereket Alemayehu, Richard Allan, Emmanuel Arinaitwe, Elizabeth A Ashley, Mamadou S Ba, Hubert Barennes, Karen I Barnes, Quique Bassat, Elisabeth Baudin, Nicole Berens-Riha, Anders Bjoerkman, Francois Bompart, Maryline Bonnet, Steffen Borrmann, Teun Bousema, Philippe Brasseur, et al.

Journal article  |  2015  |  BMC Medicine

Bayesian Hierarchical Regression on Clearance Rates in the Presence of "Lag" and "Tail" Phases with an Application to Malaria Parasites

Colin B Fogarty, Michael P Fay, Jennifer A Flegg, Kasia Stepniewska, Rick M Fairhurst, Dylan S Small

Journal article  |  2015  |  Biometrics

Healing of venous ulcers using compression therapy: Predictions of a mathematical model

Jennifer A Flegg, Jessica Kasza, Ian Darby, Carolina D Weller

Journal article  |  2015  |  Journal of Theoretical Biology

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data

NM Anstey, RN Price, TME Davis, HA Karunajeewa, I Mueller, HA Karunajeewa, U D'Alessandro, A Massougbodji, F Nikiema, J-B Ouedraogo, H Tinto, I Zongo, J-B Ouedraogo, H Tinto, A Same-Ekobo, M Kone, H Menan, AO Toure, W Yavo, W Yavo, et al.

Journal article  |  2015  |  The Lancet Infectious Diseases

Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach

Lisa J White, Jennifer A Flegg, Aung Pyae Phyo, Ja Hser Wiladpai-ngern, Delia Bethell, Christopher Plowe, Tim Anderson, Standwell Nkhoma, Shalini Nair, Rupam Tripura, Kasia Stepniewska, Wirichada Pan-Ngum, Kamolrat Silamut, Ben S Cooper, Yoel Lubell, Elizabeth A Ashley, Chea Nguon, Francois Nosten, Nicholas J White, Arjen M Dondorp

Journal article  |  2015  |  PLOS Medicine

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

Kyaw M Tun, Mallika Imwong, Khin M Lwin, Aye A Win, Tin M Hlaing, Thaung Hlaing, Khin Lin, Myat P Kyaw, Katherine Plewes, M Abut Faiz, Mehul Dhorda, Phaik Yeong Cheah, Sasithon Pukrittayakamee, Elizabeth A Ashley, Tim JC Anderson, Shalini Nair, Marina McDew-White, Jennifer A Flegg, Eric Pm Grist, Philippe Guerin, et al.

Journal article  |  2015  |  The Lancet Infectious Diseases

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

Martin A Adjuik, Richard Allan, Anupkumar R Anvikar, Elizabeth A Ashley, Mamadou S Ba, Hubert Barennes, Karen I Barnes, Quique Bassat, Elisabeth Baudin, Anders Bjorkman, Francois Bompart, Maryline Bonnet, Steffen Borrmann, Philippe Brasseur, Hasifa Bukirwa, Francesco Checchi, Michel Cot, Prabin Dahal, Umberto D'Alessandro, Philippe Deloron, et al.

Journal article  |  2015  |  BMC Medicine

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

EA Ashley, M Dhorda, RM Fairhurst, C Amaratunga, P Lim, S Suon, S Sreng, JM Anderson, S Mao, B Sam, C Sopha, CM Chuor, C Nguon, S Sovannaroth, S Pukrittayakamee, P Jittamala, K Chotivanich, K Chutasmit, C Suchatsoonthorn, R Runcharoen, et al.

Journal article  |  2014  |  New England Journal of Medicine

Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections

Aimee R Taylor, Jennifer A Flegg, Samuel L Nsobya, Adoke Yeka, Moses R Kamya, Philip J Rosenthal, Grant Dorsey, Carol H Sibley, Philippe J Guerin, Chris C Holmes

Journal article  |  2014  |  Malaria Journal

The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data

Jane Achan, Ishag Adam, Emmanuel Arinaitwe, Elizabeth A Ashley, Ghulam Rahim Awab, Mamadou S Ba, Karen I Barnes, Quique Bassat, Steffen Borrmann, Teun Bousema, Prabin Dahal, Umberto D'Alessandro, Timothy ME Davis, Arjen M Dondorp, Grant Dorsey, Chris J Drakeley, Caterina I Fanello, Babacar Faye, Jennifer A Flegg, Oumar Gaye, et al.

Journal article  |  2013  |  PLoS Medicine

Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives

Jennifer A Flegg, Philippe J Guerin, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Arjen M Dondorp, Rick M Fairhurst, Duong Socheat, Steffen Borrmann, Anders Bjorkman, Andreas Martensson, Mayfong Mayxay, Paul N Newton, Delia Bethell, Youry Se, Harald Noedl, Mahamadou Diakite, Abdoulaye A Djimde, Tran T Hien, Nicholas J White, et al.

Journal article  |  2013  |  Malaria Journal

Trends in Antimalarial Drug Use in Africa

Jennifer A Flegg, Charlotte JE Metcalf, Myriam Gharbi, Meera Venkatesan, Tanya Shewchuk, Carol Hopkins Sibley, Philippe J Guerin

Journal article  |  2013  |  The American Journal of Tropical Medicine and Hygiene

Surveillance of Travellers: An Additional Tool for Tracking Antimalarial Drug Resistance in Endemic Countries

Myriam Gharbi, Jennifer A Flegg, Bruno Pradines, Ako Berenger, Magatte Ndiaye, Abdoulaye A Djimde, Cally Roper, Veronique Hubert, Eric Kendjo, Meera Venkatesan, Philippe Brasseur, Oumar Gaye, Andre T Offianan, Louis Penali, Jacques Le Bras, Philippe J Guerin

Journal article  |  2013  |  PLoS ONE

Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum

Jennifer A Flegg, Anand P Patil, Meera Venkatesan, Cally Roper, Inbarani Naidoo, Simon I Hay, Carol Hopkins Sibley, Philippe J Guerin

Journal article  |  2013  |  Malaria Journal

High-Throughput Analysis of Antimalarial Susceptibility Data by the WorldWide Antimalarial Resistance Network (WWARN) In Vitro Analysis and Reporting Tool

Charles J Woodrow, Sabina Dahlstroem, Richard Cooksey, Jennifer A Flegg, Herve Le Nagard, France Mentre, Claribel Murillo, Didier Menard, Francois Nosten, Kanlaya Sriprawat, Lise Musset, Neils B Quashie, Pharath Lim, Rick M Fairhurst, Sam L Nsobya, Veronique Sinou, Harald Noedl, Bruno Pradines, Jacob D Johnson, Philippe J Guerin, et al.

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Students' approaches to learning a new mathematical model

JA Flegg, DG Mallet, M Lupton

Journal article  |  2013  |  Teaching Mathematics and its Applications

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011

Myriam Gharbi, Jennifer A Flegg, Veronique Hubert, Eric Kendjo, Jessica E Metcalf, Lionel Bertaux, Philippe J Guerin, Jacques Le Bras

Journal article  |  2013  |  Malaria Journal

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

Shannon Takala-Harrison, Taane G Clark, Christopher G Jacob, Michael P Cummings, Olivo Miotto, Arjen M Dondorp, Mark M Fukuda, Francois Nosten, Harald Noedl, Mallika Imwong, Delia Bethell, Youry Se, Chanthap Lon, Stuart D Tyner, David L Saunders, Duong Socheat, Frederic Ariey, Aung Pyae Phyo, Peter Starzengruber, Hans-Peter Fuehrer, et al.

Journal article  |  2013  |  Proceedings of the National Academy of Sciences

Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach

D Loessner, JA Flegg, HM Byrne, JA Clements, DW Hutmacher

Journal article  |  2013  |  Integrative Biology

Students' perceptions of the relevance of mathematics in engineering

J Flegg, D Mallet, M Lupton

Journal article  |  2012  |  International Journal of Mathematical Education in Science and Technology

Modelling the interaction of keratinocytes and fibroblasts during normal and abnormal wound healing processes

Shakti N Menon, Jennifer A Flegg, Scott W McCue, Richard C Schugart, Rebecca A Dawson, DL Sean McElwain

Journal article  |  2012  |  Proceedings of the Royal Society B: Biological Sciences

Wound healing angiogenesis: The clinical implications of a simple mathematical model

Jennifer A Flegg, Helen M Byrne, Mark B Flegg, DL Sean McElwain

Journal article  |  2012  |  Journal of Theoretical Biology

Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

Jennifer A Flegg, Philippe J Guerin, Nicholas J White, Kasia Stepniewska

Journal article  |  2011  |  Malaria Journal

Mathematical Model of Hyperbaric Oxygen Therapy Applied to Chronic Diabetic Wounds

Jennifer A Flegg, Helen M Byrne, L Sean McElwain

Journal article  |  2010  |  Bulletin of Mathematical Biology

A Three Species Model to Simulate Application of Hyperbaric Oxygen Therapy to Chronic Wounds

Jennifer A Flegg, Donald LS McElwain, Helen M Byrne, Ian W Turner

Journal article  |  2009  |  PLoS Computational Biology

Computational Approaches to Solving Equations Arising from Wound Healing

Jennifer A Thackham, DL Sean McElwain, Ian W Turner

Journal article  |  2009  |  Bulletin of Mathematical Biology

The use of hyperbaric oxygen therapy to treat chronic wounds: A review

Jennifer A Thackham, DL Sean McElwain, Robert J Long

Journal article  |  2008  |  Wound Repair and Regeneration