Rebecca Feltham

RIPK1 ubiquitination: Evidence, correlations and the undefined

Daniel S Simpson, Anna Gabrielyan, Rebecca Feltham

Journal article  |  2021  |  Seminars in Cell and Developmental Biology

Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in..

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2020  |  Cell Death and Differentiation

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1 beta Release

Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James M Murphy, Ian P Wicks, James E Vince

Journal article  |  2019  |  The Journal of Immunology

The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-depe..

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham

Journal article  |  2019  |  Cell Death & Differentiation

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schunke, Luca L Fava, Manuel D Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A Harris, John Bertin, Peter J Gough, et al.

Journal article  |  2019  |  Molecular Cell

Ion Man: GSDMD Punches Pores to Knock Out cGAS

Rebecca Feltham, James E Vince

Journal article  |  2018  |  Immunity

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential

Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J Kearney, Danielle Clancy, Paul R Elliott, Timo Glatter, Qi Qiao, Andrew J Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, et al.

Journal article  |  2018  |  Cell Reports

Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch be..

XIAP Loss Triggers RIPK3-and Caspase-8-Driven IL-1 beta Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

Kate E Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A Conos, Kaiwen W Chen, Stephanie Ziehe, Carina Grass, Yifan Zhan, Tan A Nguyen, Cathrine Hall, Angelina J Vince, Simon M Chatfield, Damian B D'Silva, Kenneth C Pang, Kate Schroder, John Silke, David L Vaux, Philipp J Jost, James E Vince

Journal article  |  2017  |  Cell Reports