Rebecca Feltham

Design and characterization of a heterobifunctional degrader of KEAP1

Hao Chen, Nghi H Nguyen, Charlene M Magtoto, Simon A Cobbold, Grace M Bidgood, Lizeth G Meza Guzman, Lachlan W Richardson, Jason Corbin, Amanda E Au, Bernhard C Lechtenberg, Rebecca Feltham, Kate D Sutherland, Christoph Grohmann, Sandra E Nicholson, Brad E Sleebs

Journal article  |  2023  |  REDOX BIOLOGY

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reac..

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

Daniel Frank, Sarah E Garnish, Jarrod J Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A Cobbold, Simon R Scutts, Marcel Doerflinger, Holly Anderton, Kate E Lawlor, Najoua Lalaoui, Andrew J Kueh, Vik Ven Eng, Rebecca L Ambrose, Marco J Herold, Andre L Samson, Rebecca Feltham, et al.

Journal article  |  2022  |  ISCIENCE

Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, incl..

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette Jacobsen, Emma Morrish, Natasha Silke, James M Murphy, Joan K Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12F36V (dTAGs) or HaloTag7 (HaloP..

Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S Simpson, Jiyi Pang, Ashley Weir, Isabella Y Kong, Melanie Fritsch, Maryam Rashidi, James P Cooney, Kathryn C Davidson, Mary Speir, Tirta M Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A Conos, Hazel Tye, Seong H Chow, et al.

Journal article  |  2022  |  IMMUNITY

Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to ..

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Edmond M Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J Calleja, Narelle Keating, Rebecca Feltham, Andrew J Brooks, Shawn S Li, Sachdev S Sidhu, Jeffrey J Babon, Nadia J Kershaw, Sandra E Nicholson

Journal article  |  2021  |  NATURE COMMUNICATIONS

Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Sig..

The ubiquitylation of IL-1 beta limits its cleavage by caspase-1 and targets it for proteasomal degradation

Swarna L Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S Simpson, Gregor Ebert, Angelina Vince, Marco J Herold, Andrew Kueh, Jaclyn S Pearson, Laura F Dagley, James M Murphy, Andrew I Webb, Kate E Lawlor, James E Vince

Journal article  |  2021  |  NATURE COMMUNICATIONS

Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of o..

K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2(VHL)

Charlene M Magtoto, Rebecca Feltham

Journal article  |  2021  |  MOLECULAR CELL

In this issue of Molecular Cell, Kaiho-Soma et al. (2021) demonstrate that the HECT-type E3 ubiquitin ligase TRIP12 cooperates wit..

RIPK1 ubiquitination: Evidence, correlations and the undefined

Daniel S Simpson, Anna Gabrielyan, Rebecca Feltham

Journal article  |  2021  |  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in..

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  EMBO JOURNAL

The SARS-CoV-2 coronavirus encodes an essential papain-like protease domain as part of its non-structural protein (nsp)-3, namely ..

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..