Lab focus: Therapeutically targeting the ubiquitin system
Ubiquitin (Ub) is a small protein found in almost all tissues in humans that helps to regulate cellular processes. Deregulated Ub signalling has been linked to a number of diseases.
The Feltham laboratory focuses on understanding how Ub signalling is deregulated in cancer and inflammatory disease to aid in the development of new therapies and the identification of diagnostic biomarkers.
Find out more about Rebecca Feltham's experience
Rebecca Feltham's highlights
Rebecca Feltham's selected work
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated ..
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid C..
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death ..
Displaying the 23 most recent scholarly works by Rebecca Feltham.
An Erg-driven transcriptional program controls B cell lymphopoiesis.
Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.
Journal article | 2020 | Nature Communications
B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer
Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.
Journal article | 2020 | Cell Death & Differentiation
Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1 beta Release
Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James M Murphy, Ian P Wicks, James E Vince
Journal article | 2019 | The Journal of Immunology
The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-depe..
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham
Journal article | 2019 | Cell Death & Differentiation
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schunke, Luca L Fava, Manuel D Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A Harris, John Bertin, Peter J Gough, et al.
Journal article | 2019 | Molecular Cell
Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential
Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J Kearney, Danielle Clancy, Paul R Elliott, Timo Glatter, Qi Qiao, Andrew J Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, et al.
Journal article | 2018 | Cell Reports
Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch be..
XIAP Loss Triggers RIPK3-and Caspase-8-Driven IL-1 beta Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
Kate E Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A Conos, Kaiwen W Chen, Stephanie Ziehe, Carina Grass, Yifan Zhan, Tan A Nguyen, Cathrine Hall, Angelina J Vince, Simon M Chatfield, Damian B D'Silva, Kenneth C Pang, Kate Schroder, John Silke, David L Vaux, Philipp J Jost, James E Vince
Journal article | 2017 | Cell Reports
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier
Journal article | 2017 | Molecular Cell
The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.
Mariam H Orme, Gianmaria Liccardi, Nina Moderau, Rebecca Feltham, Sidonie Wicky-John, Tencho Tenev, Lior Aram, Rebecca Wilson, Katiuscia Bianchi, Otto Morris, Celia Monteiro Domingues, David Robertson, Meghana Tare, Alexander Wepf, David Williams, Andreas Bergmann, Matthias Gstaiger, Eli Arama, Paulo S Ribeiro, Pascal Meier
Journal article | 2016 | Nature Communications
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology..
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies
Stephen M Condon, Yasuhiro Mitsuuchi, Yijun Deng, Matthew G LaPorte, Susan R Rippin, Thomas Haimowitz, Matthew D Alexander, Pavan Tirunahari Kumar, Mukta S Hendi, Yu-Hua Lee, Christopher A Benetatos, Guangyao Yu, Gurpreet Singh Kapoor, Eric Neiman, Martin E Seipel, Jennifer M Burns, Martin A Graham, Mark A McKinlay, Xiaochun Li, Jiawei Wang, et al.
Journal article | 2014 | Journal of Medicinal Chemistry
Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
Rebecca Feltham, Bodhi Bettjeman, Rhesa Budhidarmo, Peter D Mace, Sarah Shirley, Stephen M Condon, Srinivas K Chunduru, Mark A McKinlay, David L Vaux, John Silke, Catherine L Day
Journal article | 2011 | J. Biol. Chem.
Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding
Rebecca Feltham, Maryline Moulin, James E Vince, Peter D Mace, Wendy Wei-Lynn Wong, Holly Anderton, Catherine L Day, David L Vaux, John Silke
Journal article | 2010 | Journal of Biological Chemistry
TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-kappa B and to Prevent TNF-induced Apoptosis
James E Vince, Delara Pantaki, Rebecca Feltham, Peter D Mace, Stephanie M Cordier, Anna C Schmukle, Angelina J Davidson, Bernard A Callus, Wendy Wei-Lynn Wong, Ian E Gentle, Holly Carter, Erinna F Lee, Henning Walczak, Catherine L Day, David L Vaux, John Silke
Journal article | 2009 | J. Biol. Chem.
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
Tobias L Haas, Christoph H Emmerich, Bjoern Gerlach, Anna C Schmukle, Stefanie M Cordier, Eva Rieser, Rebecca Feltham, James Vince, Uwe Warnken, Till Wenger, Ronald Koschny, David Komander, John Silke, Henning Walczak
Journal article | 2009 | Molecular Cell
IAP antagonists target cIAP1 to induce TNF alpha- dependent apoptosis
James E Vince, W Wei-Lynn Wong, Nufail Khan, Rebecca Feltham, Diep Chau, Afsar U Ahmed, Christopher A Benetatos, Srinivas K Chunduru, Stephen M Condon, Mark McKinlay, Robert Brink, Martin Leverkus, Vinay Tergaonkar, Pascal Schneider, Bernard A Callus, Frank Koentgen, David L Vaux, John Silke
Journal article | 2007 | Cell
Medical Biology (W.E.H.I.)
Doctor of Philosophy
La Trobe University