Mark Davies

Role of Glutathione in Buffering Excess Intracellular Copper in Streptococcus pyogenes.

Louisa J Stewart, Cheryl-Lynn Y Ong, May M Zhang, Stephan Brouwer, Liam McIntyre, Mark R Davies, Mark J Walker, Alastair G McEwan, Kevin J Waldron, Karrera Y Djoko

Journal article  |  2020  |  mBio

Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To limit Cu levels in the cytoplasm,..

Erratum for Rivera-Hernandez et al., "An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model".

Tania Rivera-Hernandez, Diane G Carnathan, Scott Jones, Amanda J Cork, Mark R Davies, Peter M Moyle, Istvan Toth, Michael R Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J Walker

Journal article  |  2020  |  mBio

Global genomic epidemiology of Streptococcus pyogenes

Magnus G Jespersen, Jake A Lacey, Steven YC Tong, Mark R Davies

Journal article  |  2020  |  Infection Genetics and Evolution

Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations ..

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

David MP De Oliveira, Lisa Bohlmann, Trent Conroy, Freda E-C Jen, Arun Everest-Dass, Karl A Hansford, Raghu Bolisetti, Ibrahim M El-Deeb, Brian M Forde, Phan Minh-Duy, Jake A Lacey, Aimee Tan, Tania Rivera-Hernandez, Stephan Brouwer, Nadia Keller, Timothy J Kidd, Amanda J Cork, Michelle J Bauer, Gregory M Cook, Mark R Davies, et al.

Journal article  |  2020  |  Science Translational Medicine

The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a cri..

In silicocharacterisation of stand-alone response regulators ofStreptococcus pyogenes

Sean J Buckley, Mark R Davies, David J McMillan

Journal article  |  2020  |  PLoS One

Bacterial "stand-alone" response regulators (RRs) are pivotal to the control of gene transcription in response to changing cytosol..

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

Stephan Brouwer, Timothy C Barnett, Diane Ly, Katherine J Kasper, David MP De Oliveira, Tania Rivera-Hernandez, Amanda J Cork, Liam McIntyre, Magnus G Jespersen, Johanna Richter, Benjamin L Schulz, Gordon Dougan, Victor Nizet, Kwok-Yung Yuen, Yuanhai You, John K McCormick, Martina L Sanderson-Smith, Mark R Davies, Mark J Walker

Journal article  |  2020  |  Nature Communications

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) S..

Increase of emm1 isolates among group A Streptococcus strains causing scarlet fever in Shanghai, China

Mingliang Chen, Jiehao Cai, Mark R Davies, Yuefang Li, Chi Zhang, Weilei Yao, Dechuan Kong, Hao Pan, Xi Zhang, Mei Zeng, Min Chen

Journal article  |  2020  |  International Journal of Infectious Diseases

OBJECTIVE: Scarlet fever epidemics caused by group A Streptococcus (GAS) have been ongoing in China since 2011. However, limited d..

Updated emm -typing protocol for Streptococcus pyogenes

HR Frost, MR Davies, S Velusamy, V Delforge, A Erhart, S Darboe, A Steer, MJ Walker, B Beall, A Botteaux, PR Smeesters

Journal article  |  2020  |  Clinical Microbiology and Infection

OBJECTIVES: PCR-based typing of the emm gene Streptococcus pyogenes often results in the amplification of multiple bands. This has..

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection

Rebecca H Chisholm, Nikki Sonenberg, Jake A Lacey, Malcolm I McDonald, Manisha Pandey, Mark R Davies, Steven YC Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2020  |  PLOS COMPUTATIONAL BIOLOGY

Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in disadvantage..

Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell, Steven YC Tong, Nicholas Geard, Mark R Davies, Kate A Worthing, Jake A Lacey, Pierre R Smeesters, Michael R Batzloff, Joseph Kado, Adam WJ Jenney, Jodie Mcvernon, Andrew C Steer

Journal article  |  2020  |  Journal of Infectious Diseases

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relati..