Mark Davies

Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell, Steven YC Tong, Nicholas Geard, Mark R Davies, Kate A Worthing, Jake A Lacey, Pierre R Smeesters, Michael R Batzloff, Joseph Kado, Adam WJ Jenney, Jodie Mcvernon, Andrew C Steer

Journal article  |  2020  |  The Journal of Infectious Diseases

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relati..

Biphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility, New Zealand

Kate A Worthing, Anja Werno, Ramon Pink, Liam McIntyre, Glen P Carter, Deborah A Williamson, Mark R Davies

Journal article  |  2020  |  Emerging Infectious Diseases

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins.

Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong

Journal article  |  2020  |  mSphere

A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding pr..

Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae.

Andrea Rocker, Jake A Lacey, Matthew J Belousoff, Jonathan J Wilksch, Richard A Strugnell, Mark R Davies, Trevor Lithgow

Journal article  |  2020  |  mBio

In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of anti..

Updated emm-typing protocol for Streptococcus pyogenes.

HR Frost, MR Davies, S Velusamy, V Delforge, A Erhart, S Darboe, A Steer, MJ Walker, B Beall, A Botteaux, PR Smeesters

Journal article  |  2020  |  Clinical Microbiology and Infection

OBJECTIVES: PCR-based typing of the emm gene Streptococcus pyogenes often results in the amplification of multiple bands. This has..

Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins

Hannah R Frost, Mark R Davies, Valerie Delforge, Dalila Lakhloufi, Martina Sanderson-Smith, Velusamy Srinivasan, Andrew C Steer, Mark J Walker, Bernard Beall, Anne Botteaux, Pierre R Smeesters

Journal article  |  2020  |  mSphere

The core Mga (multiple gene activator) regulon of group A Streptococcus (GAS) contains genes encoding proteins involved in adhesio..

Scarlet fever changes its spots

Stephan Brouwer, Jake A Lacey, Yuanhai You, Mark R Davies, Mark J Walker

Journal article  |  2019  |  The Lancet Infectious Diseases

The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium

Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell

Journal article  |  2019  |  Biochemical Journal

Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection

Rebecca Chisholm, Nikki Sonenberg, Jake Lacey, Malcolm McDonald, Manisha Pandey, Mark Davies, Steven Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2019

Abstract Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in Ind..

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastian Duchene, Pierre R Smeesters, Hannah R Frost, David J Price, Matthew TG Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, et al.

Journal article  |  2019  |  Nature Genetics

An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model

Tania Rivera-Hernandez, Diane G Carnathan, Scott Jones, Amanda J Cork, Mark R Davies, Peter M Moyle, Istvan Toth, Michael R Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J Walker

Journal article  |  2019  |  mBio

Group A Streptococcus (GAS) infections account for an estimated 500,000 deaths every year. This bacterial pathogen is responsible ..

Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis

Kate A Worthing, Jake A Lacey, David J Price, Liam McIntyre, Andrew C Steer, Steven YC Tong, Mark R Davies

Journal article  |  2019  |  The American Journal of Tropical Medicine and Hygiene

A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?

Joshua Osowicki, Kristy Azzopardi, Liam McIntyre, Tania Rivera-Hernandez, Cheryl-Iynn Y Ong, Ciara Baker, Christine M Gillen, E Mark J Walker, Pierre R Smeesters, Mark R Davies, Andrew C Steer

Journal article  |  2019  |  mSphere

Characterization of Staphylococcal Cassette Chromosome mec Elements from Methicillin-Resistant Staphylococcus pseudintermedius Infections in Australian Animals

Kate A Worthing, Sybille Schwendener, Vincent Perreten, Sugiyono Saputra, Geoffrey W Coombs, Stanley Pang, Mark R Davies, Sam Abraham, Darren J Trott, Jacqueline M Norris

Journal article  |  2018  |  mSphere

Chemical Synergy between lonophore PBT2 and Zinc Reverses Antibiotic Resistance

Lisa Bohlmann, David MP De Oliveira, Ibrahim M El-Deeb, Erin B Brazel, Nichaela Harbison-Price, Cheryl-Iynn Y Ong, Tania Rivera-Hernandez, Scott A Ferguson, Amanda J Cork, Phan Minh-Duy, Amelia T Soderholm, Mark R Davies, Graeme R Nimmo, Gordon Dougan, Mark A Schembri, Gregory M Cook, Alastair G McEwan, Mark von Itzstein, Christopher A McDevitt, Mark J Walker

Journal article  |  2018  |  mBio

Hypotheses for the resurgence of scarlet fever in China

Yuanhai You, Mark R Davies, Mark J Walker, Jianzhong Zhang

Journal article  |  2018  |  The Lancet Infectious Diseases

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants

Rhys Grinter, Iain D Hay, Jiangning Song, Jiawei Wang, Don Teng, Vijay Dhanesakaran, Jonathan J Wilksch, Mark R Davies, Dene Littler, Simone A Beckham, Ian R Henderson, Richard A Strugnell, Gordon Dougan, Trevor Lithgow

Journal article  |  2018  |  PLOS Biology

Characterisation of Staphylococcus felis isolated from cats using whole genome sequencing

Kate Worthing, Stanley Pang, Darren J Trott, Sam Abraham, Geoffrey W Coombs, David Jordan, Liam McIntyre, Mark R Davies, Jacqueline Norris

Journal article  |  2018  |  Veterinary Microbiology

In silico characterisation of the two-component system regulators of Streptococcus pyogenes

Sean J Buckley, Peter Timms, Mark R Davies, David J McMillan

Journal article  |  2018  |  PLOS ONE

Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium

Asma Ul Husna, Nancy Wang, Simon A Cobbold, Hayley J Newton, Dianna M Hocking, Jonathan J Wilksch, Timothy A Scott, Mark R Davies, Jay C Hinton, Jai J Tree, Trevor Lithgow, Malcolm J McConville, Richard A Strugnell

Journal article  |  2018  |  Journal of Biological Chemistry

Complete Genome Sequence of a Streptococcus pyogenes Serotype M12 Scarlet Fever Outbreak Isolate from China, Compiled Using Oxford Nanopore and Illumina Sequencing

Yuanhai You, Yongjun Kou, Longfei Niu, Qiong Jia, Yahui Liu, Mark R Davies, Mark J Walker, Jiaqiang Zhu, Jianzhong Zhang

Journal article  |  2018  |  Genome Announcements

Identification and Characterization of Fluoroquinolone Non-susceptible Streptococcus pyogenes Clones Harboring Tetracycline and Macrolide Resistance in Shanghai, China

Yinfang Shen, Jiehao Cai, Mark R Davies, Chi Zhang, Kun Gao, Dan Qiao, Haoqin Jiang, Weilei Yao, Yuefang Li, Mei Zeng, Mingliang Chen

Journal article  |  2018  |  Frontiers in Microbiology

Scarlet Fever Epidemic in China Caused by Streptococcus pyogenes Serotype M12: Epidemiologic and Molecular Analysis

Yuanhai You, Mark R Davies, Melinda Protani, Liam McIntyre, Mark J Walker, Jianzhong Zhang

Journal article  |  2018  |  EBioMedicine

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

Anna Henningham, Mark R Davies, Satoshi Uchiyama, Nina M van Sorge, Sean Lund, Kelsey T Chen, Mark J Walker, Jason N Cole, Victor Nizet

Journal article  |  2018  |  mBio

Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391

Matthew J Sullivan, Brian M Forde, Darren W Prince, Deepak S Ipe, Nouri L Ben Zakour, Mark R Davies, Gordon Dougan, Scott A Beatson, Glen C Ulett

Journal article  |  2017  |  Genome Announcements

Straight from the Horse's "Mouth": Genomic Epidemiology of an Icelandic Equine Epidemic

Mark R Davies

Journal article  |  2017  |  mBio

The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes

Andrew G Turner, Cheryl-Lynn Y Ong, Karrera Y Djoko, Nicholas P West, Mark R Davies, Alastair G McEwan, Mark J Walker

Journal article  |  2017  |  Infection and Immunity

Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition

Erica Kintz, Christian Heiss, Ian Black, Nicholas Donohue, Naj Brown, Mark R Davies, Parastoo Azadi, Stephen Baker, Paul M Kaye, Marjan van der Woude

Journal article  |  2017  |  Infection and Immunity

Draft Genome Sequence of Roseomonas mucosa Strain AU37, Isolated from a Peripheral Intravenous Catheter

Md Abu Choudhury, Alexander M Wailan, Hanna E Sidjabat, Li Zhang, Nicole Marsh, Claire M Rickard, Mark R Davies, David J McMillan

Journal article  |  2017  |  Genome Announcements

Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development

Deborah A Williamson, Pierre R Smeesters, Andrew C Steer, Julie Morgan, Mark Davies, Philip Carter, Arlo Upton, Stephen YC Tong, John Fraser, Nicole J Moreland

Journal article  |  2016  |  BMC Infectious Diseases

Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes

John A Lees, Minna Vehkala, Niko Valimaki, Simon R Harris, Claire Chewapreecha, Nicholas J Croucher, Pekka Marttinen, Mark R Davies, Andrew C Steer, Steven YC Tong, Antti Honkela, Julian Parkhill, Stephen D Bentley, Jukka Corander

Journal article  |  2016  |  Nature Communications

Invasive Group A Streptococcus Infection among Children, Rural Kenya

Anna C Seale, Mark R Davies, Kirimi Anampiu, Susan C Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N Williams, J Anthony G Scott, Samuel Kariuki, Gordon Dougan, James A Berkley

Journal article  |  2016  |  Emerging Infectious Diseases

Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae

Deepak S Ipe, Nouri L Ben Zakour, Matthew J Sullivan, Scott A Beatson, Kimberly B Ulett, William H Benjamin, Mark R Davies, Samantha J Dando, Nathan P King, Allan W Cripps, Mark A Schembri, Gordon Dougan, Glen C Ulett

Journal article  |  2016  |  Infection and Immunity

Functional analysis of an unusual type IV pilus in the Gram-positive Streptococcus sanguinis

Ishwori Gurung, Ingrid Spielman, Mark R Davies, Rajan Lala, Peter Gaustad, Nicolas Biais, Vladimir Pelicic

Journal article  |  2016  |  Molecular Microbiology

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

Nouri L Ben Zakour, Mark R Davies, Yuanhai You, Jonathan HK Chen, Brian M Forde, Mitchell Stanton-Cook, Ruifu Yang, Yujun Cui, Timothy C Barnett, Carola Venturini, Cheryl-Iynn Y Ong, Herman Tse, Gordon Dougan, Jianzhong Zhang, Kwok-Yung Yuen, Scott A Beatson, Mark J Walker

Journal article  |  2015  |  Scientific Reports

A BTP1 prophage gene present in invasive non-typhoidal Salmonella determines composition and length of the O-antigen of the lipopolysaccharide

Erica Kintz, Mark R Davies, Disa L Hammarloef, Rocio Canals, Jay CD Hinton, Marjan W van der Woude

Journal article  |  2015  |  Molecular Microbiology

Manganese Homeostasis in Group A Streptococcus Is Critical for Resistance to Oxidative Stress and Virulence

Andrew G Turner, Cheryl-Lynn Y Ong, Christine M Gillen, Mark R Davies, Nicholas P West, Alastair G McEwan, Mark J Walker

Journal article  |  2015  |  mBio

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

Mark R Davies, Matthew T Holden, Paul Coupland, Jonathan HK Chen, Carola Venturini, Timothy C Barnett, Nouri L Ben Zakour, Herman Tse, Gordon Dougan, Kwok-Yung Yuen, Mark J Walker

Journal article  |  2015  |  Nature Genetics

Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Violette Da Cunha, Mark R Davies, Pierre-Emmanuel Douarre, Isabelle Rosinski-Chupin, Immaculada Margarit, Sebastien Spinali, Tim Perkins, Pierre Lechat, Nicolas Dmytruk, Elisabeth Sauvage, Laurence Ma, Benedetta Romi, Magali Tichit, Maria-Jose Lopez-Sanchez, Stephane Descorps-Declere, Erika Souche, Carmen Buchrieser, Patrick Trieu-Cuot, Ivan Moszer, Dominique Clermont, et al.

Journal article  |  2014  |  Nature Communications

The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design

Nina M van Sorge, Jason N Cole, Kirsten Kuipers, Anna Henningham, Ramy K Aziz, Ana Kasirer-Friede, Leo Lin, Evelien TM Berends, Mark R Davies, Gordon Dougan, Fan Zhang, Samira Dahesh, Laura Shaw, Jennifer Gin, Madeleine Cunningham, Joseph A Merriman, Julia Huetter, Bernd Lepenies, Suzan HM Rooijakkers, Richard Malley, et al.

Journal article  |  2014  |  Cell Host & Microbe

DrsG from Streptococcus dysgalactiae subsp equisimilis Inhibits the Antimicrobial Peptide LL-37

Danielle Smyth, Ainslie Cameron, Mark R Davies, Celia McNeilly, Louise Hafner, Kadaba S Sriprakash, David J McMillan

Journal article  |  2014  |  Infection and Immunity

Global dissemination of a multidrug resistant Escherichia coli clone

Nicola K Petty, Nouri L Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M Forde, Phan Minh-Duy, Danilo Gomes Moriel, Kate M Peters, Mark Davies, Benjamin A Rogers, Gordon Dougan, Jesus Rodriguez-Bano, Alvaro Pascual, Johann DD Pitout, Mathew Upton, David L Paterson, Timothy R Walsh, Mark A Schembri, Scott A Beatson

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Genetics and virulence role of the classical group A Streptococcus Lancefield antigen

Jason Cole, Nina van Sorge, Kirsten Kuipers, Anna Henningham, Ramy Aziz, Ana Kasirer-Friede, Leo Lin, Evelien Berends, Mark Davies, Gordan Dougan, Fan Zhang, Samira Dahesh, Laura Shaw, Jennifer Gin, Madeleine Cunningham, Joseph Merriman, Suzan Rooijakkers, Richard Malley, Mark Walker, Sanford Shattil, et al.

Conference Proceedings  |  2014  |  FASEB JOURNAL

The Globally Disseminated M1T1 Clone of Group A Streptococcus Evades Autophagy for Intracellular Replication

Timothy C Barnett, David Liebl, Lisa M Seymour, Christine M Gillen, Jin Yan Lim, Christopher N LaRock, Mark R Davies, Benjamin L Schulz, Victor Nizet, Rohan D Teasdale, Mark J Walker

Journal article  |  2013  |  Cell Host & Microbe

Extensive Diversity of Streptococcus pyogenes in a Remote Human Population Reflects Global-Scale Transmission Rather than Localised Diversification

Rebecca J Towers, Jonathan R Carapetis, Bart J Currie, Mark R Davies, Mark J Walker, Gordon Dougan, Philip M Giffard

Journal article  |  2013  |  PLoS ONE

Horizontally Acquired Glycosyltransferase Operons Drive Salmonellae Lipopolysaccharide Diversity

Mark R Davies, Sarah E Broadbent, Simon R Harris, Nicholas R Thomson, Marjan W van der Woude

Journal article  |  2013  |  PLoS Genetics

ChIP-seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization

Timothy T Perkins, Mark R Davies, Elizabeth J Klemm, Gary Rowley, Thomas Wileman, Keith James, Thomas Keane, Duncan Maskell, Jay CD Hinton, Gordon Dougan, Robert A Kingsley

Journal article  |  2013  |  Molecular Microbiology

Molecular Characterization of the 2011 Hong Kong Scarlet Fever Outbreak

Herman Tse, Jessie YJ Bao, Mark R Davies, Peter Maamary, Hoi-Wah Tsoi, Amy HY Tong, Tom CC Ho, Chi-Ho Lin, Christine M Gillen, Timothy C Barnett, Jonathan HK Chen, Mianne Lee, Wing-Cheong Yam, Chi-Kin Wong, Cheryl-lynn Y Ong, Yee-Wai Chan, Cheng-Wei Wu, Tony Ng, Wilina WL Lim, Thomas HF Tsang, et al.

Journal article  |  2012  |  Journal of Infectious Diseases

Phase variation controls expression of Salmonella lipopolysaccharide modification genes by a DNA methylation-dependent mechanism

SE Broadbent, MR Davies, MW van der Woude

Journal article  |  2010  |  Molecular Microbiology

Identification of active variants of PARF in human pathogenic group C and group G streptococci leads to an amended description of its consensus motif

Vanessa Barroso, Manfred Rohde, Mark R Davies, Christine M Gillen, D Patric Nitsche-Schmitz, Katrin Dinkla, Gursharan S Chhatwal

Journal article  |  2009  |  International Journal of Medical Microbiology

A Novel Integrative Conjugative Element Mediates Genetic Transfer from Group G Streptococcus to Other beta-Hemolytic Streptococci

Mark R Davies, Josephine Shera, Gary H Van Domselaar, Kadaba S Sriprakash, David J McMillan

Journal article  |  2009  |  Journal of Bacteriology

Virulence profiling of Streptococcus dysgalactiae subspecies equisimilis isolated from infected humans reveals 2 distinct genetic lineages that do not segregate with their phenotypes or propensity to cause diseases

Mark R Davies, David J McMillan, Robert G Beiko, Vanessa Barroso, Robert Geffers, Kadaba S Sriprakash, Gursharan S Chhatwal

Journal article  |  2007  |  Clinical Infectious Diseases

Phage 3396 from a Streptococcus dysgalactiae subsp equisimilis pathovar may have its origins in Streptococcus pyogenes

Mark R Davies, David J McMillan, Gary H Van Domselaar, Malcolm K Jones, Kadaba S Sriprakash

Journal article  |  2007  |  Journal of Bacteriology

Evidence for increased horizontal gene transfers among streptococci from group A streptococcal endemic regions

MR Davies, TN Tran, DJ McMillan, KS Sriprakash

Journal article  |  2006  |  International Congress Series

Distribution of group A streptococcal virulence genes in group C and G streptococci

MR Davies, DJ McMillan, KS Sriprakash, GS Chhatwal

Journal article  |  2006  |  International Congress Series

Toward the development of an antidisease, transmission-blocking intranasal vaccine for group A streptococcus

MR Batzloff, HR Yan, MR Davies, J Hartas, GH Lowell, G White, DS Burt, T Leanderson, MF Good

Journal article  |  2005  |  The Journal of Infectious Diseases

Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

MR Davies, TN Tran, DJ McMillan, DL Gardiner, BJ Currie, KS Sriprakash

Journal article  |  2005  |  Microbes and Infection

Identification and assessment of new vaccine candidates for group A streptococcal infections

DJ McMillan, MR Batzloff, CL Browning, MR Davies, MF Good, KS Sriprakash, R Janulczyk, M Rasmussen

Journal article  |  2004  |  Vaccine

Preclinical evaluation of a vaccine based on conserved region of M protein that prevents group A streptococcal infection

M Batzloff, HR Yan, M Davies, J Hartas, M Good

Journal article  |  2004  |  Indian Journal of Medical Research, Supplement

Prospecting for new group A streptococcal vaccine candidates

DJ McMillan, MR Davies, CL Browning, MF Good, KS Sriprakash

Journal article  |  2004  |  Indian Journal of Medical Research, Supplement

Immune response to superoxide dismutase in group A streptococcal infection

DJ McMillan, MR Davies, MF Good, KS Sriprakash

Journal article  |  2004  |  FEMS Immunology & Medical Microbiology

Protection against group A streptococcus by immunization with J8-diphtheria toxoid: Contribution of J8-and diphtheria toxoid-specific antibodies to protection

MR Batzloff, WA Hayman, MR Davies, M Zeng, S Pruksakorn, ER Brandt, MF Good

Journal article  |  2003  |  The Journal of Infectious Diseases

Restricted sequence variation in Streptococcus pyogenes penicillin binding proteins

Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong

Journal article

AbstractA recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutations in the Penicillin B..