Mark Davies

Burkholderia PglL enzymes are Serine preferring oligosaccharyltransferases which target conserved proteins across the Burkholderia genus.

Andrew J Hayes, Jessica M Lewis, Mark R Davies, Nichollas E Scott

Journal article  |  2021  |  Commun Biol

Glycosylation is increasingly recognised as a common protein modification within bacterial proteomes. While great strides have bee..

The structural basis of bacterial manganese import

Stephanie L Neville, Jennie Sjoehamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L O'Mara, Megan J Maher, Christopher A McDevitt

Journal article  |  2021  |  SCIENCE ADVANCES

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import p..

Burkholderia PglL enzymes are serine preferring oligosaccharidetransferases which target conserved proteins across the Burkholderia genus

Andrew Hayes, Jessica Lewis, Mark Davies, Nichollas Scott

Journal article  |  2021

Glycosylation is increasingly recognised as a common protein modification within bacterial proteomes. While great strides have bee..

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.

Natalie Lorenz, Timothy Kc Ho, Reuben McGregor, Mark R Davies, Deborah A Williamson, Jason K Gurney, Pierre R Smeesters, Michael G Baker, Nicole J Moreland

Journal article  |  2021  |  Clin Infect Dis

Rheumatic fever is a serious post-infectious sequela of Group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using..

Global genomic epidemiology of Streptococcus pyogenes

Magnus G Jespersen, Jake A Lacey, Steven YC Tong, Mark R Davies

Journal article  |  2020  |  INFECTION GENETICS AND EVOLUTION

Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations ..

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

David MP De Oliveira, Lisa Bohlmann, Trent Conroy, Freda E-C Jen, Arun Everest-Dass, Karl A Hansford, Raghu Bolisetti, Ibrahim M El-Deeb, Brian M Forde, Phan Minh-Duy, Jake A Lacey, Aimee Tan, Tania Rivera-Hernandez, Stephan Brouwer, Nadia Keller, Timothy J Kidd, Amanda J Cork, Michelle J Bauer, Gregory M Cook, Mark R Davies, et al.

Journal article  |  2020  |  SCIENCE TRANSLATIONAL MEDICINE

The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a cri..

Role of Glutathione in Buffering Excess Intracellular Copper in Streptococcus pyogenes

Louisa J Stewart, Cheryl-lynn Y Ong, May M Zhang, Stephan Brouwer, Liam McIntyre, Mark R Davies, Mark J Walker, Alastair G McEwan, Kevin J Waldron, Karrera Y Djoko

Journal article  |  2020  |  MBIO

Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To limit Cu levels in the cytoplasm,..

An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model (vol 10, e00693-19, 2019)

Tania Rivera-Hernandez, Diane G Carnathan, Scott Jones, Amanda J Cork, Mark R Davies, Peter M Moyle, Istvan Toth, Michael R Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J Walker

Journal article  |  2020  |  MBIO

Volume 10, issue 2, e00693-19, 2019, https://doi.org/10.1128/mBio.00693-19. On PDF page 7, the point mutations for SCPA were incor..

In silicocharacterisation of stand-alone response regulators ofStreptococcus pyogenes

Sean J Buckley, Mark R Davies, David J McMillan

Journal article  |  2020  |  PLOS ONE

Bacterial "stand-alone" response regulators (RRs) are pivotal to the control of gene transcription in response to changing cytosol..

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

Stephan Brouwer, Timothy C Barnett, Diane Ly, Katherine J Kasper, David MP De Oliveira, Tania Rivera-Hernandez, Amanda J Cork, Liam McIntyre, Magnus G Jespersen, Johanna Richter, Benjamin L Schulz, Gordon Dougan, Victor Nizet, Kwok-Yung Yuen, Yuanhai You, John K McCormick, Martina L Sanderson-Smith, Mark R Davies, Mark J Walker

Journal article  |  2020  |  NATURE COMMUNICATIONS

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) S..