Mark completed his PhD in 2007 at the Queensland Institute of Medical Research under the supervision of Assoc. Prof. Sri Sriprakash focussing on comparative genomics of Streptococcal pathogens.
He then undertook a postdoctoral position at the University of York in the UK where he studied the evolution and functional role of lipopolysaccharide modification systems in Salmonella. In 2009 Mark was awarded an NHMRC overseas postdoctoral training fellow and between 2010 and 2014 he worked between the Wellcome Trust Sanger Institute, UK and the University of Queensland under the supervision of Prof Gordon Dougan and Prof Mark Walker where he employed genome sequencing methodologies to examine the genome dynamics of microbial pathogens such as Group A and Group B Streptococcus. Mark was recently recruited to the Department of Microbiology and Immunology at the Peter Doherty Institute, University of Melbourne, where he is growing his own research themes around the application of genome sequencing to bacterial pathogens. Mark has grown extensive international collaborations and applies bioinformatic tools to examine the evolution of bacterial pathogens with a focus on antimicrobial resistance, virulence and transmission along with examining the genomic epidemiology of bacterial populations within geographical regions such as sub-Saharan Africa and remote populations in the Northern Territory of Australia. Mark's objective is to link bacterial genotype with phenotype with the objective of understanding disease mechanisms along with pathogen emergence and spread.
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Mark Davies' selected work
Contribution Of Carbohydrate Metabolism To The Maintenance Of Endemic Streptococcal Pathog..
Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority E..
Contribution Of Carbohydrate Metabolism To The Maintenance Of Endemic Streptococcal Pathog..
Displaying the 5 most recent projects by Mark Davies.
Displaying the 59 most recent scholarly works by Mark Davies.
Updated emm-typing protocol for Streptococcus pyogenes.
Hannah R Frost, Mark R Davies, Srinivasan Velusamy, Valérie Delforge, Annette Erhart, Saffiatou Darboe, Andrew Steer, Mark J Walker, Bernard Beall, Anne Botteaux, Pierre Smeesters
Journal article | 2020 | Clinical Microbiology and Infection
OBJECTIVES: PCR-based typing of the emm gene Streptococcus pyogenes often results in the amplification of multiple bands. This has..
Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins
Hannah R Frost, Mark R Davies, Valerie Delforge, Dalila Lakhloufi, Martina Sanderson-Smith, Velusamy Srinivasan, Andrew C Steer, Mark J Walker, Bernard Beall, Anne Botteaux, Pierre R Smeesters
Journal article | 2020 | mSphere
The core Mga (multiple gene activator) regulon of group A Streptococcus (GAS) contains genes encoding proteins involved in adhesio..
The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium
Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell
Journal article | 2019 | Biochemical Journal
Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..
Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection
Rebecca Chisholm, Nikki Sonenberg, Jake Lacey, Malcolm McDonald, Manisha Pandey, Mark Davies, Steven Tong, Jodie McVernon, Nicholas Geard
Journal article | 2019
Abstract Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in Ind..
Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics
Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastian Duchene, Pierre R Smeesters, Hannah R Frost, David J Price, Matthew TG Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, et al.
Journal article | 2019 | Nature Genetics
An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model.
Tania Rivera-Hernandez, Diane G Carnathan, Scott Jones, Amanda J Cork, Mark R Davies, Peter M Moyle, Istvan Toth, Michael R Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J Walker
Journal article | 2019 | mBio
Group A Streptococcus (GAS) infections account for an estimated 500,000 deaths every year. This bacterial pathogen is responsible ..
A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?
Joshua Osowicki, Kristy Azzopardi, Liam McIntyre, Tania Rivera-Hernandez, Cheryl-Iynn Y Ong, Ciara Baker, Christine M Gillen, E Mark J Walker, Pierre R Smeesters, Mark R Davies, Andrew C Steer
Journal article | 2019 | mSphere
Characterization of Staphylococcal Cassette Chromosome mec Elements from Methicillin-Resistant Staphylococcus pseudintermedius Infections in Australian Animals
Kate A Worthing, Sybille Schwendener, Vincent Perreten, Sugiyono Saputra, Geoffrey W Coombs, Stanley Pang, Mark R Davies, Sam Abraham, Darren J Trott, Jacqueline M Norris
Journal article | 2018 | mSphere
Chemical Synergy between lonophore PBT2 and Zinc Reverses Antibiotic Resistance
Lisa Bohlmann, David MP De Oliveira, Ibrahim M El-Deeb, Erin B Brazel, Nichaela Harbison-Price, Cheryl-Iynn Y Ong, Tania Rivera-Hernandez, Scott A Ferguson, Amanda J Cork, Phan Minh-Duy, Amelia T Soderholm, Mark R Davies, Graeme R Nimmo, Gordon Dougan, Mark A Schembri, Gregory M Cook, Alastair G McEwan, Mark von Itzstein, Christopher A McDevitt, Mark J Walker
Journal article | 2018 | mBio
FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants
Rhys Grinter, Iain D Hay, Jiangning Song, Jiawei Wang, Don Teng, Vijay Dhanesakaran, Jonathan J Wilksch, Mark R Davies, Dene Littler, Simone A Beckham, Ian R Henderson, Richard A Strugnell, Gordon Dougan, Trevor Lithgow
Journal article | 2018 | PLOS Biology
Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium
Asma Ul Husna, Nancy Wang, Simon A Cobbold, Hayley J Newton, Dianna M Hocking, Jonathan J Wilksch, Timothy A Scott, Mark R Davies, Jay C Hinton, Jai J Tree, Trevor Lithgow, Malcolm J McConville, Richard A Strugnell
Journal article | 2018 | Journal of Biological Chemistry
Complete Genome Sequence of a Streptococcus pyogenes Serotype M12 Scarlet Fever Outbreak Isolate from China, Compiled Using Oxford Nanopore and Illumina Sequencing
Yuanhai You, Yongjun Kou, Longfei Niu, Qiong Jia, Yahui Liu, Mark R Davies, Mark J Walker, Jiaqiang Zhu, Jianzhong Zhang
Journal article | 2018 | Genome Announcements
Identification and Characterization of Fluoroquinolone Non-susceptible Streptococcus pyogenes Clones Harboring Tetracycline and Macrolide Resistance in Shanghai, China
Yinfang Shen, Jiehao Cai, Mark R Davies, Chi Zhang, Kun Gao, Dan Qiao, Haoqin Jiang, Weilei Yao, Yuefang Li, Mei Zeng, Mingliang Chen
Journal article | 2018 | Frontiers in Microbiology
Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition
Erica Kintz, Christian Heiss, Ian Black, Nicholas Donohue, Naj Brown, Mark R Davies, Parastoo Azadi, Stephen Baker, Paul M Kaye, Marjan van der Woude
Journal article | 2017 | Infection and Immunity
Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development
Deborah A Williamson, Pierre R Smeesters, Andrew C Steer, Julie Morgan, Mark Davies, Philip Carter, Arlo Upton, Stephen YC Tong, John Fraser, Nicole J Moreland
Journal article | 2016 | BMC Infectious Diseases
Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
John A Lees, Minna Vehkala, Niko Valimaki, Simon R Harris, Claire Chewapreecha, Nicholas J Croucher, Pekka Marttinen, Mark R Davies, Andrew C Steer, Steven YC Tong, Antti Honkela, Julian Parkhill, Stephen D Bentley, Jukka Corander
Journal article | 2016 | Nature Communications
Invasive Group A Streptococcus Infection among Children, Rural Kenya
Anna C Seale, Mark R Davies, Kirimi Anampiu, Susan C Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N Williams, J Anthony G Scott, Samuel Kariuki, Gordon Dougan, James A Berkley
Journal article | 2016 | Emerging Infectious Diseases
Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae
Deepak S Ipe, Nouri L Ben Zakour, Matthew J Sullivan, Scott A Beatson, Kimberly B Ulett, William H Benjamin, Mark R Davies, Samantha J Dando, Nathan P King, Allan W Cripps, Mark A Schembri, Gordon Dougan, Glen C Ulett
Journal article | 2016 | Infection and Immunity
Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone
Nouri L Ben Zakour, Mark R Davies, Yuanhai You, Jonathan HK Chen, Brian M Forde, Mitchell Stanton-Cook, Ruifu Yang, Yujun Cui, Timothy C Barnett, Carola Venturini, Cheryl-Iynn Y Ong, Herman Tse, Gordon Dougan, Jianzhong Zhang, Kwok-Yung Yuen, Scott A Beatson, Mark J Walker
Journal article | 2015 | Scientific Reports
Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance
Mark R Davies, Matthew T Holden, Paul Coupland, Jonathan HK Chen, Carola Venturini, Timothy C Barnett, Nouri L Ben Zakour, Herman Tse, Gordon Dougan, Kwok-Yung Yuen, Mark J Walker
Journal article | 2015 | Nature Genetics
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Violette Da Cunha, Mark R Davies, Pierre-Emmanuel Douarre, Isabelle Rosinski-Chupin, Immaculada Margarit, Sebastien Spinali, Tim Perkins, Pierre Lechat, Nicolas Dmytruk, Elisabeth Sauvage, Laurence Ma, Benedetta Romi, Magali Tichit, Maria-Jose Lopez-Sanchez, Stephane Descorps-Declere, Erika Souche, Carmen Buchrieser, Patrick Trieu-Cuot, Ivan Moszer, Dominique Clermont, et al.
Journal article | 2014 | Nature Communications
The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design
Nina M van Sorge, Jason N Cole, Kirsten Kuipers, Anna Henningham, Ramy K Aziz, Ana Kasirer-Friede, Leo Lin, Evelien TM Berends, Mark R Davies, Gordon Dougan, Fan Zhang, Samira Dahesh, Laura Shaw, Jennifer Gin, Madeleine Cunningham, Joseph A Merriman, Julia Huetter, Bernd Lepenies, Suzan HM Rooijakkers, Richard Malley, et al.
Journal article | 2014 | Cell Host & Microbe
Global dissemination of a multidrug resistant Escherichia coli clone
Nicola K Petty, Nouri L Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M Forde, Phan Minh-Duy, Danilo Gomes Moriel, Kate M Peters, Mark Davies, Benjamin A Rogers, Gordon Dougan, Jesus Rodriguez-Bano, Alvaro Pascual, Johann DD Pitout, Mathew Upton, David L Paterson, Timothy R Walsh, Mark A Schembri, Scott A Beatson
Journal article | 2014 | Proceedings of the National Academy of Sciences
Genetics and virulence role of the classical group A Streptococcus Lancefield antigen
Jason Cole, Nina van Sorge, Kirsten Kuipers, Anna Henningham, Ramy Aziz, Ana Kasirer-Friede, Leo Lin, Evelien Berends, Mark Davies, Gordan Dougan, Fan Zhang, Samira Dahesh, Laura Shaw, Jennifer Gin, Madeleine Cunningham, Joseph Merriman, Suzan Rooijakkers, Richard Malley, Mark Walker, Sanford Shattil, et al.
Conference Proceedings | 2014 | FASEB JOURNAL
The Globally Disseminated M1T1 Clone of Group A Streptococcus Evades Autophagy for Intracellular Replication
Timothy C Barnett, David Liebl, Lisa M Seymour, Christine M Gillen, Jin Yan Lim, Christopher N LaRock, Mark R Davies, Benjamin L Schulz, Victor Nizet, Rohan D Teasdale, Mark J Walker
Journal article | 2013 | Cell Host & Microbe
ChIP-seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization
Timothy T Perkins, Mark R Davies, Elizabeth J Klemm, Gary Rowley, Thomas Wileman, Keith James, Thomas Keane, Duncan Maskell, Jay CD Hinton, Gordon Dougan, Robert A Kingsley
Journal article | 2013 | Molecular Microbiology
Molecular Characterization of the 2011 Hong Kong Scarlet Fever Outbreak
Herman Tse, Jessie YJ Bao, Mark R Davies, Peter Maamary, Hoi-Wah Tsoi, Amy HY Tong, Tom CC Ho, Chi-Ho Lin, Christine M Gillen, Timothy C Barnett, Jonathan HK Chen, Mianne Lee, Wing-Cheong Yam, Chi-Kin Wong, Cheryl-lynn Y Ong, Yee-Wai Chan, Cheng-Wei Wu, Tony Ng, Wilina WL Lim, Thomas HF Tsang, et al.
Journal article | 2012 | Journal of Infectious Diseases
Identification of active variants of PARF in human pathogenic group C and group G streptococci leads to an amended description of its consensus motif
Vanessa Barroso, Manfred Rohde, Mark R Davies, Christine M Gillen, D Patric Nitsche-Schmitz, Katrin Dinkla, Gursharan S Chhatwal
Journal article | 2009 | International Journal of Medical Microbiology
Virulence profiling of Streptococcus dysgalactiae subspecies equisimilis isolated from infected humans reveals 2 distinct genetic lineages that do not segregate with their phenotypes or propensity to cause diseases
Mark R Davies, David J McMillan, Robert G Beiko, Vanessa Barroso, Robert Geffers, Kadaba S Sriprakash, Gursharan S Chhatwal
Journal article | 2007 | Clinical Infectious Diseases
Restricted sequence variation in Streptococcus pyogenes penicillin binding proteins
Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong
AbstractA recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutations in the Penicillin B..
Honours, Awards and Fellowships
Deans Commendation for outstanding thesis
NHMRC Dora Lush PhD Scholarship
CJMARTIN - C.J. Martin Research Fellowship (National Health & Medical Research Council, Australia)
Senior Research Fellow (Bioinformatics)
Microbiology And Immunology
Society For General Microbiology
Society for General Microbiology
American Society For Microbiology
American Society for Microbiology
Doctor of Philosophy
The University of Queensland
Bachelor of Science (honours)
The University of Queensland
Bachelor of Applied Science (Medical and Applied Biotechnology)
Charles Sturt University