Sweta Iyer

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluck

Journal article  |  2020  |  Cell Death and Disease

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation

Colin Hockings, Sweta Iyer, Rachel T Uren, Ruth M Kluck

Journal article  |  2019  |  Cell Death & Differentiation

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams

Journal article  |  2019  |  Cell Reports

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.

Sweta Iyer, Rachel T Uren, Ruth M Kluck

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Mitochondrial permeabilization is a key event in the intrinsic pathway of apoptosis, and is mediated by either of the BCL-2 family..

Ensemble Properties of Bax Determine Its Function

Adeline Y Robin, Sweta Iyer, Richard W Birkinshaw, Jarrod Sandow, Ahmad Wardak, Cindy S Luo, Melissa Shi, Andrew Webb, Peter E Czabotar, Ruth M Kluck, Peter M Colman

Journal article  |  2018  |  Structure

Pore formation by dimeric Bak and Bax: an unusual pore?

Rachel T Uren, Sweta Iyer, Ruth M Kluck

Journal article  |  2017  |  Philosophical Transactions of the Royal Society B Biological Sciences

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E Alsop, Tahereh Noori, Mariam Lufti, Sweta Iyer, Kaylene J Simpson, Phillip I Bird, Ruth M Kluck, Ricky W Johnstone, Joseph A Trapani

Journal article  |  2017  |  Cell Death & Differentiation

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

Rachel T Uren, Martin O'Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluck

Journal article  |  2017  |  eLife

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Sweta Iyer, Khatira Anwari, Amber E Alsop, Wai Shan Yuen, David CS Huang, John Carroll, Nicholas A Smith, Brian J Smith, Grant Dewson, Ruth M Kluck

Journal article  |  2016  |  NATURE COMMUNICATIONS

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

S Iyer, F Bell, D Westphal, K Anwari, J Gulbis, BJ Smith, G Dewson, RM Kluck

Journal article  |  2015  |  Cell Death & Differentiation