Maciej Daniszewski

Automation of Organoid Cultures: Current Protocols and Applications

Alexandra Louey, Damian Hernandez, Alice Pebay, Maciej Daniszewski

Journal article  |  2021  |  SLAS DISCOVERY

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Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I)

Damian Hernandez, Stephanie Morgan Schlicht, Maciej Daniszewski, Celeste M Karch, Alison M Goate, Alice Pebay

Journal article  |  2021  |  STEM CELL RESEARCH

We report the genome-editing of an existing iPSC line carrying the London mutation in APP (V717I) into an iPSC line in which the p..

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images

Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter WM Bonnemaijer, Anne Senabouth, Alex W Hewitt, Denize Atan, Tin Aung, Jason Charng, Helene Choquet, Jamie Craig, Peng T Khaw, Caroline CW Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, et al.

Journal article  |  2021  |  PLOS GENETICS

Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseas..

Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease

Damian Hernandez, Louise A Rooney, Maciej Daniszewski, Lerna Gulluyan, Helena H Liang, Anthony L Cook, Alex W Hewitt, Alice Pebay

Journal article  |  2021  |  STEM CELL REVIEWS AND REPORTS

Apolipoprotein E (APOE) is the most important susceptibility gene for late onset of Alzheimer's disease (AD), with the presence of..

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

Drew Neavin, Quan Nguyen, Maciej S Daniszewski, Helena H Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W Lukowski, Duncan E Crombie, Grace E Lidgerwood, Damian Hernandez, James C Vickers, Anthony L Cook, Nathan J Palpant, Alice Pebay, Alex W Hewitt, Joseph E Powell

Journal article  |  2021  |  GENOME BIOLOGY

BACKGROUND: The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundati..

Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing

Anne Senabouth, Stacey Andersen, Qianyu Shi, Lei Shi, Feng Jiang, Wenwei Zhang, Kristof Wing, Maciej Daniszewski, Samuel W Lukowski, Sandy SC Hung, Quan Nguyen, Lynn Fink, Anthony Beckhouse, Alice Pebay, Alex W Hewitt, Joseph E Powell

Journal article  |  2020  |  NAR GENOMICS AND BIOINFORMATICS

The libraries generated by high-throughput single cell RNA-sequencing (scRNA-seq) platforms such as the Chromium from 10× Genomics..

An overview of human pluripotent stem cell applications for the understanding and treatment of blindness

Louise Rooney, Duncan Crombie, Grace Lidgerwood, Maciej Daniszewski, Alice Pebay

Book Chapter  |  2019

Human pluripotent stem cells (hPSCs) hold great promise for human therapies including for treatment of eye-related disease. Given ..

Using induced pluripotent stem cells to model primary open-angle glaucoma

Maciej Stanislaw Daniszewski

Thesis / Dissertation  |  2019

Glaucoma is a group of optic neuropathies that may be characterized by gradual degeneration of retinal ganglion cells (RGCs) and t..

Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

Maciej Daniszewski, Nguyen Quan, Hun S Chy, Vikrant Singh, Duncan E Crombie, Tejal Kulkarni, Helena H Liang, Priyadharshini Sivakumaran, Grace E Lidgerwood, Damien Hernandez, Alison Conquest, Louise A Rooney, Sophie Chevalier, Stacey B Andersen, Anne Senabouth, James C Vickers, David A Mackey, Jamie E Craig, Andrew L Laslett, Alex W Hewitt, et al.

Journal article  |  2018  |  ISCIENCE

We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex an..

Automated Cell Culture Systems and Their Applications to Human Pluripotent Stem Cell Studies

Maciej Daniszewski, Duncan E Crombie, Rachael Henderson, Helena H Liang, Raymond CB Wong, Alex W Hewitt, Alice Pebay

Journal article  |  2018  |  SLAS TECHNOLOGY

Pluripotent stem cells are an extremely powerful tool in modeling human diseases and hold much promise for personalized regenerati..