Susan Christo

Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay

Journal article  |  2020  |  Journal of Investigative Dermatology

Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  Science Immunology

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

Local heroes or villains: tissue-resident memory T cells in human health and disease

SC Sasson, CL Gordon, SN Christo, P Klenerman, LK Mackay

Journal article  |  2020  |  Cellular & Molecular Immunology

Tissue-resident memory T (TRM) cells are increasingly associated with the outcomes of health and disease. TRM cells can mediate lo..

Tissue-resident memory T cells mediate melanoma surveillance and are targets of immunotherapy

Simone L Park, Anthony Buzzai, Jyh Liang Hor, Maike Effern, Susan N Christo, Scott N Mueller, Michael Holzel, Jason Waithman, Laura K Mackay, Thomas Gebhardt

Conference Proceedings  |  2019  |  JOURNAL OF IMMUNOLOGY

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  Nature Immunology

Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation

Ali Zaid, Jyh Liang Hor, Susan N Christo, Joanna R Groom, William R Heath, Laura K Mackay, Scott N Mueller

Journal article  |  2017  |  The Journal of Immunology

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade.

Tessa Gargett, Wenbo Yu, Gianpietro Dotti, Eric S Yvon, Susan N Christo, John D Hayball, Ian D Lewis, Malcolm K Brenner, Michael P Brown

Journal article  |  2016  |  Molecular Therapy

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematologic malignancies but more variable re..

The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry.

Susan Christo, Akash Bachhuka, Kerrilyn R Diener, Krasimir Vasilev, John D Hayball

Journal article  |  2016  |  Scientific Reports

Implantable devices have become an established part of medical practice. However, often a negative inflammatory host response can ..

The Role of Surface Nanotopography and Chemistry on Primary Neutrophil and Macrophage Cellular Responses.

Susan N Christo, Akash Bachhuka, Kerrilyn R Diener, Agnieszka Mierczynska, John D Hayball, Krasimir Vasilev

Journal article  |  2016  |  Advanced Healthcare Materials

Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune..

Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses.

Susan N Christo, Kerrilyn R Diener, Jim Manavis, Michele A Grimbaldeston, Akash Bachhuka, Krasimir Vasilev, John D Hayball

Journal article  |  2016  |  Scientific Reports

Detailing the inflammatory mechanisms of biomaterial-implant induced foreign body responses (FBR) has implications for revealing t..