Susan Christo

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay

Journal article  |  2020  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

T cell-intrinsic expression of HIC1 links retinoic acid to tissue residency

Michael Bramhall, Grace Rodrigues, Susan Christo, Laura Mackay, Colby Zaph

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Organ-specific isoform selection of fatty acid binding proteins in tissue-resident lymphocytes

Raissa Fonseca, Hannah Frizzell, Susan Christo, Maximilien Evrard, Simone L Park, David Freestone, Laura K Mackay

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

Local heroes or villains: tissue-resident memory T cells in human health and disease

SC Sasson, CL Gordon, SN Christo, P Klenerman, LK Mackay

Journal article  |  2020  |  CELLULAR & MOLECULAR IMMUNOLOGY

Tissue-resident memory T (TRM) cells are increasingly associated with the outcomes of health and disease. TRM cells can mediate lo..

Tissue-resident memory T cells mediate melanoma surveillance and are targets of immunotherapy

Simone L Park, Anthony Buzzai, Jyh Liang Hor, Maike Effern, Susan N Christo, Scott N Mueller, Michael Holzel, Jason Waithman, Laura K Mackay, Thomas Gebhardt

Conference Proceedings  |  2019  |  JOURNAL OF IMMUNOLOGY

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  NATURE IMMUNOLOGY

Although tissue-resident memory T cells (TRM cells) are critical in fighting infection, their fate after local pathogen re-encount..

Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation

Ali Zaid, Jyh Liang Hor, Susan N Christo, Joanna R Groom, William R Heath, Laura K Mackay, Scott N Mueller

Journal article  |  2017  |  JOURNAL OF IMMUNOLOGY

Infection or inflammation of the skin recruits effector CD8+ T cells that enter the epidermis and form populations of long-lived t..

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade.

Tessa Gargett, Wenbo Yu, Gianpietro Dotti, Eric S Yvon, Susan N Christo, John D Hayball, Ian D Lewis, Malcolm K Brenner, Michael P Brown

Journal article  |  2016  |  Mol Ther

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematologic malignancies but more variable re..