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Direkt: Disarming The Intravascular Innate Immune Response To Improve Modalities For Chron..
Real pain in the neck: giant cell arteritis presenting with non-necrotising fasciitis and ..
Direkt: Disarming The Intravascular Innate Immune Response To Improve Modalities For Chron..
THE IDENTIFICATION OF POTENTIAL BIOMARKERS OF CHRONIC KIDNEY DISEASE IN INDIVIDUALS WITH D..
Displaying the 7 most recent projects by Karen Dwyer.
Displaying the 82 most recent scholarly works by Karen Dwyer.
Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study.
Erik Berglund, Mette Andersen Ljungdahl, Darko Bogdanović, David Berglund, Jonas Wadström, Jan Kowalski, Gerald Brandacher, Dorota Kamińska, Christina L Kaufman, Simon G Talbot, Kodi Azari, Luis Landin, Christoph Höhnke, Karen M Dwyer, Pedro C Cavadas, Alessandro Thione, Brendan Clarke, Simon Kay, Dan Wilks, Subramania Iyer, et al.
Journal article | 2019 | Transplantation
BACKGROUND: Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplanta..
High glucose levels affect retinal patterning during zebrafish embryogenesis.
Amitoj Singh, Hozana Andrade Castillo, Julie Brown, Jan Kaslin, Karen M Dwyer, Yann Gibert
Journal article | 2019 | Scientific Reports
Maternal hyperglycaemia has a profound impact on the developing foetus and increases the risk of developing abnormalities like obe..
In vivo endogenous proteolysis yielding beta-casein derived bioactive beta-casomorphin peptides in human breast milk for infant nutrition.
Ashwantha Kumar Enjapoori, Sonja Kukuljan, Karen M Dwyer, Julie A Sharp
Journal article | 2019 | Nutrition
Objective Beta-casein is a major protein in breast milk and an important source for several bioactive peptides that are encrypted ..
The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration.
Amitoj Singh, Yann Gibert, Karen M Dwyer
Journal article | 2018 | Pancreatology
Insulin, a key hormone produced by pancreatic beta cells precisely regulates glucose metabolism in vertebrates. In type 1 diabetes..
CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages
Anushka N Samudra, Karen M Dwyer, Carly Selan, Susanna Freddi, Lisa Murray-Segal, Mandana Nikpour, Michael J Hickey, Karlheinz Peter, Simon C Robson, Maithili Sashindranath, Peter J Cowan, Harshal H Nandurkar
Journal article | 2018 | Journal of Autoimmunity
Gender Equity in Transplantation: A Report from the Women in Transplantation Workshop of The Transplantation Society of Australia and New Zealand.
Karen M Dwyer, Carolyn J Clark, Kelli MacDonald, Miranda A Paraskeva, Natasha Rogers, Jessica Ryan, Angela C Webster, Germaine Wong
Journal article | 2017 | Transplantation
The exponential growth of young talented women choosing science and medicine as their professional career over the past decade is ..
Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein.
Simon Brooke-Taylor, Karen Dwyer, Keith Woodford, Natalya Kost
Journal article | 2017 | Advances in Nutrition: An International Review Journal
This is the first systematic review, to our knowledge, of published studies investigating the gastrointestinal effects of A1-type ..
Overexpression of Human CD55 and CD59 or Treatment with Human CD55 Protects against Renal Ischemia-Reperfusion Injury in Mice
Anjan K Bongoni, Bo Lu, Evelyn J Salvaris, Veena Roberts, Doreen Fang, Jennifer L Mcrae, Nella Fisicaro, Karen M Dwyer, Peter J Cowan
Journal article | 2017 | The Journal of Immunology
Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury
Maithili Sashindranath, Karen M Dwyer, Shala Dezfouli, Carly Selan, Sandra Crikis, Bo Lu, Yuping Yuan, Michael J Hickey, Karlheinz Peter, Simon C Robson, Peter J Cowan, Harshal H Nandurkar
Journal article | 2017 | Purinergic Signalling
A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia After Renal Transplantation
David Langsford, Varuni Obeyesekere, Sara Vogrin, Jessie Teng, Richard J MacIsaac, Glenn Ward, Frank Alford, Karen M Dwyer
Journal article | 2016 | Transplantation Direct
Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice
Roman Covarrubias, Elena Chepurko, Adam Reynolds, Zachary M Huttinger, Ryan Huttinger, Katherine Stanfill, Debra G Wheeler, Tatiana Novitskaya, Simon C Robson, Karen M Dwyer, Peter J Cowan, Richard J Gumina
Journal article | 2016 | Arteriosclerosis, Thrombosis, and Vascular Biology
A prospective study of renal transplant recipients: the interrelationship between insulin secretion and sensitivity underpins dysglycemia post following renal transplantation
Karen M Dwyer, David Langsford, Varuni Obeyesekere, Jessie Teng, Sara Vogrin, Richard MacIsaac, Glenn Ward, Frank Alford
Conference Proceedings | 2016 | TRANSPLANTATION
Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1)
Yue Zhang, Simon C Robson, Kaiya L Morris, Kristina M Heiney, Karen M Dwyer, Bellamkonda K Kishore, Carolyn M Ecelbarger
Journal article | 2015 | American Journal of Physiology-Renal Physiology
Differential Migration of Passenger Leukocytes and Rapid Deletion of Naive Alloreactive CD8 T Cells After Mouse Liver Transplantation
Szun S Tay, Bo Lu, Fred Sierro, Volker Benseler, Claire M McGuffog, G Alex Bishop, Peter J Cowan, Geoffrey W McCaughan, Karen M Dwyer, David G Bowen, Patrick Bertolino
Journal article | 2013 | Liver Transplantation
Blockade of A(2A) receptors potently suppresses the metastasis of CD73( ) tumors
Paul A Beavis, Upulie Divisekera, Christophe Paget, Melvyn T Chow, Liza B John, Christel Devaud, Karen Dwyer, John Stagg, Mark J Smyth, Phillip K Darcy
Journal article | 2013 | Proceedings of the National Academy of Sciences of the United States of America
AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1
Scott A Fraser, Suet-Wan Choy, Nuria M Pastor-Soler, Hui Li, Matthew RP Davies, Natasha Cook, Marina Katerelos, Peter F Mount, Kurt Gleich, Jennifer L McRae, Karen M Dwyer, Bryce JW van Denderen, Kenneth R Hallows, Bruce E Kemp, David A Power
Journal article | 2013 | American Journal of Physiology: Renal Physiology
First hand transplant procedure in Australia: outcome at 2 years
Karen M Dwyer, Angela R Webb, Hayley S Furniss, Katie E Anjou, Josephine M Gibbs-Dwyer, David B McCombe, Damien G Grinsell, Gillian F Dickinson, Richard A Williams, Prudence A Russell, David A Scott, Christopher Baker, Simon J Vogrin, Robyn G Langham, Helen I Opdam, Wayne A Morrison
Journal article | 2013 | Medical Journal of Australia
The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice
Joanne SJ Chia, Jennifer L McRae, Helen E Thomas, Stacey Fynch, Lorraine Elkerbout, Prue Hill, Lisa Murray-Segal, Simon C Robson, Jiang-Fan Chen, Anthony JF d'Apice, Peter J Cowan, Karen M Dwyer
Journal article | 2013 | Diabetes
Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4( ) T cells
Sandra Pommey, Bo Lu, Jennifer McRae, John Stagg, Prue Hill, Evelyn Salvaris, Simon C Robson, Anthony JF d'Apice, Peter J Cowan, Karen M Dwyer
Journal article | 2013 | Hepatology
Regulatory T cells participate in CD39-mediated protection from renal injury
Yuan Min Wang, Jennifer L McRae, Simon C Robson, Peter J Cowan, Geoff Yu Zhang, Min Hu, Tania Polhill, Yiping Wang, Guoping Zheng, Ya Wang, Vincent WS Lee, Robert J Unwin, David CH Harris, Karen M Dwyer, Stephen I Alexander
Journal article | 2012 | European Journal of Immunology
Cardiac-Specific Ectonucleoside Triphosphate Diphosphohydrolase 1 Overexpression Affords Protection from Myocardial Infarction and Reperfusion Injury
Zhaobin Xu, Debra G Wheeler, Shouvik D Mahamud, Karen M Dwyer, Simon C Robson, Peter J Cowan, Anthony J d'Apice, Richard J Gumina
Conference Proceedings | 2012 | CIRCULATION RESEARCH
Ectonucleotide Triphosphate Diphosphohydrolase-1 (CD39) Mediates Resistance to Occlusive Arterial Thrombus Formation after Vascular Injury in Mice
Zachary M Huttinger, Michael W Milks, Michael S Nickoli, William L Aurand, Lawrence C Long, Debra G Wheeler, Karen M Dwyer, Anthony JF d'Apice, Simon C Robson, Peter J Cowan, Richard J Gumina
Journal article | 2012 | American Journal of Pathology
Transgenic swine: Expression of human CD39 protects against myocardial injury
Debra G Wheeler, Matthew E Joseph, Shouvik D Mahamud, William L Aurand, Peter J Mohler, Vincent J Pompili, Karen M Dwyer, Mark B Nottle, Sharon J Harrison, Anthony JF d'Apice, Simon C Robson, Peter J Cowan, Richard J Gumina
Journal article | 2012 | Journal of Molecular and Cellular Cardiology
The Outcome of Renal Ischemia-Reperfusion Injury Is Unchanged in AMPK-beta 1 Deficient Mice
Peter F Mount, Kurt Gleich, Shanna Tam, Scott A Fraser, Suet-Wan Choy, Karen M Dwyer, Bo Lu, Bryce Van denderen, Guenter Fingerle-Rowson, Richard Bucala, Bruce E Kemp, David A Power
Journal article | 2012 | PLoS One
Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury
Ming Cai, Zachary M Huttinger, Heng He, Weizhi Zhang, Feng Li, Lauren A Goodman, Debra G Wheeler, Lawrence J Druhan, Jay L Zweier, Karen M Dwyer, Guanglong He, Anthony JF d'Apice, Simon C Robson, Peter J Cowan, Richard J Gumina
Journal article | 2011 | Journal of Molecular and Cellular Cardiology
Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer
Beat M Kuenzli, Maria-Isabell Bernlochner, Stephan Rath, Samuel Kaeser, Eva Csizmadia, Keiichi Enjyoji, Peter Cowan, Anthony d'Apice, Karen Dwyer, Robert Rosenberg, Aurel Perren, Helmut Friess, Christoph A Maurer, Simon C Robson
Journal article | 2011 | Purinergic Signalling
Antioxidant network expression abrogates oxidative posttranslational modifications in mice
R Mital, W Zhang, M Cai, ZM Huttinger, LA Goodman, DG Wheeler, MT Ziolo, KM Dwyer, AJF d'Apice, JL Zweier, G He, PJ Cowan, RJ Gumina
Journal article | 2011 | American Journal of Physiology - Heart and Circulatory Physiology
Expression of CD39 by Human Peripheral Blood CD4( )CD25( ) T Cells Denotes a Regulatory Memory Phenotype
KM Dwyer, D Hanidziar, P Putheti, PA Hill, S Pommey, JL McRae, A Winterhalter, G Doherty, S Deaglio, M Koulmanda, W Gao, SC Robson, TB Strom
Journal article | 2010 | American Journal of Transplantation
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
John Stagg, Upulie Divisekera, Nicole McLaughlin, Janelle Sharkey, Sandra Pommey, Delphine Denoyer, Karen M Dwyer, Mark J Smyth
Journal article | 2010 | Proceedings of the National Academy of Sciences of the United States of America
Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells.
M Sitkovsky, D Lukashev, S Deaglio, K Dwyer, SC Robson, A Ohta
Conference Proceedings | 2008 | British Journal of Pharmacology
The intensity and duration of host responses are determined by protective mechanisms that control tissue injury by dampening down ..
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
Silvia Deaglio, Karen M Dwyer, Wenda Gao, David Friedman, Anny Usheva, Anna Erat, Jiang-Fan Chen, Keiichii Enjyoji, Joel Linden, Mohamed Oukka, Vijay K Kuchroo, Terry B Strom, Simon C Robson
Journal article | 2007 | The Journal of Experimental Medicine
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define ..
RanBPM associates with CD39 and modulates ecto-nucleotidase activity.
Yan Wu, Xiaofeng Sun, Elzbieta Kaczmarek, Karen M Dwyer, Elisabetta Bianchi, Anny Usheva, Simon C Robson
Journal article | 2006 | Biochemical Journal
CD39/ecto-NTPDase 1 (nucleoside triphosphate diphosphohydrolase 1) is an ecto-nucleotidase that influences P2 receptor activation ..
Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets.
Ben Atkinson, Karen Dwyer, Keiichi Enjyoji, Simon C Robson
Journal article | 2006 | Blood Cells, Molecules, and Diseases
Extracellular nucleotide P2-receptor-mediated effects on platelets, leukocytes and endothelium are modulated by ecto-nucleotidases..
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation.
Simon C Robson, Yan Wu, Xiaofeng Sun, Christoph Knosalla, Karen Dwyer, Keiichi Enjyoji
Journal article | 2005 | Seminars in Thrombosis and Hemostasis
Transplantation results in exposure of the graft vasculature to warm and cold ischemia, followed by perfusion by circulating blood..
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy.
PA Hill, KM Dwyer, DA Power
Journal article | 2000 | Lupus
We report the case of a woman with systemic lupus erythematosus initially manifesting with fever, rash and arthritis, and two year..
Medicine - St Vincent'S Hospital