Ahmed Al Saedi

Differential Effects of Long-Term Caloric Restriction and Dietary Protein Source on Bone and Marrow Fat of the Aging Rat

Gustavo Duque, Ahmed Al Saedi, Daniel Rivas, Stephanie Miard, Guylaine Ferland, Frederic Picard, Pierrette Gaudreau

Journal article  |  2020  |  The Journals of Gerontology: Series A

Long-term caloric restriction (CR) has been shown to be beneficial to various tissues and organs. In contrast, CR exerts different..

1,25(OH)2D3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function.

Ahmed Al Saedi, Damian E Myers, Nicole Stupka, Gustavo Duque

Journal article  |  2020  |  Bone

Contributing to bone loss with aging is a progressive reduction in osteoblast number and function leading to decreased bone format..

Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo

Gustavo Duque, Christopher Vidal, Wei Li, Ahmed Al Saedi, Mamdouh Khalil, Chai K Lim, Damian E Myers, Gilles J Guillemin

Journal article  |  2020  |  Journal of Bone and Mineral Research

Fractures attributable to osteoporosis have a severe impact on our older population. Reports of side effects with commonly prescri..

Bioimaging of C2C12 Muscle Myoblasts Using Fluorescent Carbon Quantum Dots Synthesized from Bread

Karthiga K Anpalagan, Jimsheena Karakkat, Adam Truskewycz, Ahmed Al Saedi, Paul Joseph, Vasso Apostolopoulos, Kulmira Nurgali, Ivan Cole, Zibo Cai, Daniel TH Lai

Journal article  |  2020  |  Nanomaterials

Biocompatible carbon quantum dots (CQDs) have recently attracted increased interest in biomedical imaging owing to their advantage..

Age-Related Increases in Marrow Fat Volumes have Regional Impacts on Bone Cell Numbers and Structure

Ahmed Al Saedi, Lulu Chen, Steven Phu, Sara Vogrin, Dengshun Miao, Guylaine Ferland, Pierrette Gaudreau, Gustavo Duque

Journal article  |  2020  |  Calcified Tissue International

The increasing levels of bone marrow fat evident in aging and osteoporosis are associated with low bone mass and attributed to red..

Pathogenesis of Osteoporosis.

Ahmed Al Saedi, Nicole Stupka, Gustavo Duque

Journal article  |  2020  |  Handbook of experimental pharmacology

Osteoporosis is a condition where bone resorption exceeds bone formation leading to degeneration. With an aging population, the pr..

The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics

Walter Sepulveda-Loyola, Steven Phu, Ebrahim Bani Hassan, Sharon L Brennan-Olsen, Jesse Zanker, Sara Vogrin, Romy Conzade, Ben Kirk, Ahmed Al Saedi, Vanessa Probst, Gustavo Duque

Journal article  |  2020  |  Journal of the American Medical Directors Association

OBJECTIVES: We sought to examine the associations of osteosarcopenia with physical performance, balance, and falls and fractures i..

Rapamycin Affects Palmitate-Induced Lipotoxicity in Osteoblasts by Modulating Apoptosis and Autophagy

Ahmed Al Saedi, Craig A Goodman, Damian E Myers, Alan Hayes, Gustavo Duque

Journal article  |  2020  |  Journal of Gerontology Series A: Biological Sciences and Medical Sciences

Bone marrow fat infiltration is one of the hallmarks of aging and osteoporotic bones. Marrow adipocytes produce substantial amount..

The multiple faces of tryptophan in bone biology

Ahmed Al Saedi, Shilpa Sharma, Matthew A Summers, Kulmira Nurgali, Gustavo Duque

Journal article  |  2020  |  Experimental Gerontology

Osteoporosis is highly prevalent in older persons. While many advances have been made in the field of osteoporosis, current treatm..

Osteocalcin and its forms across the lifespan in adult men

Cassandra Smith, Sarah Voisin, Ahmed Al Saedi, Steven Phu, Tara Brennan-Speranza, Lewan Parker, Nir Eynon, Danielle Hiam, Xu Yan, David Scott, Lauren C Blekkenhorst, Joshua R Lewis, Ego Seeman, Elizabeth Byrnes, Leon Flicker, Gustavo Duque, Bu B Yeap, Itamar Levinger

Journal article  |  2020  |  Bone

PURPOSE: Osteocalcin (OC), an osteoblast-specific secreted protein expressed by mature osteoblasts, is used in clinical practice a..