Piers Blombery

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition.

Thomas E Lew, Victor S Lin, Edward Robert Scheffer Cliff, Piers Blombery, Ella R Thompson, Sasanka Mithila Handunnetti, David A Westerman, Bryone Jean Kuss, Constantine S Tam, David Ching Siang Huang, John F Seymour, Andrew W Roberts, Mary Ann Anderson

Journal article  |  2021  |  Blood Adv

Covalent Bruton tyrosine kinase inhibitors (BTKis) and the BCL2 inhibitor venetoclax have significantly improved outcomes for pati..

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.

Piers Blombery, Thomas E Lew, Michael A Dengler, Ella R Thompson, Victor S Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka Mithila Handunnetti, Dennis Carney, David A Westerman, Constantine S Tam, Jerry M Adams, Andrew H Wei, David Ching Siang Huang, John F Seymour, Andrew Roberts, Mary Ann Anderson

Journal article  |  2021  |  Blood

The BCL2 inhibitor venetoclax has established therapeutic roles in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia. ..

Proliferative Glomerulonephritis With Fibrils, Monoclonal kappa Light Chain, and C3 Deposits

Adam G Steinberg, Lucy C Fox, Sebastien Bender, Ahida Batrouney, Surender Juneja, Christophe Sirac, Guy Touchard, Piers Blombery, Moira J Finlay, Frank Bridoux, Thomas D Barbour

Journal article  |  2021  |  AMERICAN JOURNAL OF KIDNEY DISEASES

There is increasing recognition of monoclonal gammopathy as a cause of proliferative glomerulonephritis (GN), including cases in w..

Characterisation of immune checkpoints in Richter syndrome identifies LAG3 as a potential therapeutic target

Clare Gould, Jennifer Lickiss, Yamuna Kankanige, Satwica Yemeni, Stephen Lade, Maher K Gandhi, Collin Chin, Costas K Yannakou, Diego Villa, Graham W Slack, John F Markham, Constantine S Tam, Niles Nelson, John F Seymour, Michael Dickinson, Paul J Neeson, David Westerman, Piers Blombery

Journal article  |  2021  |  BRITISH JOURNAL OF HAEMATOLOGY

Richter syndrome (RS), an aggressive lymphoma occurring in the context of chronic lymphocytic leukaemia/small lymphocytic lymphoma..

Response to everolimus in a patient with refractory HGBL-NOS harboring multiple genomic aberrations in PTEN

Imogen Caldwell, David Byrne, Stephen Lade, Tim Akhurst, Adrian Minson, Michael Dickinson, Ella Thompson, Clare Scott, Piers Blombery

Journal article  |  2021  |  LEUKEMIA & LYMPHOMA

T-cell replete allogeneic stem cell transplant for mantle cell lymphoma achieves durable disease control, including against TP53-mutated disease

Thomas E Lew, Edward RS Cliff, Michael Dickinson, Constantine S Tam, John F Seymour, Piers Blombery, Ashish Bajel, David Ritchie, Amit Khot

Journal article  |  2021  |  BONE MARROW TRANSPLANTATION

Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions.

Abdulsalam I Isiaku, Zuobing Zhang, Vahid Pazhakh, Harriet R Manley, Ella R Thompson, Lucy C Fox, Satwica Yerneni, Piers Blombery, Graham J Lieschke

Journal article  |  2021  |  Dis Model Mech

Zebrafish are an important model for studying phagocyte function, but rigorous experimental systems to distinguish whether phagocy..

Cryptic molecular lesion in acute promyelocytic leukemia with negative initial FISH

Jasmine Singh, Adam Facey, Fran O'Malley, Georgina L Ryland, Piers Blombery, Gareth P Gregory

Journal article  |  2021  |  LEUKEMIA & LYMPHOMA

T cell receptor beta locus sequencing early post-allogeneic stem cell transplant identifies patients at risk of initial and recurrent cytomegalovirus infection

James A Kuzich, Yamuna Kankanige, Jerick Guinto, Georgina Ryland, Michelle McBean, Eric Wong, Rachel Koldej, Jenny Collins, David Westerman, David Ritchie, Piers Blombery

Journal article  |  2021  |  BONE MARROW TRANSPLANTATION

Identification of patients at risk of initial & recurrent cytomegalovirus (CMV) reactivation following allogeneic stem cell transp..

JAFFAL: Detecting fusion genes with long read transcriptome sequencing

Nadia Davidson, Ying Chen, Teresa Sadras, Georgina Ryland, Piers Blombery, Paul Ekert, Paul Ekert, Jonathan Göke, Alicia Oshlack

Journal article  |  2021

Massively parallel short read transcriptome sequencing has greatly expanded our knowledge of fusion genes which are drivers of tum..