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Developing G Protein-Coupled Receptor, Rxfp4, Agonists As Novel Therapeutics For Chronic C..
Signal transduction pathways activated by the orexigenic gut derived hormone insulin-like ..
Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-ba..
The relaxin receptor as a therapeutic target - perspectives from evolution Cheek for updat..
Displaying the most recent project by Martina Kocan.
Displaying the 43 most recent scholarly works by Martina Kocan.
Probing the correlation between ligand efficacy and conformational diversity at the ?(1A)-adrenoreceptor reveals allosteric coupling of its microswitches
Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael DW Griffin, Ross AD Bathgate, Daniel J Scott, Paul R Gooley
Journal article | 2020 | Journal of Biological Chemistry
G protein-coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an al..
AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis
Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel
Journal article | 2019 | Journal of the American Society of Nephrology
BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..
An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2 signaling and motility in Toxoplasma gondii
Luning Yang, Alessandro D Uboldi, Simona Seizova, Mary-Louise Wilde, Michael J Coffey, Nicholas J Katris, Yoshiki Yamaryo-Botte, Martina Kocan, Ross AD Bathgate, Rebecca J Stewart, Malcolm J McConville, Philip E Thompson, Cyrille Y Botte, Christopher J Tonkin
Journal article | 2019 | Journal of Biological Chemistry
BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via beta(2)-adrenoceptors without causing classical receptor desensitization
Saori Mukaida, Masaaki Sato, Anette Oberg, Nodi Dehvari, Jessica M Olsen, Martina Kocan, Michelle Louise Halls, Jon Merlin, Anna L Sandstrom, Robert Csikasz, Bronwyn Anne Evans, Roger James Summers, Ana Sabine Hutchinson, Tore Bengtsson
Journal article | 2019 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
The type 2 diabetes epidemic makes it important to find insulin-independent ways to improve glucose homeostasis. This study examin..
Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins
Dene R Littler, Sheng Y Ang, Danilo G Moriel, Martina Kocan, Oded Kleifeld, Matthew D Johnson, Mai T Tran, Adrienne W Paton, James C Paton, Roger J Summers, Mark A Schembri, Jamie Rossjohn, Travis Beddoe
Journal article | 2017 | Journal of Biological Chemistry
ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
Martina Kocan, Mohsin Sarwar, Sheng Y Ang, Jingbo Xiao, Juan J Marugan, Mohammed A Hossain, Chao Wang, Dana S Hutchinson, Chrishan S Samuel, Alexander I Agoulnik, Ross AD Bathgate, Roger J Summers
Journal article | 2017 | Scientific Reports
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor
Sheng Y Ang, Dana S Hutchinson, Nitin Patil, Bronwyn A Evans, Ross AD Bathgate, Michelle L Halls, Mohammed A Hossain, Roger J Summers, Martina Kocan
Journal article | 2017 | British Journal of Pharmacology
The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4
Sheng Y Ang, Dana S Hutchinson, Bronwyn A Evans, Mohammed A Hossain, Nitin Patil, Ross AD Bathgate, Martina Kocan, Roger J Summers
Journal article | 2017 | Naunyn-Schmiedeberg's Archives of Pharmacology
The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity
Nitin A Patil, Ross AD Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger Summers, Johannes Grosse, Richard A Hughes, John D Wade, Mohammed Akhter Hossain
Journal article | 2016 | AMINO ACIDS
The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate
Chao Wang, Barbara K Kemp-Harper, Martina Kocan, Sheng Yu Ang, Tim D Hewitson, Chrishan S Samuel
Journal article | 2016 | Frontiers in Pharmacology
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist
Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger J Summers, Johannes Grosse, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain
Journal article | 2016 | Journal of Medicinal Chemistry
Orthosteric, Allosteric and Biased Signalling at the Relaxin-3 Receptor RXFP3
Martina Kocan, Sheng Yu Ang, Roger J Summers
Journal article | 2016 | Neurochemical Research
Relaxin-3 is a neuropeptide that has roles in stress, memory and appetite regulation. The peptide acts on its cognate receptor RXF..
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel
Journal article | 2016 | Chemical Science
Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR(2) and TRPV4
Peishen Zhao, TinaMarie Lieu, Nicholas Barlow, Matthew Metcalf, Nicholas A Veldhuis, Dane D Jensen, Martina Kocan, Silvia Sostegni, Silke Haerteis, Vera Baraznenok, Ian Henderson, Erik Lindstrom, Raquel Guerrero-Alba, Eduardo E Valdez-Morales, Wolfgang Liedtke, Peter McIntyre, Stephen J Vanner, Christoph Korbmacher, Nigel W Bunnett
Journal article | 2014 | Journal of Biological Chemistry
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
Bryna S Man Chow, Martina Kocan, Sanja Bosnyak, Mohsin Sarwar, Belinda Wigg, Emma S Jones, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel
Journal article | 2014 | Kidney International
The Bile Acid Receptor TGR5 Does Not Interact with beta-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts
Dane D Jensen, Cody B Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel P Poole, Jane E Murphy, Farzad Alemi, Graeme S Cottrell, Christoph Korbmacher, Nevin A Lambert, Nigel W Bunnett, Carlos U Corvera
Journal article | 2013 | Journal of Biological Chemistry
beta 2-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail
Nodi Dehvari, Dana S Hutchinson, Julia Nevzorova, Olof S Dallner, Masaaki Sato, Martina Kocan, Jon Merlin, Bronwyn A Evans, Roger J Summers, Tore Bengtsson
Journal article | 2012 | British Journal of Pharmacology
BACKGROUND AND PURPOSE: β-Adrenoceptor stimulation induces glucose uptake in several insulin-sensitive tissues by poorly understoo..
Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1
Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade
Journal article | 2012 | Journal of Medicinal Chemistry
Application of G Protein-Coupled Receptor-Heteromer Identification Technology to Monitor beta-Arrestin Recruitment to G Protein-Coupled Receptor Heteromers
Heng B See, Ruth M Seeber, Martina Kocan, Karin A Eidne, Kevin DG Pfleger
Journal article | 2011 | ASSAY and Drug Development Technologies
Understanding the role of G protein-coupled receptor (GPCR; also known as a 7 transmembrane receptor) heteromerization in the phys..
Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins.
Martina Kocan, Matthew B Dalrymple, Ruth M Seeber, Brian J Feldman, Kevin DG Pfleger
Journal article | 2010 | Frontiers in Endocrinology
The bioluminescence resonance energy transfer (BRET) technique has become extremely valuable for the real-time monitoring of prote..
Agonist-Independent Interactions between beta-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis
Martina Kocan, Heng B See, Natalia G Sampaio, Karin A Eidne, Brian J Feldman, Kevin DG Pfleger
Journal article | 2009 | Molecular Endocrinology
Nephrogenic syndrome of inappropriate antidiuresis is a recently identified genetic disease first described in two unrelated male ..
Detection of GPCR/beta-Arrestin Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer Technology
Martina Kocan, Kevin DG Pfleger
Journal article | 2009 | Methods in molecular biology (Clifton, N.J.)
Bioluminescence resonance energy transfer (BRET) is a powerful and increasingly popular technique for studying protein-protein int..
Demonstration of Improvements to the Bioluminescence Resonance Energy Transfer (BRET) Technology for the Monitoring of G Protein-Coupled Receptors in Live Cells
Martina Kocan, Heng B See, Ruth M Seeber, Karin A Eidne, Kevin DG Pfleger
Journal article | 2008 | Journal of Biomolecular Screening
The bioluminescence resonance energy transfer (BRET) technique has become extremely popular for studying protein-protein interacti..
Two-component systems of Corynebacterium glutamicum: Deletion analysis and involvement of the PhoS-PhoR system in the phosphate starvation response
M Kocan, S Schaffer, T Ishige, U Sorger-Herrmann, VF Wendisch, M Bott
Journal article | 2006 | Journal of Bacteriology
Corynebacterium glutamicum contains genes for 13 two-component signal transduction systems. In order to test for their essentialit..
Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1
Fabian Bumbak, Trayder Thomas, Billy J Noonan-Williams, Tasneem M Vaid, Fei Yan, Alice R Whitehead, Shoni Bruell, Martina Kocan, Xuan Tan, Margaret A Johnson, Ross AD Bathgate, David K Chalmers, Paul R Gooley, Daniel J Scott
Journal article | ACS Pharmacology & Translational Science
Research Fellow In Biosciences
Florey Department Of Neuroscience And Mental Health
Doctor of Philosophy
Heinrich Heine Universitat Dusseldorf
Masters of Science
Slovak University of Technology in Bratislava
Bachelor of Science
Slovak University of Technology in Bratislava