Martina Kocan

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Adam L Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J Scott, Ross AD Bathgate

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclic guanosine monophosphate (cGMP) is a second messenger involved in the regulation of numerous physiological processes. The mo..

A Novel Antagonist Peptide Reveals a Physiological Role of Insulin-Like Peptide 5 in Control of Colorectal Function

Ruslan Pustovit, Xiaozhou Zhang, Jamie JM Liew, Praveen Praveen, Mengjie Liu, Ada Koo, Lalita Oparija-Rogenmozere, Qinghao Ou, Martina Kocan, Shuai Nie, Ross AD Bathgate, John B Furness, Mohammed Akhter Hossain

Journal article  |  2021  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Insulin-like peptide 5 (INSL5), the natural ligand for the relaxin family peptide receptor 4 (RXFP4), is a gut hormone that is exc..

GPR55 regulates the responsiveness to, but does not dimerise with, alpha(1A)-adrenoceptors

Sarah K Walsh, Christopher Lipina, Sheng Y Ang, Masaaki Sato, Ling Yeong Chia, Martina Kocan, Dana S Hutchinson, Roger J Summers, Cherry L Wainwright

Journal article  |  2021  |  BIOCHEMICAL PHARMACOLOGY

Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiova..

Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1

Fabian Bumbak, Trayder Thomas, Billy J Noonan-Williams, Tasneem M Vaid, Fei Yan, Alice R Whitehead, Shoni Bruell, Martina Kocan, Xuan Tan, Margaret A Johnson, Ross AD Bathgate, David K Chalmers, Paul R Gooley, Daniel J Scott

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Cell-cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and m..

Probing the correlation between ligand efficacy and conformational diversity at the ?(1A)-adrenoreceptor reveals allosteric coupling of its microswitches

Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael DW Griffin, Ross AD Bathgate, Daniel J Scott, Paul R Gooley

Journal article  |  2020  |  Journal of Biological Chemistry

G protein–coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an al..

α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism

Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael DW Griffin, Ross AD Bathgate, Daniel J Scott, Paul R Gooley

Journal article  |  2019

AbstractG-Protein Coupled Receptors (GPCRs) transmit signals across the cell membrane via an allosteric network from the ligand-bi..

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2019  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..

Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis

Bradley L Hoare, Martina Kocan, Shoni Bruell, Daniel J Scott, Ross AD Bathgate

Journal article  |  2019  |  PHARMACOLOGY RESEARCH & PERSPECTIVES

Relaxin family peptide 1 (RXFP1) is the receptor for relaxin a peptide hormone with important therapeutic potential. Like many G p..

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2 signaling and motility in Toxoplasma gondii

Luning Yang, Alessandro D Uboldi, Simona Seizova, Mary-Louise Wilde, Michael J Coffey, Nicholas J Katris, Yoshiki Yamaryo-Botte, Martina Kocan, Ross AD Bathgate, Rebecca J Stewart, Malcolm J McConville, Philip E Thompson, Cyrille Y Botte, Christopher J Tonkin

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Protozoan parasites of the phylum Apicomplexa actively move through tissue to initiate and perpetuate infection. The regulation of..

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via beta(2)-adrenoceptors without causing classical receptor desensitization

Saori Mukaida, Masaaki Sato, Anette Oberg, Nodi Dehvari, Jessica M Olsen, Martina Kocan, Michelle Louise Halls, Jon Merlin, Anna L Sandstrom, Robert Csikasz, Bronwyn Anne Evans, Roger James Summers, Ana Sabine Hutchinson, Tore Bengtsson

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The type 2 diabetes epidemic makes it important to find insulin-independent ways to improve glucose homeostasis. This study examin..