Shanti Diwakarla

Gastrointestinal Dysfunction in Parkinson's Disease: Current and Potential Therapeutics

Myat Noe Han, David I Finkelstein, Rachel M McQuade, Shanti Diwakarla

Journal article  |  2022  |  JOURNAL OF PERSONALIZED MEDICINE

Abnormalities in the gastrointestinal (GI) tract of Parkinson's disease (PD) sufferers were first reported over 200 years ago; how..

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David Finkelstein, John B Furness, Shanti Diwakarla

Journal article  |  2021  |  SCIENTIFIC REPORTS

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervou..

ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease

Shanti Diwakarla, Rachel M McQuade, Remy Constable, Olivia Artaiz, Enie Lei, Kevin J Barnham, Paul A Adlard, Robert A Cherny, Madeleine R Di Natale, Hongyi Wu, Xin-Yi Chai, Victoria A Lawson, David Finkelstein, John B Furness

Journal article  |  2021  |  JOURNAL OF PARKINSONS DISEASE

BACKGROUND: Gastrointestinal (GI) complications, that severely impact patient quality of life, are a common occurrence in patients..

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Christine L West, Yu-Kang Mao, Thilini Delungahawatta, Jessica Y Amin, Sohana Farhin, Rachel M McQuade, Shanti Diwakarla, Ruslan Pustovit, Andrew M Stanisz, John Bienenstock, Denise Barbut, Michael Zasloff, John B Furness, Wolfgang A Kunze

Journal article  |  2020  |  JOURNAL OF PARKINSONS DISEASE

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder thought to be caused by accumulation of α-synucle..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor

Shanti Diwakarla, Ross AD Bathgate, Xiaozhou Zhang, Mohammed Akhter Hossain, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Insulin-like peptide 5 (INSL5) is a hormone stored in colonic enteroendocrine cells that also contain the unrelated ho..

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease

Shanti Diwakarla, David I Finkelstein, Remy Constable, Olivia Artaiz, Madeleine Di Natale, Rachel M McQuade, Enie Lei, Xin-yi Chai, Mitchell T Ringuet, Linda J Fothergill, Victoria A Lawson, Laura J Ellett, Joel P Berger, John B Furness

Journal article  |  2019  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's..

Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Benjamin Seyer, Shanti Diwakarla, Peta Burns, Anders Hallberg, Alfhild Gronbladh, Mathias Hallberg, Siew Yeen Chai

Journal article  |  2019  |  JOURNAL OF NEUROCHEMISTRY

Ethyl2-acetylamino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carboxylate (HFI-419), the benzopyran-based inhibitor of insulin-regulat..

Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation

Ruslan V Pustovit, Yasuo Itomi, Mitchell Ringuet, Shanti Diwakarla, Xin-yi Chai, Rachel M McQuade, Yasuhiro Tsukimi, John B Furness

Journal article  |  2019  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Because M1 muscarinic receptors are expressed by enteric neurons, we investigated whether positive allosteric modulato..

Colonic motility and permeability deficits in A53T Mice

R McQuade, P Rajasekhar, S Diwakarla, R Constable, DP Poole, JP Berger, DI Finkelstein, JB Furness

Conference Proceedings  |  2018  |  NEUROGASTROENTEROLOGY AND MOTILITY