Shiraz Tyebji

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

Shiraz Tyebji, Simona Seizova, Alexandra L Garnham, Anthony J Hannan, Christopher J Tonkin

Journal article  |  2019  |  Brain, Behavior, and Immunity

Toxoplasma gondii (T. gondii) is a neurotropic parasite that is associated with various neuropsychiatric disorders. Rodents infect..

Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning.

Ana Saavedra, Jesús J Ballesteros, Shiraz Tyebji, Sara Martínez-Torres, Gloria Blázquez, Rosa López-Hidalgo, Garikoitz Azkona, Jordi Alberch, Eduardo D Martín, Esther Pérez-Navarro

Journal article  |  2019  |  Molecular Neurobiology

Striatal-enriched protein tyrosine phosphatase (STEP) modulates key signaling molecules involved in synaptic plasticity and neuron..

Toxoplasmosis: A pathway to neuropsychiatric disorders

Shiraz Tyebji, Simona Seizova, Anthony J Hannan, Christopher J Tonkin

Journal article  |  2019  |  Neuroscience & Biobehavioral Reviews

Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease

Shiraz Tyebji, Anthony J Hannan

Journal article  |  2017  |  Progress in Neurobiology

Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer's Disease and Dementia

A Shepherd, S Tyebji, AJ Hannan, EL Burrows

Journal article  |  2016  |  Journal of Molecular Neuroscience

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.

Ana Saavedra, Mar Puigdellívol, Shiraz Tyebji, Pradeep Kurup, Jian Xu, Silvia Ginés, Jordi Alberch, Paul J Lombroso, Esther Pérez-Navarro

Journal article  |  2016  |  Molecular Neurobiology

Brain-derived neurotrophic factor (BDNF) promotes synaptic strengthening through the regulation of kinase and phosphatase activity..

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Shiraz Tyebji, Ana Saavedra, Paula M Canas, Anna Pliassova, José M Delgado-García, Jordi Alberch, Rodrigo A Cunha, Agnès Gruart, Esther Pérez-Navarro

Journal article  |  2015  |  Neurobiology of Disease

Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity..

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.

Albert Giralt, Ana Saavedra, Olga Carretón, Helena Arumí, Shiraz Tyebji, Jordi Alberch, Esther Pérez-Navarro

Journal article  |  2013  |  Hippocampus

Huntington's disease (HD) causes motor disturbances, preceded by cognitive impairment, in patients and mouse models. We showed tha..

Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.

Izaskun Villar-Menéndez, Marta Blanch, Shiraz Tyebji, Thais Pereira-Veiga, José Luis Albasanz, Mairena Martín, Isidre Ferrer, Esther Pérez-Navarro, Marta Barrachina

Journal article  |  2013  |  NeuroMolecular Medicine

Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severel..