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Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's dis..
Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer's Disease a..
BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Pro..
Displaying the 9 most recent scholarly works by Shiraz Tyebji.
Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice
Shiraz Tyebji, Simona Seizova, Alexandra L Garnham, Anthony J Hannan, Christopher J Tonkin
Journal article | 2019 | Brain, Behavior, and Immunity
Toxoplasma gondii (T. gondii) is a neurotropic parasite that is associated with various neuropsychiatric disorders. Rodents infect..
Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning.
Ana Saavedra, Jesús J Ballesteros, Shiraz Tyebji, Sara Martínez-Torres, Gloria Blázquez, Rosa López-Hidalgo, Garikoitz Azkona, Jordi Alberch, Eduardo D Martín, Esther Pérez-Navarro
Journal article | 2019 | Molecular Neurobiology
Striatal-enriched protein tyrosine phosphatase (STEP) modulates key signaling molecules involved in synaptic plasticity and neuron..
BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.
Ana Saavedra, Mar Puigdellívol, Shiraz Tyebji, Pradeep Kurup, Jian Xu, Silvia Ginés, Jordi Alberch, Paul J Lombroso, Esther Pérez-Navarro
Journal article | 2016 | Molecular Neurobiology
Brain-derived neurotrophic factor (BDNF) promotes synaptic strengthening through the regulation of kinase and phosphatase activity..
Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.
Shiraz Tyebji, Ana Saavedra, Paula M Canas, Anna Pliassova, José M Delgado-García, Jordi Alberch, Rodrigo A Cunha, Agnès Gruart, Esther Pérez-Navarro
Journal article | 2015 | Neurobiology of Disease
Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity..
PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.
Albert Giralt, Ana Saavedra, Olga Carretón, Helena Arumí, Shiraz Tyebji, Jordi Alberch, Esther Pérez-Navarro
Journal article | 2013 | Hippocampus
Huntington's disease (HD) causes motor disturbances, preceded by cognitive impairment, in patients and mouse models. We showed tha..
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.
Izaskun Villar-Menéndez, Marta Blanch, Shiraz Tyebji, Thais Pereira-Veiga, José Luis Albasanz, Mairena Martín, Isidre Ferrer, Esther Pérez-Navarro, Marta Barrachina
Journal article | 2013 | NeuroMolecular Medicine
Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severel..
Florey Department Of Neuroscience And Mental Health
Medical Biology (W.E.H.I.)