Jordan Hansford

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study.

Darren R Hargrave, Eric Bouffet, Uri Tabori, Alberto Broniscer, Kenneth J Cohen, Jordan R Hansford, Birgit Geoerger, Pooja Hingorani, Ira J Dunkel, Mark W Russo, Lillian Tseng, Kohinoor Dasgupta, Eduard Gasal, James A Whitlock, Mark W Kieran

Journal article  |  2019  |  Clinical Cancer Research

PURPOSE: Pediatric low-grade glioma (pLGG) is the most prevalent childhood brain tumor. Patients with BRAF V600 mutation-positive ..

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas.

Ana S Guerreiro Stucklin, Scott Ryall, Kohei Fukuoka, Michal Zapotocky, Alvaro Lassaletta, Christopher Li, Taylor Bridge, Byungjin Kim, Anthony Arnoldo, Paul E Kowalski, Yvonne Zhong, Monique Johnson, Claire Li, Arun K Ramani, Robert Siddaway, Liana Figueiredo Nobre, Pasqualino de Antonellis, Christopher Dunham, Sylvia Cheng, Daniel R Boué, et al.

Journal article  |  2019  |  Nature Communications

Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortali..

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Patrick Sin-Chan, Iqra Mumal, Tannu Suwal, Ben Ho, Xiaolian Fan, Irtisha Singh, Yuchen Du, Mei Lu, Neilket Patel, Jonathon Torchia, Dean Popovski, Maryam Fouladi, Paul Guilhamon, Jordan R Hansford, Sarah Leary, Lindsey M Hoffman, Jean M Mulcahy Levy, Alvaro Lassaletta, Palma Solano-Paez, Eloy Rivas, et al.

Journal article  |  2019  |  Cancer Cell

Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Ch..

Report of a bi-allelic truncating germline mutation in TP53

Natasha J Brown, Kanika Bhatia, Julie Teague, Susan M White, Patrick Lo, Jackie Challis, Victoria Beshay, Michael Sullivan, David Malkin, Jordan R Hansford

Journal article  |  2019  |  Familial Cancer

Use of bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade glioma

Nataliya Zhukova, Revathi Rajagopal, Adrienne Lam, Lee Coleman, Peter Shipman, Thomas Walwyn, Molly Williams, Michael Sullivan, Martin Campbell, Kanika Bhatia, Nicholas G Gottardo, Jordan R Hanford

Journal article  |  2019  |  Cancer Medicine

Personalised medicine in paediatric oncology: Ethical practice outside the clinical trial framework?

Jordan R Hansford

Journal article  |  2019  |  Journal of Paediatrics and Child Health

Modern paediatric oncology practice has rapidly evolved from a fatal condition at diagnosis in the 1940s to modern survival rates ..

Spinal Cord Hyperintensities in Neurofibromatosis Type 1: Are They the Cord Equivalent of Unidentified Bright Objects in the Brain?

Andrea D Ruegger, Lee Coleman, Jordan R Hansford, Natalie McLean, Gabriel Dabscheck

Journal article  |  2018  |  Pediatric Neurology

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

Maximilian Y Deng, Martin Sill, Jason Chiang, Jens Schittenhelm, Martin Ebinger, Martin U Schuhmann, Camelia-Maria Monoranu, Till Milde, Andrea Wittmann, Christian Hartmann, Clemens Sommer, Werner Paulus, Jutta Gaertner, Wolfgang Brueck, Thomas Ruediger, Alfred Leipold, Zane Jaunmuktane, Sebastian Brandner, Felice Giangaspero, Paolo Nozza, et al.

Journal article  |  2018  |  Acta Neuropathologica

DNA METHYLATION ANALYSIS OF HIGH-GRADE GLIOMA IN PATIENTS WITH MISMATCH REPAIR DEFICIENCIES

Andrew Dodgshun, Kohei Fukuoka, Brittany Campbell, Melissa Edwards, Alexandra Sexton-Oates, Valerie Larouche, Vanan Magimairajan, Scott Lindhorst, Michal Oren, Gary Mason, Bruce Crooks, Shlomi Constantini, Maura Massimino, Stefano Chiaravalli, Jagadeesh Ramdas, Warren Mason, Ashraf Shamvil, Roula Farah, An van Damme, Enrico Opocher, et al.

Conference Proceedings  |  2018  |  NEURO-ONCOLOGY

DNA methylation-based classification of central nervous system tumours

David Capper, David TW Jones, Martin Sill, Volker Hovestadt, Daniel Schrimpf, Dominik Sturm, Christian Koelsche, Felix Sahm, Lukas Chavez, David E Reuss, Annekathrin Kratz, Annika K Wefers, Kristin Huang, Kristian W Pajtler, Leonille Schweizer, Damian Stichel, Adriana Olar, Nils W Engel, Kerstin Lindenberg, Patrick N Harter, et al.

Journal article  |  2018  |  Nature

Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood.

Maria Isabel Achatz, Christopher C Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D Foulkes, Christian P Kratz, Roland P Kuiper, Jordan R Hansford, Hector Salvador Hernandez, Katherine L Nathanson, Wendy K Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R Scollon, Uri Tabori, Gail E Tomlinson, D Gareth R Evans, Sharon E Plon

Journal article  |  2017  |  Clinical Cancer Research

Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillan..

Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood.

Uri Tabori, Jordan R Hansford, Maria Isabel Achatz, Christian P Kratz, Sharon E Plon, Thierry Frebourg, Laurence Brugières

Journal article  |  2017  |  Clinical Cancer Research

Replication proofreading is crucial to avoid mutation accumulation in dividing cells. In humans, proofreading and replication repa..

Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome.

Christian P Kratz, Maria Isabel Achatz, Laurence Brugières, Thierry Frebourg, Judy E Garber, Mary-Louise C Greer, Jordan R Hansford, Katherine A Janeway, Wendy K Kohlmann, Rose McGee, Charles G Mullighan, Kenan Onel, Kristian W Pajtler, Stefan M Pfister, Sharon A Savage, Joshua D Schiffman, Katherine A Schneider, Louise C Strong, D Gareth R Evans, Jonathan D Wasserman, et al.

Journal article  |  2017  |  Clinical Cancer Research

Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by germline mutations of the TP53 tumor suppresso..

Risk assessment in paediatric glioma-Time to move on from the binary classification

AJ Dodgshun, JR Hansford, MJ Sullivan

Journal article  |  2017  |  Critical Reviews in Oncology/Hematology

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Jonathon Torchia, Brian Golbourn, Shengrui Feng, King Ching Ho, Patrick Sin-Chan, Alexandre Vasiljevic, Joseph D Norman, Paul Guilhamon, Livia Garzia, Natalia R Agamez, Mei Lu, Tiffany S Chan, Daniel Picard, Pasqualino de Antonellis, Dong-Anh Khuong-Quang, Aline C Planello, Constanze Zeller, Dalia Barsyte-Lovejoy, Lucie Lafay-Cousin, Louis Letourneau, et al.

Journal article  |  2016  |  Cancer Cell

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different ..

Genome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility

Nardin Samuel, Gavin Wilson, Mathieu Lemire, Badr Id Said, Youliang Lou, Weili Li, Diana Merino, Ana Novokmet, James Tran, Kim E Nichols, Jonathan L Finlay, Sanaa Choufani, Marc Remke, Vijay Ramaswamy, Florence MG Cavalli, Christine Elser, Lynn Meister, Michael D Taylor, Uri Tabori, Meredith Irwin, et al.

Journal article  |  2016  |  Journal of Clinical Oncology

Purpose Although the link between mutant TP53 and human cancer is unequivocal, a significant knowledge gap exists in clinically ac..

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

Eric Bouffet, Valérie Larouche, Brittany B Campbell, Daniele Merico, Richard de Borja, Melyssa Aronson, Carol Durno, Joerg Krueger, Vanja Cabric, Vijay Ramaswamy, Nataliya Zhukova, Gary Mason, Roula Farah, Samina Afzal, Michal Yalon, Gideon Rechavi, Vanan Magimairajan, Michael F Walsh, Shlomi Constantini, Rina Dvir, et al.

Journal article  |  2016  |  Journal of Clinical Oncology

Purpose Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic mismatch repair deficiency (bMMRD) ..

Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation

Andrew J Dodgshun, Nadine SantaCruz, Jaeho Hwang, Shakti H Ramkissoon, Hayley Malkin, Guillaume Bergthold, Peter Manley, Susan Chi, Duncan MacGregor, Liliana Goumnerova, Michael Sullivan, Keith Ligon, Rameen Beroukhim, Betty Herrington, Mark W Kieran, Jordan R Hansford, Pratiti Bandopadhayay

Journal article  |  2016  |  Journal of Neuro-Oncology

Central Diabetes Insipidus and Cisplatin-Induced Renal Salt Wasting Syndrome: A Challenging Combination

Gerard Cortina, Jordan R Hansford, Trevor Duke

Journal article  |  2016  |  Pediatric Blood & Cancer