Brett Pearce

Low tidal volume ventilation for patients undergoing laparoscopic surgery: a secondary analysis of a randomised clinical trial.

Dharshi Karalapillai, Laurence Weinberg, Ary Serpa Neto, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Grace Liskaser, Ajay Balasubramaniam, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2023  |  BMC Anesthesiol

BACKGROUND: We recently reported the results for a large randomized controlled trial of low tidal volume ventilation (LTVV) versus..

Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications

Dharshi Karalapillai, Laurence Weinberg, Ary Serpa Neto, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Sree Appu, Anthony Wilson, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2022  |  BMC ANESTHESIOLOGY

BACKGROUND: Low tidal volume (VT) ventilation and its associated increase in arterial carbon dioxide (PaCO2) may affect postoperat..

Intra-operative ventilator mechanical power as a predictor of postoperative pulmonary complications in surgical patients: A secondary analysis of a randomised clinical trial.

Dharshi Karalapillai, Laurence Weinberg, Serpa Neto A, Philip Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2022  |  Eur J Anaesthesiol

BACKGROUND: Studies in critically ill patients suggest a relationship between mechanical power (an index of the energy delivered b..

Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery A Randomized Clinical Trial

Dharshi Karalapillai, Laurence Weinberg, Philip Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Ary Serpa Neto, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2020  |  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IMPORTANCE: In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. OBJECTIVE: To determ..

Intrathecal morphine is associated with reduction in postoperative opioid requirements and improvement in postoperative analgesia in patients undergoing open liver resection

Jefferson Tang, Leonid Churilov, Chong Oon Tan, Raymond Hu, Brett Pearce, Luka Cosic, Christopher Christophi, Laurence Weinberg

Journal article  |  2020  |  BMC ANESTHESIOLOGY

BACKGROUND: Our study aimed to test the hypothesis that the addition of intrathecal morphine (ITM) results in reduced postoperativ..

Potassium levels after liver reperfusion in adult patients undergoing cadaveric liver transplantation: A retrospective cohort study

Laurence Weinberg, Dong-Kyu Lee, Anoop Ninan Koshy, Kai Wen Leong, Shervin Tosif, Ruth Shaylor, Param Pillai, Lachlan Fraser Miles, Alexandra Drucker, Brett Pearce

Journal article  |  2020  |  ANNALS OF MEDICINE AND SURGERY

BACKGROUND: Hyperkalemia is a common cause of arrhythmias in patients undergoing liver transplantation. We examined the pattern of..

Frequency of hyperoxaemia during and after major surgery

Dharshi Karalapillai, Laurence Weinberg, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Glenn Eastwood, Rinaldo Bellomo, Daryl Jones

Journal article  |  2020  |  ANAESTHESIA AND INTENSIVE CARE

The oxygen concentration (FiO2) and arterial oxygen tension (PaO2) delivered in patients undergoing major surgery is poorly unders..

Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery

Clarence Wong, Leonid Churilov, Dean Cowie, Chong Oon Tan, Raymond Hu, David Tremewen, Brett Pearce, Param Pillai, Dharshi Karalapillai, Rinaldo Bellomo, Laurence Weinberg

Journal article  |  2020  |  BMJ OPEN

OBJECTIVES: The effects of hypercapnia on regional cerebral oxygen saturation (rSO2) during surgery are unclear. We conducted a ra..

Low tidal volume ventilation during anaesthesia for major surgery: protocol and statistical analysis plan

Dharshi Karalapillai, Laurence Weinberg, Phil Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark ODonnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Ary Serpa Neto, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2019  |  CRITICAL CARE AND RESUSCITATION

BACKGROUND: Mechanical ventilation is mandatory in patients undergoing general anaesthesia for major surgery. Tidal volumes higher..

High Frequency, Low Background Rate Extrapleural Programmed Intermittent Bolus Ropivacaine Provides Superior Analgesia Compared with Continuous Infusion for Acute Pain Management Following Thoracic Surgery: A Retrospective Cohort Study.

Bridget Bishop, Brett Pearce, Luke Willshire, Matthew Kilpin, William Howard, Laurence Weinberg, Chong Tan

Journal article  |  2019  |  Anesth Pain Med

BACKGROUND: Thoracic surgery often results in severe postoperative pain. Regional analgesia via surgically placed extrapleural loc..