Rasika Kumarasingha

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

Paul R Gilson, Rasika Kumarasingha, Jennifer Thompson, Xinxin Zhang, Jocelyn Sietsma Penington, Robabeh Kalhor, Hayley E Bullen, Adele M Lehane, Madeline G Dans, Tania F de Koning-Ward, Jessica K Holien, Tatiana P Soares da Costa, Mark D Hulett, Melissa J Buskes, Brendan S Crabb, Kiaran Kirk, Anthony T Papenfuss, Alan F Cowman, Belinda M Abbott

Journal article  |  2019  |  SCIENTIFIC REPORTS

We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved mod..

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

Daniel GW Alanine, Doris Quinkert, Rasika Kumarasingha, Shahid Mehmood, Francesca R Donnellan, Nana K Minkah, Bernadeta Dadonaite, Ababacar Diouf, Francis Galaway, Sarah E Silk, Abhishek Jamwal, Jennifer M Marshall, Kazutoyo Miura, Lander Foquet, Sean C Elias, Genevieve M Labbe, Alexander D Douglas, Jing Jin, Ruth O Payne, Joseph J Illingworth, et al.

Journal article  |  2019  |  CELL

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines agains..

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export

Sarah C Charnaud, Rasika Kumarasingha, Hayley E Bullen, Brendan S Crabb, Paul R Gilson

Journal article  |  2018  |  PLOS ONE

Malaria parasites remodel their host erythrocytes to gain nutrients and avoid the immune system. Host erythrocytes are modified by..

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour

Rasika Kumarasingha, Avinash V Karpe, Sarah Preston, Tiong-Chia Yeo, Diana SL Lim, Chu-Lee Tu, Jennii Luu, Kaylene J Simpson, Jillian M Shaw, Robin B Gasser, David J Beale, Paul D Morrison, Enzo A Palombo, Peter R Boag

Journal article  |  2016  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Anthelmintic resistance is widespread in gastrointestinal nematode populations, such that there is a consistent need to search for..

Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus

Rasika Kumarasingha, Sarah Preston, Tiong-Chia Yeo, Diana SL Lim, Chu-Lee Tu, Enzo A Palombo, Jillian M Shaw, Robin B Gasser, Peter R Boag

Journal article  |  2016  |  PARASITES & VECTORS

BACKGROUND: Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally, and consider..