Jason Tye-Din

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

Melinda Y Hardy, Amy K Russell, Catherine Pizzey, Claerwen M Jones, Katherine A Watson, Nicole L La Gruta, Donald J Cameron, Jason A Tye-Din

Journal article  |  2020  |  Gut

OBJECTIVE: Barley and rye are major components of the Western diet, and historic feeding studies indicate that they cause clinical..

Editorial: inaccuracies in attribution of symptoms due to gluten-not just in those with self-reported noncoeliac gluten sensitivity. Authors' reply

A James M Daveson, Jason A Tye-Din, Robert P Anderson

Journal article  |  2020  |  Alimentary Pharmacology & Therapeutics

Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4 T cells.

Ludvig M Sollid, Jason A Tye-Din, Shuo-Wang Qiao, Robert P Anderson, Carmen Gianfrani, Frits Koning

Journal article  |  2020  |  Immunogenetics

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leuko..

Circulating gluten-specific, but not CMV-specific, CD39( ) regulatory T cells have an oligoclonal TCR repertoire

Laura Cook, C Mee Ling Munier, Nabila Seddiki, Melinda Y Hardy, Robert P Anderson, John Zaunders, Jason A Tye-Din, Anthony D Kelleher, David van Bockel

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T-cell (Treg) populations is important for strat..

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Jan Petersen, Laura Ciacchi, Mai T Tran, Khai Lee Loh, Yvonne Kooy-Winkelaar, Nathan P Croft, Melinda Y Hardy, Zhenjun Chen, James McCluskey, Robert P Anderson, Anthony W Purcell, Jason A Tye-Din, Frits Koning, Hugh H Reid, Jamie Rossjohn

Journal article  |  2019  |  Nature Structural & Molecular Biology

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celia..

Masked bolus gluten challenge low in FODMAPs implicates nausea and vomiting as key symptoms associated with immune activation in treated coeliac disease

A James M Daveson, Jason A Tye-Din, Gautam Goel, Kaela E Goldstein, Holly L Hand, Kristin M Neff, Leslie J Williams, Kenneth E Truitt, Robert P Anderson, A Adams, J Andrews, C Behrend, G Brown, S Chen Yi Mei, A Coates, AJM Daveson, A DiMarino, H Ee, D Elliott, R Epstein, et al.

Journal article  |  2019  |  Alimentary Pharmacology & Therapeutics

Elevated serum interleukin-2 after gluten correlates with symptoms and is a potential diagnostic biomarker for coeliac disease

Jason A Tye-Din, A James M Daveson, Hooi C Ee, Gautam Goel, James MacDougall, Sarah Acaster, Kaela E Goldstein, John L Dzuris, Kristin M Neff, Kenneth E Truitt, Robert P Anderson

Journal article  |  2019  |  Alimentary Pharmacology & Therapeutics

Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease

G Goel, AJM Daveson, CE Hooi, JA Tye-Din, S Wang, E Szymczak, LJ Williams, JL Dzuris, KM Neff, KE Truitt, RP Anderson

Journal article  |  2019  |  Clinical & Experimental Immunology

Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity

Jason A Tye-Din, Gry Skodje, Vikas K Sarna, John L Dzuris, Amy K Russell, Gautam Goel, Suyue Wang, Kaela E Goldstein, Leslie J Williams, Ludvig M Sollid, Knut EA Lundin, Robert P Anderson

Journal article  |  2019  |  United European Gastroenterology Journal

Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease

Gautam Goel, Jason A Tye-Din, Shuo-Wang Qiao, Amy K Russell, Toufic Mayassi, Cezary Ciszewski, Vikas K Sarna, Suyue Wang, Kaela E Goldstein, John L Dzuris, Leslie J Williams, Ramnik J Xavier, Knut EA Lundin, Bana Jabri, Ludvig M Sollid, Robert P Anderson

Journal article  |  2019  |  Science Advances