Jason Tye-Din

Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease

RP Anderson, G Goel, MY Hardy, AR Russell, S Wang, E Szymczak, R Zhang, KE Goldstein, M Neff, KE Truitt, LJ Williams, JL Dzuris, JA Tye-Din

Journal article  |  2021  |  Clinical & Experimental Immunology

Whole blood cytokine release assays (CRA) assessing cellular immunity to gluten could simplify the diagnosis and monitoring of coe..

The Risk of Contracting COVID-19 Is Not Increased in Patients With Celiac Disease

Jamie Zhen, Juan Pablo Stefanolo, Maria de la Paz Temprano, Sebastian Tedesco, Caroline Seiler, Alberto Fernandez Caminero, Enrique de-Madaria, Miguel Montoro Huguet, Santiago Vivas, Sonia Isabel Niveloni, Premysl Bercik, Edgardo Smecuol, Luis Uscanga, Elena Trucco, Virginia Lopez, Carolina Olano, Pasquale Mansueto, Antonio Carroccio, Peter HR Green, Andrew Day, et al.

Journal article  |  2021  |  Clinical Gastroenterology and Hepatology

The World Health Organization declared coronavirus disease-2019 (COVID-19) a global pandemic in March 2020. Since then, there are ..

Iron deficiency

Sant-Rayn Pasricha, Jason Tye-Din, Martina U Muckenthaler, Dorine W Swinkels

Journal article  |  2021  |  The Lancet

Iron deficiency is one of the leading contributors to the global burden of disease, and particularly affects children, premenopaus..

Patient factors influencing acute gluten reactions and cytokine release in treated coeliac disease.

Jason A Tye-Din, A James M Daveson, Kaela E Goldstein, Holly L Hand, Kristin M Neff, Gautam Goel, Leslie J Williams, Kenneth E Truitt, Robert P Anderson, undefined RESET CeD Study Group

Journal article  |  2020  |  BMC Medicine

BACKGROUND: Patients with coeliac disease (CD) commonly report a variety of adverse symptoms to gluten, but descriptions of the sy..

Current and emerging therapies for coeliac disease

Laura Kivela, Alberto Caminero, Daniel A Leffler, Maria Ines Pinto-Sanchez, Jason A Tye-Din, Katri Lindfors

Journal article  |  2020  |  Nature Reviews Gastroenterology & Hepatology

Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals in response to the ingestion of gluten ..

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

Melinda Y Hardy, Amy K Russell, Catherine Pizzey, Claerwen M Jones, Katherine A Watson, Nicole L La Gruta, Donald J Cameron, Jason A Tye-Din

Journal article  |  2020  |  Gut

OBJECTIVE: Barley and rye are major components of the Western diet, and historic feeding studies indicate that they cause clinical..

Editorial: inaccuracies in attribution of symptoms due to gluten-not just in those with self-reported noncoeliac gluten sensitivity. Authors' reply

A James M Daveson, Jason A Tye-Din, Robert P Anderson

Journal article  |  2020  |  Alimentary Pharmacology & Therapeutics

Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4 T cells.

Ludvig M Sollid, Jason A Tye-Din, Shuo-Wang Qiao, Robert P Anderson, Carmen Gianfrani, Frits Koning

Journal article  |  2020  |  Immunogenetics

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leuko..

Circulating gluten-specific, but not CMV-specific, CD39( ) regulatory T cells have an oligoclonal TCR repertoire

Laura Cook, C Mee Ling Munier, Nabila Seddiki, Melinda Y Hardy, Robert P Anderson, John Zaunders, Jason A Tye-Din, Anthony D Kelleher, David van Bockel

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T-cell (Treg) populations is important for strat..

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Jan Petersen, Laura Ciacchi, Mai T Tran, Khai Lee Loh, Yvonne Kooy-Winkelaar, Nathan P Croft, Melinda Y Hardy, Zhenjun Chen, James McCluskey, Robert P Anderson, Anthony W Purcell, Jason A Tye-Din, Frits Koning, Hugh H Reid, Jamie Rossjohn

Journal article  |  2019  |  Nature Structural & Molecular Biology

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celia..