Sarah Best

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  JOURNAL OF THORACIC ONCOLOGY

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Sarah A Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E Vince, Vivek Rathi, Gavin M Wright, Matthew E Ritchie, Kate D Sutherland

Journal article  |  2019  |  NATURE COMMUNICATIONS

The KRAS oncoprotein, a critical driver in 33% of lung adenocarcinoma (LUAD), has remained an elusive clinical target due to its p..

FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium

Sarah A Best, Cassandra R Harapas, Ariena Kersbergen, Vivek Rathi, Marie-Liesse Asselin-Labat, Kate D Sutherland

Journal article  |  2018  |  ONCOGENE

Structural rearrangements of the genome can drive lung tumorigenesis through the generation of fusion genes with oncogenic propert..

Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs

Ariena Kersbergen, Sarah A Best, Sebastian Dworkin, Casey Ah-Cann, Michael E de Vries, Marie-Liesse Asselin-Labat, Matthew E Ritchie, Stephen M Jane, Kate D Sutherland

Journal article  |  2018  |  DEVELOPMENTAL BIOLOGY

The highly conserved transcription factor Grainyhead-like 2 (Grhl2) exhibits a dynamic expression pattern in lung epithelium throu..

Interrogating the Metabolic Effects of Keap1 Inactivation in Adenocarcinoma

S Best, S Ding, A Kersbergen, B Reljic, K Sutherland

Conference Proceedings  |  2018  |  JOURNAL OF THORACIC ONCOLOGY

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland

Journal article  |  2018  |  CELL METABOLISM

The lung presents a highly oxidative environment, which is tolerated through engagement of tightly controlled stress response path..

Combining Cell Type-Restricted Adenoviral Targeting with Immunostaining and Flow Cytometry to Identify Cells-of-Origin of Lung Cancer

Sarah A Best, Ariena Kersbergen, Marie-Liesse Asselin-Labat, Kate D Sutherland

Book Chapter  |  2018  |  Methods in Molecular Biology

Lung cancers display considerable intertumoral heterogeneity, leading to the classification of distinct tumor subtypes. Our unders..

"Keaping" a lid on lung cancer: the Keap1-Nrf2 pathway

Sarah A Best, Kate D Sutherland

Journal article  |  2018  |  CELL CYCLE

Lung cancer remains one of the world's deadliest cancers, with effective targeted treatment options available for only a small sub..

CCAR2 Is Required for Proliferation and Tumor Maintenance in Human Squamous Cell Carcinoma

Sarah A Best, Amy N Nwaobasi, Chrysalyne D Schmults, Matthew R Ramsey

Journal article  |  2017  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

CCAR2 is a widely expressed protein involved in the regulation of a variety of transcriptional complexes. High expression of CCAR2..