Rhys Brady

The need to incorporate aged animals into the preclinical modeling of neurological conditions.

Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz

Journal article  |  2019  |  Neuroscience & Biobehavioral Reviews

Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's..

Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs

Rhys D Brady, Ker Rui Wong, Dale L Robinson, Richelle Mychasiuk, Stuart J McDonald, Ryan A D'Cunha, Glenn R Yamakawa, Mujun Sun, John D Wark, Peter Vee Sin Lee, Terence J O'Brien, Pablo M Casillas-Espinosa, Sandy R Shultz

Journal article  |  2019  |  Frontiers in Pharmacology

Rationale: Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether the..

Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz

Journal article  |  2019  |  Scientific Reports

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with..

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Cesar Santana-Gomez, Pedro Andrade, Matthew R Hudson, Tomi Paananen, Robert Ciszek, Gregory Smith, Idrish Ali, Brian K Rundle, Xavier Ekolle Ndode-Ekane, Pablo M Casillas-Espinosa, Riikka Immonen, Noora Puhakka, Nigel Jones, Rhys D Brady, Piero Perucca, Sandy R Shultz, Asia Pitkanen, Terence J O'Brien, Richard Staba

Journal article  |  2019  |  Epilepsy Research

Studies of chronic epilepsy show pathological high frequency oscillations (HFOs) are associated with brain areas capable of genera..

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Pablo M Casillas-Espinosa, Pedro Andrade, Cesar Santana-Gomez, Tomi Paananen, Gregory Smith, Idrish Ali, Robert Ciszek, Xavier Ekolle Ndode-Ekane, Rhys D Brady, Jussi Tohka, Matthew R Hudson, Piero Perucca, Emma L Braine, Riikka Immonen, Noora Puhakka, Sandy R Shultz, Nigel C Jones, Richard J Staba, Asia Pitkanen, Terence J O'Brien

Journal article  |  2019  |  Epilepsy Research

RATIONALE: The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded mult..

The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice

Xin Lin Tan, Ping Zheng, David K Wright, Mujun Sun, Rhys D Brady, Shijie Liu, Stuart J McDonald, Richelle Mychasiuk, Sitare Cenap, Nigel C Jones, Terence J O'Brien, Sandy R Shultz

Journal article  |  2019  |  Brain Injury

Aged rats have an altered immune response and worse outcomes after traumatic brain injury

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz

Journal article  |  2019  |  Brain, Behavior, and Immunity

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk

David PQ Clark, Victoria M Perreau, Sandy R Shultz, Rhys D Brady, Enie Lei, Shilpi Dixit, Juliet M Taylor, Philip M Beart, Wah Chin Boon

Journal article  |  2019  |  Neurochemical Research

Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion

Louise Pham, Sandy R Shultz, Hyun Ah Kim, Rhys D Brady, Ryan C Wortman, Shannyn G Genders, Matthew W Hale, Ross D O'Shea, Elvan Djouma, Maarten van den Buuse, Jarrod E Church, Brian R Christie, Grant R Drummond, Christopher G Sobey, Stuart J McDonald

Journal article  |  2019  |  Journal of Neurotrauma

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D Brady, Pablo M Casillas-Espinosa, Denes V Agoston, Edward H Bertram, Alaa Kamnaksh, Bridgette D Semple, Sandy R Shultz

Journal article  |  2019  |  Neurobiology of Disease

The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice.

Maddison R Johnstone, Rhys D Brady, Johannes A Schuijers, Jarrod E Church, David Orr, Julian MW Quinn, Stuart J McDonald, Brian L Grills

Journal article  |  2019  |  Journal of Musculoskeletal Neuronal Interactions

OBJECTIVES: To study effects of the selective TrkA agonist, gambogic amide (GA), on fracture healing in mice and on an osteoprogen..

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Xavier Ekolle Ndode-Ekane, Cesar Santana-Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Rhys D Brady, Gregory Smith, Pedro Andrade, Riikka Immonen, Noora Puhakka, Matthew R Hudson, Emma L Braine, Sandy R Shultz, Richard J Staba, Terence J O'Brien, Asla Pitkanen

Journal article  |  2019  |  Epilepsy Research

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Riikka Immonen, Gregory Smith, Rhys D Brady, David Wright, Leigh Johnston, Neil G Harris, Eppu Manninen, Raimo Salo, Craig Branch, Dominique Duncan, Ryan Cabeen, Xavier Ekolle Ndode-Ekane, Cesar Santana Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Sandy R Shultz, Pedro Andrade, Noora Puhakka, Richard J Staba, Terence J O'Brien, et al.

Journal article  |  2019  |  Epilepsy Research

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Robert Ciszek, Xavier Ekolle Ndode-Ekane, Cesar Santana Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Gregory Smith, Noora Puhakka, Niina Lapinlampi, Pedro Andrade, Alaa Kamnaksh, Riikka Immonen, Tomi Paananen, Matthew R Hudson, Rhys D Brady, Sandy R Shultz, Terence J O'Brien, Richard J Staba, Jussi Tohka, Asla Pitkanen

Journal article  |  2019  |  Epilepsy Research

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Alaa Kamnaksh, Noora Puhakka, Idrish Ali, Gregory Smith, Roxanne Aniceto, Jesse McCullough, Shalini Das Gupta, Xavier Ekolle Ndode-Ekane, Rhys Brady, Pablo Casillas-Espinosa, Matt Hudson, Cesar Santana-Gomez, Riikka Immonen, Pedro Andrade de Abreu, Nigel Jones, Sandy Shultz, Richard J Staba, Terence J O'Brien, Denes Agoston, Asia Pitkanen

Journal article  |  2019  |  Epilepsy Research

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Xin Lin Tan, Mujun Sun, Rhys D Brady, Shijie Liu, Roxana Llanos, Steve Cheung, David K Wright, Pablo M Casillas-Espinosa, Maithili Sashindranath, Terence J O'Brien, Stuart J McDonald, Bradley J Turner, Sandy R Shultz

Journal article  |  2019  |  Journal of Neurotrauma

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Ryan C Wortman, Alicia Meconi, Katie J Neale, Rhys D Brady, Stuart J McDonald, Brian R Christie, David K Wright, Sandy R Shultz

Journal article  |  2018  |  Annals of Clinical and Translational Neurology

Mild Traumatic Brain Injury in Adolescent Mice Alters Skull Bone Properties to Influence a Subsequent Brain Impact at Adulthood: A Pilot Study

Thomas J McColl, Rhys D Brady, Sandy R Shultz, Lauren Lovick, Kyria M Webster, Mujun Sun, Stuart J McDonald, Terence J O'Brien, Bridgette D Semple

Journal article  |  2018  |  Frontiers in Neurology

Neurological heterotopic ossification: Current understanding and future directions

Rhys D Brady, Sandy R Shultz, Stuart J McDonald, Terence J O'Brien

Journal article  |  2018  |  Bone

The influence of immunological stressors on traumatic brain injury

Mujun Sun, Stuart J McDonald, Rhys D Brady, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Brain, Behavior, and Immunity

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Meaghan Clough, Steven Mutimer, David K Wright, Adrian Tsang, Daniel M Costello, Andrew J Gardner, Peter Stanwell, Richelle Mychasiuk, Mujun Sun, Rhys D Brady, Stuart J McDonald, Kyria M Webster, Maddison R Johnstone, Bridgette D Semple, Denes V Agoston, Owen B White, Richard Frayne, Joanne Fielding, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Journal of Neurotrauma

Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice

Maddison R Johnstone, Mujun Sun, Caroline J Taylor, Rhys D Brady, Brian L Grills, Jarrod E Church, Sandy R Shultz, Stuart J McDonald

Journal article  |  2018  |  Brain Injury

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Mujun Sun, Rhys D Brady, David K Wright, Hyun Ah Kim, Shenpeng R Zhang, Christopher G Sobey, Maddison R Johnstone, Terence J O'Brien, Bridgette D Semple, Stuart J McDonald, Sandy R Shultz

Journal article  |  2017  |  Brain, Behavior, and Immunity

Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease

David K Wright, Shijie Liu, Chris van der Poel, Stuart J McDonald, Rhys D Brady, Lily Taylor, Li Yang, Andrew J Gardner, Roger Ordidge, Terence J O'Brien, Leigh A Johnston, Sandy R Shultz

Journal article  |  2017  |  Cerebral Cortex

Experimental Traumatic Brain Injury Induces Bone Loss in Rats

Rhys D Brady, Sandy R Shultz, Mujun Sun, Tania Romano, Chris van der Poel, David K Wright, John D Wark, Terence J O'Brien, Brian L Grills, Stuart J McDonald

Journal article  |  2016  |  Journal of Neurotrauma

Sodium selenate treatment mitigates reduction of bone volume following traumatic brain injury in rats

RD Brady, BL Grills, T Romano, JD Wark, TJ O'Brien, SR Shultz, SJ McDonald

Journal article  |  2016  |  Journal of Musculoskeletal Neuronal Interactions

Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma

Sandy R Shultz, Mujun Sun, David K Wright, Rhys D Brady, Shijie Liu, Sinead Beynon, Shannon F Schmidt, Andrew H Kaye, John A Hamilton, Terence J O'Brien, Brian L Grills, Stuart J McDonald

Journal article  |  2015  |  Journal of Cerebral Blood Flow & Metabolism

Thymosin beta(4) Administration Enhances Fracture Healing in Mice

Rhys D Brady, Brian L Grills, Johannes A Schuijers, Alex R Ward, Brett A Tonkin, Nicole C Walsh, Stuart J McDonald

Journal article  |  2014  |  Journal of Orthopaedic Research