Rhys Brady

Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury

William T O'Brien, Louise Pham, Rhys D Brady, Jesse Bain, Glenn R Yamakawa, Mujun Sun, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald

Journal article  |  2021  |  EXPERIMENTAL NEUROLOGY

There is a widely recognized need for blood biomarkers to assist clinical decisions surrounding mild traumatic brain injury (mTBI)..

The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice.

Maddison R Johnstone, Rhys D Brady, Jarrod E Church, David Orr, Stuart J McDonald, Brian L Grills

Journal article  |  2021  |  J Musculoskelet Neuronal Interact

OBJECTIVES: To study the effects of the selective TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), on fracture healing in mice and on..

Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz

Journal article  |  2021  |  NEUROSCIENTIST

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medic..

Elevated Serum Interleukin-1 beta Levels in Male, but not Female, Collision Sport Athletes with a Concussion History

William T O'Brien, Georgia F Symons, Jesse Bain, Brendan P Major, Daniel M Costello, Mujun Sun, Joshua S Kimpton, Zhibin Chen, Rhys D Brady, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald

Journal article  |  2021  |  JOURNAL OF NEUROTRAUMA

It is increasingly reported that a history of concussion may be associated with chronic deleterious consequences. While the pathop..

Prolonged elevation of serum neurofilament light after concussion in male Australian football players

Stuart J McDonald, William T O'Brien, Georgia F Symons, Zhibin Chen, Jesse Bain, Brendan P Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz

Journal article  |  2021  |  BIOMARKER RESEARCH

BACKGROUND: Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisi..

Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still m..

Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies

Ker Rui Wong, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald, Rhys D Brady

Journal article  |  2020  |  BONE RESEARCH

Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in soft tissue, such as muscle surroundin..

The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.

GR Yamakawa, RD Brady, M Sun, SJ McDonald, SR Shultz, R Mychasiuk

Journal article  |  2020  |  Neurobiol Sleep Circadian Rhythms

Traumatic brain injury (TBI) is a complex and costly worldwide phenomenon that can lead to many negative health outcomes including..

Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes

Brendan P Major, Stuart J McDonald, William T O'Brien, Georgia F Symons, Meaghan Clough, Daniel Costello, Mujun Sun, Rhys D Brady, Jesse Mccullough, Roxanne Aniceto, I-Hsuan Lin, Meng Law, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Sandy R Shultz

Journal article  |  2020  |  FRONTIERS IN NEUROLOGY

Studies have indicated that concussive and sub-concussive brain injuries that are frequent during collision sports may lead to lon..

The Development of Adolescent Chronic Pain following Traumatic Brain Injury and Surgery: The Role of Diet and Early Life Stress

Sabrina Salberg, Marissa Sgro, Rhys D Brady, Melanie Noel, Richelle Mychasiuk

Journal article  |  2020  |  DEVELOPMENTAL NEUROSCIENCE

Pain is evolutionarily necessary for survival in that it reduces tissue damage by signaling the body to respond to a harmful stimu..