Dr. Serena Duchi is a cellular biologist with special interest in osteochondral tissue engineering.
Dr Duchi graduated in Biology in 2004 (University of Bologna, Italy) and subsequently obtained her qualification as a professional Biologist in 2005 (University of Bologna, Italy).
She obtained a Master degree in Bioinformatics in 2005 with a thesis in comparative genomics, thorugh an internship program between University of Bologna-Italy and Centro de Investigación Príncipe Felipe (CIPF) Valencia – Spain. She then obtained her PhD in Cell, Molecular and Industrial Biology in 2009 through an international program between University of Bologna-Italy and Medical University of South Carolina (MUSC), Hollings Cancer Center, Charleston, SC-USA, with a thesis in tumor cell biology and endocytosis mechanisms in in vitro and in vivo models. She was awarded a post-doctoral fellowship at the IFOM-FIRC Institute of Molecular Oncology, Milan-Italy in 2009, where she acquired a strong background in the regulation of tumor suppression and endocytosis aimed to design new molecular target chemotherapeutic drugs. She then specialized in the treatment of musculoskeletal tumors at the Rizzoli Orthopaedics Institute, Bologna-Italy, where she led as senior investigator different projects:
• identification of the differentiation capabilities, onset of senescence and tumorigenicity signal transduction in mesenchymal stem/stromal cells (MSC) isolated and expanded from osteosarcoma affected patients and from healthy subjects;
• use of MSC for the transport of chemotherapeutic drugs as innovative therapeutic approach for the treatment of osteosarcoma;
• use of MSC in scaffold based regenerative medicine for osteo-chondral defect and diseases treatments.
Dr. Duchi moved to Melbourne in April 2016 as an academic research fellow and she’s currently working at the St Vincent's Hospital, 3DBioFab facility @ ACMD. Dr Duchi is the cellular biologist member of the Cartilage Regeneration Program at the Department of Surgery-Melbourne University, branch of the large Advanced Limb Regeneration (ALR) Program, directed by Prof Peter Choong.
She is a senior biologist involved in the in vitro and in vivo studies in the laboratory for the execution of the "Next generation of Bioprinting for cartilage regeneration" project. She's also involved in article and grants writing, PhD and student supervision, and research official presentations.
The Cartilage regeneration program is centred on the use of advanced 3D printing technologies, including surgical 3D printing and stem cells, for the regeneration of healthy articular cartilage both in vitro and in vivo.
She is specialized in
• human stem cells isolation, characterizations and differentiation in osteochondral lineage;
• 3D bioprinting and cultivation of samples for cartilage tissue regeneration;
• imaging techniques for epifluorescence, confocal and time-lapse microscopy, FRET, TIRF, Light-Sheet Microscopy.
Find out more about Serena Duchi's experience
Serena Duchi's highlights
Serena Duchi's selected work
Biofabrication of human articular cartilage: a path towards the development of a clinical ..
Concise review: Human articular cartilage repair: Sources and detection of cytotoxicity an..
Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl,..
Displaying the 39 most recent scholarly works by Serena Duchi.
Concise review: Human articular cartilage repair: Sources and detection of cytotoxicity and genotoxicity in photo-crosslinkable hydrogel bioscaffolds
Cheryl Lee, Cathal D O'Connell, Carmine Onofrillo, Peter FM Choong, Claudia Di Bella, Serena Duchi
Journal article | 2019 | STEM CELLS Translational Medicine
Three-dimensional biofabrication using photo-crosslinkable hydrogel bioscaffolds has the potential to revolutionize the need for t..
Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl
Cathal D O'Connell, Carmine Onofrillo, Serena Duchi, Xin Li, Yifan Zhang, Peilin Tian, Lanyita Lu, Anna Trengove, Anita Quigley, Sanjeev Gambhir, Afsaneh Khansari, Tajanka Mladenovska, Andrea O'Connor, Claudia Di Bella, Peter F Choong, Gordon G Wallace
Journal article | 2019 | Biofabrication
Reliable and scalable sterilisation of hydrogels is critical to the clinical translation of many biofabrication approaches, such a..
Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma.
Elisa Martella, Claudia Ferroni, Andrea Guerrini, Marco Ballestri, Marta Columbaro, Spartaco Santi, Giovanna Sotgiu, Massimo Serra, Davide Maria Donati, Enrico Lucarelli, Greta Varchi, Serena Duchi
Journal article | 2018 | International Journal of Molecular Sciences
Osteosarcoma therapy might be moving toward nanotechnology-based drug delivery systems to reduce the cytotoxicity of antineoplasti..
Design, Fabrication and Validation of a Precursor Pulsed Electromagnetic Field Device for Bone Fracture Repair.
Christian Daish, Romane Blanchard, Serena Duchi, Carmine Onofrillo, Cheryl Augustine, Kate Fox, Peter Pivonka, Elena Pirogova
Journal article | 2018 | 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Pulsed electromagnetic field (PEMF) stimulation has been utilized in the medical field since the early 20th century. A number of t..
Tailoring the mechanical properties of gelatin methacryloyl hydrogels through manipulation of the photocrosslinking conditions
Cathal D O'Connell, Binbin Zhang, Carmine Onofrillo, Serena Duchi, Romane Blanchard, Anita Quigley, Justin Bourke, Sanjeev Gambhir, Robert Kapsa, Claudia Di Bella, Peter Choong, Gordon G Wallace
Journal article | 2018 | Soft Matter
In situ handheld three-dimensional bioprinting for cartilage regeneration
Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Zhilian Yue, Fletcher Thompson, Christopher Richards, Stephen Beirne, Carmine Onofrillo, Sebastien H Bauquier, Stewart D Ryan, Peter Pivonka, Gordon G Wallace, Peter F Choong
Journal article | 2018 | Journal of Tissue Engineering and Regenerative Medicine
Evidence for a novel function of Awd in maintenance of genomic stability.
Patrizia Romani, Serena Duchi, Giuseppe Gargiulo, Valeria Cavaliere
Journal article | 2017 | Scientific Reports
The abnormal wing discs (awd) gene encodes the Drosophila homolog of NME1/NME2 metastasis suppressor genes. Awd acts in multiple t..
A new holistic 3D non-invasive analysis of cellular distribution and motility on fibroin-alginate microcarriers using light sheet fluorescent microscopy
Serena Duchi, Filippo Piccinini, Michela Pierini, Alessandro Bevilacqua, Maria Luisa Torre, Enrico Lucarelli, Spartaco Santi
Journal article | 2017 | PLOS ONE
Handheld Co-Axial Bioprinting: Application to in situ surgical cartilage repair
Serena Duchi, Carmine Onofrillo, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Anita F Quigley, Robert MI Kapsa, Peter Pivonka, Gordon Wallace, Claudia Di Bella, Peter FM Choong
Journal article | 2017 | Scientific Reports
When size matters: differences in demineralized bone matrix particles affect collagen structure, mesenchymal stem cell behavior, and osteogenic potential
B Dozza, IG Lesci, S Duchi, E Della Bella, L Martini, F Salamanna, M Falconi, S Cinotti, M Fini, E Lucarelli, D Donati
Journal article | 2017 | Journal of Biomedical Materials Research Part A
Development of near-infrared photoactivable phthalocyanine-loaded nanoparticles to kill tumor cells: An improved tool for photodynamic therapy of solid cancers
Serena Duchi, Sara Ramos-Romero, Barbara Dozza, Marta Guerra-Rebollo, Luca Cattini, Marco Ballestri, Paolo Dambruoso, Andrea Guerrini, Giovanna Sotgiu, Greta Varchi, Enrico Lucarelli, Jeronimo Blanco
Journal article | 2016 | Nanomedicine: Nanotechnology, Biology and Medicine
Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel-coated OSPROLIFE(®) HA/TTCP granules and bone marrow concentrate.
Michela Pierini, Enrico Lucarelli, Serena Duchi, Susanna Prosperi, Eleonora Preve, Marzio Piccinini, Francesco Bucciotti, Davide Donati
Journal article | 2016 | Journal of Biomedical Materials Research Part B: Applied Biomaterials
The purpose of this study was to examine the in vitro cytocompatibility of a novel injectable multiphasic bone substitute (MBS) ba..
In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients
Enrico Lucarelli, Chiara Bellotti, Melissa Mantelli, Maria Antonietta Avanzini, Rita Maccario, Francesca Novara, Giulia Arrigo, Orsetta Zuffardi, Monia Zuntini, Martina Pandolfi, Luca Sangiorgi, Daniela Lisini, Davide Donati, Serena Duchi
Journal article | 2014 | Journal of Translational Medicine
Pharmacologic inhibition of vacuolar H ATPase reduces physiologic and oncogenic Notch signaling.
Francis Kobia, Serena Duchi, Gianluca Deflorian, Thomas Vaccari
Journal article | 2014 | Molecular Oncology
Notch signaling in prominently involved in growth regulation in metazoan tissues. Because of this, Notch is often upregulated in c..
Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23
Marilena Ignesti, Marilena Barraco, Gouthami Nallamothu, Julie A Woolworth, Serena Duchi, Giuseppe Gargiulo, Valeria Cavaliere, Tien Hsu
Journal article | 2014 | BMC Biology
Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma
S Duchi, G Sotgiu, E Lucarelli, M Ballestri, B Dozza, S Santi, A Guerrini, P Dambruoso, S Giannini, D Donati, C Ferroni, G Varchi
Journal article | 2013 | Journal of Controlled Release
Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells
Zrinka Bulj, Serena Duchi, Alessandro Bevilacqua, Alessandro Gherardi, Barbara Dozza, Filippo Piccinini, Giulia Adalgisa Mariani, Enrico Lucarelli, Sandro Giannini, Davide Donati, Sandra Marmiroli
Journal article | 2013 | International Journal of Oncology
Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene
Damiano Porcelli, Marta Oliva, Serena Duchi, Dominga Latorre, Valeria Cavaliere, Paolo Barsanti, Gaetano Villani, Giuseppe Gargiulo, Corrado Caggese
Journal article | 2010 | Mitochondrion
The impact on microtubule network of a bracovirus I kappa B-like protein
Serena Duchi, Valeria Cavaliere, Luca Fagnocchi, Maria Rosaria Grimaldi, Patrizia Falabella, Franco Graziani, Silvia Gigliotti, Francesco Pennacchio, Giuseppe Gargiulo
Journal article | 2010 | Cellular and Molecular Life Sciences
Honours, Awards and Fellowships
Minor Infrastructure Funding Scheme 2017 (Melbourne Medical School), 12k AUD
Research Endowment Fund, St.Vincent Hospital-Melbourne, 20k AUD
My First AIRC Grant 2015, 176k €, AIRC Italian Association for Cancer Research (Italy),
AIRC/FIRC fellowship, 60k €
Surgery - St Vincent'S Hospital
National Research Council, Institute Of Organic Synthesis And Photoreactivity, Bologna-Italy
Australasian Society For Biomaterials And Tissue Engineering, Https://Www.Asbte.Org/
Centre Of Excellence For Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, University Of Wollongong
Italian Digital Biomanufacturing Network, Http://Idbn.Org
Italian Group Mesenchymal Stem Cells, Http://Www.Gismonline.It/Index.Php
University of Bologna
University of Bologna
Qualification as a Professional Biologist
University of Bologna
University of Bologna