Fernando Fonseca Guimaraes

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

Sarah S Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-Leon, Patrick M Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington, Wei Shi, Daniel T Utzschneider, Axel Kallies

Journal article  |  2021  |  IMMUNITY

Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exha..

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  JOURNAL OF THORACIC ONCOLOGY

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

JEM regrets that in the original version of this paper, Fernando Souza-Fonseca-Guimaraes's name was mistakenly written as "Fernand..

NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS

Rebecca B Delconte, Geoffrey Guittard, Wilford Goh, Soroor Hediyeh-Zadeh, Robert J Hennessy, Jai Rautela, Melissa J Davis, Fernando Souza-Fonseca-Guimaraes, Jacques A Nunes, Nicholas D Huntington

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Natural killer (NK) cell activation is controlled by a balance of activating and inhibitory signals and cytokines such as IL-15. W..

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

Jai Rautela, Laura F Dagley, Tobias Kratina, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Rebecca B Delconte, Andrew I Webb, Ngaire Elwood, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Lynn Corcoran, Nicholas D Huntington

Journal article  |  2019  |  MOLECULAR IMMUNOLOGY

NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually express..

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Jai Rautela, Laura F Dagley, Carolina C de Oliveira, Iona S Schuster, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Joseph Cursons, Robert Hennessy, Dana S Hutchinson, Craig Harrison, Badia Kita, Eric Vivier, Andrew I Webb, Mariapia A Degli-Esposti, Melissa J Davis, Nicholas D Huntington, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2019  |  SCIENCE SIGNALING

Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metasta..

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Amania A Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C Duckworth, Nicholas D Huntington, James J Moon, Marc Pellegrini, Stephen L Nutt, Gabrielle T Belz, Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2019  |  CELL REPORTS

Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In vira..