Fernando Fonseca Guimaraes

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

Jai Rautela, Laura F Dagley, Tobias Kratina, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Rebecca B Delconte, Andrew I Webb, Ngaire Elwood, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Lynn Corcoran, Nicholas D Huntington

Journal article  |  2019  |  Molecular Immunology

NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually express..

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Jai Rautela, Laura F Dagley, Carolina C de Oliveira, Iona S Schuster, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Joseph Cursons, Robert Hennessy, Dana S Hutchinson, Craig Harrison, Badia Kita, Eric Vivier, Andrew I Webb, Mariapia A Degli-Esposti, Melissa J Davis, Nicholas D Huntington, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2019  |  Science Signaling

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Amania A Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C Duckworth, Nicholas D Huntington, James J Moon, Marc Pellegrini, Stephen L Nutt, Gabrielle T Belz, Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2019  |  Cell Reports

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington

Journal article  |  2019  |  Cell Death & Differentiation

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..

A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients

Joseph Cursons, Fernando Souza-Fonseca-Guimaraes, Momeneh Foroutan, Ashley Anderson, Frederic HoHande, Soroor Hediyeh-Zadeh, Andreas Behren, Nicholas D Huntington, Melissa J Davis

Journal article  |  2019  |  Cancer Immunology Research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF-beta

Lachlan P Healy, Gustavo P Rossi, Jai Rautela, Charlotte A Slade, Nicholas D Huntington, Ingrid M Winship, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2019  |  Frontiers in Immunology

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy

Emily J Lelliott, Carleen Cullinane, Claire A Martin, Rachael Walker, Kelly M Ramsbottom, Fernando Souza-Fonseca-Guimaraes, Shatha Abuhammad, Jessica Michie, Laura Kirby, Richard J Young, Alison Slater, Peter Lau, Katrina Meeth, Jane Oliaro, Nicole Haynes, Grant A McArthur, Karen E Sheppard

Journal article  |  2019  |  Scientific Reports

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Nicholas D Huntington

Journal article  |  2019  |  Trends in Immunology

Biomarker cruises in sepsis: who is the CAPTAIN? Discussion on "Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study".

George Briassoulis, Panagiotis Briassoulis, Marianna Miliaraki, Stavroula Ilia, Marianna Parlato, François Philippart, Alexandra Rouquette, Virginie Moucadel, Jean-Marc Cavaillon, Benoît Misset, undefined Combined Approach for The eArly diagnosis of INfection in sepsis (CAPTAIN) study group

Journal article  |  2019  |  Intensive Care Medicine

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.

Journal article  |  2018  |  Nature Communications

Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study.

Marianna Parlato, François Philippart, Alexandra Rouquette, Virginie Moucadel, Virginie Puchois, Sophie Blein, Jean-Pierre Bedos, Jean-Luc Diehl, Olfa Hamzaoui, Djillali Annane, Didier Journois, Myriam Ben Boutieb, Laurent Estève, Catherine Fitting, Jean-Marc Treluyer, Alexandre Pachot, Minou Adib-Conquy, Jean-Marc Cavaillon, Benoît Misset, undefined Captain Study Group

Journal article  |  2018  |  Intensive Care Medicine

PURPOSE: Sepsis and non-septic systemic inflammatory response syndrome (SIRS) are the same syndromes, differing by their cause, se..

Molecular insight into targeting the NK cell immune response to cancer

Jai Rautela, Fernando Souza-Fonseca-Guimaraes, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Melissa J Davis, Nicholas D Huntington

Journal article  |  2018  |  Immunology and Cell Biology

A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment

Arabella Young, Shin Foong Ngiow, Yulong Gao, Ann-Marie Patch, Deborah S Barkauskas, Meriem Messaoudene, Gene Lin, Jerome D Coudert, Kimberley A Stannard, Laurence Zitvogel, Mariapia A Degli-Esposti, Eric Vivier, Nicola Waddell, Joel Linden, Nicholas D Huntington, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth

Journal article  |  2018  |  Cancer Research

Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection

Susanna S Ng, Fernando Souza-Fonseca-Guimaraes, Fabian de Labastida Rivera, Fiona H Amante, Rajiv Kumar, Yulong Gao, Meru Sheel, Lynette Beattie, Marcela Montes de Oca, Camille Guillerey, Chelsea L Edwards, Rebecca J Faleiro, Teija Frame, Patrick T Bunn, Eric Vivier, Dale I Godfrey, Daniel G Pellicci, J Alejandro Lopez, Katherine T Andrews, Nicholas D Huntington, et al.

Journal article  |  2018  |  Clinical & Translational Immunology

A new checkpoint for Natural Killer cell activation

Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington

Journal article  |  2018  |  Immunology and Cell Biology

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel-, Michele WL Teng, Gabrielle T Belz, Christian R Engwerda, et al.

Journal article  |  2017  |  Nature Immunology

NK cell heparanase controls tumor invasion and immune surveillance.

Eva M Putz, Alyce J Mayfosh, Kevin Kos, Deborah S Barkauskas, Kyohei Nakamura, Liam Town, Katharine J Goodall, Dean Y Yee, Ivan Kh Poon, Nikola Baschuk, Fernando Souza-Fonseca-Guimaraes, Mark D Hulett, Mark J Smyth

Journal article  |  2017  |  Journal of Clinical Investigation

NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have..

Bench to bedside: NK cells and control of metastasis.

Yelena Krasnova, Eva Maria Putz, Mark J Smyth, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2017  |  Clinical Immunology

Natural killer (NK) cells play a critical role in host immune responses against tumor growth and metastasis. The numerous mechanis..

Natural Killer Cell Assessment in Peripheral Circulation and Bronchoalveolar Lavage Fluid of Patients with Severe Sepsis: A Case Control Study.

Paulo Souza-Fonseca-Guimaraes, Fernando Guimaraes, Caroline Natânia De Souza-Araujo, Lidiane Maria Boldrini Leite, Alexandra Cristina Senegaglia, Anita Nishiyama, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2017  |  International Journal of Molecular Sciences

Sepsis is a complex systemic inflammatory syndrome, the most common cause of which is attributed to systemic underlying bacterial ..

Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T(H)1/T-FH fate bifurcation in malaria

Tapio Lonnberg, Valentine Svensson, Kylie R James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan SF Soon, Lily G Fogg, Arya Sheela Nair, Urijah N Liligeto, Michael JT Stubbington, Lam-Ha Ly, Frederik Otzen Bagger, Max Zwiessele, Neil D Lawrence, Fernando Souza-Fonseca-Guimaraes, Patrick T Bunn, Christian R Engwerda, William R Heath, Oliver Billker, et al.

Journal article  |  2017  |  Science Immunology

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Mark D Bunting, Antiopi Varelias, Fernando Souza-Fonseca-Guimaraes, Iona S Schuster, Katie E Lineburg, Rachel D Kuns, Peter Fleming, Kelly R Locke, Nicholas D Huntington, Bruce R Blazar, Steven W Lane, Siok-Keen Tey, Kelli PA MacDonald, Mark J Smyth, Mariapia A Degli-Esposti, Geoffrey R Hill

Journal article  |  2017  |  Blood

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Charlotte Viant, Sophie Guia, Robert J Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T Belz, Benjamin T Kile, Andreas Strasser, Daniel Gray, Phillip D Hodgkin, Bruce Beutler, Eric Vivier, et al.

Journal article  |  2017  |  The Journal of Experimental Medicine

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection

Ismail Sebina, Kylie R James, Megan SF Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque

Journal article  |  2016  |  PLOS Pathogens

Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many ..

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Laetitia Le Texier, Katie E Lineburg, Benjamin Cao, Cameron McDonald-Hyman, Lucie Leveque-El Mouttie, Jemma Nicholls, Michelle Melino, Blessy C Nalkurthi, Kylie A Alexander, Bianca Teal, Stephen J Blake, Fernando Souza-Fonseca-Guimaraes, Christian R Engwerda, Rachel D Kuns, Steven W Lane, Michele Teng, Charis Teh, Daniel Gray, Andrew D Clouston, Susan K Nilsson, et al.

Journal article  |  2016  |  JCI Insight

Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity

F Souza-Fonseca-Guimaraes, SJ Blake, A Makkouk, C Chester, HE Kohrt, MJ Smyth

Journal article  |  2016  |  OncoImmunology

Granzyme M has a critical role in providing innate immune protection in ulcerative colitis

F Souza-Fonseca-Guimaraes, Y Krasnova, T Putoczki, K Miles, KP MacDonald, L Town, W Shi, GC Gobe, L McDade, LA Mielke, H Tye, SL Masters, GT Belz, ND Huntington, G Radford-Smith, MJ Smyth

Journal article  |  2016  |  Cell Death & Disease

NK cell-based immunotherapies: awakening the innate anti-cancer response.

Fernando Souza-Fonseca-Guimaraes

Journal article  |  2016  |  Discovery Medicine

Metastasis is the leading cause of cancer-related death, as effective therapies remain an unsolved challenge in the clinical manag..

Pravastatin induces cell cycle arrest and decreased production of VEGF and bFGF in multiple myeloma cell line.

PJJ Trojan, MS Bohatch-Junior, MF Otuki, F Souza-Fonseca-Guimarães, PV Svidnicki, V Nogaroto, D Fernandes, EA Krum, GM Favero

Journal article  |  2016  |  Brazilian Journal of Biology

Multiple myeloma (MM) is a B cell bone marrow neoplasia characterized by inflammation with an intense secretion of growth factors ..

IFN type III: in vivo NK cell response.

Fernando Souza-Fonseca-Guimaraes, Arabella Young, Mark J Smyth

Journal article  |  2015  |  Oncotarget

NK cells require IL-28R for optimal in vivo activity.

Fernando Souza-Fonseca-Guimaraes, Arabella Young, Deepak Mittal, Ludovic Martinet, Claudia Bruedigam, Kazuyoshi Takeda, Christopher E Andoniou, Mariapia A Degli-Esposti, Geoffrey R Hill, Mark J Smyth

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Natural killer (NK) cells are naturally circulating innate lymphoid cells that protect against tumor initiation and metastasis and..

DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation

Ludovic Martinet, Lucas Ferrari De Andrade, Camille Guillerey, Jason S Lee, Jing Liu, Fernando Souza-Fonseca-Guimaraes, Dana S Hutchinson, Tatiana B Kolesnik, Sandra E Nicholson, Nicholas D Huntington, Mark J Smyth

Journal article  |  2015  |  Cell Reports

CD3(bright) signals on gamma delta T cells identify IL-17A-producing V gamma 6V delta 1( ) T cells

C Paget, MT Chow, NA Gherardin, PA Beavis, AP Uldrich, H Duret, M Hassane, F Souza-Fonseca-Guimaraes, DA Mogilenko, D Staumont-Salle, NK Escalante, GR Hill, P Neeson, DS Ritchie, D Dombrowicz, T Mallevaey, F Trottein, GT Belz, DI Godfrey, MJ Smyth

Journal article  |  2015  |  Immunology and Cell Biology

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

Priyanka Sathe, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J Vandenberg, Lucille C Rankin, Lisa A Mielke, Ingela Vikstrom, Tatiana B Kolesnik, Sandra E Nicholson, Eric Vivier, Mark J Smyth, Stephen L Nutt, Stefan P Glaser, Andreas Strasser, Gabrielle T Belz, Sebastian Carotta, Nicholas D Huntington

Journal article  |  2014  |  Nature Communications

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

Christopher J Chan, Ludovic Martinet, Susan Gilfillan, Fernando Souza-Fonseca-Guimaraes, Melvyn T Chow, Liam Town, David S Ritchie, Marco Colonna, Daniel M Andrews, Mark J Smyth

Journal article  |  2014  |  Nature Immunology

CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.

Marianna Parlato, Fernando Souza-Fonseca-Guimaraes, François Philippart, Benoît Misset, undefined Captain Study Group, Minou Adib-Conquy, Jean-Marc Cavaillon

Journal article  |  2014  |  The Journal of Immunology

Apoptosis is the most common pathway of neutrophil death under both physiological and inflammatory conditions. In this study, we d..

TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals.

Minou Adib-Conquy, Daniel Scott-Algara, Jean-Marc Cavaillon, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2014  |  Immunology and Cell Biology

Natural killer (NK) cells are important in innate immunity, first described as guardians for the detection and clearance of transf..

Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?

Fernando Souza-Fonseca-Guimaraes, Jean-Marc Cavaillon, Minou Adib-Conquy

Journal article  |  2013  |  Critical Care

Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In..

Myeloid TGF-β responsiveness promotes metastases.

Fernando Souza-Fonseca-Guimaraes, Mark J Smyth

Journal article  |  2013  |  Cancer Discovery

Tumor-induced immune suppression is a major impediment to many potentially effective cancer therapies. TGF-β has previously been d..

Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).

Fernando Souza-Fonseca-Guimaraes, Marianna Parlato, Rosane B de Oliveira, Douglas Golenbock, Katherine Fitzgerald, Irina N Shalova, Subhra K Biswas, Jean-Marc Cavaillon, Minou Adib-Conquy

Journal article  |  2013  |  Journal of Biological Chemistry

Natural killer (NK) cells are important for innate immunity in particular through the production of IFN-γ and GM-CSF. Both cytokin..

Toll-like receptors expression and interferon-γ production by NK cells in human sepsis.

Fernando Souza-Fonseca-Guimaraes, Marianna Parlato, François Philippart, Benoît Misset, Jean-Marc Cavaillon, Minou Adib-Conquy, undefined Captain study group

Journal article  |  2012  |  Critical Care

INTRODUCTION: During the course of infection, natural killer (NK) cells contribute to innate immunity by producing cytokines, part..

Brown spider (Loxosceles intermedia) venom triggers endothelial cells death by anoikis.

Jenifer Nowatzki, Reginaldo Vieira Sene, Katia Sabrina Paludo, Luiz Eduardo Rizzo, Fernando Souza-Fonseca-Guimarães, Silvio Sanches Veiga, Helena Bonciani Nader, Célia Regina C Franco, Edvaldo S Trindade

Journal article  |  2012  |  Toxicon

Brown spider (Loxosceles sp.) venom affects the endothelium of vessels and triggers disruptive activity in the subendothelial matr..

NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.

Fernando Souza-Fonseca-Guimaraes, Marianna Parlato, Catherine Fitting, Jean-Marc Cavaillon, Minou Adib-Conquy

Journal article  |  2012  |  The Journal of Immunology

As sensors of infection, innate immune cells are able to recognize pathogen-associated molecular patterns by receptors such as TLR..

Natural killer (NK) cells in antibacterial innate immunity: angels or devils?

Fernando Souza-Fonseca-Guimaraes, Minou Adib-Conquy, Jean-Marc Cavaillon

Journal article  |  2012  |  Molecular Medicine

Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells and soon after were reported to ki..

Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes.

Laryssa K Rauh, Cíntia DS Horinouchi, Alliete MV Loddi, Evelise F Pietrovski, Rosalina Neris, Fernando Souza-Fonseca-Guimarães, Dorly F Buchi, Maique W Biavatti, Michel F Otuki, Daniela A Cabrini

Journal article  |  2011  |  Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Vernonia scorpioides (Asteraceae) is a native Brazilian medicinal plant that is commonly used to t..