John Fazakerley

In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance

Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Divya Narayanan, Nagaraj Moily, Hayley A McQuilten, Sandra E Nicholson, John K Fazakerley

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

Central nervous system virus infections are a major cause of morbidity and mortality worldwide and a significant global public hea..

Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection

Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Sandra E Nicholson, John K Fazakerley

Journal article  |  2022  |  VIRUSES-BASEL

CNS viral infections are one of the major causes of morbidity and mortality worldwide and a significant global public health conce..

Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections

Divya Narayanan, Nagaraj Moily, Hayley A McQuilten, Katherine Kedzierska, Jason M Mackenzie, Lukasz Kedzierski, John K Fazakerley

Journal article  |  2022  |  JOURNAL OF INNATE IMMUNITY

Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, innate a..

Superinfection Exclusion in Mosquitoes and Its Potential as an Arbovirus Control Strategy

Mathilde Laureti, Prasad N Paradkar, John K Fazakerley, Julio Rodriguez-Andres

Journal article  |  2020  |  Viruses

The continuing emergence of arbovirus disease outbreaks around the world, despite the use of vector control strategies, warrants t..

Implications of vertical transmission of Alphaviruses in Aedes aegypti mosquitoes

Julio Rodriguez, John Fazakerley

Journal article  |  2019  |  Access Microbiology

Suppressors of cytokine signalling SOCS4 and SOCS5 as controllers of neuroinflammation during viral encephalitis

L Kedzierski, Er Qi A Tan, S Nicholson, J Fazakerley

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Flavivirus Receptors: Diversity, Identity, and Cell Entry

Mathilde Laureti, Divya Narayanan, Julio Rodriguez-Andres, John K Fazakerley, Lukasz Kedzierski

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide...

Following Acute Encephalitis, Semliki Forest Virus is Undetectable in the Brain by Infectivity Assays but Functional Virus RNA Capable of Generating Infectious Virus Persists for Life

Rennos Fragkoudis, Catherine M Dixon-Ballany, Adrian K Zagrajek, Lukasz Kedzierski, John K Fazakerley

Journal article  |  2018  |  VIRUSES-BASEL

Alphaviruses are mosquito-transmitted RNA viruses which generally cause acute disease including mild febrile illness, rash, arthra..

Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import.

Susan C Jacobs, Adam Taylor, Lara J Herrero, Suresh Mahalingam, John K Fazakerley

Journal article  |  2017  |  Viruses

Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV i..

Microscopic Visualisation of Zoonotic Arbovirus Replication in Tick Cell and Organ Cultures Using Semliki Forest Virus Reporter Systems.

Lesley Bell-Sakyi, Sabine Weisheit, Claudia Rückert, Gerald Barry, John Fazakerley, Rennos Fragkoudis

Journal article  |  2016  |  Vet Sci

Ticks are vectors and reservoirs of many arboviruses pathogenic for humans or domestic animals; in addition, during bloodfeeding t..