Margaret Lee

Biology and Clinical Implications of Fecal Occult Blood Test Screen-Detected Colorectal Cancer

Shehara Mendis, Wei Hong, Sumitra Ananda, Ian Faragher, Ian Jones, Matthew Croxford, Malcolm Steel, Azim Jalali, Grace Gard, Yat Hang To, Margaret Lee, Suzanne Kosmider, Rachel Wong, Jeanne Tie, Peter Gibbs

Journal article  |  2022  |  JNCI CANCER SPECTRUM

BACKGROUND: Fecal occult blood test (FOBT)-based screening for colorectal cancer (CRC) reduces mortality, with earlier stage at di..

Use and outcomes of chemotherapy for metastatic pancreatic cancer in Australia

Amy Body, Rachel Wong, Jeremy Shapiro, Azim Jalali, Sue-Anne McLachlan, Sumitra Ananda, Lara Lipton, Prasad Cooray, Peter Gibbs, Belinda Lee, Margaret Lee

Journal article  |  2022  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Metastatic pancreatic ductal adenocarcinoma (mPDAC) is highly lethal. Combination chemotherapy regimens improve overal..

Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestine

Yumiko Hirokawa, Jordan Clarke, Michelle Palmieri, Tao Tan, Dmitri Mouradov, Shan Li, Cong Lin, Fuqiang Li, Huijuan Luo, Kui Wu, Maree Faux, Chin Wee Tan, Margaret Lee, Grace Gard, Peter Gibbs, Antony W Burgess, Oliver M Sieber

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Cell embedment into a solid support matrix is considered essential for the culture of intestinal epithelial organoids and tumoroid..

Real-world outcomes for neoadjuvant capecitabine versus infusional 5-fluorouracil in the treatment of locally advanced rectal cancer

Matthew Loft, Hui-Li Wong, Suzanne Kosmider, Margaret Lee, Jeanne Tie, Rachel Wong, Ian T Jones, Matthew Croxford, Malcolm Steel, Ian Faragher, Mario Guerrieri, Michael Christie, Peter Gibbs

Journal article  |  2021  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Neoadjuvant chemoradiation therapy is standard-of-care treatment for locally advanced rectal cancer (LARC). A patholog..

Stage dependent recurrence patterns and post-recurrence outcomes in non-metastatic colon cancer

Lucy Gately, Azim Jalali, Christine Semira, Ian Faragher, Matthew Croxford, Sumitra Ananda, Suzanne Kosmider, Kathryn Field, Sheau Wen Lok, Grace Gard, Malcolm Steel, Margaret Lee, Rachel Wong, Hui-Li Wong, Peter Gibbs

Journal article  |  2021  |  ACTA ONCOLOGICA

BACKGROUND: Multiple meta-analyses have demonstrated that routine surveillance following colorectal cancer surgery improves surviv..

Circulating Tumour DNA as a Potential Cost-Effective Biomarker to Reduce Adjuvant Chemotherapy Overtreatment in Stage II Colorectal Cancer

Yat Hang To, Koen Degeling, Suzanne Kosmider, Rachel Wong, Margaret Lee, Catherine Dunn, Grace Gard, Azim Jalali, Vanessa Wong, Maarten IJzerman, Peter Gibbs, Jeanne Tie

Journal article  |  2021  |  PHARMACOECONOMICS

BACKGROUND AND OBJECTIVE: Substantial adjuvant chemotherapy (AC) overtreatment for stage II colorectal cancer results in a health ..

Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer

Siavash Foroughi, Ryan A Hutchinson, Hui-li Wong, Michael Christie, Ahida Batrouney, Rachel Wong, Margaret Lee, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs

Journal article  |  2021  |  GROWTH FACTORS

For patients with metastatic colorectal cancer (mCRC), epidermal growth factor receptor (EGFR) inhibitors are limited to patients ..

Real-World Treatment and Outcomes of Metastatic Colorectal Cancer Patients With a Poor or Very Poor Performance Status

Avraham Travers, Azim Jalali, Stephen Begbie, Christine Semira, Suzanne Kosmider, Sumitra Ananda, Rachel Wong, Margaret Lee, Jeremy Shapiro, Matthew Burge, Desmond Yip, Javier Torres, Brigette Ma, Louise Nott, Andrew Dean, Jeanne Tie, Adnan Khattak, Stephanie Lim, Hui-li Wong, Peter Gibbs

Journal article  |  2021  |  CLINICAL COLORECTAL CANCER

BACKGROUND: The management of metastatic colorectal cancer patients with a poor performance status (PS) continues to be a clinical..

The effect of smoking, obesity and diabetes on recurrence-free and overall survival in patients with stage III colon cancer receiving adjuvant chemotherapy

Alex Croese, Richard Gartrell, Richard Hiscock, Margaret Lee, Peter Gibbs, Ian Faragher, Justin Yeung

Journal article  |  2021  |  CANCER REPORTS

BACKGROUND: The association between smoking, diabetes and obesity and oncological outcomes in patients with stage III colon cancer..

Metastasectomy and BRAF mutation; an analysis of survival outcome in metastatic colorectal cancer

Thiru Prasanna, Rachel Wong, Timothy Price, Jeremy Shapiro, Jeanne Tie, Hui-Li Wong, Louise Nott, David Roder, Margaret Lee, Suzanne Kosmider, Azim Jalali, Matthew Burge, Robert Padbury, Guy Maddern, Scott Carruthers, James Moore, Michael Sorich, Christos S Karapetis, Peter Gibbs, Desmond Yip

Journal article  |  2021  |  CURRENT PROBLEMS IN CANCER

BACKGROUND: Resection of oligometastases improves survival in metastatic colorectal cancer (mCRC). It is unclear whether the benef..