Margaret Lee

Real-world outcomes for neoadjuvant capecitabine versus infusional 5-fluorouracil in the treatment of locally advanced rectal cancer

Matthew Loft, Hui-Li Wong, Suzanne Kosmider, Margaret Lee, Jeanne Tie, Rachel Wong, Ian T Jones, Matthew Croxford, Malcolm Steel, Ian Faragher, Mario Guerrieri, Michael Christie, Peter Gibbs

Journal article  |  2021  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Neoadjuvant chemoradiation therapy is standard-of-care treatment for locally advanced rectal cancer (LARC). A patholog..

Metastasectomy and BRAF mutation; an analysis of survival outcome in metastatic colorectal cancer

Thiru Prasanna, Rachel Wong, Timothy Price, Jeremy Shapiro, Jeanne Tie, Hui-Li Wong, Louise Nott, David Roder, Margaret Lee, Suzanne Kosmider, Azim Jalali, Matthew Burge, Robert Padbury, Guy Maddern, Scott Carruthers, James Moore, Michael Sorich, Christos S Karapetis, Peter Gibbs, Desmond Yip

Journal article  |  2021  |  CURRENT PROBLEMS IN CANCER

BACKGROUND: Resection of oligometastases improves survival in metastatic colorectal cancer (mCRC). It is unclear whether the benef..

Prognostic significance of postsurgery circulating tumorDNAin nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies

Jeanne Tie, Joshua D Cohen, Serigne N Lo, Yuxuan Wang, Lu Li, Michael Christie, Margaret Lee, Rachel Wong, Suzanne Kosmider, Iain Skinner, Hui Li Wong, Belinda Lee, Matthew E Burge, Desmond Yip, Christos S Karapetis, Timothy J Price, Niall C Tebbutt, Andrew M Haydon, Janine Ptak, Mary J Schaeffer, et al.

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CANCER

Studies in multiple solid tumor types have demonstrated the prognostic significance of ctDNA analysis after curative intent surger..

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

Ming-Jie Luo, Michelle Palmieri, Chris D Riffkin, Anuratha Sakthianandeswaren, Tirta Mario Djajawi, Yumiko Hirokawa, Victoria Shuttleworth, David H Segal, Christine A White, Duong Nhu, Guillaume Lessene, Margaret Lee, Peter Gibbs, David CS Huang, Oliver M Sieber, Jia-nan Gong

Journal article  |  2020  |  CELL DEATH & DISEASE

Novel targets are required to improve the outcomes for patients with colorectal cancers. In this regard, the selective inhibitor o..

Assessing real-world outcomes in metastatic colorectal cancer with KRAS(G12C) mutation.

Hui-Li Wong, Wanyuan Cui, Matthew Loft, Margaret Lee, Rachel Wong, Jeremy David Shapiro, Jeanne Tie, Belinda Lee, Prasad Cooray, Allan Solomon Zimet, Peter Gibbs, Benjamin J Solomon, Jayesh Desai

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

e16072 Background: The KRASG12C mutation is present in 3% of colorectal cancer and is of particular interest given the recent dev..

Real-world outcomes for neoadjuvant capecitabine versus infusional 5-fluorouracil in the treatment of locally advanced rectal cancer.

Matthew Loft, Hui-Li Wong, Suzanne Kosmider, Margaret Lee, Jeanne Tie, Rachel Wong, Ian Jones, Matthew Croxford, Malcolm Steel, Ian Faragher, Mario Guerrieri, Michael Christie, Peter Gibbs

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

e16124 Background: Neoadjuvant chemoradiation therapy (CRT) is a standard of care treatment for locally advanced rectal cancer (L..

Resection of colorectal cancer liver metastases in older patients

Seema Kumari, Christine Semira, Margaret Lee, Belinda Lee, Rachel Wong, Louise Nott, Jeremy Shapiro, Peter Gibbs

Journal article  |  2020  |  ANZ JOURNAL OF SURGERY

BACKGROUND: Colorectal cancer remains a common cancer in the western world, with liver resection being the only potentially curati..

Use and impact of perioperative chemotherapy in patients with resectable colorectal cancer metastases

Amy Body, Margaret Lee, Hui-Li Wong, Alun Pope, Azim Jalali, Jeremy David Shapiro, Suzanne Kosmider, Jeanne Tie, Frances Sarah Barnett, Gary Edward Richardson, Desmond Yip, Stephanie Hui-Su Lim, Joseph James McKendrick, Peter Gibbs, Rachel Wong

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

159 Background: There is conflicting evidence regarding benefit of perioperative chemotherapy (p-chemo) for metastatic colorectal..

Utilisation of systemic therapy options in routine treatment of metastatic colorectal cancer in Australia

Rachel Delahunty, Margaret Lee, Hui-Li Wong, Julie Johns, Joseph Mckendrick, Belinda Lee, Suzanne Kosmider, Prasad Cooray, Sumitra Ananda, Jayesh Desai, Ben Tran, Jeanne Tie, Peter Gibbs, Rachel Wong

Journal article  |  2020  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: In the treatment of metastatic colorectal cancer (mCRC), exposure to all three active cytotoxic agents, 5-fluorouracil..

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

Jeanne Tie, Joshua D Cohen, Yuxuan Wang, Michael Christie, Koen Simons, Margaret Lee, Rachel Wong, Suzanne Kosmider, Sumitra Ananda, Joseph McKendrick, Belinda Lee, Jin Hee Cho, Ian Faragher, Ian T Jones, Janine Ptak, Mary J Schaeffer, Natalie Silliman, Lisa Dobbyn, Lu Li, Cristian Tomasetti, et al.

Journal article  |  2019  |  JAMA ONCOLOGY

Importance: Adjuvant chemotherapy in patients with stage III colon cancer prevents recurrence by eradicating minimal residual dise..