Agus Salim

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Adam Alexander T Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Nature Communications

Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex mo..

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

Qin Qin Huang, Howard HF Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt, Chiea Chuen Khor, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye

Journal article  |  2020  |  Nature Communications

Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neon..

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley Bush, Gawain McColl

Journal article  |  2020  |  eLife

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis,..

Associations between grass pollen exposuresin uteroand in early life with food allergy in 12-month-old infants

Nugroho Harry Susanto, Adrian J Lowe, Agus Salim, Jennifer J Koplin, Mimi LK Tang, Noor HA Suaini, Anne-Louise Ponsonby, Katrina J Allen, Shyamali C Dharmage, Bircan Erbas

Journal article  |  2020  |  International Journal of Environmental Health Research

Birth during pollen seasons may influence food allergy risk but no study has assessed pollen exposure. Using the HealthNuts popula..

Exercise as a diagnostic and therapeutic tool for preventing cardiovascular morbidity in breast cancer patients- the BReast cancer EXercise InTervention (BREXIT) trial protocol

Stephen J Foulkes, Erin J Howden, Yoland Antill, Sherene Loi, Agus Salim, Mark J Haykowsky, Robin M Daly, Steve F Fraser, Andre La Gerche

Journal article  |  2020  |  BMC Cancer

BACKGROUND: Anthracycline chemotherapy (AC) is an efficacious (neo) adjuvant treatment for early-stage breast cancer (BCa), but is..

A systematic review of trends in all-cause mortality among people with diabetes

Lei Chen, Rakibul M Islam, Joanna Wang, Thomas R Hird, Meda E Pavkov, Edward W Gregg, Agus Salim, Maryam Tabesh, Digsu N Koye, Jessica L Harding, Julian W Sacre, Elizabeth LM Barr, Dianna J Magliano, Jonathan E Shaw

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: We examined all-cause mortality trends in people with diabetes and compared them with trends among people without..

Evaluating the efficacy and safety of GKT137831 in adults with type 1 diabetes and persistently elevated urinary albumin excretion: a statistical analysis plan

Alysha M De Livera, Anne Reutens, Mark Cooper, Merlin Thomas, Karin Jandeleit-Dahm, Jonathan E Shaw, Agus Salim

Journal article  |  2020  |  Trials

BACKGROUND: The investigational medicinal product GKT137831 is a selective inhibitor of NOX 1 and 4 isoforms of the nicotinamide a..

scClassify: sample size estimation and multiscale classification of cells using single and multiple reference

Yingxin Lin, Yue Cao, Hani Jieun Kim, Agus Salim, Terence P Speed, David M Lin, Pengyi Yang, Jean Yee Hwa Yang

Journal article  |  2020  |  Molecular Systems Biology

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Anne T Reutens, Karin Jandeleit-Dahm, Merlin Thomas, Agus Salim, Alysha M De Livera, Leon A Bach, Peter G Colman, Timothy ME Davis, Elif Ekinci, Greg Fulcher, Peter Shane Hamblin, Mark A Kotowicz, Richard J MacIsaac, Claire Morbey, David Simmons, Georgia Soldatos, Gary Wittert, Ted Wu, Mark E Cooper, Jonathan E Shaw

Journal article  |  2020  |  Contemporary Clinical Trials

PURPOSE: Kidney disease caused by type 1 diabetes can progress to end stage renal disease and can increase mortality risk. Nicotin..

Risk of Rapid Kidney Function Decline, All-Cause Mortality, and Major Cardiovascular Events in Nonalbuminuric Chronic Kidney Disease in Type 2 Diabetes

Oyunchimeg Buyadaa, Dianna J Magliano, Agus Salim, Digsu N Koye, Jonathan E Shaw

Journal article  |  2020  |  Diabetes Care

OBJECTIVE: We aimed to investigate the rate of progression of nonalbuminuric chronic kidney disease (CKD) to end-stage kidney dise..